3-hydroxybutyric acid has been researched along with Fasting Hypoglycemia in 118 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrated that 6 weeks' administration of the SSRI fluoxetine can amplify a wide spectrum of ANS and metabolic counterregulatory responses during hypoglycemia in healthy individuals." | 9.13 | Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals. ( Briscoe, VJ; Davis, SN; Dawling, S; Ertl, AC; Tate, DB, 2008) |
| "To test the hypothesis that, in contrast to administration of glucose or glucagon, administration of the amino acid Ala or of the beta 2-adrenergic agonist terbutaline produces sustained glucose recovery from hypoglycemia." | 9.07 | Alanine and terbutaline in treatment of hypoglycemia in IDDM. ( Cryer, PE; Wiethop, BV, 1993) |
| "The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined." | 7.74 | Reduced carnitine level causes death from hypoglycemia: possible involvement of suppression of hypothalamic orexin expression during weaning period. ( Doi, T; Fujihara, H; Inubushi, A; Kido, H; Kuwajima, M; Okamoto, T; Sei, H; Sei, M; Sukeno, A; Tsuda, TT; Ueta, Y; Umehara, A, 2007) |
| "To assess the roles of decrements in insulin and increments in glucagon in the prevention of hypoglycemia during moderate exercise (approximately 60% peak O2 consumption for 60 min), normal young men were studied during somatostatin infusions with insulin and glucagon infused to 1) hold insulin and glucagon levels constant, 2) decrease insulin, 3) increase glucagon, and 4) decrease insulin and increase glucagon during exercise." | 7.68 | Insulin and glucagon in prevention of hypoglycemia during exercise in humans. ( Cryer, PE; Hirsch, IB; Holloszy, JO; Marker, JC; Parvin, CA; Smith, LJ; Spina, RJ, 1991) |
| "1,3-Butanediol and phlorhizin were used to induce ketonemia and hypoglycemia in steers." | 7.67 | Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers. ( Bartley, EE; Dayton, AD; Dufva, GS; Frey, RA; Nagaraja, TG, 1984) |
| "Since hypoglycemic neonates do not exhibit compensative ketosis, we investigated the possible involvement of carnitine deficiency or omega-oxidation in neonatal hypoglycemia." | 7.67 | Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia. ( Cartier, B; Divry, P; Maire, I; Sann, L; Vianey-Laud, C, 1987) |
| "The objective of this study was to assess the effects of treatment with propylene glycol (PG) and cyanocobalamin (B12) on health, milk production, and reproductive outcomes of cows diagnosed with hyperketonemia (HK), hypoglycemia (HG), or concurrent HKHG." | 5.51 | A randomized controlled trial examining the effects of treatment with propylene glycol and injectable cyanocobalamin on naturally occurring disease, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypo ( Aldridge, BM; Canisso, IF; Coelho, WM; Hubner, AM; Lima, FS; Peixoto, PM; Ribeiro, L, 2022) |
| "In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization." | 5.36 | Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs. ( An, Z; Cherrington, AD; Farmer, B; Farmer, T; Irimia, JM; Lautz, M; Ramnanan, CJ; Rivera, N; Roach, PJ; Smith, M; Snead, W, 2010) |
| "These data indicate that intrauterine growth retardation has profound effects on postnatal growth and metabolism." | 5.27 | Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. ( Bussey, ME; Finley, S; LaBarbera, A; Ogata, ES, 1985) |
| "This study demonstrated that 6 weeks' administration of the SSRI fluoxetine can amplify a wide spectrum of ANS and metabolic counterregulatory responses during hypoglycemia in healthy individuals." | 5.13 | Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals. ( Briscoe, VJ; Davis, SN; Dawling, S; Ertl, AC; Tate, DB, 2008) |
| "To test the hypothesis that, in contrast to administration of glucose or glucagon, administration of the amino acid Ala or of the beta 2-adrenergic agonist terbutaline produces sustained glucose recovery from hypoglycemia." | 5.07 | Alanine and terbutaline in treatment of hypoglycemia in IDDM. ( Cryer, PE; Wiethop, BV, 1993) |
| "The sympathoadrenal counterregulatory response to hypoglycemia is critical for individuals with type 1 diabetes due to impaired ability to produce glucagon." | 4.02 | Slow but Steady-The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats. ( Cohen, M; Farnham, MM; Nedoboy, PE, 2021) |
| "Leptin can reverse hyperglycemia in rodent models of type 1 diabetes." | 3.83 | Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy. ( Covey, SD; Denroche, HC; Kieffer, TJ; Mojibian, M; Neumann, UH, 2016) |
