3-hydroxybutyric acid has been researched along with Cerebral Ischemia in 17 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 7.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 3.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "The brain mitochondrial NAD+/NADH ratio, as a reflection of the oxidation-reduction (redox) state of cellular compartment, was determined under conditions of hypoxia, anoxia, hypoxia-ischemia, complete ischemia and hypoglycemia in immature rats." | 3.69 | Cerebral mitochondrial redox states during metabolic stress in the immature rat. ( Brucklacher, RM; Vannucci, RC, 1994) |
| "Stroke is one of the leading causes of disability and death." | 1.62 | Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway. ( Kang, Y; Li, Y; Ma, A; Zhang, X, 2021) |
| "Stroke was induced in mice by middle cerebral artery occlusion for 90 minutes, followed by reperfusion." | 1.46 | Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice. ( Berressem, D; Eckert, GP; Klein, J; Koch, K; Konietzka, J; Thinnes, A, 2017) |
| "Stroke is one of the leading causes of death." | 1.42 | Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke. ( Han, P; Liu, Q; Shi, J; Tang, Z; Yin, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Li, T | 1 |
| Du, M | 1 |
| Zhang, L | 1 |
| Xu, L | 1 |
| Song, H | 1 |
| Zhang, J | 1 |
| Cao, DM | 1 |
| Guan, QX | 1 |
| Liu, YL | 1 |
| Wang, SM | 1 |
| Li, Y | 1 |
| Zhang, X | 1 |
| Ma, A | 1 |
| Kang, Y | 1 |
| Koch, K | 1 |
| Berressem, D | 1 |
| Konietzka, J | 1 |
| Thinnes, A | 1 |
| Eckert, GP | 1 |
| Klein, J | 1 |
| Bazzigaluppi, P | 1 |
| Lake, EM | 1 |
| Beckett, TL | 1 |
| Koletar, MM | 1 |
| Weisspapir, I | 1 |
| Heinen, S | 1 |
| Mester, J | 1 |
| Lai, A | 1 |
| Janik, R | 1 |
| Dorr, A | 1 |
| McLaurin, J | 1 |
| Stanisz, GJ | 1 |
| Carlen, PL | 1 |
| Stefanovic, B | 1 |
| Pikija, S | 1 |
| Trkulja, V | 1 |
| Simundic, AM | 1 |
| Vrcek, E | 1 |
| Boskovic, K | 1 |
| Bacani, S | 1 |
| Shen, Z | 1 |
| Jiang, L | 1 |
| Yuan, Y | 1 |
| Deng, T | 1 |
| Zheng, YR | 1 |
| Zhao, YY | 1 |
| Li, WL | 1 |
| Wu, JY | 1 |
| Gao, JQ | 1 |
| Hu, WW | 1 |
| Zhang, XN | 1 |
| Chen, Z | 1 |
| Julio-Amilpas, A | 1 |
| Montiel, T | 2 |
| Soto-Tinoco, E | 1 |
| Gerónimo-Olvera, C | 1 |
| Massieu, L | 2 |
| Offermanns, S | 1 |
| Schwaninger, M | 1 |
| Yin, J | 1 |
| Han, P | 1 |
| Tang, Z | 1 |
| Liu, Q | 1 |
| Shi, J | 1 |
| Sims, NR | 1 |
| Heward, SL | 1 |
| Vannucci, RC | 2 |
| Brucklacher, RM | 1 |
| Yager, JY | 2 |
| Vannucci, SJ | 1 |
| Tuor, UI | 1 |
| Bascaramurty, S | 1 |
| Del Bigio, MR | 1 |
| Del Río, P | 1 |
| Suzuki, M | 4 |
| Sato, K | 2 |
| Dohi, S | 2 |
| Sato, T | 2 |
| Matsuura, A | 2 |
| Hiraide, A | 2 |
| Kitamura, Y | 1 |
| Mori, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketone Esters for Optimization of Cognitive Performance in Hypoxia[NCT03659825] | 16 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3-hydroxybutyric acid and Cerebral Ischemia
| Article | Year |
|---|---|
Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation.
Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Diet, Ketogenic; Dimethyl | 2015 |
16 other studies available for 3-hydroxybutyric acid and Cerebral Ischemia
| Article | Year |
|---|---|
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Topics: 3-Hydroxybutyric Acid; Animals; Blood-Brain Barrier; Brain Ischemia; Cognitive Dysfunction; Disease | 2023 |
[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR].
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Creatine; Ginsenosides; Hemolymph; Metabolome; Phosp | 2020 |
Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Ische | 2021 |
Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice.
Topics: 3-Hydroxybutyric Acid; Adrenergic beta-Antagonists; Animals; Brain; Brain Ischemia; Citric Acid; Die | 2017 |
Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Astrocytes; Blood Glucose; Brain; Brain Ischemia; Cel | 2018 |
Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Brain Ischemia; Capillaries; Diabetes Complic | 2013 |
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cells, C | 2015 |
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi | 2015 |
Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Ischemia; Forkhead Box | 2015 |
Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Brain Ischemia; Butylene Glycols; Cerebrovascular Cir | 1994 |
Cerebral mitochondrial redox states during metabolic stress in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Diseases; Brain Ischem | 1994 |
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab | 1994 |
Dexamethasone prevents hypoxia/ischemia-induced reductions in cerebral glucose utilization and high-energy phosphate metabolites in immature brain.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Carotid Arteries; Cer | 1997 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ede | 2001 |
Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Infarction, Middle | 2002 |