Page last updated: 2024-10-17

3-hydroxybutyric acid and Weight Gain

3-hydroxybutyric acid has been researched along with Weight Gain in 48 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
"The incidence of obesity and type 2 diabetes mellitus (T2DM) is increasing, and new experimental models are required to investigate the diverse aspects of these polygenic diseases, which are intimately linked in terms of aetiology."5.37Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile. ( Al-Mohanna, FA; Bakheet, R; Burrows, J; Collison, KS; Inglis, A; Makhoul, NJ; Milgram, NW; Mondreal, R; Saleh, SM; Zaidi, MZ, 2011)
"We evaluated the ability of the ketogenic diet (KD) to improve thresholds to flurothyl-induced seizures in two mouse lines with Scn1a mutations: one that models Dravet syndrome (DS) and another that models genetic (generalized) epilepsy with febrile seizures plus (GEFS+)."3.77Protective effect of the ketogenic diet in Scn1a mutant mice. ( Borges, K; Catterall, WA; Dutton, SB; Escayg, A; Jumbo-Lucioni, P; Kalume, F; Sawyer, NT, 2011)
" Results also showed that the animals fed calorie-restricted high-fat diets exhibited significant ketonemia and protection from pentylenetetrazole (PTZ)-induced seizures."3.70Higher ketogenic diet ratios confer protection from seizures without neurotoxicity. ( Bough, KJ; Eagles, DA; Yao, SG, 2000)
"0% of DM) or the supply of various N-sources (urea, rape seed meal, soya bean meal, fish meal) were investigated on rumen fermentation, blood parameters, feed intake, weight gain and dry matter (DM) intake per weight gain in three individual feeding experiments with 156 growing bulls weighing between 175 and 300 kg per animal."3.68[The influence of oral niacin doses during different dietary protein levels on indexes of rumen fermentation, blood parameters and fattening performance of young bulls]. ( Flachowsky, G; Schneider, M; Wilk, H; Wolfram, D, 1993)
"The incidence of obesity and type 2 diabetes mellitus (T2DM) is increasing, and new experimental models are required to investigate the diverse aspects of these polygenic diseases, which are intimately linked in terms of aetiology."1.37Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile. ( Al-Mohanna, FA; Bakheet, R; Burrows, J; Collison, KS; Inglis, A; Makhoul, NJ; Milgram, NW; Mondreal, R; Saleh, SM; Zaidi, MZ, 2011)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.08)18.7374
1990's16 (33.33)18.2507
2000's10 (20.83)29.6817
2010's15 (31.25)24.3611
2020's6 (12.50)2.80

