3-hydroxybutyric acid has been researched along with Diabetes Mellitus in 75 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 9.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 5.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| " Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume." | 3.88 | Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. ( Clark, M; Hoenig, M; Reiche, D; Schaeffer, DJ, 2018) |
| "Euglycemic diabetic ketoacidosis is a metabolic condition characterized by relative euglycemia, ketonemia, and metabolic acidosis that occurs through mechanisms resembling starvation." | 1.91 | Euglycemic diabetic ketoacidosis (EDKA) after pancreaticoduodenectomy: An under-recognized metabolic abnormality with outcome implications. ( Bowne, WB; Kavanagh, TR; Krampitz, GW; Lavu, H; Nevler, A; Rshaidat, H; Sholevar, C; Swaminathan, V; Torjani, A; Xiao, K; Yeo, CJ; Yudkoff, C, 2023) |
| "Diabetic ketoalkalosis is a common yet easily overlooked alkalemic variant of DKA associated with mixed acid-base disorders, and a high proportion of these presentations have severe ketoacidosis and thus, require the same treatment as traditional DKA." | 1.91 | Diabetic Ketoalkalosis: A Common Yet Easily Overlooked Alkalemic Variant of Diabetic Ketoacidosis Associated with Mixed Acid-Base Disorders. ( Cao, S, 2023) |
| "We reviewed episodes of diabetic ketoacidosis from 79 diabetes patients (one episode per patient)." | 1.72 | Hyperlactatemia in diabetic ketoacidosis. ( Brooks, GA; Lazar, AA; Masharani, U; Strycker, LA; Wu, K, 2022) |
| "Diabetes mellitus, Hyperglycemia, Diabetic ketoacidosis, Point-of-care testing, Ketosis, Urine ketones, Acetoacetates." | 1.72 | Comparing Finger-stick Βeta-hydroxybutyrate with Dipstick Urine Tests in the Detection of Ketone Bodies in the Diagnosis of Children with Diabetic Ketoacidosis. ( Baloch, SH; Gowa, M; Ibrahim, M; Lohano, PD; Raza, SJ, 2022) |
| "Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal." | 1.39 | Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013) |
| "16 cases of diabetic ketoacidosis were identified based on the results of all investigations." | 1.39 | Postmortem diagnosis of unsuspected diabetes mellitus. ( Bardy, D; Mangin, P; Palmiere, C; Werner, D, 2013) |
| "Skin acetone concentration was high (940 ppb) in a patient with diabetic ketoacidosis, and it fell to 80 ppb after insulin therapy." | 1.33 | Relationship between skin acetone and blood beta-hydroxybutyrate concentrations in diabetes. ( Ishiguro, H; Kondo, T; Nose, K; Tsuda, T; Yamamoto, A; Yamane, N, 2006) |
| "The mechanism by which ketosis causes accelerated cellular damage and vascular disease in diabetes is not known." | 1.30 | Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells. ( Jain, SK; Kannan, K; Lim, G, 1998) |