| " Alcoholism may cause hypoglycemia accompanying with AKA, due to a low carbohydrate intake, the inhibition of gluconeogenesis, and reduced hepaticglycogen storage as seen in this case." | 3.81 | Case of alcoholic ketoacidosis accompanied with severe hypoglycemia. ( Iwanaga, Y; Matsuzaki, T; Shiraishi, W; Yamamoto, A, 2015) |
| " Seizures were induced by the volatile convulsant agent flurothyl." | 3.77 | Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats. ( Khazipov, R; Minlebaev, M, 2011) |
| " Plasma concentrations of lactate, beta-hydroxybutyrate, and glycerol were low and did not alter during hypoglycemia." | 3.77 | Cot-side electroencephalography monitoring is not clinically useful in the detection of mild neonatal hypoglycemia. ( Battin, MR; Harding, JE; Harris, DL; Pleasants, AB; Spooner, CG; Weston, PJ; Williams, CE, 2011) |
| "The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined." | 3.74 | Reduced carnitine level causes death from hypoglycemia: possible involvement of suppression of hypothalamic orexin expression during weaning period. ( Doi, T; Fujihara, H; Inubushi, A; Kido, H; Kuwajima, M; Okamoto, T; Sei, H; Sei, M; Sukeno, A; Tsuda, TT; Ueta, Y; Umehara, A, 2007) |
| "The brain mitochondrial NAD+/NADH ratio, as a reflection of the oxidation-reduction (redox) state of cellular compartment, was determined under conditions of hypoxia, anoxia, hypoxia-ischemia, complete ischemia and hypoglycemia in immature rats." | 3.69 | Cerebral mitochondrial redox states during metabolic stress in the immature rat. ( Brucklacher, RM; Vannucci, RC, 1994) |
| "To assess the role of catecholamines in the prevention of hypoglycemia during moderate exercise (approximately 60% peak O2 consumption for 60 min), normal humans were studied with combined alpha- and beta-adrenergic blockade and with adrenergic blockade while changes in insulin and glucagon were prevented with the islet clamp technique (somatostatin infusion with insulin and glucagon infused at fixed rates)." | 3.68 | Catecholamines in prevention of hypoglycemia during exercise in humans. ( Cryer, PE; Hirsch, IB; Holloszy, JO; Marker, JC; Parvin, CA; Smith, LJ, 1991) |
| "To assess the roles of decrements in insulin and increments in glucagon in the prevention of hypoglycemia during moderate exercise (approximately 60% peak O2 consumption for 60 min), normal young men were studied during somatostatin infusions with insulin and glucagon infused to 1) hold insulin and glucagon levels constant, 2) decrease insulin, 3) increase glucagon, and 4) decrease insulin and increase glucagon during exercise." | 3.68 | Insulin and glucagon in prevention of hypoglycemia during exercise in humans. ( Cryer, PE; Hirsch, IB; Holloszy, JO; Marker, JC; Parvin, CA; Smith, LJ; Spina, RJ, 1991) |
| "1,3-Butanediol and phlorhizin were used to induce ketonemia and hypoglycemia in steers." | 3.67 | Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers. ( Bartley, EE; Dayton, AD; Dufva, GS; Frey, RA; Nagaraja, TG, 1984) |
| "Since hypoglycemic neonates do not exhibit compensative ketosis, we investigated the possible involvement of carnitine deficiency or omega-oxidation in neonatal hypoglycemia." | 3.67 | Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia. ( Cartier, B; Divry, P; Maire, I; Sann, L; Vianey-Laud, C, 1987) |
| "Systems that suspend basal insulin for 2 h are safe and do not lead to clinically significant ketonemia even if the blood glucose level is elevated at the time of the suspension." | 2.79 | Safety of nighttime 2-hour suspension of Basal insulin in pump-treated type 1 diabetes even in the absence of low glucose. ( Carria, L; Cengiz, E; Michaud, C; Palau Collazo, M; Sherr, JL; Steffen, AT; Tamborlane, WV; Tichy, E; Weinzimer, SA; Weyman, K; Zgorski, M, 2014) |
| " Some patients have inadvertently dosed or overdosed while awake or during sleep, causing fatal outcome in rare cases." | 2.43 | Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents. ( Hanas, R; Ludvigsson, J, 2006) |
| "Normally, the presence of ketosis implies 2 things: that lipid energy metabolism has been activated and that the entire pathway of lipid degradation is intact." | 2.39 | Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995) |
