Page last updated: 2024-10-17

3-hydroxybutyric acid and Anoxemia

3-hydroxybutyric acid has been researched along with Anoxemia in 21 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Research Excerpts

ExcerptRelevanceReference
"Acute hypoxia increases cerebral lactate and alanine in NG chick embryos; these increases are reduced by pre-exposure to substrate deprivation and chronic hypoxia."3.73Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study. ( Cady, EB; Dixon, JC; Peebles, DM; Priest, AN; Thornton, JS, 2005)
"The brain mitochondrial NAD+/NADH ratio, as a reflection of the oxidation-reduction (redox) state of cellular compartment, was determined under conditions of hypoxia, anoxia, hypoxia-ischemia, complete ischemia and hypoglycemia in immature rats."3.69Cerebral mitochondrial redox states during metabolic stress in the immature rat. ( Brucklacher, RM; Vannucci, RC, 1994)
"With intermittent anoxia, the pattern of substrate effects on the NAP changed markedly so that low concentrations of fructose became able to support neurophysiologic activity but not high concentrations of glucose."1.42Anoxia-induced changes in optimal substrate for peripheral nerve. ( Stecker, MM; Stevenson, MR, 2015)
"Glycogen depletion by anoxia or glucagon before ischemia impaired recovery."1.29Metabolic recovery of isolated working rat heart after brief global ischemia. ( Goodwin, GW; Taegtmeyer, H, 1994)
"Hypoxemia was induced by the combination of an atrial septal defect and pulmonary stenosis."1.29Left ventricular oxygen and substrate uptake in chronically hypoxemic lambs. ( Dalinghaus, M; Gerding, AM; Gratama, C; Koers, JH; Kuipers, JR; Willem, J; Zijlstra, WG, 1993)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19903 (14.29)18.7374
1990's8 (38.10)18.2507
2000's4 (19.05)29.6817
2010's5 (23.81)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Ma, X1
Dong, Z1
Liu, J1
Ma, L1
Sun, X1
Gao, R1
Pan, L1
Zhang, J1
A, D1
An, J1
Hu, K1
Sun, A1
Ge, J1
Boruczkowski, D1
Pujal, JM1
Zdolińska-Malinowska, I1
Wang, YP1
Wei, JY1
Yang, JJ1
Gao, WN1
Wu, JQ1
Guo, CJ1
Takahashi, S1
Iizumi, T1
Mashima, K1
Abe, T1
Suzuki, N1
Stecker, MM1
Stevenson, MR1
Lin, BQ1
Zeng, ZY1
Yang, SS1
Zhuang, CW1
Chalasani, N1
Gorski, JC1
Asghar, MS1
Asghar, A1
Foresman, B1
Hall, SD1
Crabb, DW1
Dixon, JC1
Cady, EB1
Priest, AN1
Thornton, JS1
Peebles, DM1
Sabatini, S1
Kurtzman, NA1
Vannucci, RC2
Brucklacher, RM1
Goodwin, GW1
Taegtmeyer, H1
Yager, JY1
Vannucci, SJ1
Dalinghaus, M1
Willem, J1
Gratama, C1
Koers, JH1
Gerding, AM1
Zijlstra, WG1
Kuipers, JR1
Willis, N1
Mogridge, J1
Brooks, KJ1
Clark, JB1
Bates, TE1
Van Cappellen Van Walsum, AM1
Jongsma, HW1
Wevers, RA1
Nijhuis, JG1
Crevels, J1
Engelke, UF1
De Abreu, RA1
Moolenaar, SH1
Oeseburg, B1
Nijland, R1
Arnould, T1
Michiels, C1
Alexandre, I1
Remacle, J1
D'Alecy, LG2
Lundy, EF1
Kluger, MJ1
Harker, CT1
LeMay, DR1
Shlafer, M1
Bossi, E1
Kohler, E1
Herschkowitz, N1
Rising, CL1
Ishikawa, S1
Vassalle, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fish Oil and Diet for the Treatment of Non-Alcoholic Steatohepatitis (NASH)[NCT00845845]Phase 212 participants (Actual)Interventional2006-03-31Terminated (stopped due to Terminated due to low enrollment.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for 3-hydroxybutyric acid and Anoxemia

ArticleYear
Autologous cord blood in children with cerebral palsy: a review.
    International journal of molecular sciences, 2019, May-16, Volume: 20, Issue:10

    Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Brain Diseases; Brain Injuries; Carnitine; Cerebral Pal

2019

Other Studies

20 other studies available for 3-hydroxybutyric acid and Anoxemia

ArticleYear
β-Hydroxybutyrate Exacerbates Hypoxic Injury by Inhibiting HIF-1α-Dependent Glycolysis in Cardiomyocytes-Adding Fuel to the Fire?
    Cardiovascular drugs and therapy, 2022, Volume: 36, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Disease Models, Animal; Glucose; Glycolysis; Humans; Hypoxia; Hypoxi

2022
Riboflavin supplementation improves energy metabolism in mice exposed to acute hypoxia.
    Physiological research, 2014, Volume: 63, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Carnitine; Dietary Supplements; Drug Evaluation, Prec

2014
Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia.
    ASN neuro, 2014, Sep-11, Volume: 6, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Astrocytes; Carbon Isotopes; Carnitine; Cells, Cultur

2014
Anoxia-induced changes in optimal substrate for peripheral nerve.
    Neuroscience, 2015, Jan-22, Volume: 284

    Topics: 3-Hydroxybutyric Acid; Acetates; Action Potentials; Animals; Fructose; Galactose; Glucose; Hypoxia;

2015
Dietary restriction suppresses tumor growth, reduces angiogenesis, and improves tumor microenvironment in human non-small-cell lung cancer xenografts.
    Lung cancer (Amsterdam, Netherlands), 2013, Volume: 79, Issue:2

    Topics: 3-Hydroxybutyric Acid; Actins; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferatio

2013
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Body Mass Index; Chlorzoxazone; Cholesterol, HDL; Cytoc

2003
Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study.
    Brain research. Developmental brain research, 2005, Dec-07, Volume: 160, Issue:2

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Aspartic Acid; Cerebellum; Chick Embryo; Fetal Hypoxia; Hyp

2005
Bicarbonate therapy in severe metabolic acidosis.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Bicarbonates; Cell Death; Diabetic Ketoacidosis; Hum

2009
Cerebral mitochondrial redox states during metabolic stress in the immature rat.
    Brain research, 1994, Aug-08, Volume: 653, Issue:1-2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Diseases; Brain Ischem

1994
Metabolic recovery of isolated working rat heart after brief global ischemia.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Fasting; Glucose-6-Phosphate; Glucosephospha

1994
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab

1994
Left ventricular oxygen and substrate uptake in chronically hypoxemic lambs.
    Pediatric research, 1993, Volume: 34, Issue:4

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Carbon Dioxide; Coronary Circulation; Coronary Vesse

1993
Indicators of histohypoxia.
    Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 107

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Carbon Dioxide; Cardiac Output; Cell Hypoxia; Cell Survival; C

1995
3-Hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices.
    Journal of neurochemistry, 1998, Volume: 70, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Brain; Energy Metabolism; Female; H

1998
1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery.
    Pediatric research, 2002, Volume: 52, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Choline; Citric Acid; Creatinine; Energy Metabolism; Femal

2002
Effect of hypoxia upon intracellular calcium concentration of human endothelial cells.
    Journal of cellular physiology, 1992, Volume: 152, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Calcium; Cell Survival; Cells, Cultured; Endothelium,

1992
Beta-hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1990, Volume: 96, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Hibernation; Hydroxybutyrates; Hypoxia; In Vitro Techniques; Ketones

1990
Utilization of D-beta-hydroxybutyrate and oleate as alternate energy fuels in brain cell cultures of newborn mice after hypoxia at different glucose concentrations.
    Pediatric research, 1989, Volume: 26, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Brain; Carbon Dioxide; Cells, Cultured; Energy Met

1989
Hypoxia-induced increases in hypoxic tolerance augmented by beta-hydroxybutyrate in mice.
    Stroke, 1989, Volume: 20, Issue:9

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Temperature; Glucose; Hydroxybutyrates; Hypoxia;

1989
Reversal of strophanthidin negative inotropy by metabolic substrates in cardiac Purkinje fibres.
    Cardiovascular research, 1985, Volume: 19, Issue:9

    Topics: 3-Hydroxybutyric Acid; Action Potentials; Animals; Calcium; Depression, Chemical; Dogs; Female; Gluc

1985