3-hydroxybutyric acid has been researched along with Alloxan Diabetes in 107 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Excerpt | Relevance | Reference |
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"In the diabetic ketoacidosis series, treatment with either alkali resulted in deterioration of mean arterial blood pressure and substantial elevation of blood lactate, despite a significant rise in myocardial intracellular pH determined by 31P-magnetic resonance spectroscopy." | 5.29 | Haemodynamic and metabolic effects in diabetic ketoacidosis in rats of treatment with sodium bicarbonate or a mixture of sodium bicarbonate and sodium carbonate. ( Beech, JS; Cohen, RD; Evans, SJ; Going, TC; Iles, RA; Nolan, KM; Williams, SC, 1995) |
"Leptin can reverse hyperglycemia in rodent models of type 1 diabetes." | 3.83 | Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy. ( Covey, SD; Denroche, HC; Kieffer, TJ; Mojibian, M; Neumann, UH, 2016) |
" We further demonstrate that activation of FXR in db/db mice repressed hepatic gluconeogenic genes and increased hepatic glycogen synthesis and glycogen content by a mechanism that involves enhanced insulin sensitivity." | 3.73 | Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. ( Barrera, G; Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Vales, C; Willson, TM; Zhang, Y, 2006) |
"To elucidate the peripheral disposal of ketone bodies in hyperketonemia accompanied with starvation, hyperthyroidism, or diabetes mellitus, the uptake of acetoacetic acid (AcAc) and beta-hydroxybutyrate (BOHB) was investigated in the perfused hindquarter and kidney of starved, thyrotoxic, and diabetic rats." | 3.68 | Uptake of ketone bodies in perfused hindquarter and kidney of starved, thyrotoxic, and diabetic rats. ( Fujiyama, K; Hoshino, T; Ikeda, T; Ishimura, M; Mashiba, H; Ochi, H; Ohtani, I; Tanaka, Y; Terasawa, H, 1993) |
"The plasma concentration of arginine vasopressin (AVP) is increased in diabetic ketoacidosis (DKA) in man and the rat." | 3.67 | Possible mechanisms responsible for the rise in plasma vasopressin associated with diabetic ketoacidosis in the rat. ( Baylis, PH; Charlton, JA; Thompson, CJ, 1988) |
" To test the role of beta-hydroxybutyric acid (BHB) and acidosis in generating such changes, we studied the pituitary-thyroid axis of streptozotocin-diabetic rats, BHB or ammonium chloride (NH4Cl)-treated normal rats." | 3.67 | Effects of diabetes, beta-hydroxybutyric acid and metabolic acidosis on the pituitary-thyroid axis in the rat. ( Boado, R; Colombo, O; Zaninovich, AA, 1985) |
