Page last updated: 2024-10-17

3-hydroxybutyric acid and Blood Poisoning

3-hydroxybutyric acid has been researched along with Blood Poisoning in 12 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Research Excerpts

ExcerptRelevanceReference
"Sepsis is a systemic inflammatory disease caused by multiple pathogens, with the most commonly affected organ being the lung."1.913-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages. ( Dong, R; Gong, S; Huang, L; Huang, M; Jin, Y; Li, F; Li, X; Tang, X; Wang, X; Yang, H; Yu, Y; Zeng, Z, 2023)
"Sepsis is a major cause of acute kidney injury (AKI)."1.91β-hydroxybutyrate ameliorates sepsis-induced acute kidney injury. ( Kim, IY; Kim, MJ; Kim, SR; Kim, YS; Lee, DW; Lee, SB, 2023)
"Sepsis is a life-threatening condition of organ dysfunction caused by dysregulated inflammation which predisposes patients to developing cardiovascular disease."1.72Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis. ( Dyck, JRB; Ferdaoussi, M; Maayah, ZH; Martens, MD; Silver, HL; Soni, S; Takahara, S; Ussher, JR, 2022)
"The 'obesity paradox' of critical illness refers to better survival with a higher body mass index."1.46Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness. ( De Bock, K; Derde, S; Dufour, T; Goossens, C; Güiza, F; Hermans, G; Janssens, T; Langouche, L; Marques, MB; Thiessen, SE; Van den Berghe, G; Vander Perre, S; Vanhorebeek, I, 2017)
"Fatal ketoacidosis due to diabetes mellitus, alcoholism, and starvation may produce characteristic basal vacuolization of renal tubular epithelial cells (RTEC)."1.46Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization. ( Byard, RW; Zhou, C, 2017)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's2 (16.67)18.2507
2000's0 (0.00)29.6817
2010's2 (16.67)24.3611
2020's7 (58.33)2.80

Authors

AuthorsStudies
Weckx, R1
Goossens, C2
Derde, S2
Pauwels, L1
Vander Perre, S2
Van den Bergh, G1
Langouche, L2
Soni, S1
Martens, MD1
Takahara, S1
Silver, HL1
Maayah, ZH1
Ussher, JR1
Ferdaoussi, M1
Dyck, JRB1
Huang, M1
Yu, Y1
Tang, X1
Dong, R1
Li, X1
Li, F1
Jin, Y1
Gong, S1
Wang, X2
Zeng, Z1
Huang, L1
Yang, H1
Kim, MJ1
Kim, YS1
Kim, SR1
Lee, DW1
Lee, SB1
Kim, IY1
Song, Y1
Chen, J1
Zhang, S1
Le, Y1
Xie, Z1
Ouyang, W1
Tong, J1
Soto-Mota, A1
Norwitz, NG1
Clarke, K1
Ginn, C1
Ateh, D1
Martin, J1
Marques, MB1
Dufour, T1
Thiessen, SE1
Güiza, F1
Janssens, T1
Hermans, G1
Vanhorebeek, I1
De Bock, K1
Van den Berghe, G1
Zhou, C1
Byard, RW1
Tanaka, J1
Kono, Y1
Shimahara, Y1
Sato, T1
Jones, RT1
Cowley, RA1
Trump, BF1
Beylot, M1
Chassard, D1
Chambrier, C1
Guiraud, M1
Odeon, M1
Beaufrère, B1
Bouletreau, P1
Yassen, KA1
Galley, HF1
Lee, A1
Webster, NR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371]30 participants (Anticipated)Interventional2022-10-31Recruiting
Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293]18 participants (Anticipated)Interventional2023-06-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for 3-hydroxybutyric acid and Blood Poisoning

ArticleYear
Why a d-β-hydroxybutyrate monoester?
    Biochemical Society transactions, 2020, 02-28, Volume: 48, Issue:1

    Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H

2020
Why a d-β-hydroxybutyrate monoester?
    Biochemical Society transactions, 2020, 02-28, Volume: 48, Issue:1

    Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H

2020
Why a d-β-hydroxybutyrate monoester?
    Biochemical Society transactions, 2020, 02-28, Volume: 48, Issue:1

    Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H

2020
Why a d-β-hydroxybutyrate monoester?
    Biochemical Society transactions, 2020, 02-28, Volume: 48, Issue:1

    Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H

2020
The use of point-of-care testing to establish cause of death in the autopsy setting.
    Journal of forensic and legal medicine, 2020, Volume: 71

    Topics: 3-Hydroxybutyric Acid; Autopsy; Bacteria; Blood Alcohol Content; Blood Glucose; C-Reactive Protein;

2020

Trials

1 trial available for 3-hydroxybutyric acid and Blood Poisoning

ArticleYear
Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation.
    Critical care medicine, 1994, Volume: 22, Issue:7

    Topics: 3-Hydroxybutyric Acid; Aged; Aged, 80 and over; Analysis of Variance; Carbon Isotopes; Depression, C

1994

Other Studies

9 other studies available for 3-hydroxybutyric acid and Blood Poisoning

ArticleYear
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice.
    BMC pharmacology & toxicology, 2021, 09-20, Volume: 22, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Aldosterone; Animals; Brain; Dietary Supplements; Dose

2021
Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis.
    Biochimica et biophysica acta. Molecular basis of disease, 2022, 11-01, Volume: 1868, Issue:11

    Topics: 3-Hydroxybutyric Acid; Animals; Anti-Inflammatory Agents; Cardiovascular Diseases; Esters; Inflammat

2022
3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages.
    Biochemical pharmacology, 2023, Volume: 213

    Topics: 3-Hydroxybutyric Acid; Acute Lung Injury; Animals; Autophagy; Lung; Macrophages; Mice; Sepsis; Ultra

2023
β-hydroxybutyrate ameliorates sepsis-induced acute kidney injury.
    Molecular biology reports, 2023, Volume: 50, Issue:11

    Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Animals; Apoptosis; Kidney; Lipopolysaccharides; Male; M

2023
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020, Volume: 17, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Cognitive Dysfunction; Hippocampus; Injections, Intraventricular; In

2020
Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness.
    Journal of cachexia, sarcopenia and muscle, 2017, Volume: 8, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aged; Animals; Body Composition; Critical Illness; Fasting; Fatty Acids; Fema

2017
Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization.
    Journal of forensic sciences, 2017, Volume: 62, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Epithelial Cells; Fatal Outcome; Female; Humans; Ketones; Ketosi

2017
A study of oxidative phosphorylative activity and calcium-induced respiration of rat liver mitochondria following living Escherichia coli injection.
    Advances in shock research, 1982, Volume: 7

    Topics: 3-Hydroxybutyric Acid; Adenosine Diphosphate; Animals; Calcium; Escherichia coli Infections; Glutama

1982
Mitochondrial redox state in the critically ill.
    British journal of anaesthesia, 1999, Volume: 83, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Biomarkers; Critical Illness; Humans; Ketone Bodi

1999