| "Thus, in NIDDM patients, fasting corrects the defect in glycogen storage without modifying the action of insulin on glucose uptake and improves beta-cell responsiveness, the latter two effects being opposite to those observed in nondiabetic subjects." | 1.29 | Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. ( Balasse, EO; Féry, F, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (34.67) | 18.7374 |
| 1990's | 15 (20.00) | 18.2507 |
| 2000's | 9 (12.00) | 29.6817 |
| 2010's | 10 (13.33) | 24.3611 |
| 2020's | 15 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masharani, U | 1 |
| Strycker, LA | 1 |
| Lazar, AA | 1 |
| Wu, K | 1 |
| Brooks, GA | 1 |
| Kilpatrick, ES | 1 |
| Butler, AE | 1 |
| Ostlundh, L | 1 |
| Atkin, SL | 1 |
| Sacks, DB | 1 |
| Lohano, PD | 1 |
| Ibrahim, M | 1 |
| Raza, SJ | 1 |
| Gowa, M | 1 |
| Baloch, SH | 1 |
| Sholevar, C | 1 |
| Torjani, A | 1 |
| Kavanagh, TR | 1 |
| Yudkoff, C | 1 |
| Xiao, K | 1 |
| Swaminathan, V | 1 |
| Rshaidat, H | 1 |
| Bowne, WB | 1 |
| Krampitz, GW | 1 |
| Nevler, A | 1 |
| Yeo, CJ | 1 |
| Lavu, H | 1 |
| Li, J | 1 |
| Yang, Y | 1 |
| Peng, Z | 1 |
| Yang, J | 1 |
| Li, Y | 1 |
| Wang, S | 1 |
| Neumann, D | 1 |
| Westenbrink, BD | 1 |
| Schianchi, F | 1 |
| Wong, LY | 1 |
| Sun, A | 1 |
| Strzelecka, A | 1 |
| Glatz, JFC | 1 |
| Luiken, JJFP | 1 |
| Nabben, M | 1 |
| Cao, S | 2 |
| Hui, SA | 1 |
| Chiew, AL | 1 |
| Depczynski, B | 1 |
| Wang, J | 1 |
| Yang, X | 1 |
| Shen, L | 1 |
| Ni, R | 1 |
| Huang, Y | 1 |
| Sui, Z | 1 |
| Wang, X | 1 |
| Wan, SR | 1 |
| Teng, FY | 1 |
| Fan, W | 1 |
| Xu, BT | 1 |
| Li, XY | 1 |
| Tan, XZ | 1 |
| Guo, M | 1 |
| Gao, CL | 1 |
| Zhang, CX | 1 |
| Jiang, ZZ | 1 |
| Xu, Y | 1 |
| Gharib, R | 1 |
| Khatibi, A | 1 |
| Khodarahmi, R | 1 |
| Haidari, M | 1 |
| Husseinzadeh, S | 1 |
| Tremblay, ES | 1 |
| Millington, K | 1 |
| Monuteaux, MC | 1 |
| Bachur, RG | 1 |
| Wolfsdorf, JI | 1 |
| Soto-Mota, A | 1 |
| Norwitz, NG | 1 |
| Clarke, K | 1 |
| Møller, N | 1 |
| Fang, Y | 1 |
| Chen, B | 1 |
| Gong, AY | 1 |
| Malhotra, DK | 1 |
| Gupta, R | 1 |
| Dworkin, LD | 1 |
| Gong, R | 1 |
| Hoenig, M | 1 |
| Clark, M | 1 |
| Schaeffer, DJ | 1 |
| Reiche, D | 1 |
| Keltanen, T | 1 |
| Sajantila, A | 1 |
| Palo, JU | 1 |
| Partanen, T | 1 |
| Valonen, T | 1 |
| Lindroos, K | 1 |
| Qiao, Y | 1 |
| Gao, Z | 1 |
| Liu, Y | 2 |
| Cheng, Y | 1 |
| Yu, M | 1 |
| Zhao, L | 1 |
| Duan, Y | 1 |
| Zeugswetter, F | 1 |
| Handl, S | 1 |
| Iben, C | 1 |
| Schwendenwein, I | 1 |
| Yamada, T | 1 |
| Zhang, SJ | 1 |
| Westerblad, H | 1 |
| Katz, A | 1 |
| Aroch, I | 1 |
| Shechter-Polak, M | 1 |
| Segev, G | 1 |
| Arora, S | 1 |
| Probst, MA | 1 |
| Agy, C | 1 |
