3-hydroxybutyric acid has been researched along with Prediabetes in 7 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute ketosis consistently does not affect both objective and subjective parameters of appetite regulation in prediabetes." | 3.30 | Effect of d-β-Hydroxybutyrate-(R)-1,3 Butanediol on Appetite Regulation in People with Prediabetes. ( Bharmal, SH; Kimita, W; Liu, Y; Petrov, MS, 2023) |
| "Acute ketosis resulted in significantly lower AUCs for remnant cholesterol (p = 0." | 3.11 | Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial. ( Bharmal, SH; Kimita, W; Liu, Y; Petrov, MS, 2022) |
| "Effects of ketone supplements as well as relevant dose-response relationships and time effects on blood β-hydroxybutyrate (BHB), glucose and insulin are controversial." | 3.01 | Effects of ketone supplements on blood β-hydroxybutyrate, glucose and insulin: A systematic review and three-level meta-analysis. ( Falkenhain, K; Kong, Z; Little, JP; Nie, J; Shi, Q; Wong, KK; Yu, Q, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 5 (71.43) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 2 |
| Bharmal, SH | 3 |
| Kimita, W | 2 |
| Petrov, MS | 3 |
| Yu, Q | 1 |
| Falkenhain, K | 1 |
| Little, JP | 1 |
| Wong, KK | 1 |
| Nie, J | 1 |
| Shi, Q | 1 |
| Kong, Z | 1 |
| Cho, J | 1 |
| Alarcon Ramos, GC | 1 |
| Ko, J | 1 |
| Cameron-Smith, D | 1 |
| McKenzie, AL | 1 |
| Athinarayanan, SJ | 1 |
| McCue, JJ | 1 |
| Adams, RN | 1 |
| Keyes, M | 1 |
| McCarter, JP | 1 |
| Volek, JS | 1 |
| Phinney, SD | 1 |
| Hallberg, SJ | 1 |
| Baudon, MA | 1 |
| Ferré, P | 1 |
| Pénicaud, L | 1 |
| Maulard, P | 1 |
| Ktorza, A | 1 |
| Castano, L | 1 |
| Girard, J | 1 |
| Diani, AR | 1 |
| Peterson, T | 1 |
| Sawada, GA | 1 |
| Wyse, BM | 1 |
| Blanks, MC | 1 |
| Gerritsen, GC | 1 |
| Terenghi, G | 1 |
| Varndell, IM | 1 |
| Polak, JM | 1 |
| Blank, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cross-over, Placebo-controlled, Randomized Trial of β-hydroxybutyrate in Prediabetes[NCT03889210] | 18 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3-hydroxybutyric acid and Prediabetes
| Article | Year |
|---|---|
Effects of ketone supplements on blood β-hydroxybutyrate, glucose and insulin: A systematic review and three-level meta-analysis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Dietary Supplements; Glucose; Humans; Insulin; Ketones; Obesit | 2023 |
4 trials available for 3-hydroxybutyric acid and Prediabetes
| Article | Year |
|---|---|
Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial.
Topics: 3-Hydroxybutyric Acid; Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; F | 2022 |
Effect of d-β-Hydroxybutyrate-(R)-1,3 Butanediol on Appetite Regulation in People with Prediabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Appetite; Appetite Regulation; Ghrelin; Humans; Ketosis; Peptide YY; P | 2023 |
Acute Nutritional Ketosis and Its Implications for Plasma Glucose and Glucoregulatory Peptides in Adults with Prediabetes: A Crossover Placebo-Controlled Randomized Trial.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Dietary Supplement | 2021 |
Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Res | 2021 |
2 other studies available for 3-hydroxybutyric acid and Prediabetes
| Article | Year |
|---|---|
Normal insulin sensitivity during the phase of glucose intolerance but insulin resistance at the onset of diabetes in the spontaneously diabetic BB rat.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Crosses, Genetic; Diabetes Mellitus, Experimental; Ep | 1989 |
Elevated levels of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic Chinese hamsters.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Cricetinae; Cricetulus; Diabetes Mellitu | 1985 |