3-hydroxybutyric acid has been researched along with Hypoxia-Ischemia, Brain in 10 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemic ketosis (approx." | 1.48 | Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy. ( Kim, KS; Lee, BS; Woo, CW; Woo, DC, 2018) |
| "Fetal ketoacidosis with hypoxic-ischemic brain damage was determined to be the cause of death." | 1.48 | Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis. ( Fliss, B; Gascho, D; Heimer, J; Martinez, RM; Zoelch, N, 2018) |
| "However, chronic in vitro ketosis abolished hippocampal network hyperexcitability following a metabolic insult, hypoxia, demonstrating for the first time a direct link between metabolic resistance and better control of excessive, synchronous, abnormal electrical activity." | 1.36 | Chronic in vitro ketosis is neuroprotective but not anti-convulsant. ( Abdelmalik, P; Carlen, PL; Samoilova, M; Velumian, AA; Weisspapir, M, 2010) |
| "During seizures, ATP and PCr values declined significantly below their homologous controls." | 1.31 | Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. ( Armstrong, EA; Miyashita, H; Wirrell, EC; Yager, JY, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cascant-Vilaplana, MM | 1 |
| Lara-Cantón, I | 1 |
| Núñez-Ramiro, A | 2 |
| Solaz-García, Á | 1 |
| Llorens-Salvador, R | 1 |
| Quintás, G | 1 |
| Kuligowski, J | 2 |
| Vento, M | 2 |
| Odorcyk, FK | 1 |
| Duran-Carabali, LE | 1 |
| Rocha, DS | 1 |
| Sanches, EF | 1 |
| Martini, AP | 1 |
| Venturin, GT | 1 |
| Greggio, S | 1 |
| da Costa, JC | 1 |
| Kucharski, LC | 1 |
| Zimmer, ER | 1 |
| Netto, CA | 1 |
| Sánchez-Illana, Á | 1 |
| Cernada, M | 1 |
| Parra-Llorca, A | 1 |
| Valverde, E | 1 |
| Blanco, D | 1 |
| Moral-Pumarega, MT | 1 |
| Cabañas, F | 1 |
| Boix, H | 1 |
| Pavon, A | 1 |
| Chaffanel, M | 1 |
| Benavente-Fernández, I | 1 |
| Tofe, I | 1 |
| Loureiro, B | 1 |
| Fernández-Lorenzo, JR | 1 |
| Fernández-Colomer, B | 1 |
| García-Robles, A | 1 |
| Lee, BS | 1 |
| Woo, DC | 1 |
| Woo, CW | 1 |
| Kim, KS | 1 |
| Heimer, J | 1 |
| Gascho, D | 1 |
| Fliss, B | 1 |
| Martinez, RM | 1 |
| Zoelch, N | 1 |
| Boruczkowski, D | 1 |
| Pujal, JM | 1 |
| Zdolińska-Malinowska, I | 1 |
| Reinke, SN | 1 |
| Walsh, BH | 1 |
| Boylan, GB | 1 |
| Sykes, BD | 1 |
| Kenny, LC | 1 |
| Murray, DM | 1 |
| Broadhurst, DI | 1 |
| Samoilova, M | 1 |
| Weisspapir, M | 1 |
| Abdelmalik, P | 1 |
| Velumian, AA | 1 |
| Carlen, PL | 1 |
| Yager, JY | 1 |
| Armstrong, EA | 1 |
| Miyashita, H | 1 |
| Wirrell, EC | 1 |
| Dardzinski, BJ | 1 |
| Smith, SL | 1 |
| Towfighi, J | 1 |
| Williams, GD | 1 |
| Vannucci, RC | 1 |
| Smith, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.[NCT02019147] | 500 participants (Actual) | Observational | 2012-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3-hydroxybutyric acid and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Autologous cord blood in children with cerebral palsy: a review.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Brain Diseases; Brain Injuries; Carnitine; Cerebral Pal | 2019 |
1 trial available for 3-hydroxybutyric acid and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Case-Control Studies; Female; Gas Chromatography-M | 2017 |
8 other studies available for 3-hydroxybutyric acid and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2023 |
Differential glucose and beta-hydroxybutyrate metabolism confers an intrinsic neuroprotection to the immature brain in a rat model of neonatal hypoxia ischemia.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Disease Models, Animal; Glucose; Hypoxia-Ischemia, | 2020 |
Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Brain; Disease Models, Animal; Hypoxia-Ischemia, B | 2018 |
Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Acetone; Acidosis, Lactic; Alcoholism; Cerebrum; Fasting; Female; Fetal Blood | 2018 |
1H NMR derived metabolomic profile of neonatal asphyxia in umbilical cord serum: implications for hypoxic ischemic encephalopathy.
Topics: 3-Hydroxybutyric Acid; Acetone; Asphyxia Neonatorum; Case-Control Studies; Female; Fetal Blood; Glyc | 2013 |
Chronic in vitro ketosis is neuroprotective but not anti-convulsant.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Cytoprotection; Diet, Ketogenic; Disease Models, A | 2010 |
Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Excitatory | 2002 |
Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Brain; Dexamethasone; Energy Metabolism; Hypoxia-I | 2000 |