Authors

AuthorsStudies
Martins, C1
Nymo, S1
Coutinho, SR1
Rehfeld, JF1
Hunter, GR1
Gower, BA1
Lee, YK1
Oh, TJ1
Lee, JI1
Choi, BY1
Cho, HC1
Jang, HC1
Choi, SH1
Sternberg, F1
Leitner, J1
Aminzadeh-Gohari, S1
Weber, DD1
Sanio, P1
Koller, A1
Feichtinger, RG1
Weiss, R1
Kofler, B1
Lang, R1
Morittu, VM1
Minuti, A1
Spina, A1
Riboni, MV1
Piccioli-Cappelli, F1
Trevisi, E1
Britti, D1
Lopreiato, V1
Belanche, A1
Palma-Hidalgo, JM1
Nejjam, I1
Jiménez, E1
Martín-García, AI1
Yáñez-Ruiz, DR1
Sahagun, E1
Bachman, BB1
Kinzig, KP1
Rodríguez-Sánchez, JA1
Sanz, A1
Ferrer, J1
Casasús, I1
Wu, S1
Zhang, Y1
De Luca, F1
McCoard, S1
Heiser, A1
Lowe, K1
Molenaar, A1
MacLean, P1
Johnstone, P1
Leath, S1
Hoskin, SO1
Khan, MA1
McIntosh, AL2
Atshaves, BP2
Landrock, D1
Landrock, KK2
Martin, GG1
Storey, SM2
Kier, AB2
Schroeder, F2
Yang, B1
He, B1
Wang, SS1
Liu, JX1
Wang, JK1
Franco, M1
Contreras, C1
Place, NJ1
Bozinovic, F1
Nespolo, RF1
Schäff, CT1
Gruse, J1
Maciej, J1
Mielenz, M1
Wirthgen, E1
Hoeflich, A1
Schmicke, M1
Pfuhl, R1
Jawor, P1
Stefaniak, T1
Hammon, HM1
Schreurs, M1
van Dijk, TH1
Gerding, A1
Havinga, R1
Reijngoud, DJ1
Kuipers, F1
Tucker, AL1
Atkinson, JL1
Millman, ST1
Widowski, TM1
Kelly, AK1
McGee, M1
Crews, DH1
Sweeney, T1
Boland, TM1
Kenny, DA1
Oliveira, RA1
Narciso, CD1
Bisinotto, RS1
Perdomo, MC1
Ballou, MA1
Dreher, M1
Santos, JE1
Collison, KS1
Zaidi, MZ1
Saleh, SM1
Inglis, A1
Mondreal, R1
Makhoul, NJ1
Bakheet, R1
Burrows, J1
Milgram, NW1
Al-Mohanna, FA1
Norouzian, MA1
Valizadeh, R1
Vahmani, P1
Dutton, SB1
Sawyer, NT1
Kalume, F1
Jumbo-Lucioni, P1
Borges, K1
Catterall, WA1
Escayg, A1
Ghorbani, A1
Sadri, H1
Alizadeh, AR1
Bruckmaier, RM1
Coverdale, JA1
Tyler, HD1
Quigley, JD5
Brumm, JA1
Lesmeister, KE1
Heinrichs, AJ1
DeFrain, JM1
Hippen, AR1
Kalscheur, KF1
Jardon, PW1
Mann, GE1
Mann, SJ1
Blache, D1
Webb, R1
Gauthier, MS1
Favier, R1
Lavoie, JM1
Klotz, JL1
Heitmann, RN2
Phiri, IK1
Phiri, AM1
Harrison, LJ1
Flachowsky, G1
Wolfram, D1
Wilk, H1
Schneider, M1
Pinchasov, Y1
Elmaliah, S1
Grummer, RR1
Hoffman, PC1
Luck, ML1
Bertics, SJ1
Bernard, JK2
Tyberendt, TL1
Martin, KR1
Bianchi, PB1
Lehotay, DC1
Davis, AT1
Stunff, CL1
Bougnères, PF1
McKee, JS1
Harrison, PC1
Riskowski, GL1
Greenwood, RH1
Morrill, JL1
Titgemeyer, EC1
Kennedy, GA1
Van der Werf, JH1
Jonker, LJ1
Oldenbroek, JK1
Rho, JM1
Kim, DW1
Robbins, CA1
Anderson, GD1
Schwartzkroin, PA1
Bough, KJ1
Yao, SG1
Eagles, DA1
Abu-Elheiga, L1
Matzuk, MM1
Abo-Hashema, KA1
Wakil, SJ1
Montelongo, A1
Lasunción, MA1
Pallardo, LF1
Herrera, E1
Lynch, GP1
Elsasser, TH1
Jackson, C1
Rumsey, TS1
Camp, MJ1
Caldwell, LA1
Sinks, GD1
Goodlad, JS1
Mathers, JC1
Fegeros, K1
Papadopoulos, G1
Zervas, G1
Ziras, E1
Cafantaris, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Maternal-fetal Gradient of Free and Esterified Phytosterols in Term Human Pregnancy at Delivery[NCT03705767]68 participants (Actual)Observational2016-10-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for 3-hydroxybutyric acid and Weight Gain

ArticleYear
Age-related metabolic changes of pre-weaned Simmental calves fed whole bulk milk and ad libitum calf starter.
    Research in veterinary science, 2021, Volume: 135

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Biom

2021
Effect of weaning age on growth, mammary gland development, and immune function in Holstein Friesian calves fed conserved alfalfa (FiberStart).
    Journal of dairy science, 2019, Volume: 102, Issue:7

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Cattle; Dairying; Diet; Female; Male; Mammary Glands, A

2019
Early supplementation of starter pellets with alfalfa improves the performance of pre- and postweaning Hu lambs.
    Journal of animal science, 2015, Volume: 93, Issue:10

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Blood Urea

2015

Other Studies

45 other studies available for 3-hydroxybutyric acid and Weight Gain

ArticleYear
Association between Fat-Free Mass Loss, Changes in Appetite, and Weight Regain in Individuals with Obesity.
    The Journal of nutrition, 2023, Volume: 153, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Appetite; Ghrelin; Humans; Male; Middle Aged; Obesity; Peptide YY; Wei

2023
Complementary effects of dapagliflozin and lobeglitazone on metabolism in a diet-induced obese mouse model.
    European journal of pharmacology, 2023, Oct-15, Volume: 957

    Topics: 3-Hydroxybutyric Acid; Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Diet

2023
The Influence of Ketogenic Diets on Psoriasiform-Like Skin Inflammation.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Biopsy; Blood Glucose; Diet, Ketogenic; Disease Models, Animal; Fatt

2020
Inoculation with rumen fluid in early life as a strategy to optimize the weaning process in intensive dairy goat systems.
    Journal of dairy science, 2020, Volume: 103, Issue:6

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Animals, Newborn; Body Fluids; Butyrates; Diet; Fatty A