"However, existing therapeutics for type 2 diabetes mellitus have limited success on the prevention of diabetic cardiomyopathy." | 1.62 | Ketone Ester D-β-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice. ( Bers, DM; Chiamvimonvat, N; Dedkova, EN; King, MT; Miller, CV; Schaefer, S; Thai, PN; Veech, RL, 2021) |
"The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes." | 1.46 | Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice. ( Cavino, K; Cheng, X; Gromada, J; Kim, SY; Krumm, E; Murphy, AJ; Na, E; Okamoto, H; Yancopoulos, GD, 2017) |
") implantation, its therapeutic effect lasted for over 130 h, and its bioavailability was enhanced by 4-fold." | 1.39 | The implantable and biodegradable PHBHHx 3D scaffolds loaded with protein-phospholipid complex for sustained delivery of proteins. ( Gong, T; Peng, Q; Sun, X; Wu, CY; Yang, Q; Yang, YJ; Zhang, L; Zhang, T; Zhang, ZR, 2013) |
"As L-carnitine plays a pivotal role in the balanced metabolism of fatty acids and carbohydrates, this study was carried out to investigate whether long-term mildronate treatment could influence glucose levels and prevent diabetic complications in an experimental model of type 2 diabetes in Goto-Kakizaki (GK) rats." | 1.35 | Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. ( Cirule, H; Dambrova, M; Grinberga, S; Kalvinsh, I; Kuka, J; Liepinsh, E; Skapare, E; Svalbe, B; Vilskersts, R; Zvejniece, L, 2009) |
"Diabetic TPN rats without insulin treatment had weight loss and negative nitrogen balance during the experiment." | 1.30 | MCT/LCT emulsion ameliorate liver fat deposition in insulin-treated diabetic rats receiving total parenteral nutrition. ( Chen, WJ; Lin, MT; Yeh, SL, 1998) |
" In conclusion, this study suggests that short-term administration of LA at high dosage to normal and diabetic rats causes an inhibition of gluconeogenesis secondary to an interference with hepatic fatty acid oxidation." | 1.30 | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. ( Bashan, N; Gutman, A; Khamaisi, M; Potashnik, R; Rudich, A; Tritschler, HJ, 1999) |
"In the diabetic ketoacidosis series, treatment with either alkali resulted in deterioration of mean arterial blood pressure and substantial elevation of blood lactate, despite a significant rise in myocardial intracellular pH determined by 31P-magnetic resonance spectroscopy." | 1.29 | Haemodynamic and metabolic effects in diabetic ketoacidosis in rats of treatment with sodium bicarbonate or a mixture of sodium bicarbonate and sodium carbonate. ( Beech, JS; Cohen, RD; Evans, SJ; Going, TC; Iles, RA; Nolan, KM; Williams, SC, 1995) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 41 (38.32) | 18.7374 |
