Page last updated: 2024-10-17

3-hydroxybutyric acid and Obesity, Morbid

3-hydroxybutyric acid has been researched along with Obesity, Morbid in 4 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Obesity, Morbid: The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.

Research Excerpts

ExcerptRelevanceReference
"Three clinical studies were conducted: a bariatric surgery cohort study of participants with morbid obesity who underwent either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) studied over four and twelve weeks, and two randomized placebo-controlled, crossover double blind studies of liraglutide vs."5.69Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. ( Alexandrou, A; Angelidi, AM; Connelly, MA; Kokkinos, A; Mantzoros, CS; Mingrone, G; Sanoudou, D, 2023)
"In cancer patients with hypersplenism-related thrombocytopenia, PSAE is a safe intervention that effects a durable elevation in platelet counts across a range of malignancies and following the re-initiation of chemotherapy."2.73 ( Aasbrenn, M; Abd El-Aty, AM; Abdu, A; Abraha, HB; Achour, A; Acquaroni, M; Addeo, P; Agback, P; Agback, T; Al-Alwan, M; Al-Mazrou, A; Al-Mohanna, F; Aliste, M; Almquist, J; Andel, J; Ando, M; Angelov, A; Annuar, MSM; Antwi, K; Arroliga, AC; Arruda, SLM; Asch, SM; Averous, G; Ayaz, S; Ayer, GB; Bachellier, P; Ball, S; Banijamali, AR; Barden, TC; Bartoncini, S; Bedanie, G; Bellò, M; Benić, F; Berhe, GG; Bertiger, G; Beumer, JH; Bhandari, B; Bond, DS; Boules, M; Braüner Christensen, J; Brown-Johnson, C; Burgstaller, S; Cao, L; Capasso, C; Carlevato, R; Carvalho, AE; Ceci, F; Chagas, ATA; Chavan, SG; Chen, AP; Chen, HC; Chen, J; Chen, Q; Chen, Y; Chen, YF; Christ, ER; Chu, CW; Covey, JM; Coyne, GO'; Cristea, MC; Currie, MG; Dahdal, DN; Dai, L; Dang, Z; de Abreu, NL; de Carvalho, KMB; de la Plaza Llamas, R; Deandreis, D; Del Prete, S; Dennis, JA; Deur, J; Díaz Candelas, DA; Divyapriya, G; Djanani, A; Dodig, D; Doki, Y; Doroshow, JH; Dos Santos, RC; Durairaj, N; Dutra, ES; Eguchi, H; Eisterer, W; Ekmann, A; Elakkad, A; Evans, WE; Fan, W; Fang, Z; Faria, HP; Farris, SG; Fenoll, J; Fernandez-Botran, R; Flores, P; Fujita, J; Gan, L; Gandara, DR; Gao, X; Garcia, AA; Garrido, I; Gebru, HA; Gerger, A; Germano, P; Ghamande, S; Ghebeh, H; Giver Jensen, T; Go, A; Goichot, B; Goldwater, M; Gontero, P; Greil, R; Gruenberger, B; Guarneri, A; Guo, Y; Gupta, S; Haxholdt Lunn, T; Hayek, AJ; He, ML; Hellín, P; Hepprich, M; Hernández de Rodas, E; Hill, A; Hndeya, AG; Holdsworth, LM; Hookey, L; Howie, W; Hu, G; Huang, JD; Huang, SY; Hubmann, E; Hwang, SY; Imamura, H; Imperiale, A; Jiang, JQ; Jimenez, JL; Jin, F; Jin, H; Johnson, KL; Joseph, A; Juwara, L; Kalapothakis, E; Karami, H; Karayağiz Muslu, G; Kawabata, R; Kerwin, J; Khan, I; Khin, S; Kidanemariam, HG; Kinders, RJ; Klepov, VV; Koehler, S; Korger, M; Kovačić, S; Koyappayil, A; Kroll, MH; Kuban, J; Kummar, S; Kung, HF; Kurokawa, Y; Laengle, F; Lan, J; Leal, HG; Lee, MH; Lemos, KGE; Li, B; Li, G; Li, H; Li, X; Li, Y; Li, Z; Liebl, W; Lillaz, B; Lin, F; Lin, L; Lin, MCM; Lin, Y; Lin, YP; Lipton, RB; Liu, J; Liu, W; Liu, Z; Lu, J; Lu, LY; Lu, YJ; Ludwig, S; Luo, Y; Ma, L; Ma, W; Machado-Coelho, GLL; Mahmoodi, B; Mahoney, M; Mahvash, A; Mansour, FA; Mao, X; Marinho, CC; Masferrer, JL; Matana