3-hydroxybutyric acid has been researched along with Sepsis in 12 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is a systemic inflammatory disease caused by multiple pathogens, with the most commonly affected organ being the lung." | 1.91 | 3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages. ( Dong, R; Gong, S; Huang, L; Huang, M; Jin, Y; Li, F; Li, X; Tang, X; Wang, X; Yang, H; Yu, Y; Zeng, Z, 2023) |
| "Sepsis is a major cause of acute kidney injury (AKI)." | 1.91 | β-hydroxybutyrate ameliorates sepsis-induced acute kidney injury. ( Kim, IY; Kim, MJ; Kim, SR; Kim, YS; Lee, DW; Lee, SB, 2023) |
| "Sepsis is a life-threatening condition of organ dysfunction caused by dysregulated inflammation which predisposes patients to developing cardiovascular disease." | 1.72 | Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis. ( Dyck, JRB; Ferdaoussi, M; Maayah, ZH; Martens, MD; Silver, HL; Soni, S; Takahara, S; Ussher, JR, 2022) |
| "The 'obesity paradox' of critical illness refers to better survival with a higher body mass index." | 1.46 | Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness. ( De Bock, K; Derde, S; Dufour, T; Goossens, C; Güiza, F; Hermans, G; Janssens, T; Langouche, L; Marques, MB; Thiessen, SE; Van den Berghe, G; Vander Perre, S; Vanhorebeek, I, 2017) |
| "Fatal ketoacidosis due to diabetes mellitus, alcoholism, and starvation may produce characteristic basal vacuolization of renal tubular epithelial cells (RTEC)." | 1.46 | Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization. ( Byard, RW; Zhou, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 7 (58.33) | 2.80 |
| Authors | Studies |
|---|---|
| Weckx, R | 1 |
| Goossens, C | 2 |
| Derde, S | 2 |
| Pauwels, L | 1 |
| Vander Perre, S | 2 |
| Van den Bergh, G | 1 |
| Langouche, L | 2 |
| Soni, S | 1 |
| Martens, MD | 1 |
| Takahara, S | 1 |
| Silver, HL | 1 |
| Maayah, ZH | 1 |
| Ussher, JR | 1 |
| Ferdaoussi, M | 1 |
| Dyck, JRB | 1 |
| Huang, M | 1 |
| Yu, Y | 1 |
| Tang, X | 1 |
| Dong, R | 1 |
| Li, X | 1 |
| Li, F | 1 |
| Jin, Y | 1 |
| Gong, S | 1 |
| Wang, X | 2 |
| Zeng, Z | 1 |
| Huang, L | 1 |
| Yang, H | 1 |
| Kim, MJ | 1 |
| Kim, YS | 1 |
| Kim, SR | 1 |
| Lee, DW | 1 |
| Lee, SB | 1 |
| Kim, IY | 1 |
| Song, Y | 1 |
| Chen, J | 1 |
| Zhang, S | 1 |
| Le, Y | 1 |
| Xie, Z | 1 |
| Ouyang, W | 1 |
| Tong, J | 1 |
| Soto-Mota, A | 1 |
| Norwitz, NG | 1 |
| Clarke, K | 1 |
| Ginn, C | 1 |
| Ateh, D | 1 |
| Martin, J | 1 |
| Marques, MB | 1 |
| Dufour, T | 1 |
| Thiessen, SE | 1 |
| Güiza, F | 1 |
| Janssens, T | 1 |
| Hermans, G | 1 |
| Vanhorebeek, I | 1 |
| De Bock, K | 1 |
| Van den Berghe, G | 1 |
| Zhou, C | 1 |
| Byard, RW | 1 |
| Tanaka, J | 1 |
| Kono, Y | 1 |
| Shimahara, Y | 1 |
| Sato, T | 1 |
| Jones, RT | 1 |
| Cowley, RA | 1 |
| Trump, BF | 1 |
| Beylot, M | 1 |
| Chassard, D | 1 |
| Chambrier, C | 1 |
| Guiraud, M | 1 |
| Odeon, M | 1 |
| Beaufrère, B | 1 |
| Bouletreau, P | 1 |
| Yassen, KA | 1 |
| Galley, HF | 1 |
| Lee, A | 1 |
| Webster, NR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371] | 30 participants (Anticipated) | Interventional | 2022-10-31 | Recruiting | |||
| Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293] | 18 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 3-hydroxybutyric acid and Sepsis
| Article | Year |
|---|---|
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
The use of point-of-care testing to establish cause of death in the autopsy setting.
Topics: 3-Hydroxybutyric Acid; Autopsy; Bacteria; Blood Alcohol Content; Blood Glucose; C-Reactive Protein; | 2020 |
1 trial available for 3-hydroxybutyric acid and Sepsis
| Article | Year |
|---|---|
Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation.
Topics: 3-Hydroxybutyric Acid; Aged; Aged, 80 and over; Analysis of Variance; Carbon Isotopes; Depression, C | 1994 |
9 other studies available for 3-hydroxybutyric acid and Sepsis
| Article | Year |
|---|---|
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice.
Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Aldosterone; Animals; Brain; Dietary Supplements; Dose | 2021 |
Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis.
Topics: 3-Hydroxybutyric Acid; Animals; Anti-Inflammatory Agents; Cardiovascular Diseases; Esters; Inflammat | 2022 |
3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages.
Topics: 3-Hydroxybutyric Acid; Acute Lung Injury; Animals; Autophagy; Lung; Macrophages; Mice; Sepsis; Ultra | 2023 |
β-hydroxybutyrate ameliorates sepsis-induced acute kidney injury.
Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Animals; Apoptosis; Kidney; Lipopolysaccharides; Male; M | 2023 |
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
Topics: 3-Hydroxybutyric Acid; Animals; Cognitive Dysfunction; Hippocampus; Injections, Intraventricular; In | 2020 |
Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness.
Topics: 3-Hydroxybutyric Acid; Aged; Animals; Body Composition; Critical Illness; Fasting; Fatty Acids; Fema | 2017 |
Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Epithelial Cells; Fatal Outcome; Female; Humans; Ketones; Ketosi | 2017 |
A study of oxidative phosphorylative activity and calcium-induced respiration of rat liver mitochondria following living Escherichia coli injection.
Topics: 3-Hydroxybutyric Acid; Adenosine Diphosphate; Animals; Calcium; Escherichia coli Infections; Glutama | 1982 |
Mitochondrial redox state in the critically ill.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Biomarkers; Critical Illness; Humans; Ketone Bodi | 1999 |