| Menchine, M | 1 |
| Weingart, C | 1 |
| Lotz, F | 1 |
| Kohn, B | 1 |
| Tsutsui, H | 1 |
| Mochizuki, T | 1 |
| Maeda, T | 1 |
| Noge, I | 1 |
| Kitagawa, Y | 1 |
| Min, JZ | 1 |
| Todoroki, K | 1 |
| Inoue, K | 1 |
| Toyo'oka, T | 1 |
| Palmiere, C | 1 |
| Bardy, D | 1 |
| Mangin, P | 1 |
| Werner, D | 1 |
| Ren, FQ | 1 |
| Yan, SK | 1 |
| Mao, DY | 1 |
| Li, YX | 1 |
| Xiao, XH | 1 |
| Xu, EM | 1 |
| Huang, BW | 1 |
| Chiang, MT | 1 |
| Yao, HT | 1 |
| Chiang, W | 1 |
| Meckling, KA | 1 |
| O'Sullivan, C | 1 |
| Saari, D | 1 |
| Bektas, F | 1 |
| Eray, O | 1 |
| Sari, R | 1 |
| Akbas, H | 1 |
| Kanetake, J | 1 |
| Kanawaku, Y | 1 |
| Mimasaka, S | 1 |
| Sakai, J | 1 |
| Hashiyada, M | 1 |
| Nata, M | 1 |
| Funayama, M | 1 |
| Penders, J | 1 |
| Fiers, T | 1 |
| Giri, M | 1 |
| Wuyts, B | 1 |
| Ysewyn, L | 1 |
| Delanghe, JR | 1 |
| Yamane, N | 1 |
| Tsuda, T | 1 |
| Nose, K | 1 |
| Yamamoto, A | 1 |
| Ishiguro, H | 1 |
| Kondo, T | 1 |
| Kataoka, T | 1 |
| Aoyama, Y | 1 |
| Sakoda, A | 1 |
| Nakagawa, S | 1 |
| Yamaoka, K | 1 |
| Metzger, BE | 2 |
| Ravnikar, V | 1 |
| Vileisis, RA | 1 |
| Freinkel, N | 2 |
| Scheen, AJ | 2 |
| Krzentowski, G | 3 |
| Castillo, M | 2 |
| Lefèbvre, PJ | 4 |
| Luyckx, AS | 3 |
| Scheen, A | 1 |
| Vaughan, NJ | 1 |
| Matthews, JA | 1 |
| Kurtz, AB | 1 |
| Nabarro, JD | 1 |
| Harano, Y | 1 |
| Kosugi, K | 1 |
| Hyosu, T | 1 |
| Uno, S | 1 |
| Ichikawa, Y | 1 |
| Shigeta, Y | 1 |
| Eckfeldt, JH | 1 |
| Leiendecker-Foster, C | 1 |
| Kershaw, MJ | 1 |
| Nankervis, A | 1 |
| Proietto, J | 1 |
| Aitken, P | 1 |
| Harewood, M | 1 |
| Alford, F | 1 |
| Martin, MJ | 1 |
| Robbins, DC | 1 |
| Bergenstal, R | 1 |
| LaGrange, B | 1 |
| Rubenstein, AH | 1 |
| Home, PD | 2 |
| Massi-Benedetti, M | 1 |
| Gill, GV | 1 |
| Capaldo, B | 1 |
| Shepherd, GA | 1 |
| Alberti, KG | 7 |
| Sutherland, DE | 1 |
| Najarian, JS | 1 |
| Greenberg, BZ | 1 |
| Senske, BJ | 1 |
| Anderson, GE | 1 |
| Francis, RS | 1 |
| Goetz, FC | 1 |
| Sheppard, MC | 1 |
| Burrin, J | 1 |
| Nattrass, M | 1 |
| Sherwin, RS | 1 |
| Fantus, IG | 1 |
| Ryan, J | 1 |
| Gorden, P | 1 |
| Pirnay, F | 1 |
| Pallikarakis, N | 1 |
| Lacroix, M | 1 |
| Mosora, F | 1 |
| Taskinen, MR | 1 |
| Nikkilä, EA | 1 |
| Nousiainen, R | 1 |
| Gordin, A | 1 |
| Pickup, JC | 1 |
| Viberti, GC | 1 |
| Bilous, RW | 1 |
| Keen, H | 1 |
| Binder, C | 2 |
| Madsbad, S | 1 |
| Faber, OK | 1 |
| Kurtz, A | 1 |
| Krarup, T | 1 |
| Regeur, L | 1 |
| Tronier, B | 1 |
| Orskov, H | 2 |
| MacGillivray, MH | 1 |
| Li, PK | 1 |
| Lee, JT | 1 |
| Mills, BJ | 1 |
| Voorhess, ML | 1 |
| Putnam, TI | 1 |
| Schaefer, PA | 1 |
| Burrin, JM | 1 |
| Worth, R | 1 |
| Law, S | 1 |
| Féry, F | 2 |
| Balasse, EO | 2 |
| Ohkawa, H | 1 |
| Iwakawa, T | 1 |
| Ohtomo, N | 1 |
