3-hydroxybutyric acid has been researched along with Hyperlipidemias in 11 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Hyperlipidemias: Conditions with excess LIPIDS in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Overweight patients with hyperlipidemia (serum triglyceride ≥ 1." | 6.80 | Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. ( Du, S; Jiang, S; Li, Y; Na, L; Niu, Y; Sun, C; Zhang, Q; Zhang, W, 2015) |
| " We further demonstrate that activation of FXR in db/db mice repressed hepatic gluconeogenic genes and increased hepatic glycogen synthesis and glycogen content by a mechanism that involves enhanced insulin sensitivity." | 3.73 | Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. ( Barrera, G; Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Vales, C; Willson, TM; Zhang, Y, 2006) |
| "Overweight patients with hyperlipidemia (serum triglyceride ≥ 1." | 2.80 | Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. ( Du, S; Jiang, S; Li, Y; Na, L; Niu, Y; Sun, C; Zhang, Q; Zhang, W, 2015) |
| "Ketones increased with hyperlipidemia and were subsequently reduced with hyperinsulinemia during the clamp procedure (Saline: Basal = 0." | 1.91 | Ketogenic propensity is differentially related to lipid-induced hepatic and peripheral insulin resistance. ( Axelrod, CL; Belmont, KP; Dantas, WS; Kirwan, JP; Mey, JT; Vandagmansar, B, 2023) |
| "As a treatment for dyslipidemia, oral doses of 1-3 grams of nicotinic acid per day lower serum triglycerides, raise high density lipoprotein cholesterol, and reduce mortality from coronary heart disease (Tavintharan, S." | 1.33 | (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. ( Cai, TQ; Chen, R; Cheng, K; Connolly, D; Gan, X; Ippolito, M; Jin, L; Kaplan, R; Kero, J; Liaw, C; Offermanns, S; Ren, N; Richman, J; Taggart, AK; Waters, MG; Wright, SD; Wu, K; Wu, TJ, 2005) |
| "Maternal lipemia (L), one of the consequences of poorly controlled diabetes in gestation, was induced in pregnant rats by feedings of a diet containing 45% fat." | 1.27 | Fetal glycerol metabolism in experimental maternal lipemia. ( Stiel, L; Wapnir, RA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Mey, JT | 1 |
| Vandagmansar, B | 1 |
| Dantas, WS | 1 |
| Belmont, KP | 1 |
| Axelrod, CL | 1 |
| Kirwan, JP | 1 |
| Xu, QY | 1 |
| Liu, YH | 1 |
| Zhang, Q | 2 |
| Ma, B | 1 |
| Yang, ZD | 1 |
| Liu, L | 1 |
| Yao, D | 1 |
| Cui, GB | 1 |
| Sun, JJ | 1 |
| Wu, ZM | 1 |
| Na, L | 1 |
| Jiang, S | 1 |
| Du, S | 1 |
| Zhang, W | 1 |
| Li, Y | 1 |
| Sun, C | 1 |
| Niu, Y | 1 |
| Trombold, JR | 1 |
| Christmas, KM | 1 |
| Machin, DR | 1 |
| Kim, IY | 1 |
| Coyle, EF | 1 |
| Taggart, AK | 1 |
| Kero, J | 1 |
| Gan, X | 1 |
| Cai, TQ | 1 |
| Cheng, K | 1 |
| Ippolito, M | 1 |
| Ren, N | 1 |
| Kaplan, R | 1 |
| Wu, K | 1 |
| Wu, TJ | 1 |
| Jin, L | 1 |
| Liaw, C | 1 |
| Chen, R | 1 |
| Richman, J | 1 |
| Connolly, D | 1 |
| Offermanns, S | 1 |
| Wright, SD | 1 |
| Waters, MG | 1 |
| Zhang, Y | 1 |
| Lee, FY | 1 |
| Barrera, G | 1 |
| Lee, H | 1 |
| Vales, C | 1 |
| Gonzalez, FJ | 1 |
| Willson, TM | 1 |
| Edwards, PA | 1 |
| Chutkow, WA | 1 |
| Patwari, P | 1 |
| Yoshioka, J | 1 |
| Lee, RT | 1 |
| Nicholson, JK | 1 |
| O'Flynn, MP | 1 |
| Sadler, PJ | 1 |
| Macleod, AF | 1 |
| Juul, SM | 1 |
| Sönksen, PH | 1 |
| O'Doherty, RM | 1 |
| Lehman, DL | 1 |
| Télémaque-Potts, S | 1 |
| Newgard, CB | 1 |
| Koutsari, C | 1 |
| Malkova, D | 1 |
| Hardman, AE | 1 |
| Wapnir, RA | 1 |
| Stiel, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Moderate-Intensity Exercise on Postprandial Plasma Triglyceride Levels Following a High Fat Meal[NCT05291767] | 7 participants (Actual) | Interventional | 2022-03-28 | Terminated (stopped due to Personnel and funding issues) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 3-hydroxybutyric acid and Hyperlipidemias
| Article | Year |
|---|---|
Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Carnitine; Cholesterol, HDL; Dietary Supplement | 2015 |
Acute high-intensity endurance exercise is more effective than moderate-intensity exercise for attenuation of postprandial triglyceride elevation.
Topics: 3-Hydroxybutyric Acid; Adult; Analysis of Variance; Bicycling; Biomarkers; Blood Glucose; Calorimetr | 2013 |
9 other studies available for 3-hydroxybutyric acid and Hyperlipidemias
| Article | Year |
|---|---|
Ketogenic propensity is differentially related to lipid-induced hepatic and peripheral insulin resistance.
Topics: 3-Hydroxybutyric Acid; Adult; Glucose Clamp Technique; Humans; Hyperlipidemias; Insulin; Insulin Res | 2023 |
Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatin | 2014 |
(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Cell Line; Feedback, Physiological; Humans; Hyperlipidem | 2005 |
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; | 2006 |
Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.
Topics: 3-Hydroxybutyric Acid; Amino Acid Substitution; Animals; Blood Glucose; Carrier Proteins; Fasting; G | 2008 |
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Amino Acids; Diabetes Mellitus, Type 1; Diabet | 1984 |
Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; DNA, Recombinant; Fasting; Fatty Acids, | 1999 |
Postprandial lipemia after short-term variation in dietary fat and carbohydrate.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Cholesterol, HDL; Dietary Carbohydrates; Dietary Fats; | 2000 |
Fetal glycerol metabolism in experimental maternal lipemia.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Fats; Fatty Acids, Nonesterified; Female; Fetus; Glycerol; G | 1985 |