Page last updated: 2024-10-17

3-hydroxybutyric acid and Glucose Intolerance

3-hydroxybutyric acid has been researched along with Glucose Intolerance in 7 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

Research Excerpts

ExcerptRelevanceReference
"Overexpression of the rate-limiting enzyme for hexosamine synthesis (glutamine:fructose-6-phosphate amidotransferase) in muscle and adipose tissue of transgenic mice was previously shown to result in insulin resistance and hyperleptinemia."3.72Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. ( Cooksey, RC; Gulve, EA; Hazel, M; Jones, D; McClain, DA; Neidigh, JL; Parker, G; Witherbee, B, 2004)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Nakagata, T1
Tamura, Y1
Kaga, H1
Sato, M1
Yamasaki, N1
Someya, Y1
Kadowaki, S1
Sugimoto, D1
Satoh, H1
Kawamori, R1
Watada, H1
Sahagun, E1
Bachman, BB1
Kinzig, KP1
Murata, Y1
Nishio, K1
Mochiyama, T1
Konishi, M1
Shimada, M1
Ohta, H1
Itoh, N1
Ferrannini, E1
Baldi, S1
Frascerra, S1
Astiarraga, B1
Heise, T1
Bizzotto, R1
Mari, A1
Pieber, TR1
Muscelli, E1
Lima, MS1
Cota, JB1
Vaz, YM1
Ajuda, IG1
Pascoal, RA1
Carolino, N1
Hjerpe, CA1
Hazel, M1
Cooksey, RC1
Jones, D1
Parker, G1
Neidigh, JL1
Witherbee, B1
Gulve, EA1
McClain, DA1
Shelgikar, KM1
Naik, SS1
Khopkar, M1
Bhat, DS1
Raut, KN1
Joglekar, CV1
Gerard, ME1
Yajnik, CS1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of SGLT-2 Inhibitor on Myocardial Perfusion, Function and Metabolism in Type 2 DM Patients at High Cardiovascular Risk: The SIMPle Randomized Clinical Trial[NCT03151343]Phase 392 participants (Actual)Interventional2017-03-29Completed
Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130]Early Phase 118 participants (Anticipated)Interventional2022-08-17Recruiting
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]Phase 1/Phase 260 participants (Anticipated)Interventional2023-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for 3-hydroxybutyric acid and Glucose Intolerance

ArticleYear
Ingestion of an exogenous ketone monoester improves the glycemic response during oral glucose tolerance test in individuals with impaired glucose tolerance: A cross-over randomized trial.
    Journal of diabetes investigation, 2021, Volume: 12, Issue:5

    Topics: 3-Hydroxybutyric Acid; Area Under Curve; Blood Glucose; C-Peptide; Cross-Over Studies; Eating; Fatty

2021
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism

2016

Other Studies

5 other studies available for 3-hydroxybutyric acid and Glucose Intolerance

ArticleYear
Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021, 03-10, Volume: 31, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adiposity; Animals; Biomarkers; Blood Glucose; Corticosterone; Diet, High-Fat

2021
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Blood Glucose; Body Weight; Diet, Carbohydrate-Restricte

2013
Glucose intolerance in dairy goats with pregnancy toxemia: Lack of correlation between blood pH and beta hydroxybutyric acid values.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2016, Volume: 57, Issue:6

    Topics: 3-Hydroxybutyric Acid; Animals; Female; Glucose Intolerance; Goat Diseases; Goats; Hydrogen-Ion Conc

2016
Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
    Endocrinology, 2004, Volume: 145, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Deoxyglucose; Fasting; F

2004
Circulating lipids and cardiovascular risk in newly diagnosed non-insulin-dependent diabetic subjects in India.
    Diabetic medicine : a journal of the British Diabetic Association, 1997, Volume: 14, Issue:9

    Topics: 3-Hydroxybutyric Acid; Adult; Albuminuria; Angina Pectoris; Cardiovascular Diseases; Cholesterol; Co

1997