3-hydroxybutyric acid has been researched along with Depression in 8 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by β-hydroxybutyrate, may participate in the development of depression." | 3.85 | β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation. ( Chen, L; Miao, Z; Xu, X, 2017) |
| "Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments." | 1.56 | Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. ( Amadieu, C; Bindels, LB; Cani, PD; Colet, JM; Coste, V; de Timary, P; Delzenne, NM; Dricot, L; Furgiuele, S; Le Roy, T; Leclercq, S; Leyrolle, Q; Neyrinck, AM; Petit, G; Quoilin, C; Stärkel, P; Tagliatti, V; Verbeke, K, 2020) |
| "Neuro-inflammation has been shown to play a critical role in the development of depression." | 1.46 | Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. ( Duman, RS; Iitsuka, T; Iwata, M; Kajitani, N; Kamiya, N; Kaneko, K; Miura, A; Pu, S; Shirayama, Y; Tsunetomi, K; Wada, N; Watanabe, K; Yamanashi, T; Yamauchi, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shirayama, Y | 4 |
| Iwata, M | 4 |
| Miyano, K | 1 |
| Hirose, Y | 1 |
| Oda, Y | 1 |
| Fujita, Y | 1 |
| Hashimoto, K | 1 |
| Kajitani, N | 3 |
| Miura, A | 3 |
| Tsunetomi, K | 2 |
| Yamanashi, T | 3 |
| Matsuo, R | 2 |
| Nishiguchi, T | 2 |
| Fukuda, S | 1 |
| Nagata, M | 1 |
| Shibushita, M | 1 |
| Yamauchi, T | 2 |
| Pu, S | 3 |
| Watanabe, K | 3 |
| Kaneko, K | 3 |
| Leclercq, S | 1 |
| Le Roy, T | 1 |
| Furgiuele, S | 1 |
| Coste, V | 1 |
| Bindels, LB | 1 |
| Leyrolle, Q | 1 |
| Neyrinck, AM | 1 |
| Quoilin, C | 1 |
| Amadieu, C | 1 |
| Petit, G | 1 |
| Dricot, L | 1 |
| Tagliatti, V | 1 |
| Cani, PD | 1 |
| Verbeke, K | 1 |
| Colet, JM | 1 |
| Stärkel, P | 1 |
| de Timary, P | 1 |
| Delzenne, NM | 1 |
| Murakami, S | 1 |
| Nakada, Y | 1 |
| Shimizu, Y | 1 |
| Tsubakino, T | 1 |
| Shinozaki, G | 1 |
| Tsubota, J | 1 |
| Chen, L | 1 |
| Miao, Z | 1 |
| Xu, X | 1 |
| Kamiya, N | 1 |
| Wada, N | 1 |
| Iitsuka, T | 1 |
| Duman, RS | 1 |
| Setoyama, D | 1 |
| Kato, TA | 1 |
| Hashimoto, R | 1 |
| Kunugi, H | 1 |
| Hattori, K | 1 |
| Hayakawa, K | 1 |
| Sato-Kasai, M | 1 |
| Shimokawa, N | 1 |
| Kaneko, S | 1 |
| Yoshida, S | 1 |
| Goto, YI | 1 |
| Yasuda, Y | 1 |
| Yamamori, H | 1 |
| Ohgidani, M | 1 |
| Sagata, N | 1 |
| Miura, D | 1 |
| Kang, D | 1 |
| Kanba, S | 1 |
| Murphy, P | 1 |
| Likhodii, S | 1 |
| Nylen, K | 1 |
| Burnham, WM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835] | 0 participants (Actual) | Interventional | 2020-09-01 | Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for 3-hydroxybutyric acid and Depression
| Article | Year |
|---|---|
Infusions of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produce antidepressant-like effects on learned helplessness rats through BDNF-TrkB signaling and AMPA receptor activation, and strengthen learning ability.
Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression | 2023 |
Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.
Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, A | 2020 |
Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Anti-Bacterial Agents; Bacteria; Behavior, Animal; Brain | 2020 |
Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model.
Topics: 3-Hydroxybutyric Acid; Animals; Depression; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain | 2021 |
β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Depression; Histones; Lysine; Male; Mice; Mice, In | 2017 |
Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses.
Topics: 3-Hydroxybutyric Acid; Animals; Anxiety; Behavior, Animal; Biomarkers; Cytokines; Depression; Hippoc | 2017 |
Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis.
Topics: 3-Hydroxybutyric Acid; Betaine; Biomarkers; Chromatography, Liquid; Citric Acid; Creatinine; Depress | 2016 |
The antidepressant properties of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Depression; Di | 2004 |