3-hydroxybutyric acid has been researched along with Aura in 38 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "Forty children with refractory epilepsy were included in the present study." | 5.91 | The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy. ( Afghan, M; Barzegar, M; Golchinfar, Z; Poorshiri, B; Raeisi, S; Shahabi, P; Shiva, S; Yousefi Nodeh, HR, 2023) |
| "Short-term MAD was associated with metabolic differences in plasma and resected epilepsy brain tissue when compared to control participants, in combination with trending expression changes observed in hippocampal NADH-related signaling pathways." | 4.31 | Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet. ( Devinsky, O; Devore, S; Friedman, D; Jones, DR; Kanshin, E; Korman, A; Leitner, DF; Lin, Z; Siu, Y; Tsirigos, A; Ueberheide, B; Wisniewski, T, 2023) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "Carnitine metabolism was monitored in seven children started on a KD for pharmacoresistant epilepsy after a conventional initial fasting period." | 2.72 | Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. ( Baumeister, FA; Bieger, I; Busch, R; Busch, V; Gempel, K; Hack, A; Pascher, B, 2006) |
| "Forty children with refractory epilepsy were included in the present study." | 1.91 | The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy. ( Afghan, M; Barzegar, M; Golchinfar, Z; Poorshiri, B; Raeisi, S; Shahabi, P; Shiva, S; Yousefi Nodeh, HR, 2023) |
| "Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide." | 1.46 | Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. ( Becker, HM; Deitmer, JW; Forero-Quintero, LS, 2017) |
| "We found that the KD postpones disease progression by delaying the onset of severe seizures and increases the lifespan of these mutant mice by 47%." | 1.43 | Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. ( Matthews, SA; Rho, JM; Simeone, KA; Simeone, TA, 2016) |
| "However, chronic in vitro ketosis abolished hippocampal network hyperexcitability following a metabolic insult, hypoxia, demonstrating for the first time a direct link between metabolic resistance and better control of excessive, synchronous, abnormal electrical activity." | 1.36 | Chronic in vitro ketosis is neuroprotective but not anti-convulsant. ( Abdelmalik, P; Carlen, PL; Samoilova, M; Velumian, AA; Weisspapir, M, 2010) |
| "A consistently strong ketosis (beta-hydroxybutyrate of >3 mmol/L) seemed to be important for maintaining the efficacy of the diet therapy." | 1.34 | Use of a modified Atkins diet in intractable childhood epilepsy. ( Kang, du C; Kang, HC; Kim, HD; Ko, TS; Lee, HS; You, SJ, 2007) |
| "The level of ketosis, however, was not predictive of seizure protection in EL mice." | 1.31 | The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. ( Madore, RA; Seyfried, TN; Stafstrom, CE; Tandon, P; Todorova, MT, 2000) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 16 (42.11) | 29.6817 |
| 2010's | 12 (31.58) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Poorshiri, B | 1 |
| Barzegar, M | 1 |
| Afghan, M | 1 |
| Shiva, S | 1 |
| Shahabi, P | 1 |
| Golchinfar, Z | 1 |
| Yousefi Nodeh, HR | 1 |
| Raeisi, S | 1 |
| Leitner, DF | 1 |
| Siu, Y | 1 |
| Korman, A | 1 |
| Lin, Z | 1 |