2020
Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021, 03-10, Volume: 31, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adiposity; Animals; Biomarkers; Blood Glucose; Corticosterone; Diet, High-Fat

2021
Influence of postweaning feeding management of beef heifers on performance and physiological profiles through rearing and first lactation.
    Domestic animal endocrinology, 2018, Volume: 65

    Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Breeding;

2018
The effect of a high-calorie diet on bone growth is mediated by the insulin receptor.
    Bone, 2019, Volume: 122

    Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Bone Development; Cell Differentiation; Cell Proliferatio

2019
Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice.
    Lipids, 2013, Volume: 48, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acyl-CoA Oxidase; Adipose Tissue; Animals; Diet, High-Fat; Eating; Fatty Acid

2013
Leptin levels, seasonality and thermal acclimation in the Microbiotherid marsupial Dromiciops gliroides: Does photoperiod play a role?
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2017, Volume: 203

    Topics: 3-Hydroxybutyric Acid; Acclimatization; Adiposity; Animals; Chile; Cholesterol; Hibernation; Leptin;

2017
Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: 3-Hydroxybutyric Acid; Acute-Phase Proteins; Animal Feed; Animal Husbandry; Animal Nutritional Physi

2016
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
    Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:10

    Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Animals; Cholesterol; Diet; Dietary Fats; Glucose Cla

2009
High dietary fat exacerbates weight gain and obesity in female liver fatty acid binding protein gene-ablated mice.
    Lipids, 2010, Volume: 45, Issue:2

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; 3-Hydroxybutyric Acid; Absorptiometry, Photon; Acyl-CoA Oxidase; A

2010
Metabolic indicators of nutritional stress are not predictive of abnormal oral behavior in piglets.
    Physiology & behavior, 2010, Jun-16, Volume: 100, Issue:4

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Behavior, Animal; Blood Glucose; Drinking; Eating;

2010
Repeatability of feed efficiency, carcass ultrasound, feeding behavior, and blood metabolic variables in finishing heifers divergently selected for residual feed intake.
    Journal of animal science, 2010, Volume: 88, Issue:10

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Husbandry; Animals; Blood Glucose; Cattle; Diet; Eating;

2010
Effects of feeding polyphenols from pomegranate extract on health, growth, nutrient digestion, and immunocompetence of calves.
    Journal of dairy science, 2010, Volume: 93, Issue:9

    Topics: 3-Hydroxybutyric Acid; Animals; Antibody Formation; Blood Glucose; Cattle; Cytokines; Diet; Digestio

2010
Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile.
    The British journal of nutrition, 2011, Volume: 106, Issue:2

    Topics: 3-Hydroxybutyric Acid; Absorptiometry, Photon; Adipokines; Adipose Tissue; Adiposity; Animals; Bioma

2011
Rumen development and growth of Balouchi lambs offered alfalfa hay pre- and post-weaning.
    Tropical animal health and production, 2011, Volume: 43, Issue:6

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet

2011
Protective effect of the ketogenic diet in Scn1a mutant mice.
    Epilepsia, 2011, Volume: 52, Issue:11

    Topics: 3-Hydroxybutyric Acid; Animals; Convulsants; Diet, Ketogenic; Disease Models, Animal; Dose-Response

2011
Performance and metabolic responses of Holstein calves to supplemental chromium in colostrum and milk.
    Journal of dairy science, 2012, Volume: 95, Issue:10

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Cattle; Cholesterol; Chromium; Colo

2012
Effect of various levels of forage and form of diet on rumen development and growth in calves.
    Journal of dairy science, 2004, Volume: 87, Issue:8

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Catt

2004
Effects of corn processing on growth characteristics, rumen development, and rumen parameters in neonatal dairy calves.
    Journal of dairy science, 2004, Volume: 87, Issue:10

    Topics: 3-Hydroxybutyric Acid; Ammonia; Animal Nutritional Physiological Phenomena; Animals; Animals, Newbor

2004
Feeding glycerol to transition dairy cows: effects on blood metabolites and lactation performance.
    Journal of dairy science, 2004, Volume: 87, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Area Under

2004
Metabolic variables and plasma leptin concentrations in dairy cows exhibiting reproductive cycle abnormalities identified through milk progesterone monitoring during the post partum period.
    Animal reproduction science, 2005, Volume: 88, Issue:3-4

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Composition; Cattle; Female; Lactation; Leptin;

2005
Time course of the development of non-alcoholic hepatic steatosis in response to high-fat diet-induced obesity in rats.
    The British journal of nutrition, 2006, Volume: 95, Issue:2

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Diet; Dietary Fats; Energy Intake; Fatty Acids, None

2006
Effects of weaning and ionophore supplementation on selected blood metabolites and growth in dairy calves.
    Journal of dairy science, 2006, Volume: 89, Issue:9