1990's | 38 (35.51) | 18.2507 |
2000's | 13 (12.15) | 29.6817 |
2010's | 9 (8.41) | 24.3611 |
2020's | 6 (5.61) | 2.80 |
Authors | Studies |
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Thai, PN | 1 |
Miller, CV | 1 |
King, MT | 1 |
Schaefer, S | 1 |
Veech, RL | 1 |
Chiamvimonvat, N | 1 |
Bers, DM | 1 |
Dedkova, EN | 1 |
Trotta, MC | 1 |
Gesualdo, C | 1 |
Herman, H | 1 |
Gharbia, S | 1 |
Balta, C | 1 |
Lepre, CC | 1 |
Russo, M | 1 |
Itro, A | 1 |
D'Amico, G | 1 |
Peluso, L | 1 |
Panarese, I | 1 |
Pieretti, G | 1 |
Ferraro, G | 1 |
Simonelli, F | 1 |
D'Amico, M | 1 |
Rossi, S | 1 |
Hermenean, A | 1 |
Zhang, F | 2 |
Wang, S | 1 |
Zhao, C | 1 |
Jiang, D | 1 |
Wang, Y | 2 |
Qi, J | 4 |
Li, Y | 5 |
Wu, X | 1 |
Miao, D | 1 |
Liu, Z | 1 |
Liu, K | 3 |
Zhang, B | 1 |
Li, J | 1 |
Li, B | 1 |
Yu, Y | 1 |
Zhang, Y | 2 |
Geng, Q | 1 |
Qi, H | 1 |
Gu, L | 1 |
Xu, D | 1 |
Zhou, M | 1 |
Wang, X | 1 |
Sadek, KM | 1 |
Shaheen, H | 1 |
Glaser, N | 1 |
Bundros, A | 1 |
Anderson, S | 1 |
Tancredi, D | 1 |
Lo, W | 1 |
Orgain, M | 1 |
O'Donnell, M | 1 |
Neumann, UH | 1 |
Denroche, HC | 1 |
Mojibian, M | 1 |
Covey, SD | 1 |
Kieffer, TJ | 1 |
Okamoto, H | 1 |
Cavino, K | 1 |
Na, E | 1 |
Krumm, E | 1 |
Kim, SY | 1 |
Cheng, X | 1 |
Murphy, AJ | 1 |
Yancopoulos, GD | 1 |
Gromada, J | 1 |
Liu, Y | 1 |
Chen, G | 2 |
Liepinsh, E | 1 |
Vilskersts, R | 1 |
Zvejniece, L | 1 |
Svalbe, B | 1 |
Skapare, E | 1 |
Kuka, J | 1 |
Cirule, H | 1 |
Grinberga, S | 1 |
Kalvinsh, I | 1 |
Dambrova, M | 1 |
Barrena, HC | 1 |
Gazola, VA | 1 |
Furlan, MM | 1 |
Garcia, RF | 1 |
de Souza, HM | 1 |
Bazotte, RB | 1 |
Hsu, WY | 1 |
Kuo, CY | 1 |
Fukushima, T | 2 |
Imai, K | 2 |
Chen, CM | 1 |
Lin, PY | 1 |
Lee, JA | 2 |
Gambhir, D | 1 |
Ananth, S | 1 |
Veeranan-Karmegam, R | 1 |
Elangovan, S | 1 |
Hester, S | 1 |
Jennings, E | 1 |
Offermanns, S | 1 |
Nussbaum, JJ | 1 |
Smith, SB | 1 |
Thangaraju, M | 1 |
Ganapathy, V | 1 |
Martin, PM | 1 |
Yamai, K | 1 |
Funada, T | 1 |
Ohkuwa, T | 1 |
Itoh, H | 1 |
Tsuda, T | 1 |
Peng, Q | 1 |
Yang, YJ | 1 |
Zhang, T | 1 |
Wu, CY | 1 |
Yang, Q | 1 |
Sun, X | 1 |
Gong, T | 1 |
Zhang, L | 1 |
Zhang, ZR | 1 |
Giannessi, F | 1 |
Pessotto, P | 1 |
Tassoni, E | 1 |
Chiodi, P | 1 |
Conti, R | 1 |
De Angelis, F | 1 |
Dell'Uomo, N | 1 |
Catini, R | 1 |
Deias, R | 1 |
Tinti, MO | 1 |
Carminati, P | 1 |
Arduini, A | 1 |
Linke, A | 1 |
Zhao, G | 1 |
Recchia, FA | 1 |
Williams, J | 1 |
Xu, X | 1 |
Hintze, TH | 1 |
Olson, DE | 1 |
Paveglio, SA | 1 |
Huey, PU | 1 |
Porter, MH | 1 |
Thulé, PM | 1 |
El Midaoui, A | 3 |
Chiasson, JL | 2 |
Tancrède, G | 3 |
Nadeau, A | 3 |
Otero, P | 1 |
Bonet, B | 2 |
Herrera, E | 3 |
Rabano, A | 1 |