| Kanshin, E | 1 |
| Friedman, D | 1 |
| Devore, S | 1 |
| Ueberheide, B | 1 |
| Tsirigos, A | 1 |
| Jones, DR | 1 |
| Wisniewski, T | 1 |
| Devinsky, O | 1 |
| Soto-Mota, A | 1 |
| Norwitz, NG | 1 |
| Clarke, K | 1 |
| Jin, N | 1 |
| Ziyatdinova, S | 1 |
| Gureviciene, I | 1 |
| Tanila, H | 1 |
| Forero-Quintero, LS | 1 |
| Deitmer, JW | 1 |
| Becker, HM | 1 |
| Bonnet, U | 1 |
| Bingmann, D | 1 |
| Speckmann, EJ | 1 |
| Wiemann, M | 1 |
| Guo, Q | 1 |
| Liu, S | 1 |
| Wang, S | 1 |
| Wu, M | 1 |
| Li, Z | 1 |
| Wang, Y | 1 |
| Bertoli, S | 1 |
| Trentani, C | 1 |
| Ferraris, C | 1 |
| De Giorgis, V | 1 |
| Veggiotti, P | 1 |
| Tagliabue, A | 1 |
| Mantis, JG | 1 |
| Meidenbauer, JJ | 2 |
| Zimick, NC | 1 |
| Centeno, NA | 1 |
| Seyfried, TN | 3 |
| Roberts, MF | 1 |
| Law, TH | 1 |
| Davies, ES | 1 |
| Pan, Y | 1 |
| Zanghi, B | 1 |
| Want, E | 1 |
| Volk, HA | 1 |
| Simeone, KA | 2 |
| Matthews, SA | 2 |
| Rho, JM | 1 |
| Simeone, TA | 2 |
| Samson, KK | 1 |
| Xu, X | 1 |
| Sun, R | 1 |
| Jin, R | 1 |
| Porta, N | 1 |
| Vallée, L | 1 |
| Lecointe, C | 1 |
| Bouchaert, E | 1 |
| Staels, B | 1 |
| Bordet, R | 1 |
| Auvin, S | 1 |
| Samoilova, M | 1 |
| Weisspapir, M | 1 |
| Abdelmalik, P | 1 |
| Velumian, AA | 1 |
| Carlen, PL | 1 |
| Luan, G | 1 |
| Zhao, Y | 1 |
| Zhai, F | 1 |
| Chen, Y | 1 |
| Li, T | 1 |
| Fraser, DD | 1 |
| Whiting, S | 1 |
| Andrew, RD | 1 |
| Macdonald, EA | 1 |
| Musa-Veloso, K | 2 |
| Cunnane, SC | 2 |
| Cahill, GF | 2 |
| Veech, RL | 2 |
| SHINDO, H | 1 |
| Tabb, K | 1 |
| Szot, P | 1 |
| White, SS | 1 |
| Liles, LC | 1 |
| Weinshenker, D | 1 |
| Hack, A | 1 |
| Busch, V | 1 |
| Pascher, B | 1 |
| Busch, R | 1 |
| Bieger, I | 1 |
| Gempel, K | 1 |
| Baumeister, FA | 1 |
| Xu, XP | 1 |
| Sun, RP | 1 |
| Jin, RF | 1 |
| Kang, HC | 1 |
| Lee, HS | 1 |
| You, SJ | 1 |
| Kang, du C | 1 |
| Ko, TS | 1 |
| Kim, HD | 1 |
| Raffo, E | 1 |
| François, J | 1 |
| Ferrandon, A | 1 |
| Koning, E | 1 |
| Nehlig, A | 1 |
| Hallböök, T | 1 |
| Köhler, S | 1 |
| Rosén, I | 1 |
| Lundgren, J | 1 |
| Hartman, AL | 1 |
| Lyle, M | 1 |
| Rogawski, MA | 1 |
| Gasior, M | 1 |
| Shen, J | 1 |
| Novotny, EJ | 1 |
| Rothman, DL | 1 |
| Bough, KJ | 1 |
| Eagles, DA | 1 |
| Sankar, R | 1 |
| Sotero de Menezes, M | 1 |
| Bergqvist, AG | 1 |
| Chee, CM | 1 |
| Lutchka, LM | 1 |
| Brooks-Kayal, AR | 1 |
| Thio, LL | 1 |
| Wong, M | 1 |
| Yamada, KA | 1 |
| Todorova, MT | 2 |
| Tandon, P | 1 |
| Madore, RA | 1 |
| Stafstrom, CE | 1 |
| Chance, B | 1 |
| Kashiwaya, Y | 1 |
| Lardy, HA | 1 |
| Greene, AE | 1 |
| McGowan, R | 1 |
| Likhodii, SS | 1 |
| Sills, MA | 1 |
| Forsythe, WI | 1 |
| Haidukewych, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.[NCT05584371] | 30 participants (Anticipated) | Interventional | 2022-10-31 | Recruiting | |||
| Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction[NCT04921293] | 18 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for 3-hydroxybutyric acid and Aura
| Article | Year |
|---|---|
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Why a d-β-hydroxybutyrate monoester?
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus; Diet, Ketogenic; Dietary Supplements; Epilepsy; Fasting; H | 2020 |
Ketoacids? Good medicine?