Kaštelan, Z; Melendez-Araújo, MS; Méndez-Chacón, E; Miletić, D; Miller, B; Miller, E; Miller, SB; Mo, L; Moazzen, M; Mohammadniaei, M; Montaz-Rosset, MS; Mousavi Khaneghah, A; Mühlethaler, K; Mukhopadhyay, S; Mulugeta, A; Nambi, IM; Navarro, S; Nazmara, S; Neumann, HJ; Newman, EM; Nguyen, HTT; Nicolato, AJPG; Nicolotti, DG; Nieva, JJ; Nilvebrant, J; Nocentini, A; Nugent, K; Nunez-Rodriguez, DL; Nygren, PÅ; Oberli, A; Oderda, M; Odisio, B; Oehler, L; Otludil, B; Overman, M; Özdemir, M; Pace, KA; Palm, H; Parchment, RE; Parise, R; Passera, R; Pavlovic, J; Pecherstorfer, M; Peng, Z; Pérez Coll, C; Petzer, A; Philipp-Abbrederis, K; Pichler, P; Piekarz, RL; Pilati, E; Pimentel, JDSM; Posch, F; Prager, G; Pressel, E; Profy, AT; Qi, P; Qi, Y; Qiu, C; Rajasekhar, B; Ramia, JM; Raynor, HA; Reis, VW; Reubi, JC; Ricardi, U; Riedl, JM; Romano, F; Rong, X; Rubinstein, L; Rumboldt, Z; Sabir, S; Safaeinili, N; Sala, BM; Sandoval Castillo, L; Sau, M; Sbhatu, DB; Schulte, T; Scott, V; Shan, H; Shao, Y; Shariatifar, N; Shaw, JG; She, Y; Shen, B; Shernyukov, A; Sheth, RA; Shi, B; Shi, R; Shum, KT; Silva, JC; Singh, A; Sinha, N; Sirajudeen, AAO; Slaven, J; Sliwa, T; Somme, F; Song, S; Steinberg, SM; Subramaniam, R; Suetta, C; Sui, Y; Sun, B; Sun, C; Sun, H; Sun, Y; Supuran, CT; Surger, M; Svartz, G; Takahashi, T; Takeno, A; Tam, AL; Tang, Z; Tanner, JA; Tannich, E; Taye, MG; Tekle, HT; Thomas, GJ; Tian, Y; Tobin, JV; Todd Milne, G; Tong, X; Une, C; Vela, N; Venkateshwaran, U; Villagrán de Tercero, CI; Wakefield, JD; Wampfler, R; Wan, M; Wang, C; Wang, J; Wang, L; Wang, S; Waser, B; Watt, RM; Wei, B; Wei, L; Weldemichael, MY; Wellmann, IA; Wen, A; Wild, D; Wilthoner, K; Winder, T; Wing, RR; Winget, M; Wöll, E; Wong, KL; Wong, KT; Wu, D; Wu, Q; Wu, Y; Xiang, T; Xiang, Z; Xu, F; Xu, L; Yamasaki, M; Yamashita, K; Yan, H; Yan, Y; Yang, C; Yang, H; Yang, J; Yang, N; Yang, Y; Yau, P; Yu, M; Yuan, Q; Zhan, S; Zhang, B; Zhang, H; Zhang, J; Zhang, N; Zhang, Y; Zhao, X; Zheng, BJ; Zheng, H; Zheng, W; Zhou, H; Zhou, X; Zhu, S; Zimmer, DP; Zionts, D; Zitella, A; Zlott, J; Zolfaghari, K; Zuo, D; Zur Loye, HC; Žuža, I, 2007)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Angelidi, AM1
Kokkinos, A1
Sanoudou, D1
Connelly, MA1
Alexandrou, A1
Mingrone, G1
Mantzoros, CS1
Yang, N1
Tanner, JA1
Zheng, BJ1
Watt, RM1
He, ML1
Lu, LY1
Jiang, JQ1
Shum, KT1
Lin, YP1
Wong, KL1
Lin, MCM1
Kung, HF1
Sun, H1
Huang, JD1
Marinho, CC1
Nicolato, AJPG1
Reis, VW1
Dos Santos, RC1
Silva, JC1
Faria, HP1
Machado-Coelho, GLL1
Sun, Y2
Zhang, N1
Wang, J2
Guo, Y1
Sun, B1
Liu, W1
Zhou, H1
Yang, C1
Wei, L1
Ball, S1
Dennis, JA1
Bedanie, G1
Nugent, K1
Hayek, AJ1
Scott, V1
Yau, P1
Zolfaghari, K1
Goldwater, M1
Almquist, J1
Arroliga, AC1
Ghamande, S1
Wu, Q1
Ma, W1
Shi, R1
Zhang, B1
