Page last updated: 2024-10-17

3-hydroxybutyric acid and Breast Cancer

3-hydroxybutyric acid has been researched along with Breast Cancer in 9 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) for breast cancer treatment."7.83Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy. ( Denkbas, EB; Hazer, B; Karahaliloglu, Z; Kilicay, E; Tekin, IÖ, 2016)
"The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) for breast cancer treatment."3.83Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy. ( Denkbas, EB; Hazer, B; Karahaliloglu, Z; Kilicay, E; Tekin, IÖ, 2016)
"In cancer patients with hypersplenism-related thrombocytopenia, PSAE is a safe intervention that effects a durable elevation in platelet counts across a range of malignancies and following the re-initiation of chemotherapy."2.73 ( Aasbrenn, M; Abd El-Aty, AM; Abdu, A; Abraha, HB; Achour, A; Acquaroni, M; Addeo, P; Agback, P; Agback, T; Al-Alwan, M; Al-Mazrou, A; Al-Mohanna, F; Aliste, M; Almquist, J; Andel, J; Ando, M; Angelov, A; Annuar, MSM; Antwi, K; Arroliga, AC; Arruda, SLM; Asch, SM; Averous, G; Ayaz, S; Ayer, GB; Bachellier, P; Ball, S; Banijamali, AR; Barden, TC; Bartoncini, S; Bedanie, G; Bellò, M; Benić, F; Berhe, GG; Bertiger, G; Beumer, JH; Bhandari, B; Bond, DS; Boules, M; Braüner Christensen, J; Brown-Johnson, C; Burgstaller, S; Cao, L; Capasso, C; Carlevato, R; Carvalho, AE; Ceci, F; Chagas, ATA; Chavan, SG; Chen, AP; Chen, HC; Chen, J; Chen, Q; Chen, Y; Chen, YF; Christ, ER; Chu, CW; Covey, JM; Coyne, GO'; Cristea, MC; Currie, MG; Dahdal, DN; Dai, L; Dang, Z; de Abreu, NL; de Carvalho, KMB; de la Plaza Llamas, R; Deandreis, D; Del Prete, S; Dennis, JA; Deur, J; Díaz Candelas, DA; Divyapriya, G; Djanani, A; Dodig, D; Doki, Y; Doroshow, JH; Dos Santos, RC; Durairaj, N; Dutra, ES; Eguchi, H; Eisterer, W; Ekmann, A; Elakkad, A; Evans, WE; Fan, W; Fang, Z; Faria, HP; Farris, SG; Fenoll, J; Fernandez-Botran, R; Flores, P; Fujita, J; Gan, L; Gandara, DR; Gao, X; Garcia, AA; Garrido, I; Gebru, HA; Gerger, A; Germano, P; Ghamande, S; Ghebeh, H; Giver Jensen, T; Go, A; Goichot, B; Goldwater, M; Gontero, P; Greil, R; Gruenberger, B; Guarneri, A; Guo, Y; Gupta, S; Haxholdt Lunn, T; Hayek, AJ; He, ML; Hellín, P; Hepprich, M; Hernández de Rodas, E; Hill, A; Hndeya, AG; Holdsworth, LM; Hookey, L; Howie, W; Hu, G; Huang, JD; Huang, SY; Hubmann, E; Hwang, SY; Imamura, H; Imperiale, A; Jiang, JQ; Jimenez, JL; Jin, F; Jin, H; Johnson, KL; Joseph, A; Juwara, L; Kalapothakis, E; Karami, H; Karayağiz Muslu, G; Kawabata, R; Kerwin, J; Khan, I; Khin, S; Kidanemariam, HG; Kinders, RJ; Klepov, VV; Koehler, S; Korger, M; Kovačić, S; Koyappayil, A; Kroll, MH; Kuban, J; Kummar, S; Kung, HF; Kurokawa, Y; Laengle, F; Lan, J; Leal, HG; Lee, MH; Lemos, KGE; Li, B; Li, G; Li, H; Li, X; Li, Y; Li, Z; Liebl, W; Lillaz, B; Lin, F; Lin, L; Lin, MCM; Lin, Y; Lin, YP; Lipton, RB; Liu, J; Liu, W; Liu, Z; Lu, J; Lu, LY; Lu, YJ; Ludwig, S; Luo, Y; Ma, L; Ma, W; Machado-Coelho, GLL; Mahmoodi, B; Mahoney, M; Mahvash, A; Mansour, FA; Mao, X; Marinho, CC; Masferrer, JL; Matana