3-hydroxybutyric acid has been researched along with Epilepsy in 38 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "Forty children with refractory epilepsy were included in the present study." | 5.91 | The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy. ( Afghan, M; Barzegar, M; Golchinfar, Z; Poorshiri, B; Raeisi, S; Shahabi, P; Shiva, S; Yousefi Nodeh, HR, 2023) |
| "Short-term MAD was associated with metabolic differences in plasma and resected epilepsy brain tissue when compared to control participants, in combination with trending expression changes observed in hippocampal NADH-related signaling pathways." | 4.31 | Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet. ( Devinsky, O; Devore, S; Friedman, D; Jones, DR; Kanshin, E; Korman, A; Leitner, DF; Lin, Z; Siu, Y; Tsirigos, A; Ueberheide, B; Wisniewski, T, 2023) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "Carnitine metabolism was monitored in seven children started on a KD for pharmacoresistant epilepsy after a conventional initial fasting period." | 2.72 | Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. ( Baumeister, FA; Bieger, I; Busch, R; Busch, V; Gempel, K; Hack, A; Pascher, B, 2006) |
| "Forty children with refractory epilepsy were included in the present study." | 1.91 | The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy. ( Afghan, M; Barzegar, M; Golchinfar, Z; Poorshiri, B; Raeisi, S; Shahabi, P; Shiva, S; Yousefi Nodeh, HR, 2023) |
| "Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide." | 1.46 | Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. ( Becker, HM; Deitmer, JW; Forero-Quintero, LS, 2017) |
| "We found that the KD postpones disease progression by delaying the onset of severe seizures and increases the lifespan of these mutant mice by 47%." | 1.43 | Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. ( Matthews, SA; Rho, JM; Simeone, KA; Simeone, TA, 2016) |
| "However, chronic in vitro ketosis abolished hippocampal network hyperexcitability following a metabolic insult, hypoxia, demonstrating for the first time a direct link between metabolic resistance and better control of excessive, synchronous, abnormal electrical activity." | 1.36 | Chronic in vitro ketosis is neuroprotective but not anti-convulsant. ( Abdelmalik, P; Carlen, PL; Samoilova, M; Velumian, AA; Weisspapir, M, 2010) |
| "A consistently strong ketosis (beta-hydroxybutyrate of >3 mmol/L) seemed to be important for maintaining the efficacy of the diet therapy." | 1.34 | Use of a modified Atkins diet in intractable childhood epilepsy. ( Kang, du C; Kang, HC; Kim, HD; Ko, TS; Lee, HS; You, SJ, 2007) |
| "The level of ketosis, however, was not predictive of seizure protection in EL mice." | 1.31 | The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. ( Madore, RA; Seyfried, TN; Stafstrom, CE; Tandon, P; Todorova, MT, 2000) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 16 (42.11) | 29.6817 |
| 2010's | 12 (31.58) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Poorshiri, B | 1 |
| Barzegar, M | 1 |
| Afghan, M | 1 |
| Shiva, S | 1 |
| Shahabi, P | 1 |
| Golchinfar, Z | 1 |
| Yousefi Nodeh, HR | 1 |
