3-hydroxybutyric acid has been researched along with Glucose Intolerance in 7 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
Excerpt | Relevance | Reference |
---|---|---|
"Overexpression of the rate-limiting enzyme for hexosamine synthesis (glutamine:fructose-6-phosphate amidotransferase) in muscle and adipose tissue of transgenic mice was previously shown to result in insulin resistance and hyperleptinemia." | 3.72 | Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. ( Cooksey, RC; Gulve, EA; Hazel, M; Jones, D; McClain, DA; Neidigh, JL; Parker, G; Witherbee, B, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (14.29) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 3 (42.86) | 24.3611 |
2020's | 2 (28.57) | 2.80 |
Authors | Studies |
---|---|
Nakagata, T | 1 |
Tamura, Y | 1 |
Kaga, H | 1 |
Sato, M | 1 |
Yamasaki, N | 1 |
Someya, Y | 1 |
Kadowaki, S | 1 |
Sugimoto, D | 1 |
Satoh, H | 1 |
Kawamori, R | 1 |
Watada, H | 1 |
Sahagun, E | 1 |
Bachman, BB | 1 |
Kinzig, KP | 1 |
Murata, Y | 1 |
Nishio, K | 1 |
Mochiyama, T | 1 |
Konishi, M | 1 |
Shimada, M | 1 |
Ohta, H | 1 |
Itoh, N | 1 |
Ferrannini, E | 1 |
Baldi, S | 1 |
Frascerra, S | 1 |
Astiarraga, B | 1 |
Heise, T | 1 |
Bizzotto, R | 1 |
Mari, A | 1 |
Pieber, TR | 1 |
Muscelli, E | 1 |
Lima, MS | 1 |
Cota, JB | 1 |
Vaz, YM | 1 |
Ajuda, IG | 1 |
Pascoal, RA | 1 |
Carolino, N | 1 |
Hjerpe, CA | 1 |
Hazel, M | 1 |
Cooksey, RC | 1 |
Jones, D | 1 |
Parker, G | 1 |
Neidigh, JL | 1 |
Witherbee, B | 1 |
Gulve, EA | 1 |
McClain, DA | 1 |
Shelgikar, KM | 1 |
Naik, SS | 1 |
Khopkar, M | 1 |
Bhat, DS | 1 |
Raut, KN | 1 |
Joglekar, CV | 1 |
Gerard, ME | 1 |
Yajnik, CS | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effects of SGLT-2 Inhibitor on Myocardial Perfusion, Function and Metabolism in Type 2 DM Patients at High Cardiovascular Risk: The SIMPle Randomized Clinical Trial[NCT03151343] | Phase 3 | 92 participants (Actual) | Interventional | 2017-03-29 | Completed | ||
Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 trials available for 3-hydroxybutyric acid and Glucose Intolerance
5 other studies available for 3-hydroxybutyric acid and Glucose Intolerance
Article | Year |
---|---|
Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats.
Topics: 3-Hydroxybutyric Acid; Adiposity; Animals; Biomarkers; Blood Glucose; Corticosterone; Diet, High-Fat | 2021 |
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Blood Glucose; Body Weight; Diet, Carbohydrate-Restricte | 2013 |
Glucose intolerance in dairy goats with pregnancy toxemia: Lack of correlation between blood pH and beta hydroxybutyric acid values.
Topics: 3-Hydroxybutyric Acid; Animals; Female; Glucose Intolerance; Goat Diseases; Goats; Hydrogen-Ion Conc | 2016 |
Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
Topics: 3-Hydroxybutyric Acid; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Deoxyglucose; Fasting; F | 2004 |
Circulating lipids and cardiovascular risk in newly diagnosed non-insulin-dependent diabetic subjects in India.
Topics: 3-Hydroxybutyric Acid; Adult; Albuminuria; Angina Pectoris; Cardiovascular Diseases; Cholesterol; Co | 1997 |