Topics: 3-Hydroxybutyric Acid; Animals; Cerebral Cortex; Diet; Epilepsy; Fasting; Humans; Ketone Bodies; Ket | 2003 |
Metabolic and endocrine aspects of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Anticonvulsants; Carnitine; Dietary Fats; Energy Metabolism; Epilepsy; Fatty | 1999 |
Treatment of acquired epileptic aphasia with the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adolescent; Anticonvulsants; Aphasia; Child; Combined Modality Therapy; Dieta | 1999 |
Ketone bodies, potential therapeutic uses.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Energy Metabolism; Epilepsy; Fasting; Humans; Ketone Bodies; | 2001 |
3 trials available for 3-hydroxybutyric acid and Aura
| Article | Year |
|---|---|
A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Blood Glucose; Bromides; Cross-Over Studies; Diet, | 2015 |
Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.
Topics: 3-Hydroxybutyric Acid; Acetylcarnitine; Biological Transport; Carnitine; Child; Child, Preschool; Di | 2006 |
In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Epilepsy; Humans; Lactic Acid; Magnetic Resonance Spectros | 1998 |
30 other studies available for 3-hydroxybutyric acid and Aura
| Article | Year |
|---|---|
The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy.
Topics: 3-Hydroxybutyric Acid; Arachidonic Acid; Child; Diet, Ketogenic; Drug Resistant Epilepsy; Epilepsy; | 2023 |
Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet.
Topics: 3-Hydroxybutyric Acid; Adult; Diet, Carbohydrate-Restricted; Diet, High-Protein Low-Carbohydrate; Di | 2023 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis | 2020 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy | 2017 |
Small intraneuronal acidification via short-chain monocarboxylates: First evidence of an inhibitory action on over-excited human neocortical neurons.
Topics: 3-Hydroxybutyric Acid; Carboxylic Acids; Child, Preschool; Electrophysiological Phenomena; Epilepsy; | 2018 |
Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Epilepsy; Glutathione Peroxidase; Hippocampus; Male; Malo | 2019 |
[Prospective multicenter study on long-term ketogenic diet therapy for intractable childhood epilepsy].
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Diarrhea; Diet, Carbohydrate-Restricted; | 2013 |
Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Body Composition; Body Mass Index; Body Weight; Bone D | 2014 |
Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Blood Glucose; Body Weight; Caloric Restrictio | 2014 |
Reduced glucose utilization underlies seizure protection with dietary therapy in epileptic EL mice.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Caloric Restriction; Diet, Ketogenic; Disease Models, Animal; | 2014 |
Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blood Glucose; | 2016 |
Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Anilides; Animals; Animals, Newborn; Anticonvulsants; Blood Gluc | 2017 |
The effect of the ketogenic diet on hippocampal GluR5 and Glu(6 mRNA expression and Q/R site editing in the kainate-induced epilepsy model.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Base Sequence; Behavior, Animal; Body Weight; | 2008 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Chronic in vitro ketosis is neuroprotective but not anti-convulsant.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Cytoprotection; Diet, Ketogenic; Disease Models, A | 2010 |
Ketogenic diet reduces Smac/Diablo and cytochrome c release and attenuates neuronal death in a mouse model of limbic epilepsy.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Carrier Protein | 2012 |
Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adolescent; Arachidonic Acids; Child; Child, Preschool; Diet; Epilepsy; Fatty | 2003 |
[Clinical information on gama-amino-beta-hydroxybutyric acid in epilepsy].
Topics: 3-Hydroxybutyric Acid; Amino Acids; Antifibrinolytic Agents; Epilepsy | 1962 |
The ketogenic diet does not alter brain expression of orexigenic neuropeptides.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Chemistry; Eating; Energy Metabolism; Epilepsy; Galanin; In Si | 2004 |
Effect of ketogenic diet on hippocampus mossy fiber sprouting and GluR5 expression in kainic acid induced rat model.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Disease Model | 2006 |
Use of a modified Atkins diet in intractable childhood epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Child; Cohort Studies; Diet, Carbohydrate-Restricted; Dietary Pr | 2007 |
Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cerebral Cortex; Di | 2008 |
Effects of ketogenic diet on epileptiform activity in children with therapy resistant epilepsy.
Topics: 3-Hydroxybutyric Acid; Adolescent; Attention; Child; Child, Preschool; Data Interpretation, Statisti | 2007 |
Efficacy of the ketogenic diet in the 6-Hz seizure test.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Confounding Factors, Epidemiologic; Diet | 2008 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Co | 2000 |
The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Association Learning; Behavior, Animal; Blood Glucose; Dietary Carbo | 2000 |
Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Body Weig | 2001 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |
Role of octanoic and decanoic acids in the control of seizures.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Alanine; Caprylates; Child; Child, Preschool; Circ | 1986 |