Lee, FY | 1 |
Barrera, G | 1 |
Lee, H | 1 |
Vales, C | 1 |
Gonzalez, FJ | 1 |
Willson, TM | 1 |
Edwards, PA | 1 |
Herberg, L | 1 |
Buchanan, KD | 1 |
Hermansen, K | 1 |
Lefebvre, PJ | 1 |
Luyckx, AS | 1 |
Scheen, AJ | 1 |
Castillo, M | 1 |
Jandrain, B | 1 |
Krzentowski, G | 1 |
Stangassinger, M | 1 |
Peruche, T | 1 |
Giesecke, D | 1 |
Hutson, JC | 1 |
Diani, AR | 2 |
Peterson, T | 2 |
Gilchrist, BJ | 1 |
Stevenson, RW | 2 |
Orskov, H | 1 |
Parsons, JA | 2 |
Alberti, KG | 2 |
Dahlkvist, HH | 3 |
Arnqvist, HJ | 2 |
Norrby, K | 2 |
Ogihara, M | 1 |
Tokumitsu, Y | 1 |
Ui, M | 1 |
Chen, V | 1 |
Wagner, G | 1 |
Spitzer, JJ | 1 |
Kasser, TR | 1 |
Gahagan, JH | 1 |
Martin, RJ | 1 |
Kielducka, A | 1 |
Paradies, G | 1 |
Papa, S | 1 |
Beech, JS | 2 |
Williams, SC | 1 |
Iles, RA | 2 |
Cohen, RD | 2 |
Nolan, KM | 1 |
Evans, SJ | 1 |
Going, TC | 1 |
Shin, M | 1 |
Maeda, S | 1 |
Hashimoto, Y | 1 |
Sano, K | 1 |
Umezawa, C | 1 |
Sultan, AM | 2 |
Szutowicz, A | 1 |
Tomaszewicz, M | 1 |
Jankowska, A | 1 |
Kisielevski, Y | 1 |
Buchanan, TA | 1 |
Denno, KM | 1 |
Sipos, GF | 1 |
Sadler, TW | 2 |
Moley, KH | 1 |
Vaughn, WK | 1 |
Diamond, MP | 1 |
Gibson, R | 1 |
Zhao, Y | 1 |
Jaskiewicz, J | 1 |
Fineberg, SE | 1 |
Harris, RA | 1 |
Cole, DR | 1 |
Waterfall, M | 1 |
Ashworth, L | 1 |
Bone, AJ | 1 |
Baird, JD | 1 |
Nakao, M | 1 |
Matsubara, T | 1 |
Sakamoto, N | 3 |
Shi, ZQ | 1 |
Giacca, A | 1 |
Yamatani, K | 1 |
Fisher, SJ | 1 |
Lickley, HL | 1 |
Vranic, M | 1 |
Hotta, N | 2 |
Komori, T | 1 |
Kobayashi, M | 1 |
Sakakibara, F | 1 |
Koh, N | 2 |
Ikeda, T | 2 |
Ishimura, M | 1 |
Terasawa, H | 1 |
Ochi, H | 1 |
Ohtani, I | 2 |
Fujiyama, K | 2 |
Hoshino, T | 2 |
Tanaka, Y | 2 |
Mashiba, H | 2 |
Wentzel, P | 1 |
Eriksson, UJ | 4 |
Jiffri, E | 1 |
Broom, J | 1 |
Whiting, PH | 1 |
McLean, MP | 1 |
Warden, KJ | 1 |
Sandhoff, TW | 1 |
Irby, RB | 1 |
Hales, DB | 1 |
Brignone, JA | 1 |
de Brignone, CM | 1 |
Ricci, CR | 1 |
de Mignone, IR | 1 |
Susemihl, MC | 1 |
Rodríguez, RR | 1 |
Viana, M | 1 |
Fischer, Y | 1 |
Böttcher, U | 1 |
Eblenkamp, M | 1 |
Thomas, J | 1 |
Jüngling, E | 1 |
Rösen, P | 1 |
Kammermeier, H | 1 |
Shimabukuro, M | 1 |
Koyama, K | 1 |
Wang, MY | 1 |
Trieu, F | 1 |
Lee, Y | 1 |
Newgard, CB | 1 |
Unger, RH | 1 |
Forsberg, H | 1 |
Melefors, O | 1 |
Welsh, N | 1 |
Oshida, Y | 2 |
Iwao, N | 1 |
Ohsawa, I | 2 |
Sato, J | 2 |
Nakao, T | 1 |
Sato, Y | 2 |
Nakai, N | 1 |
Shimomura, Y | 1 |
Rodríguez, T | 1 |
Busquets, S | 1 |
Alvarez, B | 1 |
Agell, N | 1 |
Lpez-Soriano, FJ | 1 |
Argilś, JM | 1 |
Yeh, SL | 1 |
Lin, MT | 1 |
Chen, WJ | 1 |
Khamaisi, M | 1 |
Rudich, A | 1 |
Potashnik, R | 1 |
Tritschler, HJ | 1 |