| "Distinguishing physiologic ketosis from pathologic over-production/underutilization of ketones is critical as part of the diagnostic evaluation of disorders of carbohydrate metabolism, but there is limited literature on normal ketone production with fasting." | 1.91 | Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia. ( Mosha, M; Parmar, K; Riba-Wolman, R; Weinstein, DA, 2023) |
| "Hypoglycemia has emerged as a prominent complication in anti-diabetic drug therapy or negative energy balance of animals, which causes brain damage, cognitive impairment, and even death." | 1.72 | β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. ( Chai, X; Huang, J; Li, C; Pan, J; Wu, Y; Xue, Y; Yang, J; Zhao, S; Zhou, W; Zhu, X, 2022) |
| "Hyperketonemia was defined as β-hydroxybutyrate ≥1." | 1.48 | Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows. ( Buczinski, S; Dubuc, J, 2018) |
| "The first behavioral hypoglycemic seizure symptoms such as jump, clonus or barrel rotations considered as seizure onset and we analyzed the blood glucose level (BGL) and serum beta-hydroxybutyrate (BHB) level." | 1.43 | Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice. ( Afrin, MR; Arumugam, S; Harima, M; Karuppagounder, V; Miyashita, S; Nakamura, M; Nakamura, T; Pitchaimani, V; Sreedhar, R; Suzuki, H; Suzuki, K; Thandavarayan, RA; Ueno, K; Watanabe, K, 2016) |
| "In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization." | 1.36 | Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs. ( An, Z; Cherrington, AD; Farmer, B; Farmer, T; Irimia, JM; Lautz, M; Ramnanan, CJ; Rivera, N; Roach, PJ; Smith, M; Snead, W, 2010) |
| "However, chronic in vitro ketosis abolished hippocampal network hyperexcitability following a metabolic insult, hypoxia, demonstrating for the first time a direct link between metabolic resistance and better control of excessive, synchronous, abnormal electrical activity." | 1.36 | Chronic in vitro ketosis is neuroprotective but not anti-convulsant. ( Abdelmalik, P; Carlen, PL; Samoilova, M; Velumian, AA; Weisspapir, M, 2010) |
| " In conclusion, this study suggests that short-term administration of LA at high dosage to normal and diabetic rats causes an inhibition of gluconeogenesis secondary to an interference with hepatic fatty acid oxidation." | 1.30 | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. ( Bashan, N; Gutman, A; Khamaisi, M; Potashnik, R; Rudich, A; Tritschler, HJ, 1999) |
| "Compared with nondiabetic subjects, IDDM with or without CDAN exhibited reduced epinephrine (P = 0." | 1.29 | Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. ( Craft, S; Cryer, PE; Dagogo-Jack, SE, 1993) |
| "From 1981 to 1994, 112 IDDM patients were on IT." | 1.29 | Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia. ( Annibale, B; Bartocci, L; Bolli, GB; Brunetti, P; Ciofetta, M; Di Vincenzo, A; Epifano, L; Fanelli, C; Lalli, C; Lepore, M; Modarelli, F; Pampanelli, S; Rambotti, AM; Sindaco, PD, 1996) |
| "To achieve this aim, one would need ketosis, severe hypoglycemia, and low lactatemia." | 1.29 | Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. ( Agarwal, KC; Ciraolo, ST; David, F; Fernandez, CA; Koshy, J; Lucas, D; Previs, SF; Stevens, MP; Tammaro, A; Tserng, KY, 1995) |
| "Severe hypoglycemia was observed (glucose < 20 mg/dl) in several meal-fed rats given repeated daily doses of 3MP, yet food intake did not occur despite food availability." | 1.29 | The indirect pathway of hepatic glycogen synthesis and reduction of food intake by metabolic inhibitors. ( Hellerstein, MK; Xie, Y, 1993) |
| "Hypothermia is a well-known concomitant of hypoglycemia in mammals." | 1.28 | Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats. ( Buchanan, TA; Cane, P; Eng, CC; Lee, C; Sipos, GF, 1991) |
| "Fasting hypoglycemia was found to be due both to an insulin-induced decrease in hepatic glucose output to 3." | 1.27 | Glucose metabolism in hyperinsulinemic infants: the effects of fasting and sodium DL-beta-hydroxybutyrate on glucose production and utilization rates. ( Bougnères, PF; Chaussain, JL; Ferré, P; Job, JC, 1983) |
| "These data indicate that intrauterine growth retardation has profound effects on postnatal growth and metabolism." | 1.27 | Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. ( Bussey, ME; Finley, S; LaBarbera, A; Ogata, ES, 1985) |
| "Furthermore, the occurrence of fasting hypoglycemia necessitates careful monitoring of postnatal blood glucose values." | 1.27 | Intrauterine growth and postnatal fasting metabolism in infants of obese mothers. ( Dunnington, R; Gross, T; Kliegman, R; Morton, S, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (19.49) | 18.7374 |
