3-hydroxybutyric acid has been researched along with Brain Injuries in 11 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ischemic stroke is a leading cause of disability worldwide." | 1.91 | Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke. ( Bernal-Vicente, BN; Gerónimo-Olvera, C; Gómora-García, JC; Heras-Romero, Y; Massieu, L; Montiel, T; Pérez-Martínez, X; Tovar-Y-Romo, LB, 2023) |
| "Hypoglycemia has emerged as a prominent complication in anti-diabetic drug therapy or negative energy balance of animals, which causes brain damage, cognitive impairment, and even death." | 1.72 | β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. ( Chai, X; Huang, J; Li, C; Pan, J; Wu, Y; Xue, Y; Yang, J; Zhao, S; Zhou, W; Zhu, X, 2022) |
| "Rats fed a KD had a higher seizure threshold (longer latency to flurothyl-induced seizure activity) than rats fed a standard diet (SD); this effect was seen when KD was in place at the time of seizure testing (3 and 6 weeks following FPI), but was absent when KD had been replaced by SD at time of testing." | 1.36 | Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury? ( Campos, L; Delance, A; Lyeth, BG; Nguyen, DV; Poon, CC; Schwartzkroin, PA; Van, KC; Wenzel, HJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Chai, X | 1 |
| Pan, J | 1 |
| Huang, J | 1 |
| Wu, Y | 1 |
| Xue, Y | 1 |
| Zhou, W | 1 |
| Yang, J | 1 |
| Zhu, X | 1 |
| Zhao, S | 1 |
| Cascant-Vilaplana, MM | 1 |
| Lara-Cantón, I | 1 |
| Núñez-Ramiro, A | 1 |
| Solaz-García, Á | 1 |
| Llorens-Salvador, R | 1 |
| Quintás, G | 1 |
| Kuligowski, J | 1 |
| Vento, M | 1 |
| Montiel, T | 2 |
| Gómora-García, JC | 1 |
| Gerónimo-Olvera, C | 2 |
| Heras-Romero, Y | 1 |
| Bernal-Vicente, BN | 1 |
| Pérez-Martínez, X | 1 |
| Tovar-Y-Romo, LB | 1 |
| Massieu, L | 2 |
| Boruczkowski, D | 1 |
| Pujal, JM | 1 |
| Zdolińska-Malinowska, I | 1 |
| Julio-Amilpas, A | 1 |
| Soto-Tinoco, E | 1 |
| White, H | 1 |
| Venkatesh, B | 1 |
| Jones, M | 1 |
| Fuentes, H | 1 |
| Hu, ZG | 1 |
| Wang, HD | 1 |
| Jin, W | 1 |
| Yin, HX | 1 |
| Schwartzkroin, PA | 1 |
| Wenzel, HJ | 1 |
| Lyeth, BG | 1 |
| Poon, CC | 1 |
| Delance, A | 1 |
| Van, KC | 1 |
| Campos, L | 1 |
| Nguyen, DV | 1 |
| Deng-Bryant, Y | 1 |
| Prins, ML | 2 |
| Hovda, DA | 2 |
| Harris, NG | 1 |
| Lee, SM | 1 |
| Fujima, LS | 1 |
| Robertson, CS | 1 |
| Goodman, JC | 1 |
| Narayan, RK | 1 |
| Contant, CF | 1 |
| Grossman, RG | 1 |
1 review available for 3-hydroxybutyric acid and Brain Injuries
| Article | Year |
|---|---|
Autologous cord blood in children with cerebral palsy: a review.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Brain Diseases; Brain Injuries; Carnitine; Cerebral Pal | 2019 |
1 trial available for 3-hydroxybutyric acid and Brain Injuries
| Article | Year |
|---|---|
The effect of glucose administration on carbohydrate metabolism after head injury.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Blood Glucose; Brain Injuries; Carbohydrate Metab | 1991 |
9 other studies available for 3-hydroxybutyric acid and Brain Injuries
| Article | Year |
|---|---|
β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Injuries; Caspase 3; Glucose; Hypoglycemia; NF-kapp | 2022 |
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2023 |
Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Brain Injuries; Endoplasmic Reticulum Stress; Endoribonuc | 2023 |
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi | 2015 |
Serial changes in plasma ketone concentrations in patients with acute brain injury.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Brain Injuries; Female; Glasgow Coma Scale; Human | 2017 |
Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Blood Glucose; Brain; Brain Injuries; Caspase 3; Cytochro | 2009 |
Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury?
Topics: 3-Hydroxybutyric Acid; Animals; Brain Injuries; CD11b Antigen; Cell Count; Cell Death; Diet, Ketogen | 2010 |
Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury.
Topics: 3-Hydroxybutyric Acid; Age Factors; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Diet | 2011 |
Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Brain; Brain Injuries; Carbon Dioxide; Carbo | 2004 |