Kaštelan, Z; Melendez-Araújo, MS; Méndez-Chacón, E; Miletić, D; Miller, B; Miller, E; Miller, SB; Mo, L; Moazzen, M; Mohammadniaei, M; Montaz-Rosset, MS; Mousavi Khaneghah, A; Mühlethaler, K; Mukhopadhyay, S; Mulugeta, A; Nambi, IM; Navarro, S; Nazmara, S; Neumann, HJ; Newman, EM; Nguyen, HTT; Nicolato, AJPG; Nicolotti, DG; Nieva, JJ; Nilvebrant, J; Nocentini, A; Nugent, K; Nunez-Rodriguez, DL; Nygren, PÅ; Oberli, A; Oderda, M; Odisio, B; Oehler, L; Otludil, B; Overman, M; Özdemir, M; Pace, KA; Palm, H; Parchment, RE; Parise, R; Passera, R; Pavlovic, J; Pecherstorfer, M; Peng, Z; Pérez Coll, C; Petzer, A; Philipp-Abbrederis, K; Pichler, P; Piekarz, RL; Pilati, E; Pimentel, JDSM; Posch, F; Prager, G; Pressel, E; Profy, AT; Qi, P; Qi, Y; Qiu, C; Rajasekhar, B; Ramia, JM; Raynor, HA; Reis, VW; Reubi, JC; Ricardi, U; Riedl, JM; Romano, F; Rong, X; Rubinstein, L; Rumboldt, Z; Sabir, S; Safaeinili, N; Sala, BM; Sandoval Castillo, L; Sau, M; Sbhatu, DB; Schulte, T; Scott, V; Shan, H; Shao, Y; Shariatifar, N; Shaw, JG; She, Y; Shen, B; Shernyukov, A; Sheth, RA; Shi, B; Shi, R; Shum, KT; Silva, JC; Singh, A; Sinha, N; Sirajudeen, AAO; Slaven, J; Sliwa, T; Somme, F; Song, S; Steinberg, SM; Subramaniam, R; Suetta, C; Sui, Y; Sun, B; Sun, C; Sun, H; Sun, Y; Supuran, CT; Surger, M; Svartz, G; Takahashi, T; Takeno, A; Tam, AL; Tang, Z; Tanner, JA; Tannich, E; Taye, MG; Tekle, HT; Thomas, GJ; Tian, Y; Tobin, JV; Todd Milne, G; Tong, X; Une, C; Vela, N; Venkateshwaran, U; Villagrán de Tercero, CI; Wakefield, JD; Wampfler, R; Wan, M; Wang, C; Wang, J; Wang, L; Wang, S; Waser, B; Watt, RM; Wei, B; Wei, L; Weldemichael, MY; Wellmann, IA; Wen, A; Wild, D; Wilthoner, K; Winder, T; Wing, RR; Winget, M; Wöll, E; Wong, KL; Wong, KT; Wu, D; Wu, Q; Wu, Y; Xiang, T; Xiang, Z; Xu, F; Xu, L; Yamasaki, M; Yamashita, K; Yan, H; Yan, Y; Yang, C; Yang, H; Yang, J; Yang, N; Yang, Y; Yau, P; Yu, M; Yuan, Q; Zhan, S; Zhang, B; Zhang, H; Zhang, J; Zhang, N; Zhang, Y; Zhao, X; Zheng, BJ; Zheng, H; Zheng, W; Zhou, H; Zhou, X; Zhu, S; Zimmer, DP; Zionts, D; Zitella, A; Zlott, J; Zolfaghari, K; Zuo, D; Zur Loye, HC; Žuža, I, 2007)
"Growth of primary breast tumors and lung metastases were inhibited, and lifespans were longer in the KD mice compared to mice on the SD (p<0."1.56The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. ( Feinman, RD; Fine, EJ; Fineberg, S; Pearlman, A; Zou, Y, 2020)
"However, the crosstalk between breast cancer cells and adipocytes has been given less attention compared to cancer-associated fibroblasts."1.46Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate. ( Chang, KJ; Chang, PH; Chen, CL; Hu, CM; Huang, CK; Jeng, YM; Kuo, WH; Lee, WH; Shew, JY, 2017)