| 1990's | 36 (30.51) | 18.2507 |
| 2000's | 28 (23.73) | 29.6817 |
| 2010's | 23 (19.49) | 24.3611 |
| 2020's | 8 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Chai, X | 1 |
| Pan, J | 1 |
| Huang, J | 1 |
| Wu, Y | 1 |
| Xue, Y | 1 |
| Zhou, W | 1 |
| Yang, J | 2 |
| Zhu, X | 1 |
| Zhao, S | 1 |
| Rokamp, KZ | 1 |
| Holst, JJ | 1 |
| Olsen, NV | 1 |
| Dela, F | 1 |
| Secher, NH | 2 |
| Juul, A | 1 |
| Faber, J | 1 |
| Wiberg, S | 1 |
| Thorsteinsson, B | 1 |
| Pedersen-Bjergaard, U | 1 |
| Hubner, AM | 1 |
| Canisso, IF | 2 |
| Peixoto, PM | 2 |
| Coelho, WM | 2 |
| Ribeiro, L | 2 |
| Aldridge, BM | 2 |
| Lima, FS | 2 |
| Hubner, A | 1 |
| Menta, P | 1 |
| Machado, VS | 1 |
| Parmar, K | 1 |
| Mosha, M | 1 |
| Weinstein, DA | 1 |
| Riba-Wolman, R | 1 |
| Harris, DL | 4 |
| Weston, PJ | 4 |
| Harding, JE | 4 |
| Stokes, J | 1 |
| Freed, A | 1 |
| Bornstein, R | 1 |
| Su, KN | 1 |
| Snell, J | 1 |
| Pan, A | 1 |
| Sun, GX | 1 |
| Park, KY | 1 |
| Jung, S | 1 |
| Worstman, H | 1 |
| Johnson, BM | 1 |
| Morgan, PG | 1 |
| Sedensky, MM | 1 |
| Johnson, SC | 1 |
| Nedoboy, PE | 1 |
| Cohen, M | 1 |
| Farnham, MM | 1 |
| Zakian, A | 1 |
| Tehrani-Sharif, M | 1 |
| Mokhber-Dezfouli, MR | 1 |
| Nouri, M | 1 |
| Constable, PD | 1 |
| Sakakibara, A | 1 |
| Hashimoto, Y | 1 |
| Kawakita, R | 1 |
| Hosokawa, Y | 1 |
| Nagahara, K | 1 |
| Hasegawa, Y | 1 |
| Hoshino, S | 1 |
| Nagasaka, H | 1 |
| Yorifuji, T | 1 |
| Macmillan, K | 1 |
| López Helguera, I | 1 |
| Behrouzi, A | 1 |
| Gobikrushanth, M | 1 |
| Hoff, B | 1 |
| Colazo, MG | 1 |
| Polidori, D | 1 |
| Iijima, H | 1 |
| Goda, M | 1 |
| Maruyama, N | 1 |
| Inagaki, N | 1 |
| Crawford, PA | 2 |
| Dubuc, J | 1 |
| Buczinski, S | 1 |
| Buffet, A | 1 |
| Vezzosi, D | 1 |
| Maiza, JC | 1 |
| Grunenwald, S | 1 |
| Bennet, A | 1 |
| Caron, P | 1 |
| Cotter, DG | 1 |
| Ercal, B | 1 |
| d'Avignon, DA | 1 |
| Dietzen, DJ | 1 |
| Al-Otaibi, H | 1 |
| Senniappan, S | 1 |
| Alam, S | 1 |
| Hussain, K | 2 |
| Akram, M | 1 |
| Sherr, JL | 1 |
| Palau Collazo, M | 1 |
| Cengiz, E | 1 |
| Michaud, C | 1 |
| Carria, L | 1 |
| Steffen, AT | 1 |
| Weyman, K | 1 |
| Zgorski, M | 1 |
| Tichy, E | 1 |
| Tamborlane, WV | 1 |
| Weinzimer, SA | 1 |
| Julio-Amilpas, A | 1 |
| Montiel, T | 1 |
| Soto-Tinoco, E | 1 |
| Gerónimo-Olvera, C | 1 |
| Massieu, L | 1 |
| Matsuzaki, T | 1 |
| Shiraishi, W | 1 |
| Iwanaga, Y | 1 |
| Yamamoto, A | 1 |
| Maliszewski-Hall, AM | 1 |
| Stein, AB | 1 |
| Alexander, M | 1 |
| Ennis, K | 1 |
| Rao, R | 1 |
| Neumann, UH | 1 |
| Denroche, HC | 1 |
| Mojibian, M | 1 |
| Covey, SD | 1 |
| Kieffer, TJ | 1 |
| Pitchaimani, V | 1 |
| Arumugam, S | 1 |
| Thandavarayan, RA | 1 |
| Karuppagounder, V | 1 |
| Afrin, MR | 1 |
| Sreedhar, R | 1 |
| Harima, M | 1 |
| Suzuki, H | 1 |
| Miyashita, S | 1 |
| Nakamura, T | 1 |
| Suzuki, K | 1 |
| Nakamura, M | 1 |
| Ueno, K | 1 |
| Watanabe, K | 1 |
| Briscoe, VJ | 1 |
| Ertl, AC | 2 |
| Tate, DB | 1 |
| Dawling, S | 1 |
| Davis, SN | 5 |
| Ismail, ZA | 1 |
| Al-Majali, AM | 1 |
| Amireh, F | 1 |
| Al-Rawashdeh, OF | 1 |
| Page, KA | 1 |
| Williamson, A | 1 |
| Yu, N | 1 |
| McNay, EC | 1 |
| Dzuira, J | 1 |
| McCrimmon, RJ | 1 |
| Sherwin, RS | 2 |
| Barrena, HC | 1 |
| Gazola, VA | 1 |
| Furlan, MM | 1 |
| Garcia, RF | 1 |
| de Souza, HM | 1 |
| Bazotte, RB | 1 |
| Samoilova, M | 1 |
| Weisspapir, M | 1 |
| Abdelmalik, P | 1 |
| Velumian, AA | 1 |
| Carlen, PL | 1 |
| Lucidi, P | 1 |
| Rossetti, P | 2 |
| Porcellati, F | 2 |
| Pampanelli, S | 5 |
| Candeloro, P | 2 |
| Andreoli, AM | 1 |
| Perriello, G | 2 |
| Bolli, GB | 7 |
| Fanelli, CG | 2 |
| Schutz, PW | 1 |
| Wong, PK | 1 |
| O'Kusky, J | 1 |
| Innis, SM | 1 |
| Stockler, S | 1 |
| Rivera, N | 1 |
| Ramnanan, CJ | 1 |
| An, Z | 1 |
| Farmer, T | 1 |
| Smith, M | 1 |
| Farmer, B | 1 |
| Irimia, JM | 1 |
| Snead, W | 1 |
| Lautz, M | 1 |
| Roach, PJ | 1 |
| Cherrington, AD | 4 |
| Minlebaev, M | 1 |
| Khazipov, R | 1 |
| Williams, CE | 1 |
| Pleasants, AB | 1 |
| Battin, MR | 1 |
| Spooner, CG | 1 |
| Plecko, B | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Schober, E | 1 |
| Harrer, G | 1 |
| Mlynarik, V | 1 |
| Gruber, S | 1 |
| Moser, E | 1 |
| Moeslinger, D | 1 |
| Silgoner, H | 1 |
| Ipsiroglu, O | 1 |
| Hafezparast, M | 1 |
| Ball, S | 1 |
| Nicholson, SJ | 1 |
| Witherden, A | 1 |
| Arac, D | 1 |
| Broadway, N | 1 |
| Saggerson, D | 1 |
| Cooper, E | 1 |
| Naase, M | 1 |
| Gokhale, S | 1 |
| Quant, P | 1 |
| Lascelles, C | 1 |
| Nickols, C | 1 |
