3-hydroxybutyric acid has been researched along with Hyperinsulinism in 24 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The human fatty liver takes up 2-arachidonoylglycerol and overproduces triacylglycerols containing saturated fatty acids, which might reflect increased de novo lipogenesis." | 5.14 | Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. ( Arola, J; Castillo, S; Fielding, BA; Frayn, KN; Hodson, L; Hultcrantz, R; Kotronen, A; Olkkonen, VM; Orešič, M; Perttilä, J; Seppänen-Laakso, T; Suortti, T; Wahren, J; Westerbacka, J; Yki-Järvinen, H, 2010) |
| "A high-fat diet-induced hyperinsulinemia model in ZDF rats was used to test the expression of key enzymes/proteins of ketone body metabolism in the kidney." | 1.72 | Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis ( Chang, B; Gao, Z; Guo, Z; Li, X; Wang, J; Xie, J; Yang, J; Zhong, F, 2022) |
| "Thirty minutes of hyperinsulinemia resulted in an increase in phospho-FOXO1, a decrease in GNG enzyme mRNA expression, an increase in F2,6P(2), a decrease in fat oxidation, and a transient decrease in net GNG flux." | 1.36 | Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. ( Cherrington, AD; Donahue, EP; Edgerton, DS; Farmer, B; Irimia-Dominguez, J; Lautz, M; Meyer, CM; Neal, DW; Ramnanan, CJ; Rivera, N; Roach, PJ, 2010) |
| "Compared with nondiabetic subjects, IDDM with or without CDAN exhibited reduced epinephrine (P = 0." | 1.29 | Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. ( Craft, S; Cryer, PE; Dagogo-Jack, SE, 1993) |
| "Fasting hypoglycemia was found to be due both to an insulin-induced decrease in hepatic glucose output to 3." | 1.27 | Glucose metabolism in hyperinsulinemic infants: the effects of fasting and sodium DL-beta-hydroxybutyrate on glucose production and utilization rates. ( Bougnères, PF; Chaussain, JL; Ferré, P; Job, JC, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, J | 1 |
| Zhong, F | 1 |
| Guo, Z | 1 |
| Li, X | 1 |
| Wang, J | 1 |
| Gao, Z | 1 |
| Chang, B | 1 |
| Yang, J | 1 |
| Vanacker, N | 1 |
| Hooper, HB | 1 |
| Blouin, R | 1 |
| Lacasse, P | 1 |
| Buffet, A | 1 |
| Vezzosi, D | 1 |
| Maiza, JC | 1 |
| Grunenwald, S | 1 |
| Bennet, A | 1 |
| Caron, P | 1 |
| Ramnanan, CJ | 1 |
| Edgerton, DS | 1 |
| Rivera, N | 1 |
| Irimia-Dominguez, J | 1 |
| Farmer, B | 1 |
| Neal, DW | 1 |
| Lautz, M | 1 |
| Donahue, EP | 1 |
| Meyer, CM | 1 |
| Roach, PJ | 1 |
| Cherrington, AD | 1 |
| Lucidi, P | 1 |
| Rossetti, P | 1 |
| Porcellati, F | 1 |
| Pampanelli, S | 1 |
| Candeloro, P | 1 |
| Andreoli, AM | 1 |
| Perriello, G | 1 |
| Bolli, GB | 1 |
| Fanelli, CG | 1 |
| Westerbacka, J | 1 |
| Kotronen, A | 1 |
| Fielding, BA | 1 |
| Wahren, J | 1 |
| Hodson, L | 1 |
| Perttilä, J | 1 |
| Seppänen-Laakso, T | 1 |
| Suortti, T | 1 |
| Arola, J | 1 |
| Hultcrantz, R | 1 |
| Castillo, S | 1 |
| Olkkonen, VM | 1 |
| Frayn, KN | 1 |
| Orešič, M | 1 |
| Yki-Järvinen, H | 1 |
| Plecko, B | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Schober, E | 1 |
| Harrer, G | 1 |
| Mlynarik, V | 1 |
| Gruber, S | 1 |
| Moser, E | 1 |
| Moeslinger, D | 1 |
| Silgoner, H | 1 |
| Ipsiroglu, O | 1 |
| Hussain, K | 1 |
| Eaton, S | 1 |
| Clayton, P | 1 |
| Courtney, CH | 1 |
| Atkinson, AB | 1 |
| Ennis, CN | 1 |
| Sheridan, B | 1 |
| Bell, PM | 1 |
| Wiesli, P | 1 |
| Brändle, M | 1 |
| Zapf, J | 1 |
| Seiler, H | 1 |
| Zwimpfer, C | 1 |
| Spinas, GA | 1 |
| Schmid, C | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Griffiths, MJ | 1 |
| Gama, R | 1 |
| Connolly, CC | 1 |
| Papa, T | 1 |
| Smith, MS | 1 |
| Lacy, DB | 1 |
| Williams, PE | 1 |
| Moore, MC | 1 |
| Bougnères, PF | 1 |
| Ferré, P | 1 |
| Chaussain, JL | 1 |
| Job, JC | 1 |
| Verdin, E | 1 |
| Castillo, M | 1 |
| Luyckx, AS | 1 |
| Lefebvre, PJ | 1 |
| Campillo, B | 1 |
| Bories, PN | 1 |
| Fouet, P | 1 |
| Dagogo-Jack, SE | 1 |
| Craft, S | 1 |
| Cryer, PE | 1 |
| Morris, AA | 1 |
| Thekekara, A | 1 |
| Wilks, Z | 1 |
| Clayton, PT | 1 |
| Leonard, JV | 1 |
| Aynsley-Green, A | 1 |
| Acerini, CL | 1 |
| Harris, DA | 1 |
| Matyka, KA | 1 |
| Watts, AP | 1 |
| Umpleby, AM | 1 |
| Russell-Jones, DL | 1 |
| Dunger, DB | 1 |
| Ricciolini, R | 1 |
| Scalibastri, M | 1 |
| Carminati, P | 1 |
| Arduini, A | 1 |
| Jensen, CB | 1 |
| Storgaard, H | 1 |
| Dela, F | 1 |
| Holst, JJ | 1 |
| Madsbad, S | 1 |
| Vaag, AA | 1 |
| Scott, AR | 1 |
| Macdonald, IA | 1 |
| Bowman, CA | 1 |
| Jeffcoate, WJ | 1 |
| Stevenson, RW | 1 |
| Hutson, NJ | 1 |
| Krupp, MN | 1 |
| Volkmann, RA | 1 |
| Holland, GF | 1 |
| Eggler, JF | 1 |
| Clark, DA | 1 |