"The presence of the tumor in women with breast cancer provokes a profile of biochemical change characterized by hypoglycemia, hyperuremia and high levels of free fatty acids and ketone bodies in plasma."1.30Alterations in circulating fatty acids and the compartmentation of selected metabolites in women with breast cancer. ( Benito, E; Crespi, C; Palou, A; Quevedo-Coli, S; Roca, P, 1997)
"The glucose uptake rate of human mammary carcinomas transplanted into nude rats is comparable to values obtained in isotransplanted rodent tumors."1.27Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo. ( Baessler, KH; Davel, S; Kallinowskil, F; Vaupell, P; Wagner, K, 1985)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Yang, N1
Tanner, JA1
Zheng, BJ1
Watt, RM1
He, ML1
Lu, LY1
Jiang, JQ1
Shum, KT1
Lin, YP1
Wong, KL1
Lin, MCM1
Kung, HF1
Sun, H1
Huang, JD1
Marinho, CC1
Nicolato, AJPG1
Reis, VW1
Dos Santos, RC1
Silva, JC1
Faria, HP1
Machado-Coelho, GLL1
Sun, Y2
Zhang, N1
Wang, J2
Guo, Y1
Sun, B1
Liu, W1
Zhou, H1
Yang, C1
Wei, L1
Ball, S1
Dennis, JA1
Bedanie, G1
Nugent, K1
Hayek, AJ1
Scott, V1
Yau, P1
Zolfaghari, K1
Goldwater, M1
Almquist, J1
Arroliga, AC1
Ghamande, S1
Wu, Q1
Ma, W1
Shi, R1
Zhang, B1
Mao, X1
Zheng, W1
Sbhatu, DB1
Berhe, GG1
Hndeya, AG1
Abraha, HB1
Abdu, A1
Gebru, HA1
Taye, MG1
Mulugeta, A1
Weldemichael, MY1
Tekle, HT1
Kidanemariam, HG1
Surger, M1
Angelov, A1
Liebl, W1
Hookey, L1
Bertiger, G1
Johnson, KL1
Boules, M1
Ando, M1
Dahdal, DN1
Riedl, JM1
Posch, F1
Prager, G1
Eisterer, W1
Oehler, L1
Sliwa, T1
Wilthoner, K1
Petzer, A1
Pichler, P1
Hubmann, E1
Winder, T1
Burgstaller, S1
Korger, M1
Andel, J1
Greil, R1
Neumann, HJ1
Pecherstorfer, M1
Philipp-Abbrederis, K1
Djanani, A1
Gruenberger, B1
Laengle, F1
Wöll, E1
Gerger, A1
Evans, WE1
Raynor, HA1
Howie, W1
Lipton, RB1
Thomas, GJ1
Wing, RR1
Pavlovic, J1
Farris, SG1
Bond, DS1
Hepprich, M1
Antwi, K1
Waser, B1
Reubi, JC1
Wild, D1
Christ, ER1
Braüner Christensen, J1
Aasbrenn, M1
Sandoval Castillo, L1
Ekmann, A1
Giver Jensen, T1
Pressel, E1
Haxholdt Lunn, T1
Suetta, C1
Palm, H1
Mansour, FA1
Al-Mazrou, A1
Al-Mohanna, F1
Al-Alwan, M1
Ghebeh, H1
Brown-Johnson, C1
Safaeinili, N1
Zionts, D1
Holdsworth, LM1
Shaw, JG1
Asch, SM1
Mahoney, M1
Winget, M1
Luo, Y1
Shan, H1
Gao, X1
Qi, P1
Li, Y2
Li, B1
Rong, X1
Shen, B1
Zhang, H1
Lin, F1
Tang, Z1
Fang, Z1
Peng, Z1
Jimenez, JL1
Ayer, GB1
Klepov, VV1
Pace, KA1
Zur Loye, HC1
Acquaroni, M1
Svartz, G1
Pérez Coll, C1
Otludil, B1
Ayaz, S1
Hill, A1
Elakkad, A1
Kuban, J1
Sabir, S1
Odisio, B1
Huang, SY1
Mahvash, A1
Miller, E1
Kroll, MH1
Overman, M1
Tam, AL1
Gupta, S1
Sheth, RA1
Deandreis, D1
Guarneri, A1
Ceci, F1
Lillaz, B1
Bartoncini, S1
Oderda, M1
Nicolotti, DG1
Pilati, E1
Passera, R1
Zitella, A1
Bellò, M1
Parise, R1
Carlevato, R1
Ricardi, U1
Gontero, P1
Coyne, GO'1
Wang, L2
Zlott, J1
Juwara, L1
Covey, JM1
Beumer, JH1
Cristea, MC1
Newman, EM1
Koehler, S1
Nieva, JJ1
Garcia, AA1
Gandara, DR1
Miller, B1
Khin, S1
Miller, SB1
Steinberg, SM1
Rubinstein, L1
Parchment, RE1
Kinders, RJ1
Piekarz, RL1
Kummar, S1
Chen, AP1