| Baker, CS | 1 |
| Peters, J | 1 |
| Martin, JE | 1 |
| Fisher, EM | 1 |
| Eaton, S | 1 |
| Clayton, P | 1 |
| Nybo, L | 1 |
| Møller, K | 1 |
| Pedersen, BK | 1 |
| Nielsen, B | 1 |
| Chammas, NK | 1 |
| Teale, JD | 1 |
| Quin, JD | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Griffiths, MJ | 1 |
| Gama, R | 1 |
| Hanas, R | 1 |
| Ludvigsson, J | 1 |
| Schmid, SM | 1 |
| Hallschmid, M | 1 |
| Jauch-Chara, K | 1 |
| Bandorf, N | 1 |
| Born, J | 1 |
| Schultes, B | 1 |
| Schlumbohm, C | 1 |
| Harmeyer, J | 1 |
| Marcus, C | 1 |
| Alkén, J | 1 |
| Eriksson, J | 1 |
| Blom, L | 1 |
| Gustafsson, J | 1 |
| Meier, S | 1 |
| Gore, PJ | 1 |
| Barnett, CM | 1 |
| Cursons, RT | 1 |
| Phipps, DE | 1 |
| Watkins, KA | 1 |
| Verkerk, GA | 1 |
| Kuwajima, M | 1 |
| Fujihara, H | 1 |
| Sei, H | 1 |
| Umehara, A | 1 |
| Sei, M | 1 |
| Tsuda, TT | 1 |
| Sukeno, A | 1 |
| Okamoto, T | 1 |
| Inubushi, A | 1 |
| Ueta, Y | 1 |
| Doi, T | 1 |
| Kido, H | 1 |
| Ricci, NB | 1 |
| Cioli, P | 1 |
| Metzger, BE | 1 |
| Ravnikar, V | 1 |
| Vileisis, RA | 1 |
| Freinkel, N | 1 |
| Scheen, AJ | 1 |
| Krzentowski, G | 1 |
| Castillo, M | 1 |
| Lefèbvre, PJ | 1 |
| Luyckx, AS | 1 |
| Haymond, MW | 1 |
| Pagliara, AS | 1 |
| White, NJ | 1 |
| Warrell, DA | 1 |
| Chanthavanich, P | 1 |
| Looareesuwan, S | 1 |
| Warrell, MJ | 1 |
| Krishna, S | 1 |
| Williamson, DH | 1 |
| Turner, RC | 1 |
| Kerr, DS | 2 |
| Hansen, IL | 2 |
| Levy, MM | 2 |
| Bougnères, PF | 1 |
| Ferré, P | 1 |
| Chaussain, JL | 1 |
| Job, JC | 1 |
| Wolfsdorf, JI | 1 |
| Sadeghi-Nejad, A | 1 |
| Senior, B | 1 |
| Kliegman, R | 1 |
| Gross, T | 1 |
| Morton, S | 1 |
| Dunnington, R | 1 |
| Dufva, GS | 1 |
| Bartley, EE | 1 |
| Nagaraja, TG | 1 |
| Dayton, AD | 1 |
| Frey, RA | 1 |
| Rosak, C | 1 |
| Vogel, D | 1 |
| Althoff, PH | 1 |
| Neubauer, M | 1 |
| Brecht, HM | 1 |
| Schöffling, K | 1 |
| Martin, MJ | 1 |
| Robbins, DC | 1 |
| Bergenstal, R | 1 |
| LaGrange, B | 1 |
| Rubenstein, AH | 1 |
| Frølund, L | 1 |
| Kehlet, H | 1 |
| Christensen, NJ | 1 |
| Alberti, KG | 1 |
| Linz, DN | 1 |
| Garcia, VF | 1 |
| Arya, G | 1 |
| Hug, G | 1 |
| Tombragel, E | 1 |
| Landrigan, E | 1 |
| Chuck, G | 1 |
| Tsoras, M | 1 |
| Ryan, M | 1 |
| Ziegler, MM | 1 |
| Mitchell, GA | 1 |
| Kassovska-Bratinova, S | 1 |
| Boukaftane, Y | 1 |
| Robert, MF | 1 |
| Wang, SP | 1 |
| Ashmarina, L | 1 |
| Lambert, M | 1 |
| Lapierre, P | 1 |
| Potier, E | 1 |
| Morris, AA | 2 |
| Deshphande, S | 1 |
| Ward-Platt, MP | 1 |
| Whitfield, AE | 1 |
| Aynsley-Green, A | 2 |
| Leonard, JV | 2 |
| Pourfarzam, M | 1 |
| Bartlett, K | 1 |
| Ciraolo, ST | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467] | 58 participants (Actual) | Observational [Patient Registry] | 2022-03-15 | Completed | |||
| Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280] | 33 participants (Actual) | Interventional | 2013-06-30 | Completed | |||
| Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997] | 200 participants (Anticipated) | Interventional | 2017-08-31 | Not yet recruiting | |||
| The Effect of Intravenous Lactate Administration on Brain Lactate Concentrations and pH During Euglycemia and Hypoglycemia in Patients With Type 1 Diabetes With and Without Impaired Awareness of Hypoglycemia[NCT03286816] | 19 participants (Actual) | Interventional | 2016-11-30 | Completed | |||
| Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964] | Phase 2 | 2 participants (Actual) | Interventional | 2017-10-19 | Terminated (stopped due to Statistical power could not be achieved due to low enrollment.) | ||
| Restoration of Hypoglycemia Awareness With Metoclopramide[NCT03970720] | Phase 2 | 36 participants (Anticipated) | Interventional | 2019-05-28 | Recruiting | ||
| Fasting Tolerance in Patients With Medium-chain Acyl-CoA Dehydrogenase Deficiency (MCADD) in the First Six Months of Life: an Investigator-initiated Human Pilot-study[NCT03761693] | 20 participants (Anticipated) | Interventional | 2019-05-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for 3-hydroxybutyric acid and Fasting Hypoglycemia
| Article | Year |
|---|---|
A focused review of the role of ketone bodies in health and disease.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alzheimer Disease; Blood Glucose; Diabetic Ketoacidos | 2013 |
Adult spontaneous hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Reactive Protein; Fasting; Glucose Tolerance Test; Hu | 2005 |
Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents.