Mao, X1
Zheng, W1
Sbhatu, DB1
Berhe, GG1
Hndeya, AG1
Abraha, HB1
Abdu, A1
Gebru, HA1
Taye, MG1
Mulugeta, A1
Weldemichael, MY1
Tekle, HT1
Kidanemariam, HG1
Surger, M1
Angelov, A1
Liebl, W1
Hookey, L1
Bertiger, G1
Johnson, KL1
Boules, M1
Ando, M1
Dahdal, DN1
Riedl, JM1
Posch, F1
Prager, G1
Eisterer, W1
Oehler, L1
Sliwa, T1
Wilthoner, K1
Petzer, A1
Pichler, P1
Hubmann, E1
Winder, T1
Burgstaller, S1
Korger, M1
Andel, J1
Greil, R1
Neumann, HJ1
Pecherstorfer, M1
Philipp-Abbrederis, K1
Djanani, A1
Gruenberger, B1
Laengle, F1
Wöll, E1
Gerger, A1
Evans, WE1
Raynor, HA1
Howie, W1
Lipton, RB1
Thomas, GJ1
Wing, RR1
Pavlovic, J1
Farris, SG1
Bond, DS1
Hepprich, M1
Antwi, K1
Waser, B1
Reubi, JC1
Wild, D1
Christ, ER1
Braüner Christensen, J1
Aasbrenn, M1
Sandoval Castillo, L1
Ekmann, A1
Giver Jensen, T1
Pressel, E1
Haxholdt Lunn, T1
Suetta, C1
Palm, H1
Mansour, FA1
Al-Mazrou, A1
Al-Mohanna, F1
Al-Alwan, M1
Ghebeh, H1
Brown-Johnson, C1
Safaeinili, N1
Zionts, D1
Holdsworth, LM1
Shaw, JG1
Asch, SM1
Mahoney, M1
Winget, M1
Luo, Y1
Shan, H1
Gao, X1
Qi, P1
Li, Y2
Li, B1
Rong, X1
Shen, B1
Zhang, H1
Lin, F1
Tang, Z1
Fang, Z1
Peng, Z1
Jimenez, JL1
Ayer, GB1
Klepov, VV1
Pace, KA1
Zur Loye, HC1
Acquaroni, M1
Svartz, G1
Pérez Coll, C1
Otludil, B1
Ayaz, S1
Hill, A1
Elakkad, A1
Kuban, J1
Sabir, S1
Odisio, B1
Huang, SY1
Mahvash, A1
Miller, E1
Kroll, MH1
Overman, M1
Tam, AL1
Gupta, S1
Sheth, RA1
Deandreis, D1
Guarneri, A1
Ceci, F1
Lillaz, B1
Bartoncini, S1
Oderda, M1
Nicolotti, DG1
Pilati, E1
Passera, R1
Zitella, A1
Bellò, M1
Parise, R1
Carlevato, R1
Ricardi, U1
Gontero, P1
Coyne, GO'1
Wang, L2
Zlott, J1
Juwara, L1
Covey, JM1
Beumer, JH1
Cristea, MC1
Newman, EM1
Koehler, S1
Nieva, JJ1
Garcia, AA1
Gandara, DR1
Miller, B1
Khin, S1
Miller, SB1
Steinberg, SM1
Rubinstein, L1
Parchment, RE1
Kinders, RJ1
Piekarz, RL1
Kummar, S1
Chen, AP1
Doroshow, JH1
Li, X2
Chen, J2
Gan, L1
Tian, Y1
Shi, B1
Yang, Y1
Li, G1
Wu, D1
Wen, A1
Wu, Y1
Zhou, X1
Koyappayil, A1
Chavan, SG1
Mohammadniaei, M1
Go, A1
Hwang, SY1
Lee, MH1
Kurokawa, Y1
Yamashita, K1
Kawabata, R1
Fujita, J1
Imamura, H1
Takeno, A1
Takahashi, T1
Yamasaki, M1
Eguchi, H1
Doki, Y1
Schulte, T1
Sala, BM1
Nilvebrant, J1
Nygren, PÅ1
Achour, A1
Shernyukov, A1
Agback, T1
Agback, P1
Karami, H1
Shariatifar, N1
Nazmara, S1
Moazzen, M1
Mahmoodi, B1
Mousavi Khaneghah, A1
Sinha, N1
Mukhopadhyay, S1
Sau, M1
Qi, Y1
Wan, M1
Abd El-Aty, AM1
Li, H2
Cao, L1
She, Y1
Shao, Y1
Jin, F1
Wang, S1
Melendez-Araújo, MS1
Lemos, KGE1
Arruda, SLM1
Dutra, ES1
de Carvalho, KMB1
de la Plaza Llamas, R1
Díaz Candelas, DA1
Ramia, JM1
Zhu, S1
Liu, Z1
Lu, J2
Xiang, Z1
Lan, J1
Liu, J1
Yu, M1
Chen, Y2
Sirajudeen, AAO1
Annuar, MSM1
Subramaniam, R1
Somme, F1
Montaz-Rosset, MS1
Averous, G1
Deur, J1
Goichot, B1
Bachellier, P1
Addeo, P1
Imperiale, A1
Xu, L1
Li, Z2
Song, S1
Chen, Q1
Mo, L1
Wang, C1
Fan, W1
Yan, Y1
Tong, X1
Yan, H1
Singh, A1
Chen, HC1
Chen, YF1
Lu, YJ1
Wong, KT1
Chu, CW1
Banijamali, AR1
Carvalho, AE1
Wakefield, JD1
Germano, P1
Barden, TC1
Tobin, JV1
Zimmer, DP1
Masferrer, JL1
Profy, AT1
Currie, MG1