Doroshow, JH1
Li, X2
Chen, J2
Gan, L1
Tian, Y1
Shi, B1
Yang, Y1
Li, G1
Wu, D1
Wen, A1
Wu, Y1
Zhou, X1
Koyappayil, A1
Chavan, SG1
Mohammadniaei, M1
Go, A1
Hwang, SY1
Lee, MH1
Kurokawa, Y1
Yamashita, K1
Kawabata, R1
Fujita, J1
Imamura, H1
Takeno, A1
Takahashi, T1
Yamasaki, M1
Eguchi, H1
Doki, Y1
Schulte, T1
Sala, BM1
Nilvebrant, J1
Nygren, PÅ1
Achour, A1
Shernyukov, A1
Agback, T1
Agback, P1
Karami, H1
Shariatifar, N1
Nazmara, S1
Moazzen, M1
Mahmoodi, B1
Mousavi Khaneghah, A1
Sinha, N1
Mukhopadhyay, S1
Sau, M1
Qi, Y1
Wan, M1
Abd El-Aty, AM1
Li, H2
Cao, L1
She, Y1
Shao, Y1
Jin, F1
Wang, S1
Melendez-Araújo, MS1
Lemos, KGE1
Arruda, SLM1
Dutra, ES1
de Carvalho, KMB1
de la Plaza Llamas, R1
Díaz Candelas, DA1
Ramia, JM1
Zhu, S1
Liu, Z1
Lu, J2
Xiang, Z1
Lan, J1
Liu, J1
Yu, M1
Chen, Y2
Sirajudeen, AAO1
Annuar, MSM1
Subramaniam, R1
Somme, F1
Montaz-Rosset, MS1
Averous, G1
Deur, J1
Goichot, B1
Bachellier, P1
Addeo, P1
Imperiale, A1
Xu, L1
Li, Z2
Song, S1
Chen, Q1
Mo, L1
Wang, C2
Fan, W1
Yan, Y1
Tong, X1
Yan, H1
Singh, A1
Chen, HC1
Chen, YF1
Lu, YJ1
Wong, KT1
Chu, CW1
Banijamali, AR1
Carvalho, AE1
Wakefield, JD1
Germano, P1
Barden, TC1
Tobin, JV1
Zimmer, DP1
Masferrer, JL1
Profy, AT1
Currie, MG1
Todd Milne, G1
Zhang, Y1
Yang, H1
Dang, Z1
Zhan, S1
Sun, C1
Hu, G1
Lin, Y1
Yuan, Q1
Karayağiz Muslu, G1
Özdemir, M1
Del Prete, S1
Nocentini, A1
Supuran, CT1
Capasso, C1
Chagas, ATA1
Ludwig, S1
Pimentel, JDSM1
de Abreu, NL1
Nunez-Rodriguez, DL1
Leal, HG1
Kalapothakis, E1
Zhang, J1
Lin, L1
Dodig, D1
Kovačić, S1
Matana Kaštelan, Z1
Žuža, I1
Benić, F1
Slaven, J1
Miletić, D1
Rumboldt, Z1
Fernandez-Botran, R1
Wellmann, IA1
Une, C1
Méndez-Chacón, E1
Hernández de Rodas, E1
Bhandari, B1
Villagrán de Tercero, CI1
Nguyen, HTT1
Romano, F1
Wampfler, R1
Mühlethaler, K1
Tannich, E1
Oberli, A1
Yang, J1
Xiang, T1
Dai, L1
Zhao, X1
Ma, L1
Zuo, D1
Wei, B1
Sui, Y1
Xu, F1
Zheng, H1
Qiu, C1
Jin, H1
Kerwin, J1
Khan, I1
Rajasekhar, B1
Venkateshwaran, U1
Durairaj, N1
Divyapriya, G1
Nambi, IM1
Joseph, A1
Aliste, M1
Garrido, I1
Flores, P1
Hellín, P1
Vela, N1
Navarro, S1
Fenoll, J1
Zou, Y1
Fineberg, S1
Pearlman, A1
Feinman, RD1
Fine, EJ1
Cuyàs, E1
Fernández-Arroyo, S1
Buxó, M1
Pernas, S1
Dorca, J1
Álvarez, I1
Martínez, S1
Pérez-Garcia, JM1
Batista-López, N1
Rodríguez-Sánchez, CA1
Amillano, K1
Domínguez, S1
Luque, M1
Morilla, I1
Stradella, A1
Viñas, G1
Cortés, J1
Verdura, S1
Brunet, J1
López-Bonet, E1
Garcia, M1
Saidani, S1
Joven, J1
Martin-Castillo, B1
Menendez, JA1
Kilicay, E1
Karahaliloglu, Z1
Hazer, B1
Tekin, IÖ1
Denkbas, EB1
Huang, CK1
Chang, PH1
Kuo, WH1
Chen, CL1
Jeng, YM1
Chang, KJ1
Shew, JY1
Hu, CM1
Lee, WH1
Bonuccelli, G1
Tsirigos, A2
Whitaker-Menezes, D2
Pavlides, S2
Pestell, RG2
Chiavarina, B2
Frank, PG2
Flomenberg, N2
Howell, A2
Martinez-Outschoorn, UE2
Sotgia, F2
Lisanti, MP2
Migneco, G1
Casimiro, MC1
Quevedo-Coli, S1
Crespi, C1
Benito, E1
Palou, A1
Roca, P1
Kallinowskil, F1
Davel, S1
Vaupell, P1
Baessler, KH1
Wagner, K1