| Kitayama, M | 1 |
| Miyahara, A | 1 |
| Ishihara, H | 1 |
| Matsuki, A | 1 |
| Castillo, MJ | 1 |
| Pontiroli, AE | 1 |
| Pacchioni, M | 1 |
| Piatti, PM | 1 |
| Cassisa, C | 1 |
| Camisasca, R | 1 |
| Pozza, G | 1 |
| Szutowicz, A | 1 |
| Tomaszewicz, M | 1 |
| Bielarczyk, H | 1 |
| Jain, SK | 2 |
| Kannan, K | 1 |
| Lim, G | 2 |
| Fulop, M | 1 |
| Murthy, V | 1 |
| Michilli, A | 1 |
| Nalamati, J | 1 |
| Qian, Q | 1 |
| Saitowitz, A | 1 |
| McVie, R | 1 |
| Jackson, R | 1 |
| Levine, SN | 1 |
| Tatewaki, R | 1 |
| Kagohashi, Y | 1 |
| Furuse, K | 1 |
| Otani, H | 1 |
| Fulcher, GR | 1 |
| Walker, M | 1 |
| Catalano, C | 1 |
| Agius, L | 1 |
| Chan, SP | 1 |
| Gelding, SV | 1 |
| McManus, RJ | 1 |
| Nicholls, JS | 1 |
| Anyaoku, V | 1 |
| Niththyananthan, R | 1 |
| Johnston, DG | 1 |
| Dornhorst, A | 1 |
| Yajnik, CS | 1 |
| Shelgikar, KM | 1 |
| Naik, SS | 1 |
| Kanitkar, SV | 1 |
| Hockaday, TD | 1 |
| Ruell, PA | 1 |
| Gass, GC | 1 |
| Barnett, CR | 1 |
| Flatt, PR | 1 |
| Ioannides, C | 1 |
| Watts, NB | 1 |
| DiGirolamo, M | 1 |
| d'Attellis, NP | 1 |
| Avogaro, A | 3 |
| Bier, DM | 1 |
| Gray, DS | 1 |
| Takahashi, M | 1 |
| Fisler, JS | 1 |
| LoPresti, J | 1 |
| Nicoloff, JT | 1 |
| Bray, GA | 1 |
| Heitmann, RN | 1 |
| Fernandez, JM | 1 |
| Nosadini, R | 2 |
| Trevisan, R | 2 |
| Duner, E | 1 |
| Marescotti, C | 1 |
| Iori, E | 1 |
| Cobelli, C | 2 |
| Toffolo, G | 2 |
| Kimura, M | 1 |
| Kobayashi, K | 1 |
| Matsuoka, A | 1 |
| Hayashi, K | 1 |
| Kimura, Y | 1 |
| Saccà, L | 1 |
| Vigorito, C | 1 |
| de Kreutzenberg, S | 1 |
| Tessari, P | 1 |
| Tiengo, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371] | 30 participants (Anticipated) | Interventional | 2022-10-31 | Recruiting | |||
| Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293] | 18 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Breath Test to Predict Breast Cancer and Outcome of Mammography[NCT04755829] | 1,000 participants (Anticipated) | Observational | 2021-03-31 | Not yet recruiting | |||
| Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997] | 200 participants (Anticipated) | Interventional | 2017-08-31 | Not yet recruiting | |||
| Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467] | 58 participants (Actual) | Observational [Patient Registry] | 2022-03-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for 3-hydroxybutyric acid and Diabetes Mellitus
| Article | Year |
|---|---|
Controversies Around the Measurement of Blood Ketones to Diagnose and Manage Diabetic Ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Ketones; Point-of-Care Syst | 2022 |
What is the utility of blood beta-hydroxybutyrate measurements in emergency department in patients without diabetes: a systematic review.