Topics: 3-Hydroxybutyric Acid; Adolescent; Blood Glucose; Child; Clinical Trials as Topic; Diabetes Mellitus | 2006 |
Ketotic hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adrenocorticotropic Hormone; Adult; Alan | 1983 |
Medical aspects of ketone body metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biological Evolution; Brain; Humans; Hydroxybutyrates | 1995 |
12 trials available for 3-hydroxybutyric acid and Fasting Hypoglycemia
| Article | Year |
|---|---|
A randomized controlled trial examining the effects of treatment with propylene glycol and injectable cyanocobalamin on naturally occurring disease, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypo
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Glucose; Hypoglycemia; Ketosis; Lac | 2022 |
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biological Variation, Population; Blood Glucose; Canagliflozin | 2018 |
Safety of nighttime 2-hour suspension of Basal insulin in pump-treated type 1 diabetes even in the absence of low glucose.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Ketoaci | 2014 |
Lactate, rather than ketones, may provide alternative cerebral fuel in hypoglycaemic newborns.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Birth Weight; Blood Glucose; Breast Feeding; Double-Blind Method; | 2015 |
Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Autonomic Nervous System; Blood Glucose; Blood Pressure; Fatt | 2008 |
Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Blood Glucose; Brain Chemistry; Dietary Supplements; El | 2002 |
Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise.
Topics: 3-Hydroxybutyric Acid; Adult; Analysis of Variance; Blood Glucose; Brain; Cerebrovascular Circulatio | 2003 |
Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adrenocorticotropic Hormone; Adult; C-Peptide; Cross-Over Studies; Epinephrin | 2007 |
Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Brain; C-Peptide; Dose-Response Relationship, | 2008 |
Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Cognition; Female; Hormones; Humans; Hydroxybutyrates; | 1994 |
Alanine and terbutaline in treatment of hypoglycemia in IDDM.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, T | 1993 |
Fasting medium chain acyl-coenzyme A dehydrogenase--deficient children can make ketones.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acyl-CoA Dehydrogenase; Age of Onset; Carbon Isotopes; Child; | 2001 |
101 other studies available for 3-hydroxybutyric acid and Fasting Hypoglycemia
| Article | Year |
|---|---|
β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Injuries; Caspase 3; Glucose; Hypoglycemia; NF-kapp | 2022 |
Impact of Polymorphism in the β2-Receptor Gene on Metabolic Responses to Repeated Hypoglycemia in Healthy Humans.
Topics: 3-Hydroxybutyric Acid; Epinephrine; Fatty Acids, Nonesterified; Glucose Clamp Technique; Glycerol; H | 2022 |
Characterization of metabolic profile, health, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Animals; Calcium; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female | 2022 |
Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Fasting; Female; Humans; Hypoglycemia; I | 2023 |
Alternative Cerebral Fuels in the First Five Days in Healthy Term Infants: The Glucose in Well Babies (GLOW) Study.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Blood Glucose; Brain; Female; Humans; Hypoglycemia; Infant, Newbo | 2021 |
Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Anesthetics; Animals; Citrates; Citric Acid; Fatty Ac | 2021 |
Slow but Steady-The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats.
Topics: 3-Hydroxybutyric Acid; Adrenal Glands; Animals; Blood Glucose; Diet, Ketogenic; Disease Models, Anim | 2021 |
Evaluation of a point-of-care electrochemical meter to detect subclinical ketosis and hypoglycaemia in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Chemical Analysis; Blood Glucose; Cattle; Cattle Diseases; Dai | 2017 |
Diagnosis of congenital hyperinsulinism: Biochemical profiles during hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Child; Child, Preschool; Congenital Hyperinsulinism; Fatty Acids, | 2018 |
Accuracy of a cow-side test for the diagnosis of hyperketonemia and hypoglycemia in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Glucose; | 2017 |
Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Canada; Cattle; Cattle Diseases; Dairying; Female; Hypoglycemia; Ket | 2018 |
Point-of-care measurements of blood ketones in newborns.
Topics: 3-Hydroxybutyric Acid; Dimensional Measurement Accuracy; Female; Gestational Age; Humans; Hypoglycem | 2019 |
Increased plasma β-hydroxybutyrate levels during the fasting test in patients with endogenous hyperinsulinaemic hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; C-Peptide; Diagnos | 2013 |
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Citric Acid Cycle; Coenzyme A-Transferases; Female | 2013 |
Biochemical studies in patients with hyperinsulinaemic hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Blood Glucose; Congenital Hyperinsulinism; Fatty Acids, Nonesteri | 2013 |
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi | 2015 |
Case of alcoholic ketoacidosis accompanied with severe hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Coma; Dietary Carbohydrates; Fluid Therapy; Gluconeogenesis; Gluc | 2015 |
Acute hypoglycemia results in reduced cortical neuronal injury in the developing IUGR rat.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Temperature; Cerebral Cortex; Disease Models, An | 2015 |
Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus, Exper | 2016 |
Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Disease Models, Animal; Fasting; Hypoglycemia; Infusi | 2016 |
Metabolic profiles in goat does in late pregnancy with and without subclinical pregnancy toxemia.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Proteins; Female; Goat Diseases; Goats; Hypoglycemia; Pre-Ecla | 2008 |
Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Cognition; Cognition Disorders; Diabetes Mellitus, Type 1; Fat | 2009 |
Ketogenesis evaluation in perfused liver of diabetic rats submitted to short-term insulin-induced hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Caprylates; Diabetes Mellitus, Experim | 2009 |
Chronic in vitro ketosis is neuroprotective but not anti-convulsant.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Cytoprotection; Diet, Ketogenic; Disease Models, A | 2010 |
Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Epinephrine; Fat Emulsions, Intravenous; Fatty Acids, Nonester | 2010 |
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Animals, Newborn; Basic Helix-Loop-Helix Trans | 2011 |
Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs.