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animal Feed; Animals; Blood Glucose; Cattle; Dairying; Diet; E

2006
The serum glucose and beta-hydroxybutyrate levels in sheep with experimental Fasciola hepatica and Fasciola gigantica infection.
    Veterinary parasitology, 2007, Feb-28, Volume: 143, Issue:3-4

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Fasciola; Fasciola hepatica; Fascioliasis; gamma-Glut

2007
[The influence of oral niacin doses during different dietary protein levels on indexes of rumen fermentation, blood parameters and fattening performance of young bulls].
    Archiv fur Tierernahrung, 1993, Volume: 45, Issue:2

    Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animal Feed; Animals; Blood Glucose; Calcium; Cattle; D

1993
Broiler chick responses to anorectic agents: dietary acetic and propionic acids and the blood metabolites.
    Annals of nutrition & metabolism, 1995, Volume: 39, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetates; Alkaline Phosphatase; Animals; Appetite Depressants; Blood Glucose;

1995
Effect of prepartum and postpartum dietary energy on growth and lactation of primiparous cows.
    Journal of dairy science, 1995, Volume: 78, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Cattle; D

1995
Intake, growth, and selected blood parameters in calves fed calf starter via bucket or bottle.
    Journal of dairy science, 1994, Volume: 77, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animals; Blood Glucose; Blood Urea Nitrogen; Bottle Feedi

1994
Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats.
    The Journal of nutrition, 1996, Volume: 126, Issue:11

    Topics: 3-Hydroxybutyric Acid; Animals; Carbonates; Carnitine; Dicarboxylic Acids; Fatty Acids; Food, Fortif

1996
Alterations of plasma lactate and glucose metabolism in obese children.
    The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 1

    Topics: 3-Hydroxybutyric Acid; Blood Glucose; Calorimetry, Indirect; Carbon Isotopes; Child; Child, Preschoo

1996
Influence of weaning method on growth, intake, and selected blood metabolites in Jersey calves.
    Journal of dairy science, 1996, Volume: 79, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Blood Urea

1996
Effects of supplemental ascorbic acid on the energy conversion of broiler chicks during heat stress and feed withdrawal.
    Poultry science, 1997, Volume: 76, Issue:9

    Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Ascorbic Acid; Calorimetry; Carbon Dioxide; Ch

1997
A new method of measuring diet abrasion and its effect on the development of the forestomach.
    Journal of dairy science, 1997, Volume: 80, Issue:10

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Cattle; Chemical Phenomena; Chemistry, Physical; Diet;

1997
Effect of monensin on milk production by Holstein and Jersey cows.
    Journal of dairy science, 1998, Volume: 81, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Composition; Cattle; Female; Hydroxybutyrates; I

1998
Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet.
    Epilepsy research, 1999, Volume: 37, Issue:3

    Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Convulsants; Flurothyl; Humans; Ketone Bodies; Ketosis;

1999
Higher ketogenic diet ratios confer protection from seizures without neurotoxicity.
    Epilepsy research, 2000, Volume: 38, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Basal Metabolism; Behavior, Animal; Convulsants; Diet; Dietary Fats;

2000
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
    Science (New York, N.Y.), 2001, Mar-30, Volume: 291, Issue:5513

    Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Blood Glucose; Body Weight;

2001
Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women.
    Diabetes, 1992, Volume: 41, Issue:12

    Topics: 3-Hydroxybutyric Acid; Adult; Analysis of Variance; Apolipoproteins; Body Mass Index; Cholesterol; D

1992
Effects of nutrient source and time of feeding on changes in blood metabolites in young calves.
    Journal of animal science, 1992, Volume: 70, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Blood Glucose; Blood Urea Nitrogen; Cattle; Eating; Ene

1992
Nitrogen metabolism of lactating ewes fed rumen-protected methionine and lysine.
    Journal of dairy science, 1991, Volume: 74, Issue:7

    Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Animals, Newborn; Blood Glucose; Blood Urea Nitrogen; D

1991
Changes in blood glucose, nonesterified fatty acids, and ketones in response to weaning and feed intake in young calves.
    Journal of dairy science, 1991, Volume: 74, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animal Feed; Animals; Blood Glucose; Cattle; Eating; Fatty Aci

1991
Large bowel fermentation in rats given diets containing raw peas (Pisum sativum).
    The British journal of nutrition, 1990, Volume: 64, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Cecum; Digestion; Fabaceae; Fatty Acids, Volatile; Fermentation; Gas

1990
Effect of lasalocid sodium and molasses on performance of fattening lambs and on rumen liquor and blood parameters.
    Archiv fur Tierernahrung, 1989, Volume: 39, Issue:11

    Topics: 3-Hydroxybutyric Acid; Ammonia; Animal Feed; Animals; Eating; Eukaryota; Fatty Acids, Nonesterified;

1989