3-hydroxybutyric acid has been researched along with Neural Tube Defects in 7 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results suggest that genetic susceptibility plays an important role in inducing underdevelopment and NTD in cultured CDs embryos in sub-teratogenic medium and in protecting the CDr embryos under the same conditions." | 1.32 | Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions. ( Ornoy, A; Weksler-Zangen, S; Yaffe, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weksler-Zangen, S | 1 |
| Yaffe, P | 1 |
| Ornoy, A | 1 |
| Horton, WE | 1 |
| Sadler, TW | 6 |
| Buchanan, TA | 1 |
| Denno, KM | 1 |
| Sipos, GF | 1 |
| Shum, L | 1 |
| Hunter, ES | 3 |
| Wynn, RE | 2 |
| Phillips, LS | 1 |
7 other studies available for 3-hydroxybutyric acid and Neural Tube Defects
| Article | Year |
|---|---|
Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Catalase; Diabetes Mellitus, Type 2; Disease Models, | 2003 |
Effects of maternal diabetes on early embryogenesis. Alterations in morphogenesis produced by the ketone body, B-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Gestati | 1983 |
Diabetic teratogenesis. In vitro evidence for a multifactorial etiology with little contribution from glucose per se.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Congenital Abnormalities; Diabetes Mellitus, Experime | 1994 |
Biochemical basis for D,L,-beta-hydroxybutyrate-induced teratogenesis.
Topics: 3-Hydroxybutyric Acid; Animals; Culture Techniques; Hydroxybutyrates; Mice; Mice, Inbred Strains; Mu | 1990 |
Evidence for multifactorial origin of diabetes-induced embryopathies.
Topics: 3-Hydroxybutyric Acid; Animals; Congenital Abnormalities; Diabetes Mellitus, Experimental; Female; F | 1989 |
A potential mechanism of DL-beta-hydroxybutyrate-induced malformations in mouse embryos.
Topics: 3-Hydroxybutyric Acid; 6-Aminonicotinamide; Abnormalities, Drug-Induced; Acetoacetates; Animals; Bio | 1987 |
D-(-)-beta-hydroxybutyrate-induced effects on mouse embryos in vitro.
Topics: 3-Hydroxybutyric Acid; Abnormalities, Drug-Induced; Animals; Embryonic and Fetal Development; Female | 1987 |