| Raeisi, S | 1 |
| Leitner, DF | 1 |
| Siu, Y | 1 |
| Korman, A | 1 |
| Lin, Z | 1 |
| Kanshin, E | 1 |
| Friedman, D | 1 |
| Devore, S | 1 |
| Ueberheide, B | 1 |
| Tsirigos, A | 1 |
| Jones, DR | 1 |
| Wisniewski, T | 1 |
| Devinsky, O | 1 |
| Soto-Mota, A | 1 |
| Norwitz, NG | 1 |
| Clarke, K | 1 |
| Jin, N | 1 |
| Ziyatdinova, S | 1 |
| Gureviciene, I | 1 |
| Tanila, H | 1 |
| Forero-Quintero, LS | 1 |
| Deitmer, JW | 1 |
| Becker, HM | 1 |
| Bonnet, U | 1 |
| Bingmann, D | 1 |
| Speckmann, EJ | 1 |
| Wiemann, M | 1 |
| Guo, Q | 1 |
| Liu, S | 1 |
| Wang, S | 1 |
| Wu, M | 1 |
| Li, Z | 1 |
| Wang, Y | 1 |
| Bertoli, S | 1 |
| Trentani, C | 1 |
| Ferraris, C | 1 |
| De Giorgis, V | 1 |
| Veggiotti, P | 1 |
| Tagliabue, A | 1 |
| Mantis, JG | 1 |
| Meidenbauer, JJ | 2 |
| Zimick, NC | 1 |
| Centeno, NA | 1 |
| Seyfried, TN | 3 |
| Roberts, MF | 1 |
| Law, TH | 1 |
| Davies, ES | 1 |
| Pan, Y | 1 |
| Zanghi, B | 1 |
| Want, E | 1 |
| Volk, HA | 1 |
| Simeone, KA | 2 |
| Matthews, SA | 2 |
| Rho, JM | 1 |
| Simeone, TA | 2 |
| Samson, KK | 1 |
| Xu, X | 1 |
| Sun, R | 1 |
| Jin, R | 1 |
| Porta, N | 1 |
| Vallée, L | 1 |
| Lecointe, C | 1 |
| Bouchaert, E | 1 |
| Staels, B | 1 |
| Bordet, R | 1 |
| Auvin, S | 1 |
| Samoilova, M | 1 |
| Weisspapir, M | 1 |
| Abdelmalik, P | 1 |
| Velumian, AA | 1 |
| Carlen, PL | 1 |
| Luan, G | 1 |
| Zhao, Y | 1 |
| Zhai, F | 1 |
| Chen, Y | 1 |
| Li, T | 1 |
| Fraser, DD | 1 |
| Whiting, S | 1 |
| Andrew, RD | 1 |
| Macdonald, EA | 1 |
| Musa-Veloso, K | 2 |
| Cunnane, SC | 2 |
| Cahill, GF | 2 |
| Veech, RL | 2 |
| SHINDO, H | 1 |
| Tabb, K | 1 |
| Szot, P | 1 |
| White, SS | 1 |
| Liles, LC | 1 |
| Weinshenker, D | 1 |
| Hack, A | 1 |
| Busch, V | 1 |
| Pascher, B | 1 |
| Busch, R | 1 |
| Bieger, I | 1 |
| Gempel, K | 1 |
| Baumeister, FA | 1 |
| Xu, XP | 1 |
| Sun, RP | 1 |
| Jin, RF | 1 |
| Kang, HC | 1 |
| Lee, HS | 1 |
| You, SJ | 1 |
| Kang, du C | 1 |
| Ko, TS | 1 |
| Kim, HD | 1 |
| Raffo, E | 1 |
| François, J | 1 |
| Ferrandon, A | 1 |
| Koning, E | 1 |
| Nehlig, A | 1 |
| Hallböök, T | 1 |
| Köhler, S | 1 |
| Rosén, I | 1 |
| Lundgren, J | 1 |
| Hartman, AL | 1 |
| Lyle, M | 1 |
| Rogawski, MA | 1 |
| Gasior, M | 1 |
| Shen, J | 1 |
| Novotny, EJ | 1 |
| Rothman, DL | 1 |
| Bough, KJ | 1 |
| Eagles, DA | 1 |
| Sankar, R | 1 |
| Sotero de Menezes, M | 1 |
| Bergqvist, AG | 1 |
| Chee, CM | 1 |
| Lutchka, LM | 1 |
| Brooks-Kayal, AR | 1 |
| Thio, LL | 1 |
| Wong, M | 1 |
| Yamada, KA | 1 |
| Todorova, MT | 2 |
| Tandon, P | 1 |
| Madore, RA | 1 |
| Stafstrom, CE | 1 |
| Chance, B | 1 |
| Kashiwaya, Y | 1 |
| Lardy, HA | 1 |
| Greene, AE | 1 |
| McGowan, R | 1 |
| Likhodii, SS | 1 |
| Sills, MA | 1 |
| Forsythe, WI | 1 |
| Haidukewych, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371] | 30 participants (Anticipated) | Interventional | 2022-10-31 | Recruiting | |||
| Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293] | 18 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for 3-hydroxybutyric acid and Epilepsy
| Article | Year |
|---|---|
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Ketoacids? Good medicine?