| McPherson, RK | 1 |
| Hall, KL | 1 |
| Danbury, BH | 1 |
| Zuniga-Guajardo, S | 1 |
| Garfinkel, PE | 1 |
| Zinman, B | 1 |
1 review available for 3-hydroxybutyric acid and Hyperinsulinism
| Article | Year |
|---|---|
Adult spontaneous hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Reactive Protein; Fasting; Glucose Tolerance Test; Hu | 2005 |
6 trials available for 3-hydroxybutyric acid and Hyperinsulinism
| Article | Year |
|---|---|
Effect of intravenous lipid infusion on biomarkers of insulin resistance and immune functions of dry and nonpregnant dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Cattle; Cattle Diseases; Fatty Acids, Non | 2023 |
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Topics: 3-Hydroxybutyric Acid; Cannabinoid Receptor Modulators; Catheterization; Deuterium; Endocannabinoids | 2010 |
Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Blood Glucose; Brain Chemistry; Dietary Supplements; El | 2002 |
Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Circadian Rhythm; Fatty Acids; Female; Gastr | 2003 |
Similar metabolic effects of pulsatile versus continuous human insulin delivery during euglycemic, hyperinsulinemic glucose clamp in normal man.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Glucagon; Humans | 1984 |
Effects of low-dose recombinant human insulin-like growth factor-I on insulin sensitivity, growth hormone and glucagon levels in young adults with insulin-dependent diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; D | 1998 |
17 other studies available for 3-hydroxybutyric acid and Hyperinsulinism
| Article | Year |
|---|---|
Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Albumins; Animals; Epithelial Cells; Glucose; Hexosam | 2022 |
Increased plasma β-hydroxybutyrate levels during the fasting test in patients with endogenous hyperinsulinaemic hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; C-Peptide; Diagnos | 2013 |
Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Female | 2010 |
Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Epinephrine; Fat Emulsions, Intravenous; Fatty Acids, Nonester | 2010 |
Exogenous administered DL- sodium beta-hydroxybutyrate (beta-OHB) can cross the blood brain barrier.
Topics: 3-Hydroxybutyric Acid; Blood-Brain Barrier; Brain; Humans; Hyperinsulinism; Hypoglycemia; Infant | 2003 |
Assessment of hyperinsulinaemia at the termination of the prolonged fast.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Enzyme- | 2004 |
Increasing serum betahydroxybutyrate concentrations during the 72-hour fast: evidence against hyperinsulinemic hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Biomarkers; Fasting; Female; Humans; Hyperinsulinism; Hypoglycem | 2005 |
Hepatic and muscle insulin action during late pregnancy in the dog.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Female; Gl | 2007 |
Glucose metabolism in hyperinsulinemic infants: the effects of fasting and sodium DL-beta-hydroxybutyrate on glucose production and utilization rates.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; C-Peptide; Fasting; Humans; Hydroxybutyrates; Hyperinsulinism; | 1983 |
Postprandial de novo lipogenesis in alcoholic liver cirrhosis: relationship with fuel homeostasis and nutritional status.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Adult; Body Composition; Body Weight; Butyrate | 1993 |
Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; Cognition; Diabetes Mellitus, Type 1; D | 1993 |
Evaluation of fasts for investigating hypoglycaemia or suspected metabolic disease.
Topics: 3-Hydroxybutyric Acid; Age Distribution; Child; Child, Preschool; Evaluation Studies as Topic; Fasti | 1996 |
The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Carnitine; Female; Hyperinsulinism; | 2001 |
Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight.
Topics: 3-Hydroxybutyric Acid; Alanine; Birth Weight; Blood Glucose; C-Peptide; Denmark; Fatty Acids, Nonest | 2002 |
Effect of phase of menstrual cycle on insulin sensitivity, peripheral blood flow and cardiovascular responses to hyperinsulinaemia in young women with type 1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Female; Fore | 1990 |
Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice.
Topics: 3-Hydroxybutyric Acid; Animals; Benzopyrans; Blood Glucose; Cholesterol; Fatty Acids, Nonesterified; | 1990 |
Changes in insulin sensitivity and clearance in anorexia nervosa.
Topics: 3-Hydroxybutyric Acid; Adult; Anorexia Nervosa; Body Weight; Fatty Acids, Nonesterified; Female; Gly | 1986 |