3-hydroxybutyric acid has been researched along with Chronic Disease in 10 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Study 2: In a dose-response study, 8 HFrEF patients were examined at increasing 3-OHB infusion rates." | 2.90 | Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients. ( Bøtker, HE; Eiskjaer, H; Frøkiær, J; Gormsen, LC; Hansson, NH; Harms, HJ; Jespersen, NR; Lassen, TR; Mellemkjaer, S; Møller, N; Nielsen, R; Pryds, K; Sorensen, J; Tolbod, LP; Wiggers, H, 2019) |
| "These results demonstrate that alcoholic fatty liver was not exaggerated by dietary NA deficiency, but was ameliorated by dietary NA supplementation." | 1.40 | Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats. ( Jia, W; Li, Q; Sun, X; Tan, X; Xie, G; Zhang, W; Zhong, W; Zhou, Z, 2014) |
| "Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature." | 1.39 | Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. ( Dwyer, JB; Tamama, K, 2013) |
| "Hypothermia is a well-known concomitant of hypoglycemia in mammals." | 1.28 | Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats. ( Buchanan, TA; Cane, P; Eng, CC; Lee, C; Sipos, GF, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pietschner, R | 1 |
| Kolwelter, J | 1 |
| Bosch, A | 1 |
| Striepe, K | 1 |
| Jung, S | 1 |
| Kannenkeril, D | 1 |
| Ott, C | 1 |
| Schiffer, M | 1 |
| Achenbach, S | 1 |
| Schmieder, RE | 1 |
| Nielsen, R | 1 |
| Møller, N | 1 |
| Gormsen, LC | 1 |
| Tolbod, LP | 1 |
| Hansson, NH | 1 |
| Sorensen, J | 1 |
| Harms, HJ | 1 |
| Frøkiær, J | 1 |
| Eiskjaer, H | 1 |
| Jespersen, NR | 1 |
| Mellemkjaer, S | 1 |
| Lassen, TR | 1 |
| Pryds, K | 1 |
| Bøtker, HE | 1 |
| Wiggers, H | 1 |
| Li, Q | 1 |
| Xie, G | 1 |
| Zhang, W | 1 |
| Zhong, W | 1 |
| Sun, X | 2 |
| Tan, X | 1 |
| Jia, W | 1 |
| Zhou, Z | 1 |
| Cui, J | 1 |
| Liu, Y | 1 |
| Hu, Y | 1 |
| Tong, J | 1 |
| Li, A | 1 |
| Qu, T | 1 |
| Qin, X | 1 |
| Du, G | 1 |
| Dwyer, JB | 1 |
| Tamama, K | 1 |
| Jacob, RJ | 1 |
| Fan, X | 1 |
| Evans, ML | 1 |
| Dziura, J | 1 |
| Sherwin, RS | 1 |
| El Midaoui, A | 1 |
| Chiasson, JL | 1 |
| Tancrède, G | 1 |
| Nadeau, A | 1 |
| Buchanan, TA | 1 |
| Cane, P | 1 |
| Eng, CC | 1 |
| Sipos, GF | 1 |
| Lee, C | 1 |
| Larsen, S | 1 |
| Hilsted, J | 1 |
| Philipsen, EK | 1 |
| Tronier, B | 1 |
| Damkjaer Nielsen, M | 1 |
| Worning, H | 1 |
| Alexander, HR | 1 |
| DePippo, P | 1 |
| Rao, S | 1 |
| Burt, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-blind, Placebo Controlled, Parallel-group, Prospective Clinical Study to Analyse the Effect of Empagliflozin on Reduction of Tissue Sodium Content in Patients With Chronic Heart Failure[NCT03128528] | Phase 2 | 84 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371] | 30 participants (Anticipated) | Interventional | 2022-10-31 | Recruiting | |||
| Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293] | 18 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Functional and Metabolic Effects of Ketone Bodies on Human Atrial Tissue in Patients With and Without Heart Failure[NCT04379934] | 40 participants (Anticipated) | Interventional | 2020-06-01 | Not yet recruiting | |||
| Physiological Effects of Lactate in Individuals With Chronic Heart Failure[NCT06121323] | 12 participants (Anticipated) | Interventional | 2023-11-22 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 3-hydroxybutyric acid and Chronic Disease
| Article | Year |
|---|---|
Effect of empagliflozin on ketone bodies in patients with stable chronic heart failure.
Topics: 3-Hydroxybutyric Acid; Aged; Benzhydryl Compounds; Biomarkers; Blood Pressure; Chronic Disease; Doub | 2021 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acetates; Aged; Carbon Radioisotopes; Chronic Disease; Female; Heart Failure; | 2019 |
8 other studies available for 3-hydroxybutyric acid and Chronic Disease
| Article | Year |
|---|---|
Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats.
Topics: 3-Hydroxybutyric Acid; Acyl-CoA Oxidase; Adiponectin; Animals; Chronic Disease; Cytochrome P-450 CYP | 2014 |
NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis.
Topics: 3-Hydroxybutyric Acid; Animals; Arginine; Biomarkers; Body Weight; Chronic Disease; Disease Progress | 2017 |
Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adult; Alcoholism; Blood Glucose; Chronic Disease; Human | 2013 |
Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adaptation, Physiological; Animals; Blood-Brain Barrier; Brain | 2002 |
Physical training reverses the increased activity of the hepatic ketone body synthesis pathway in chronically diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Animals; Chronic Disease; Diabetes Mellitus, Exper | 2006 |
Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood; Body Temperature; Chronic Disease; Female; Glucose; Hydroxybu | 1991 |
The effect of insulin withdrawal on intermediary metabolism in patients with diabetes secondary to chronic pancreatitis.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Chronic Disease; Diabetes Mellitus, Type 1; Epinephrine | 1991 |
Substrate alterations in a sarcoma-bearing rat model: effect of tumor growth and resection.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Body Weight; Cholesterol; Chronic Dise | 1990 |