Topics: 3-Hydroxybutyric Acid; Adult; Child; Diabetes Mellitus; Emergency Service, Hospital; Gastroenteritis | 2023 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Ketone Body, 3-Hydroxybutyrate: Minor Metabolite - Major Medical Manifestations.
Topics: 3-Hydroxybutyric Acid; Animals; Cardiovascular System; Central Nervous System; Diabetes Mellitus; Ex | 2020 |
Key role of acetyl-CoA in cytoplasm of nerve terminals in disturbances of acetylcholine metabolism in brain.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Acetylcholine; Aluminum; Animals; Brain; Brain Diseases; C | 1997 |
Accelerated starvation in pregnancy: implications for dietary treatment of obesity and gestational diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterified; Female | 1987 |
6 trials available for 3-hydroxybutyric acid and Diabetes Mellitus
| Article | Year |
|---|---|
Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Pressure; Body Composition; Cardiovascular Diseases; Diabetes Me | 2004 |
Point of care blood ketone testing of diabetic patients in the emergency department.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Critical Illness; Diabetes Complications; Diabetes M | 2004 |
Basic study on biochemical mechanism of thoron and thermal therapy.
Topics: 3-Hydroxybutyric Acid; Administration, Inhalation; Adult; Atrial Natriuretic Factor; Blood Glucose; | 2006 |
A 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 1. Metabolic and hormonal consequences and scheme for a prompt return to adequate control.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; | 1983 |
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mel | 1996 |
Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Ty | 1992 |
63 other studies available for 3-hydroxybutyric acid and Diabetes Mellitus
| Article | Year |
|---|---|
Hyperlactatemia in diabetic ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Hyperglycemi | 2022 |
Comparing Finger-stick Βeta-hydroxybutyrate with Dipstick Urine Tests in the Detection of Ketone Bodies in the Diagnosis of Children with Diabetic Ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Diabetes Mellit | 2022 |
Euglycemic diabetic ketoacidosis (EDKA) after pancreaticoduodenectomy: An under-recognized metabolic abnormality with outcome implications.
Topics: 3-Hydroxybutyric Acid; Acidosis; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Insulin; Male; Pa | 2023 |
A novel photoelectrochemical microfluidic chip for multi-index determination of diabetes and its complications.
Topics: 3-Hydroxybutyric Acid; Acidosis, Lactic; Biomarkers; Biosensing Techniques; Diabetes Mellitus; Diabe | 2022 |
Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H
Topics: 3-Hydroxybutyric Acid; Amino Acids; Diabetes Mellitus; Dietary Supplements; Humans; Insulin Resistan | 2022 |
Diabetic Ketoalkalosis: A Common Yet Easily Overlooked Alkalemic Variant of Diabetic Ketoacidosis Associated with Mixed Acid-Base Disorders.
Topics: 3-Hydroxybutyric Acid; Acid-Base Imbalance; Acidosis; Adult; Alkalosis; Bicarbonates; Diabetes Melli | 2023 |
A new turn-on fluorescent probe for fast detection of diabetic biomarker beta-hydroxybutyrate in vitro.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Diabetes Mellitus; Diabetic Ketoacidosis; Fluorescent Dyes; Human | 2024 |
BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Diabetes Mellitus; Diabetic Nephropathies; Humans; Kid | 2023 |
Study of glycation process of human carbonic anhydrase II as well as investigation concerning inhibitory influence of 3-beta-hydroxybutyrate on it.
Topics: 3-Hydroxybutyric Acid; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Diabetes Mellitus; Gluc | 2020 |
Plasma β-Hydroxybutyrate for the Diagnosis of Diabetic Ketoacidosis in the Emergency Department.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Cross-Sectional Studies; Diabetes Mellitus; Diabetic Ketoa | 2021 |
The ketone body β-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults.
Topics: 3-Hydroxybutyric Acid; Albuminuria; Animals; Diabetes Mellitus; Diabetic Nephropathies; Glycogen Syn | 2021 |
Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats.