Topics: 3-Hydroxybutyric Acid; Animals; Cerebral Cortex; Diet; Epilepsy; Fasting; Humans; Ketone Bodies; Ket | 2003 |
Metabolic and endocrine aspects of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Anticonvulsants; Carnitine; Dietary Fats; Energy Metabolism; Epilepsy; Fatty | 1999 |
Treatment of acquired epileptic aphasia with the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adolescent; Anticonvulsants; Aphasia; Child; Combined Modality Therapy; Dieta | 1999 |
Ketone bodies, potential therapeutic uses.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Energy Metabolism; Epilepsy; Fasting; Humans; Ketone Bodies; | 2001 |
3 trials available for 3-hydroxybutyric acid and Epilepsy
| Article | Year |
|---|---|
A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Blood Glucose; Bromides; Cross-Over Studies; Diet, | 2015 |
Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.
Topics: 3-Hydroxybutyric Acid; Acetylcarnitine; Biological Transport; Carnitine; Child; Child, Preschool; Di | 2006 |
In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Epilepsy; Humans; Lactic Acid; Magnetic Resonance Spectros | 1998 |
30 other studies available for 3-hydroxybutyric acid and Epilepsy
| Article | Year |
|---|---|
The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy.
Topics: 3-Hydroxybutyric Acid; Arachidonic Acid; Child; Diet, Ketogenic; Drug Resistant Epilepsy; Epilepsy; | 2023 |
Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet.
Topics: 3-Hydroxybutyric Acid; Adult; Diet, Carbohydrate-Restricted; Diet, High-Protein Low-Carbohydrate; Di | 2023 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis | 2020 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy | 2017 |
Small intraneuronal acidification via short-chain monocarboxylates: First evidence of an inhibitory action on over-excited human neocortical neurons.
Topics: 3-Hydroxybutyric Acid; Carboxylic Acids; Child, Preschool; Electrophysiological Phenomena; Epilepsy; | 2018 |
Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Epilepsy; Glutathione Peroxidase; Hippocampus; Male; Malo | 2019 |
[Prospective multicenter study on long-term ketogenic diet therapy for intractable childhood epilepsy].
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Diarrhea; Diet, Carbohydrate-Restricted; | 2013 |
Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Body Composition; Body Mass Index; Body Weight; Bone D | 2014 |
Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Blood Glucose; Body Weight; Caloric Restrictio | 2014 |
Reduced glucose utilization underlies seizure protection with dietary therapy in epileptic EL mice.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Caloric Restriction; Diet, Ketogenic; Disease Models, Animal; | 2014 |
Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blood Glucose; | 2016 |
Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Anilides; Animals; Animals, Newborn; Anticonvulsants; Blood Gluc | 2017 |
The effect of the ketogenic diet on hippocampal GluR5 and Glu(6 mRNA expression and Q/R site editing in the kainate-induced epilepsy model.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Base Sequence; Behavior, Animal; Body Weight; | 2008 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Chronic in vitro ketosis is neuroprotective but not anti-convulsant.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Cytoprotection; Diet, Ketogenic; Disease Models, A | 2010 |
Ketogenic diet reduces Smac/Diablo and cytochrome c release and attenuates neuronal death in a mouse model of limbic epilepsy.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Carrier Protein | 2012 |
Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adolescent; Arachidonic Acids; Child; Child, Preschool; Diet; Epilepsy; Fatty | 2003 |
[Clinical information on gama-amino-beta-hydroxybutyric acid in epilepsy].
Topics: 3-Hydroxybutyric Acid; Amino Acids; Antifibrinolytic Agents; Epilepsy | 1962 |
The ketogenic diet does not alter brain expression of orexigenic neuropeptides.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Chemistry; Eating; Energy Metabolism; Epilepsy; Galanin; In Si | 2004 |
Effect of ketogenic diet on hippocampus mossy fiber sprouting and GluR5 expression in kainic acid induced rat model.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Disease Model | 2006 |
Use of a modified Atkins diet in intractable childhood epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Child; Cohort Studies; Diet, Carbohydrate-Restricted; Dietary Pr | 2007 |
Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cerebral Cortex; Di | 2008 |
Effects of ketogenic diet on epileptiform activity in children with therapy resistant epilepsy.
Topics: 3-Hydroxybutyric Acid; Adolescent; Attention; Child; Child, Preschool; Data Interpretation, Statisti | 2007 |
Efficacy of the ketogenic diet in the 6-Hz seizure test.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Confounding Factors, Epidemiologic; Diet | 2008 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Co | 2000 |
The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Association Learning; Behavior, Animal; Blood Glucose; Dietary Carbo | 2000 |
Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Body Weig | 2001 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |
Role of octanoic and decanoic acids in the control of seizures.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Alanine; Caprylates; Child; Child, Preschool; Circ | 1986 |