3-hydroxybutyric acid has been researched along with Glucose Intolerance in 7 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Overexpression of the rate-limiting enzyme for hexosamine synthesis (glutamine:fructose-6-phosphate amidotransferase) in muscle and adipose tissue of transgenic mice was previously shown to result in insulin resistance and hyperleptinemia." | 3.72 | Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. ( Cooksey, RC; Gulve, EA; Hazel, M; Jones, D; McClain, DA; Neidigh, JL; Parker, G; Witherbee, B, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Nakagata, T | 1 |
| Tamura, Y | 1 |
| Kaga, H | 1 |
| Sato, M | 1 |
| Yamasaki, N | 1 |
| Someya, Y | 1 |
| Kadowaki, S | 1 |
| Sugimoto, D | 1 |
| Satoh, H | 1 |
| Kawamori, R | 1 |
| Watada, H | 1 |
| Sahagun, E | 1 |
| Bachman, BB | 1 |
| Kinzig, KP | 1 |
| Murata, Y | 1 |
| Nishio, K | 1 |
| Mochiyama, T | 1 |
| Konishi, M | 1 |
| Shimada, M | 1 |
| Ohta, H | 1 |
| Itoh, N | 1 |
| Ferrannini, E | 1 |
| Baldi, S | 1 |
| Frascerra, S | 1 |
| Astiarraga, B | 1 |
| Heise, T | 1 |
| Bizzotto, R | 1 |
| Mari, A | 1 |
| Pieber, TR | 1 |
| Muscelli, E | 1 |
| Lima, MS | 1 |
| Cota, JB | 1 |
| Vaz, YM | 1 |
| Ajuda, IG | 1 |
| Pascoal, RA | 1 |
| Carolino, N | 1 |
| Hjerpe, CA | 1 |
| Hazel, M | 1 |
| Cooksey, RC | 1 |
| Jones, D | 1 |
| Parker, G | 1 |
| Neidigh, JL | 1 |
| Witherbee, B | 1 |
| Gulve, EA | 1 |
| McClain, DA | 1 |
| Shelgikar, KM | 1 |
| Naik, SS | 1 |
| Khopkar, M | 1 |
| Bhat, DS | 1 |
| Raut, KN | 1 |
| Joglekar, CV | 1 |
| Gerard, ME | 1 |
| Yajnik, CS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of SGLT-2 Inhibitor on Myocardial Perfusion, Function and Metabolism in Type 2 DM Patients at High Cardiovascular Risk: The SIMPle Randomized Clinical Trial[NCT03151343] | Phase 3 | 92 participants (Actual) | Interventional | 2017-03-29 | Completed | ||
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 3-hydroxybutyric acid and Glucose Intolerance
5 other studies available for 3-hydroxybutyric acid and Glucose Intolerance
| Article | Year |
|---|---|
Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats.
Topics: 3-Hydroxybutyric Acid; Adiposity; Animals; Biomarkers; Blood Glucose; Corticosterone; Diet, High-Fat | 2021 |
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Blood Glucose; Body Weight; Diet, Carbohydrate-Restricte | 2013 |
Glucose intolerance in dairy goats with pregnancy toxemia: Lack of correlation between blood pH and beta hydroxybutyric acid values.
Topics: 3-Hydroxybutyric Acid; Animals; Female; Glucose Intolerance; Goat Diseases; Goats; Hydrogen-Ion Conc | 2016 |
Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
Topics: 3-Hydroxybutyric Acid; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Deoxyglucose; Fasting; F | 2004 |
Circulating lipids and cardiovascular risk in newly diagnosed non-insulin-dependent diabetic subjects in India.
Topics: 3-Hydroxybutyric Acid; Adult; Albuminuria; Angina Pectoris; Cardiovascular Diseases; Cholesterol; Co | 1997 |