3-hydroxybutyric acid has been researched along with Disease Exacerbation in 12 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten autosomal dominant PKD (ADPKD) patients with rapid disease progression were enrolled at visit V1 and initially maintained a carbohydrate-rich diet." | 3.30 | RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease. ( Arjune, S; Grundmann, F; Heinrich Lindemann, C; Meyer, F; Müller, RU; Oehm, S; Schmidt, J; Siedek, F; Steinke, K; Todorova, P; Weimbs, T; Wöstmann, F, 2023) |
| "We found that the KD postpones disease progression by delaying the onset of severe seizures and increases the lifespan of these mutant mice by 47%." | 1.43 | Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. ( Matthews, SA; Rho, JM; Simeone, KA; Simeone, TA, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Oehm, S | 3 |
| Steinke, K | 3 |
| Schmidt, J | 3 |
| Arjune, S | 3 |
| Todorova, P | 3 |
| Heinrich Lindemann, C | 3 |
| Wöstmann, F | 3 |
| Meyer, F | 3 |
| Siedek, F | 3 |
| Weimbs, T | 4 |
| Müller, RU | 3 |
| Grundmann, F | 3 |
| Torres, JA | 1 |
| Kruger, SL | 1 |
| Broderick, C | 1 |
| Amarlkhagva, T | 1 |
| Agrawal, S | 1 |
| Dodam, JR | 1 |
| Mrug, M | 1 |
| Lyons, LA | 1 |
| Song, JP | 1 |
| Chen, L | 1 |
| Chen, X | 1 |
| Ren, J | 1 |
| Zhang, NN | 1 |
| Tirasawasdichai, T | 1 |
| Hu, ZL | 1 |
| Hua, W | 1 |
| Hu, YR | 1 |
| Tang, HR | 1 |
| Chen, HV | 1 |
| Hu, SS | 1 |
| Krishnan, M | 1 |
| Hwang, JS | 1 |
| Kim, M | 1 |
| Kim, YJ | 1 |
| Seo, JH | 1 |
| Jung, J | 1 |
| Ha, E | 1 |
| Liao, YJ | 1 |
| Wang, YH | 1 |
| Wu, CY | 1 |
| Hsu, FY | 1 |
| Chien, CY | 1 |
| Lee, YC | 1 |
| Perry, HM | 1 |
| Huang, L | 1 |
| Wilson, RJ | 1 |
| Bajwa, A | 1 |
| Sesaki, H | 1 |
| Yan, Z | 1 |
| Rosin, DL | 1 |
| Kashatus, DF | 1 |
| Okusa, MD | 1 |
| Horton, JL | 1 |
| Davidson, MT | 1 |
| Kurishima, C | 1 |
| Vega, RB | 1 |
| Powers, JC | 1 |
| Matsuura, TR | 1 |
| Petucci, C | 1 |
| Lewandowski, ED | 1 |
| Crawford, PA | 1 |
| Muoio, DM | 1 |
| Recchia, FA | 1 |
| Kelly, DP | 1 |
| Malloy, VL | 1 |
| Perrone, CE | 1 |
| Mattocks, DA | 1 |
| Ables, GP | 1 |
| Caliendo, NS | 1 |
| Orentreich, DS | 1 |
| Orentreich, N | 1 |
| Schutsky, K | 1 |
| Portocarrero, C | 1 |
| Hooper, DC | 1 |
| Dietzschold, B | 1 |
| Faber, M | 1 |
| Simeone, KA | 1 |
| Matthews, SA | 1 |
| Rho, JM | 1 |
| Simeone, TA | 1 |
| Jehle, D | 1 |
| Johnson, D | 1 |
| Martel, T | 1 |
| Molnar, J | 1 |
| Lark, MC | 1 |
| Falkowitz, J | 1 |
| Short, R | 1 |
| Plexousakis, M | 1 |
| Schmitt, R | 1 |
| Nambudiri, V | 1 |
| Cui, J | 1 |
| Liu, Y | 1 |
| Hu, Y | 1 |
| Tong, J | 1 |
| Li, A | 1 |
| Qu, T | 1 |
| Qin, X | 1 |
| Du, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Short Term Induction of Ketosis in PKD[NCT04472624] | 10 participants (Actual) | Interventional | 2020-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 3-hydroxybutyric acid and Disease Exacerbation
| Article | Year |
|---|---|
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Disease Progression; Glomerular Filtration Rate; Kidney; Pi | 2023 |
11 other studies available for 3-hydroxybutyric acid and Disease Exacerbation
| Article | Year |
|---|---|
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease.
Topics: 3-Hydroxybutyric Acid; Animals; Cats; Cysts; Diet, Ketogenic; Disease Models, Animal; Disease Progre | 2019 |
Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy.
Topics: 3-Hydroxybutyric Acid; Cardiomyopathies; Disease Progression; Heart Ventricles; Humans; Myocytes, Ca | 2020 |
β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice.
Topics: 3-Hydroxybutyric Acid; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Aorta; Apolipoproteins | 2020 |
Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Actins; Animals; Becaplermin; Carbon Tetrachloride; Catalase; | 2021 |
Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI.
Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Animals; Apoptosis; Disease Progression; Dynamins; Fibro | 2018 |
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Topics: 3-Hydroxybutyric Acid; Animals; Disease Models, Animal; Disease Progression; Dogs; Energy Metabolism | 2019 |
Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Diet; Disease Progression; Fatty Acids; F | 2013 |
Limited brain metabolism changes differentiate between the progression and clearance of rabies virus.
Topics: 3-Hydroxybutyric Acid; Adaptive Immunity; Animals; Antiviral Agents; Brain; Carnitine; Corticosteron | 2014 |
Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blood Glucose; | 2016 |
Severe diabetic ketoacidosis presenting with negative serum ketones.
Topics: 3-Hydroxybutyric Acid; Adult; Diabetic Ketoacidosis; Disease Progression; Female; Humans; Ketones; S | 2017 |
NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis.
Topics: 3-Hydroxybutyric Acid; Animals; Arginine; Biomarkers; Body Weight; Chronic Disease; Disease Progress | 2017 |