Topics: 3-Hydroxybutyric Acid; Adiponectin; Animals; Cat Diseases; Cats; Diabetes Mellitus; Drinking; Electr | 2018 |
Assessment of Traub formula and ketone bodies in cause of death investigations.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl | 2013 |
Breath ketone testing: a new biomarker for diagnosis and therapeutic monitoring of diabetic ketosis.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Blood | 2014 |
Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers, Tumor; Blood Glucose; Case-Control Studies; Cat Diseases | 2010 |
{beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle.
Topics: 3-Hydroxybutyric Acid; Aminoimidazole Carboxamide; Animals; Antioxidants; Blotting, Western; Cyclic | 2010 |
A retrospective study of serum β-hydroxybutyric acid in 215 ill cats: clinical signs, laboratory findings and diagnoses.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cat Diseases; Cats; Diabetes Mellitus; Diabetic Ketoacid | 2012 |
Point-of-care beta-hydroxybutyrate testing for assessing diabetic ketoacidosis severity prior to treatment in the emergency department.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Ket | 2011 |
Validation of a portable hand-held whole-blood ketone meter for use in cats.
Topics: 3-Hydroxybutyric Acid; Animals; Cat Diseases; Cats; Diabetes Mellitus; Female; Ketones; Male; Point- | 2012 |
Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus; Female; | 2012 |
Postmortem diagnosis of unsuspected diabetes mellitus.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Acute-Phase Proteins; Adolescent; Adult; Benzodiazepines | 2013 |
[Evaluation of enzymatic method for determination of serum beta-hydroxybutyrate and its clinical application].
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Autoanalysis; Diabetes Mellitus; Diabetic Ketoacidosis; Ev | 2003 |
The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats.
Topics: 3-Hydroxybutyric Acid; Amylases; Animals; Blood Glucose; Diabetes Mellitus; Dietary Fats; Dietary Su | 2004 |
The relationship of a high level of serum beta-hydroxybutyrate to cause of death.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Cause of Death; Diabetes Mellitus; Fatty Live | 2005 |
Quantitative measurement of ketone bodies in urine using reflectometry.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Diabetes Mellitus; Female; Humans; Insulin Inf | 2005 |
Relationship between skin acetone and blood beta-hydroxybutyrate concentrations in diabetes.
Topics: 3-Hydroxybutyric Acid; Acetone; Aged; Case-Control Studies; Diabetes Mellitus; Humans; Middle Aged | 2006 |
"Accelerated starvation" and the skipped breakfast in late normal pregnancy.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterifie | 1982 |
A 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 2. Marked attenuation of the metabolic deterioration by somatostatin.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; | 1983 |
The bioavailability of circulating antibody-bound insulin following insulin withdrawal in Type 1 (insulin-dependent) diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Animals; Biological Availability; Blood Glucose; Diabetes Mellitus; Fe | 1983 |
Sensitive and simplified method for the differential determination of serum levels of ketone bodies.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Diabetes Mellitus; Diazonium Compounds; Humans; Hydroxybutyrat | 1983 |
Error in calibration.
Topics: 3-Hydroxybutyric Acid; Calibration; Diabetes Mellitus; Humans; Hydroxybutyrates | 1984 |
Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes.
Topics: 3-Hydroxybutyric Acid; Aged; Diabetes Mellitus; Erythrocytes; Fatty Acids, Nonesterified; Female; Gl | 1982 |
Absence of exercise-induced hypoglycaemia in type i (insulin-dependent) diabetic patients during maintenance of normoglycaemia by short-term, open-loop insulin infusion.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon | 1982 |
Impaired subcutaneous absorption of insulin in 'brittle' diabetics.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Fema | 1982 |
Hormonal and metabolic effects of a pancreatic endocrine graft. Vascularized segmental transplantation in insulin-dependent diabetic patients.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Glucagon; Ho | 1981 |
The effect of diet on intermediary metabolite concentrations in Type 2 (non-insulin-dependent) diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alanine; Diabetes Mellitus; Female; Glycerol; Humans; Hydroxybut | 1983 |
The effect of ketone bodies and dietary carbohydrate intake on protein metabolism.