Topics: 3-Hydroxybutyric Acid; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 1; Disease Mo | 2010 |
Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Suckling; Anticonvulsants; Brain; Bumetanide; Convulsants; | 2011 |
Cot-side electroencephalography monitoring is not clinically useful in the detection of mild neonatal hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Electroencephalography; Glucose Oxidase; Glycerol; Humans; Hyp | 2011 |
A new mouse mutant, skijumper.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Chromosome Mapping; Chromosomes, Ma | 2002 |
Exogenous administered DL- sodium beta-hydroxybutyrate (beta-OHB) can cross the blood brain barrier.
Topics: 3-Hydroxybutyric Acid; Blood-Brain Barrier; Brain; Humans; Hyperinsulinism; Hypoglycemia; Infant | 2003 |
Insulinoma: how reliable is the biochemical evidence?
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; Humans; Hyp | 2003 |
Increasing serum betahydroxybutyrate concentrations during the 72-hour fast: evidence against hyperinsulinemic hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Biomarkers; Fasting; Female; Humans; Hyperinsulinism; Hypoglycem | 2005 |
Twin-pregnancy increases susceptibility of ewes to hypoglycaemic stress and pregnancy toxaemia.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Fasting; Female; Hypoglycemia; Ketones; Postprandial | 2008 |
Insufficient ketone body use is the cause of ketotic hypoglycemia in one of a pair of homozygotic twins.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Child, Preschool; Diabetic Ketoacidosis; Fatigue; Glycerol; Hu | 2007 |
Metabolic adaptations associated with irreversible glucose loss are different to those observed during under-nutrition.
Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Animals; Cattle; Cattle Diseases; Fatty Acids, Non | 2008 |
Reduced carnitine level causes death from hypoglycemia: possible involvement of suppression of hypothalamic orexin expression during weaning period.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Blood Glucose; Carnitine; Cellulose; Darkness; Fem | 2007 |
"Accelerated starvation" and the skipped breakfast in late normal pregnancy.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterifie | 1982 |
A 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 2. Marked attenuation of the metabolic deterioration by somatostatin.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; | 1983 |
Severe hypoglycemia and hyperinsulinemia in falciparum malaria.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Blood Glucose; Brain Diseases; C-Peptide; Child; | 1983 |
Metabolic and hormonal responses of children and adolescents to fasting and 2-deoxyglucose.
Topics: 3-Hydroxybutyric Acid; Adolescent; Age Factors; Blood Glucose; Child; Child, Preschool; Deoxy Sugars | 1983 |
Differential diagnosis of hypoglycemia in children by responses to fasting and 2-deoxyglucose.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Blood Glucose; Child; Child, Preschool; Deoxy Sug | 1983 |
Glucose metabolism in hyperinsulinemic infants: the effects of fasting and sodium DL-beta-hydroxybutyrate on glucose production and utilization rates.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; C-Peptide; Fasting; Humans; Hydroxybutyrates; Hyperinsulinism; | 1983 |
Ketonuria does not exclude hyperinsulinemic hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adolescent; Blood Glucose; Child; Child, Preschool; Fasting; Fatty Acids, Non | 1984 |
Intrauterine growth and postnatal fasting metabolism in infants of obese mothers.
Topics: 3-Hydroxybutyric Acid; Birth Weight; Blood Glucose; Body Weight; Fasting; Fatty Acids, Nonesterified | 1984 |
Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Butylene Glycols; Cattle; Cattle Diseases; Fatty Acid | 1984 |
Hormonal and metabolic parameters following insulin-induced hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Catecholamines; Fatty Acids, Nonesterified; Hormones; Humans; | 1982 |
Absence of exercise-induced hypoglycaemia in type i (insulin-dependent) diabetic patients during maintenance of normoglycaemia by short-term, open-loop insulin infusion.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon | 1982 |
Effect of ketone body infusion on plasma catecholamine and substrate concentrations during acute hypoglycemia in man.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Catecholamines; Epinephrine; Humans; Hydroxybutyrates; | 1980 |
Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Bacterial Infections; Blood Glucose; Carnitine; Fatty Acids; | 1995 |
Impaired ketogenesis in fructose-1,6-bisphosphatase deficiency: a pitfall in the investigation of hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Fatty Acids, Nonesterified; Female; Fructose-1,6-Diphosphatase Deficiency; Gl | 1995 |
Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Butylene Glycols; Dichloroacetic Acid; | 1995 |
Effect of hepatic vagotomy on plasma catecholamines during exercise-induced hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Catecholamines; Epinephrine; Fatty Acids, Nonesterifi | 1995 |
Evidence that the brain of the conscious dog is insulin sensitive.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Brain; Cerebrovascular Circulation; Consciou | 1995 |
Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Awareness; Blood Glucose; Diabetes Mellitus, Type 1; Epine | 1994 |
Cerebral mitochondrial redox states during metabolic stress in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Diseases; Brain Ischem | 1994 |
Hormonal, metabolic, and circulatory responses to insulin-induced hypoglycemia in pregnant and nonpregnant women with insulin-dependent diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Circulation; Blood Glucose; Blood Pressure; Catecholamines; Diab | 1994 |
Hypoglycemia-induced autonomic failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Analysis of Variance; Autonomic Nervous System; Blood Glucose | 1994 |
Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; C-Peptide; Diabetes Mellitus, Type 1; E | 1994 |
Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Atropine; Autonomic Nervous System; Awareness; Blood Glucose; | 1993 |
The indirect pathway of hepatic glycogen synthesis and reduction of food intake by metabolic inhibitors.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Citrates; Eating; Gluconeogenesis; Hydroxybuty | 1993 |
Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced hypoglycaemia in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Brain; Cognition; Diabetes Mellitus, Type 1; Female; Glycerol | 1993 |
The investigation of beta-hydroxybutyrate as a marker for sudden death due to hypoglycemia in alcoholics.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Alcoholism; Cause of Death; Death, Sudden; Ev | 1993 |
Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Blood Glucose; Epinephrine; Fasting; Female; G | 1993 |
Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; Cognition; Diabetes Mellitus, Type 1; D | 1993 |
Improved postprandial metabolic control after subcutaneous injection of a short-acting insulin analog in IDDM of short duration with residual pancreatic beta-cell function.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Drug Adm | 1995 |
Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Fatty | 1996 |
Evaluation of fasts for investigating hypoglycaemia or suspected metabolic disease.
