3-hydroxybutyric acid has been researched along with Brain Ischemia in 17 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 7.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 3.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "The brain mitochondrial NAD+/NADH ratio, as a reflection of the oxidation-reduction (redox) state of cellular compartment, was determined under conditions of hypoxia, anoxia, hypoxia-ischemia, complete ischemia and hypoglycemia in immature rats." | 3.69 | Cerebral mitochondrial redox states during metabolic stress in the immature rat. ( Brucklacher, RM; Vannucci, RC, 1994) |
| "Stroke is one of the leading causes of disability and death." | 1.62 | Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway. ( Kang, Y; Li, Y; Ma, A; Zhang, X, 2021) |
| "Stroke was induced in mice by middle cerebral artery occlusion for 90 minutes, followed by reperfusion." | 1.46 | Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice. ( Berressem, D; Eckert, GP; Klein, J; Koch, K; Konietzka, J; Thinnes, A, 2017) |
| "Stroke is one of the leading causes of death." | 1.42 | Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke. ( Han, P; Liu, Q; Shi, J; Tang, Z; Yin, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Li, T | 1 |
| Du, M | 1 |
| Zhang, L | 1 |
| Xu, L | 1 |
| Song, H | 1 |
| Zhang, J | 1 |
| Cao, DM | 1 |
| Guan, QX | 1 |
| Liu, YL | 1 |
| Wang, SM | 1 |
| Li, Y | 1 |
| Zhang, X | 1 |
| Ma, A | 1 |
| Kang, Y | 1 |
| Koch, K | 1 |
| Berressem, D | 1 |
| Konietzka, J | 1 |
| Thinnes, A | 1 |
| Eckert, GP | 1 |
| Klein, J | 1 |
| Bazzigaluppi, P | 1 |
| Lake, EM | 1 |
| Beckett, TL | 1 |
| Koletar, MM | 1 |
| Weisspapir, I | 1 |
| Heinen, S | 1 |
| Mester, J | 1 |
| Lai, A | 1 |
| Janik, R | 1 |
| Dorr, A | 1 |
| McLaurin, J | 1 |
| Stanisz, GJ | 1 |
| Carlen, PL | 1 |
| Stefanovic, B | 1 |
| Pikija, S | 1 |
| Trkulja, V | 1 |
| Simundic, AM | 1 |
| Vrcek, E | 1 |
| Boskovic, K | 1 |
| Bacani, S | 1 |
| Shen, Z | 1 |
| Jiang, L | 1 |
| Yuan, Y | 1 |
| Deng, T | 1 |
| Zheng, YR | 1 |
| Zhao, YY | 1 |
| Li, WL | 1 |
| Wu, JY | 1 |
| Gao, JQ | 1 |
| Hu, WW | 1 |
| Zhang, XN | 1 |
| Chen, Z | 1 |
| Julio-Amilpas, A | 1 |
| Montiel, T | 2 |
| Soto-Tinoco, E | 1 |
| Gerónimo-Olvera, C | 1 |
| Massieu, L | 2 |
| Offermanns, S | 1 |
| Schwaninger, M | 1 |
| Yin, J | 1 |
| Han, P | 1 |
| Tang, Z | 1 |
| Liu, Q | 1 |
| Shi, J | 1 |
| Sims, NR | 1 |
| Heward, SL | 1 |
| Vannucci, RC | 2 |
| Brucklacher, RM | 1 |
| Yager, JY | 2 |
| Vannucci, SJ | 1 |
| Tuor, UI | 1 |
| Bascaramurty, S | 1 |
| Del Bigio, MR | 1 |
| Del Río, P | 1 |
| Suzuki, M | 4 |
| Sato, K | 2 |
| Dohi, S | 2 |
| Sato, T | 2 |
| Matsuura, A | 2 |
| Hiraide, A | 2 |
| Kitamura, Y | 1 |
| Mori, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketone Esters for Optimization of Cognitive Performance in Hypoxia[NCT03659825] | 16 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3-hydroxybutyric acid and Brain Ischemia
| Article | Year |
|---|---|
Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation.
Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Diet, Ketogenic; Dimethyl | 2015 |
16 other studies available for 3-hydroxybutyric acid and Brain Ischemia
| Article | Year |
|---|---|
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Topics: 3-Hydroxybutyric Acid; Animals; Blood-Brain Barrier; Brain Ischemia; Cognitive Dysfunction; Disease | 2023 |
[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR].
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Creatine; Ginsenosides; Hemolymph; Metabolome; Phosp | 2020 |
Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS Pathway.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Ische | 2021 |
Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice.
Topics: 3-Hydroxybutyric Acid; Adrenergic beta-Antagonists; Animals; Brain; Brain Ischemia; Citric Acid; Die | 2017 |
Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Astrocytes; Blood Glucose; Brain; Brain Ischemia; Cel | 2018 |
Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Brain Ischemia; Capillaries; Diabetes Complic | 2013 |
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cells, C | 2015 |
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi | 2015 |
Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Ischemia; Forkhead Box | 2015 |
Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Brain Ischemia; Butylene Glycols; Cerebrovascular Cir | 1994 |
Cerebral mitochondrial redox states during metabolic stress in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Diseases; Brain Ischem | 1994 |
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab | 1994 |
Dexamethasone prevents hypoxia/ischemia-induced reductions in cerebral glucose utilization and high-energy phosphate metabolites in immature brain.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Carotid Arteries; Cer | 1997 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ede | 2001 |
Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Infarction, Middle | 2002 |