Topics: 3-Hydroxybutyric Acid; Alanine; Diabetes Mellitus; Dietary Carbohydrates; Humans; Hydroxybutyrates; | 1981 |
The insulin receptor in insulin-dependent diabetes mellitus: an in vivo and in vitro study.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Cells, Cultured; Diabetes Mellitus; Female; Humans; Hydrox | 1981 |
Glucose utilization during exercise in normal and diabetic subjects. The role of insulin.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Fatty Acids, | 1981 |
Lipoprotein lipase activity in adipose tissue and skeletal muscle of human diabetics during insulin deprivation and restoration.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabetes | 1981 |
Safety of continuous subcutaneous insulin infusion: metabolic deterioration and glycaemic autoregulation after deliberate cessation of infusion.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Fasting; Humans; Hydroxyb | 1982 |
The significance of the portal insulin secretion in insulin dependent patients with residual beta-cell function: a safeguard against hormonal and metabolic derangement.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Blood Glucose; Diabetes Mellitus; Humans; Hydroxybutyrates | 1982 |
Elevated plasma beta-hydroxybutyrate concentrations without ketonuria in healthy insulin-dependent diabetic patients.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Female | 1982 |
Simple filter paper method for home monitoring of blood glucose, lactate, and 3-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Blood Specimen Collection; Diabetes Mellitus; Humans; Hydroxyb | 1981 |
Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; | 1994 |
[Clinical study on intraoperative hyperketonemia in non-diabetic surgical patients under general anesthesia].
Topics: 3-Hydroxybutyric Acid; Adult; Anesthesia, General; Diabetes Mellitus; Female; Glucose Tolerance Test | 1993 |
The degree/rapidity of the metabolic deterioration following interruption of a continuous subcutaneous insulin infusion is influenced by the prevailing blood glucose Level.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Fatty Acids, Nones | 1996 |
Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cell Division; Cells, Cultured; Cytochrome c Group; Diabetes M | 1998 |
Serum beta-hydroxybutyrate measurement in patients with uncontrolled diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Adult; Carbon Dioxide; Diabetes Complications; Diabete | 1999 |
Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Di | 1999 |
Chromosome analysis of blastocysts cultured under the diabetic condition.
Topics: 3-Hydroxybutyric Acid; Aneuploidy; Animals; Blastocyst; Cells, Cultured; Chromosome Aberrations; Chr | 2002 |
Abnormalities of intermediary metabolism following a gestational diabetic pregnancy.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Female; Glucose Tolerance Test; Glyc | 1992 |
The ketosis-resistance in fibro-calculous-pancreatic-diabetes. 1. Clinical observations and endocrine-metabolic measurements during oral glucose tolerance test.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Cholesterol; Diabetes Mellitus; Diabetes Mel | 1992 |
Enzymatic measurement of 3-hydroxybutyrate in extracts of blood without neutralization.
Topics: 3-Hydroxybutyric Acid; Cost-Benefit Analysis; Diabetes Mellitus; Humans; Hydrogen-Ion Concentration; | 1991 |
Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzy | 1990 |
Carbohydrate tolerance improves with fasting in obese subjects with noninsulin-dependent (type II) diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2 | 1990 |
Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Fasting; Fatty Acids, Non | 1990 |
Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects.
Topics: 3-Hydroxybutyric Acid; Adult; Diabetes Mellitus; False Positive Reactions; Fasting; Fluorometry; Foo | 1989 |
Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus; Dietary Carboh | 1989 |
Autoregulation of alimentary and hepatic ketogenesis in sheep.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus; Fatty Acids, Nonesterified; Female | 1986 |
Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic | 1985 |
Head-space gas-chromatographic determination of 3-hydroxybutyrate in plasma after enzymic reactions, and the relationship among the three ketone bodies.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Carboxy-Lyases; Chromatograp | 1985 |
Ketone body metabolism in normal and diabetic human skeletal muscle.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Carbon Radioisotopes; Diabetes Mellitus; Diabetes Melli | 1985 |