3-hydroxybutyric acid has been researched along with Stroke in 8 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ischemic stroke is a leading cause of disability worldwide." | 1.91 | Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke. ( Bernal-Vicente, BN; Gerónimo-Olvera, C; Gómora-García, JC; Heras-Romero, Y; Massieu, L; Montiel, T; Pérez-Martínez, X; Tovar-Y-Romo, LB, 2023) |
| "Stroke is one of the leading causes of disability and death." | 1.62 | Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway. ( Kang, Y; Li, Y; Ma, A; Zhang, X, 2021) |
| "Stroke is one of the leading causes of death." | 1.42 | Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke. ( Han, P; Liu, Q; Shi, J; Tang, Z; Yin, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montiel, T | 1 |
| Gómora-García, JC | 1 |
| Gerónimo-Olvera, C | 1 |
| Heras-Romero, Y | 1 |
| Bernal-Vicente, BN | 1 |
| Pérez-Martínez, X | 1 |
| Tovar-Y-Romo, LB | 1 |
| Massieu, L | 1 |
| Li, Y | 1 |
| Zhang, X | 1 |
| Ma, A | 1 |
| Kang, Y | 1 |
| Vojinovic, D | 1 |
| van der Lee, SJ | 1 |
| van Duijn, CM | 1 |
| Vernooij, MW | 1 |
| Kavousi, M | 1 |
| Amin, N | 1 |
| Demirkan, A | 1 |
| Ikram, MA | 1 |
| van der Lugt, A | 1 |
| Bos, D | 1 |
| Pikija, S | 1 |
| Trkulja, V | 1 |
| Simundic, AM | 1 |
| Vrcek, E | 1 |
| Boskovic, K | 1 |
| Bacani, S | 1 |
| Rahman, M | 1 |
| Muhammad, S | 1 |
| Khan, MA | 1 |
| Chen, H | 1 |
| Ridder, DA | 1 |
| Müller-Fielitz, H | 1 |
| Pokorná, B | 1 |
| Vollbrandt, T | 1 |
| Stölting, I | 1 |
| Nadrowitz, R | 1 |
| Okun, JG | 1 |
| Offermanns, S | 2 |
| Schwaninger, M | 2 |
| Yin, J | 1 |
| Han, P | 1 |
| Tang, Z | 1 |
| Liu, Q | 1 |
| Shi, J | 1 |
| Du Yan, S | 1 |
| Zhu, Y | 1 |
| Stern, ED | 1 |
| Hwang, YC | 1 |
| Hori, O | 1 |
| Ogawa, S | 1 |
| Frosch, MP | 1 |
| Connolly, ES | 1 |
| McTaggert, R | 1 |
| Pinsky, DJ | 1 |
| Clarke, S | 1 |
| Stern, DM | 1 |
| Ramasamy, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma[NCT05119010] | 60 participants (Anticipated) | Interventional | 2023-03-24 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3-hydroxybutyric acid and Stroke
| Article | Year |
|---|---|
Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation.
Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Diet, Ketogenic; Dimethyl | 2015 |
7 other studies available for 3-hydroxybutyric acid and Stroke
| Article | Year |
|---|---|
Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Brain Injuries; Endoplasmic Reticulum Stress; Endoribonuc | 2023 |
Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Ische | 2021 |
Metabolic profiling of intra- and extracranial carotid artery atherosclerosis.
Topics: 3-Hydroxybutyric Acid; Aged; Atherosclerosis; Calcinosis; Carotid Artery Diseases; Carotid Artery, I | 2018 |
Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Brain Ischemia; Capillaries; Diabetes Complic | 2013 |
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Diet, Ketogenic; Macrophages; Mice; Mice, Knockout; Monocytes | 2014 |
Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Ischemia; Forkhead Box | 2015 |
Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress.
Topics: 3-Hydroxybutyric Acid; Alcohol Dehydrogenase; Amyloid beta-Peptides; Animals; COS Cells; Magnetic Re | 2000 |