Todd Milne, G1
Zhang, Y1
Yang, H1
Dang, Z1
Zhan, S1
Sun, C1
Hu, G1
Lin, Y1
Yuan, Q1
Karayağiz Muslu, G1
Özdemir, M1
Del Prete, S1
Nocentini, A1
Supuran, CT1
Capasso, C1
Chagas, ATA1
Ludwig, S1
Pimentel, JDSM1
de Abreu, NL1
Nunez-Rodriguez, DL1
Leal, HG1
Kalapothakis, E1
Zhang, J1
Lin, L1
Dodig, D1
Kovačić, S1
Matana Kaštelan, Z1
Žuža, I1
Benić, F1
Slaven, J1
Miletić, D1
Rumboldt, Z1
Fernandez-Botran, R1
Wellmann, IA1
Une, C1
Méndez-Chacón, E1
Hernández de Rodas, E1
Bhandari, B1
Villagrán de Tercero, CI1
Nguyen, HTT1
Romano, F1
Wampfler, R1
Mühlethaler, K1
Tannich, E1
Oberli, A1
Yang, J1
Xiang, T1
Dai, L1
Zhao, X1
Ma, L1
Zuo, D1
Wei, B1
Sui, Y1
Xu, F1
Zheng, H1
Qiu, C1
Jin, H1
Kerwin, J1
Khan, I1
Rajasekhar, B1
Venkateshwaran, U1
Durairaj, N1
Divyapriya, G1
Nambi, IM1
Joseph, A1
Aliste, M1
Garrido, I1
Flores, P1
Hellín, P1
Vela, N1
Navarro, S1
Fenoll, J1
Männistö, VT1
Simonen, M1
Hyysalo, J1
Soininen, P1
Kangas, AJ1
Kaminska, D1
Matte, AK1
Venesmaa, S1
Käkelä, P1
Kärjä, V1
Arola, J1
Gylling, H1
Cederberg, H1
Kuusisto, J1
Laakso, M1
Yki-Järvinen, H1
Ala-Korpela, M1
Pihlajamäki, J1
Krotkiewski, M1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk[NCT03851874]28 participants (Actual)Interventional2011-10-31Completed
Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI[NCT01562678]Phase 428 participants (Actual)Interventional2012-03-31Completed
Saxenda: Underlying Mechanisms and Clinical Outcomes[NCT02944500]Phase 428 participants (Actual)Interventional2016-11-30Active, not recruiting
Use of MCT Oil for Enhancement of Weight Loss in Obese Patients-Preliminary Phase 2002-291G[NCT00207272]24 participants (Anticipated)Interventional2003-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change Between Highly Desirable vs. Less Desirable Food Cues in the Effect Size of Cortical Activation During Food Visualization

Effect size (region of interest z-scores, derived from z-maps of the brain) shown below is the difference in parietal cortex activation to highly desirable (high fat or high calorie, e.g. cakes, pies, fries) versus less desirable (low fat or low calorie, e.g. vegetables, fruits) food cues for each treatment condition (liraglutide or placebo) at the end of the treatment period. (NCT01562678)
Timeframe: 18 days of Liraglutide or placebo treatment

Interventionz-scores of activation in cortex (Mean)
Liraglutide-0.42
Placebo0.53

Trials

3 trials available for 3-hydroxybutyric acid and Obesity, Morbid

ArticleYear
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
Value of VLCD supplementation with medium chain triglycerides.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:9

    Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Adult; Appetite; Body Composition; Body Weight; Di

2001

Other Studies

1 other study available for 3-hydroxybutyric acid and Obesity, Morbid

ArticleYear
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:7

    Topics: 3-Hydroxybutyric Acid; Acetate-CoA Ligase; Acetyl-CoA C-Acetyltransferase; Adult; Aged; Biomarkers;

2015