Topics: 3-Hydroxybutyric Acid; Age Distribution; Child; Child, Preschool; Evaluation Studies as Topic; Fasti | 1996 |
Contribution of autonomic neuropathy to reduced plasma adrenaline responses to hypoglycemia in IDDM: evidence for a nonselective defect.
Topics: 3-Hydroxybutyric Acid; Autonomic Nervous System Diseases; Blood Glucose; Carbon Dioxide; Diabetes Me | 1997 |
beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices.
Topics: 3-Hydroxybutyric Acid; Animals; Glucose; Glycolysis; Hippocampus; Hydroxybutyrates; Hypoglycemia; In | 1998 |
Reduced counterregulation during hypoglycemia with raised circulating nonglucose lipid substrates: evidence for regional differences in metabolic capacity in the human brain?
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood-Brain Barrier; Brain; C-Peptide; Epinephrine; Fat | 1998 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; | 1999 |
Secondary adrenal failure in a young woman presenting as hypoglycaemic coma.
Topics: 3-Hydroxybutyric Acid; Adrenal Gland Diseases; Adrenocorticotropic Hormone; C-Peptide; Coma; Female; | 1999 |
Attenuation of brain hyperbaric oxygen toxicity by fasting is not related to ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Butylene Glycols; Electroencephalography; | 1999 |
Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.
Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Ammonia; Animals; Carbohydrate Metabolism; CCAAT-Enhancer- | 2001 |
Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion.
Topics: 3-Hydroxybutyric Acid; Animals; Carbohydrate Metabolism; Chickens; Fatty Acids, Nonesterified; Hypog | 2000 |
Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Cold Temperature; Consciousness; Dogs; Epine | 2000 |
Energy fuel utilization by fetal versus young rabbit brain: a 13C MRS isotopomer analysis of [U-(13)C]glucose metabolites.
Topics: 3-Hydroxybutyric Acid; Age Factors; Amino Acids; Animals; Astrocytes; Brain; Carbon Isotopes; Energy | 2001 |
Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adrenocorticotropic Hormone; Adult; Alanine; Blood Glucose; Blood Pressure; E | 2001 |
Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Cell Line, Transformed; Codon, Nonsense; Diabetic Ketoacidosi | 2001 |
Sexual dimorphism in counterregulatory responses to hypoglycemia after antecedent exercise.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Blood Pressure; Body Mass Index; Epinephrine; | 2001 |
Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adrenal Medulla; Adult; C-Peptide; Cosyntropin; Epinephrine; Fatty Acids, Non | 2002 |
Effect of near physiologic insulin therapy on hypoglycemia counterregulation in type-1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Acids, None | 2001 |
Attenuated glucose recovery from hypoglycemia in the elderly.
Topics: 3-Hydroxybutyric Acid; Adult; Age Factors; Aged; Alanine; Analysis of Variance; Blood Glucose; Blood | 1992 |
Catecholamines in prevention of hypoglycemia during exercise in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; C-Peptide; Epinephrine; Fatty Acids, No | 1991 |
Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Femal | 1991 |
Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood; Body Temperature; Chronic Disease; Female; Glucose; Hydroxybu | 1991 |
Insulin and glucagon in prevention of hypoglycemia during exercise in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Analysis of Variance; Blood Glucose; C-Peptide; Epinephrine; Fatty Aci | 1991 |
Failure of nocturnal hypoglycemia to cause daytime hyperglycemia in patients with IDDM.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; E | 1990 |
The fasting test in paediatrics: application to the diagnosis of pathological hypo- and hyperketotic states.
Topics: 3-Hydroxybutyric Acid; Adolescent; Blood Glucose; Child; Child, Preschool; Fasting; Fatty Acids, Non | 1990 |
Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental | 1990 |
Glucose counterregulation during recovery from neuroglucopenia: which mechanism is important?
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Brain Diseases, Metabolic; Deoxyglucose; Epinephrine; | 1985 |
Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels.
Topics: 3-Hydroxybutyric Acid; Animals; Capillaries; Cerebrovascular Circulation; Diabetes Mellitus, Experim | 1988 |
Effect of anaesthesia on insulin-induced hypoglycemia in rabbits.
Topics: 3-Hydroxybutyric Acid; Anesthetics; Animals; Fatty Acids, Nonesterified; Hydroxybutyrates; Hypoglyce | 1988 |
Beta-hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Brain; Energy Metabolism; Hydroxybutyrat | 1986 |
Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Brain; Cognition Disorders; Fatty Acids, Nonesterified; | 1988 |
Glucoregulation during exercise: hypoglycemia is prevented by redundant glucoregulatory systems, sympathochromaffin activation, and changes in islet hormone secretion.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; C-Peptide; Chromaffin System; Epinephrine; Fat | 1986 |
Hypoglycemia following insulin and proinsulin. A comparison.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Humans; Hydrox | 1986 |
Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Epinephrine; Fatty Acids, Nonesterified; Fem | 1987 |
Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Carnitine; Creatinine; Dicarboxylic Acids; Fatt | 1987 |
Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Animals, Newborn; Body Weight; Brain; DNA; Female; Fetal Gr | 1985 |