3-hydroxybutyric acid has been researched along with Dry Eye Syndromes in 3 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Dry Eye Syndromes: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study suggested that 1% D-3-hydroxybutyrate eye drops are safe and effective in treating ocular surface disorders in patients with tear-deficient dry eye disease." | 2.82 | Randomized, Multicenter, Double-Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease. ( Arai, H; Fukagawa, K; Hata, S; Kawakita, T; Okano, T; Sakatani, K; Shimazaki, S; Tanaka, M; Toda, I; Tsubota, K; Uchino, M; Yoshino, K, 2016) |
| "This rat dry eye model, established by repeated JB treatment in desiccating conditions, induced abnormal tear dynamics and superficial punctate keratopathy similar to that in humans." | 1.33 | D-beta-hydroxybutyrate protects against corneal epithelial disorders in a rat dry eye model with jogging board. ( Imagawa, T; Nakamura, S; Nakashima, H; Shibuya, M; Tsubota, K; Uehara, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawakita, T | 1 |
| Uchino, M | 1 |
| Fukagawa, K | 1 |
| Yoshino, K | 1 |
| Shimazaki, S | 1 |
| Toda, I | 1 |
| Tanaka, M | 1 |
| Arai, H | 1 |
| Sakatani, K | 1 |
| Hata, S | 1 |
| Okano, T | 1 |
| Tsubota, K | 3 |
| Nakamura, S | 2 |
| Shibuya, M | 2 |
| Saito, Y | 1 |
| Nakashima, H | 2 |
| Saito, F | 1 |
| Higuchi, A | 1 |
| Imagawa, T | 1 |
| Uehara, M | 1 |
1 trial available for 3-hydroxybutyric acid and Dry Eye Syndromes
| Article | Year |
|---|---|
Randomized, Multicenter, Double-Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Animals; Conjunctiva; Cornea; Double-Blind Method; Dry Eye Syndr | 2016 |
2 other studies available for 3-hydroxybutyric acid and Dry Eye Syndromes
| Article | Year |
|---|---|
Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis.
Topics: 3-Hydroxybutyric Acid; Administration, Topical; Animals; Apoptosis; Blood; Cell Survival; Corneal Di | 2003 |
D-beta-hydroxybutyrate protects against corneal epithelial disorders in a rat dry eye model with jogging board.
Topics: 3-Hydroxybutyric Acid; Animals; Blinking; Corneal Diseases; Disease Models, Animal; Dry Eye Syndrome | 2005 |