3-hydroxybutyric acid has been researched along with Hypertension in 8 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension is the most important risk factor for the development of terminal cardiovascular diseases, such as heart failure, chronic kidney disease, and atherosclerosis." | 2.82 | The janus face of ketone bodies in hypertension. ( Costa, TJ; Fontes, M; Hester, S; Linder, BA; McCarthy, CG; Pernomian, L; Robinson, AT; Wenceslau, CF, 2022) |
| "Peripheral insulin resistance is a feature of essential hypertension, but there is little information about hepatic insulin sensitivity." | 1.28 | Insulin action and hepatic glucose cycling in essential hypertension. ( Atkinson, AB; Bell, NP; Bell, PM; Ennis, CN; Neely, RD; Rooney, DP; Sheridan, B; Trimble, ER, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, TJ | 1 |
| Linder, BA | 1 |
| Hester, S | 1 |
| Fontes, M | 1 |
| Pernomian, L | 1 |
| Wenceslau, CF | 1 |
| Robinson, AT | 1 |
| McCarthy, CG | 1 |
| Yu, Z | 1 |
| Wang, L | 1 |
| Wu, S | 1 |
| Zhao, W | 1 |
| Chakraborty, S | 2 |
| Mandal, J | 1 |
| Cheng, X | 2 |
| Galla, S | 2 |
| Hindupur, A | 1 |
| Saha, P | 2 |
| Yeoh, BS | 1 |
| Mell, B | 2 |
| Yeo, JY | 2 |
| Vijay-Kumar, M | 2 |
| Yang, T | 1 |
| Joe, B | 2 |
| Singh, V | 1 |
| Yeoh, B | 1 |
| Mathew, AV | 1 |
| Place, DE | 1 |
| Kanneganti, TD | 1 |
| Kataoka, T | 1 |
| Aoyama, Y | 1 |
| Sakoda, A | 1 |
| Nakagawa, S | 1 |
| Yamaoka, K | 1 |
| Rooney, DP | 1 |
| Neely, RD | 1 |
| Ennis, CN | 1 |
| Bell, NP | 1 |
| Sheridan, B | 1 |
| Atkinson, AB | 1 |
| Trimble, ER | 1 |
| Bell, PM | 1 |
| Peden, NR | 1 |
| Dow, RJ | 1 |
| Isles, TE | 1 |
| Martin, BT | 1 |
| Yee, KF | 1 |
| Buchanan, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketone Ester and Acute Salt: Can Ketone Supplementation Prevent the Adverse Negative Effects of High Salt on Blood Vessel Health in Young Adults?[NCT05545501] | 35 participants (Anticipated) | Interventional | 2023-03-24 | Recruiting | |||
| The Effects of Ketone Ester Supplementation on Nocturnal Blood Pressure in Middle-Aged and Older Adults[NCT05888506] | 40 participants (Actual) | Interventional | 2023-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 3-hydroxybutyric acid and Hypertension
| Article | Year |
|---|---|
The janus face of ketone bodies in hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Antihypertensive Agents; Hypertension; Ketone Bodies | 2022 |
Fueling Ketone Metabolism Quenches Salt-Induced Hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Butylene Glycols; Humans; Hypertension; Ketone Bodies; Sodium Chlori | 2019 |
2 trials available for 3-hydroxybutyric acid and Hypertension
| Article | Year |
|---|---|
Basic study on biochemical mechanism of thoron and thermal therapy.
Topics: 3-Hydroxybutyric Acid; Administration, Inhalation; Adult; Atrial Natriuretic Factor; Blood Glucose; | 2006 |
The effect of chronic treatment with a non-selective beta-adrenoceptor antagonist on the enteroinsular axis and intermediary metabolites.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alanine; Antihypertensive Agents; Blood Glucose; Clinical Trials | 1985 |
4 other studies available for 3-hydroxybutyric acid and Hypertension
| Article | Year |
|---|---|
Dissecting the potential mechanism of antihypertensive effects of RVPSL on spontaneously hypertensive rats via widely targeted kidney metabolomics.
Topics: 3-Hydroxybutyric Acid; Animals; Antihypertensive Agents; Arachidonic Acid; Biomarkers; Blood Pressur | 2023 |
Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage.
Topics: 3-Hydroxybutyric Acid; Animals; Base Sequence; Blood Pressure; Circadian Rhythm; Diet, Sodium-Restri | 2020 |
Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Flavoring Agents; Gastrointestinal Microbiome; Hyper | 2018 |
Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Flavoring Agents; Gastrointestinal Microbiome; Hyper | 2018 |
Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Flavoring Agents; Gastrointestinal Microbiome; Hyper | 2018 |
Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Flavoring Agents; Gastrointestinal Microbiome; Hyper | 2018 |
Insulin action and hepatic glucose cycling in essential hypertension.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Tec | 1992 |