Trials

2 trials available for 3-hydroxybutyric acid and Breast Cancer

ArticleYear
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
    Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2007, Aug-27, Volume: 119, Issue:34

    Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aer

2007
Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients.
    Aging, 2019, 05-09, Volume: 11, Issue:9

    Topics: 3-Hydroxybutyric Acid; Breast Neoplasms; Female; Folic Acid Antagonists; Humans; Hypoglycemic Agents

2019

Other Studies

7 other studies available for 3-hydroxybutyric acid and Breast Cancer

ArticleYear
The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animals; Antineoplastic Agents; Blood Glucose; Breast Neoplasms; Diet, Ketoge

2020
Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy.
    Journal of microencapsulation, 2016, Volume: 33, Issue:3

    Topics: 3-Hydroxybutyric Acid; Antineoplastic Agents; Breast; Breast Neoplasms; Canavalia; Caproates; Cell L

2016
Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
    Nature communications, 2017, 03-10, Volume: 8

    Topics: 3-Hydroxybutyric Acid; Acetylation; Adipocytes; Adipose Tissue; Animals; Armadillo Domain Proteins;

2017
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Sep-01, Volume: 9, Issue:17

    Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female

2010
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Sep-01, Volume: 9, Issue:17

    Topics: 3-Hydroxybutyric Acid; Animals; Arginine; Autophagy; Biomarkers; Breast Neoplasms; Caveolin 1; Femal

2010
Alterations in circulating fatty acids and the compartmentation of selected metabolites in women with breast cancer.
    Biochemistry and molecular biology international, 1997, Volume: 41, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aged; Amino Acids; Blood Glucose; Breast Neoplasms; Cell Compartmentation; Fa

1997
Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo.
    Advances in experimental medicine and biology, 1985, Volume: 191

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Breast Neoplasms; Carcinoma; Female; Glucose; Humans;

1985