Gutman, A | 1 |
Bashan, N | 1 |
Ladrière, L | 1 |
Malaisse, WJ | 2 |
Lapidot, A | 2 |
Haber, S | 2 |
Korenaga, T | 1 |
Ichihara, H | 1 |
Kato, M | 1 |
Ferré, P | 2 |
Pénicaud, L | 2 |
Hitier, Y | 1 |
Meier, M | 1 |
Girard, J | 2 |
Mori, K | 1 |
Kaku, K | 1 |
Inoue, H | 1 |
Aoki, M | 1 |
Matsutani, A | 1 |
Kaneko, T | 1 |
Elayan, IM | 1 |
Cartmill, DC | 1 |
Eckersell, CB | 1 |
Wilkin, J | 1 |
Winder, WW | 1 |
Ramirez, R | 1 |
Sener, A | 1 |
Takeuchi, T | 1 |
Feingold, KR | 1 |
Soued, M | 1 |
Adi, S | 1 |
Staprans, I | 1 |
Shigenaga, J | 1 |
Doerrler, W | 1 |
Moser, A | 1 |
Grunfeld, C | 1 |
Weinstein, I | 1 |
Patel, TB | 1 |
Heimberg, M | 1 |
Kaloyianni, M | 1 |
Freedland, RA | 1 |
Bailey, JW | 1 |
Haymond, MW | 1 |
Miles, JM | 1 |
Styrud, J | 2 |
Avogaro, A | 1 |
Nosadini, R | 1 |
Doria, A | 1 |
Tremolada, C | 1 |
Baccaglini, U | 1 |
Ambrosio, F | 1 |
Merkel, C | 1 |
Nosadini, A | 1 |
Trevisan, R | 1 |
Fioretto, P | 1 |
Williams, SR | 1 |
Kamei, I | 1 |
Kakuta, H | 1 |
Kimura, M | 1 |
Fukasawa, H | 1 |
Moore, DC | 1 |
Stanisstreet, M | 1 |
Clarke, CA | 1 |
Baudon, MA | 1 |
Maulard, P | 1 |
Ktorza, A | 1 |
Castano, L | 1 |
Hofert, JF | 1 |
Goldstein, S | 1 |
Phillips, LS | 3 |
Hunter, ES | 1 |
Wynn, RE | 1 |
Hawkins, RA | 1 |
Mans, AM | 1 |
Davis, DW | 1 |
McCall, AL | 1 |
Sussman, I | 1 |
Tornheim, K | 1 |
Cordero, R | 1 |
Ruderman, NB | 1 |
Gil, J | 1 |
Carreras, J | 1 |
Bartrons, R | 1 |
Okuda, Y | 1 |
Kawai, K | 1 |
Yamashita, K | 1 |
Nagy, LE | 1 |
Kretchmer, N | 1 |
Charlton, JA | 1 |
Thompson, CJ | 1 |
Baylis, PH | 1 |
Fusco, AC | 1 |
Unterman, TG | 1 |
Boado, R | 1 |
Colombo, O | 1 |
Zaninovich, AA | 1 |
Bellward, GD | 1 |
Chang, T | 1 |
Rodrigues, B | 1 |
McNeill, JH | 1 |
Maines, S | 1 |
Ryan, DE | 1 |
Levin, W | 1 |
Thomas, PE | 1 |
Grantham, BD | 1 |
Zammit, VA | 1 |
Spanheimer, RG | 1 |
Freed, LE | 1 |
Endemann, G | 1 |
Tomera, JF | 1 |
Gavino, VC | 1 |
Brunengraber, H | 1 |
Albisser, AM | 1 |
Nomura, M | 1 |
McPhedran, NT | 1 |
Zusman, I | 1 |
Yaffe, P | 1 |
Ornoy, A | 1 |
Bedetti, CD | 1 |
Montero, GA | 1 |
Stoppani, AO | 1 |
Karlsson, MG | 1 |
Young, JC | 1 |
Treadway, JL | 1 |
Fader, EI | 1 |
Caslin, RF | 1 |
Cheng, L | 1 |
el-Seifi, S | 1 |
Sacktor, B | 1 |
Palacin, M | 1 |
Martin, A | 1 |
Lasuncion, MA | 1 |
Sawada, GA | 1 |
Wyse, BM | 1 |
Blanks, MC | 1 |
Gerritsen, GC | 1 |
Terenghi, G | 1 |
Varndell, IM | 1 |
Polak, JM | 1 |
Blank, MA | 1 |
2 reviews available for 3-hydroxybutyric acid and Alloxan Diabetes
Article | Year |
---|---|
[Metabolic consequences of insulin deficiency].
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hydroxybutyr | 1984 |
Mechanisms of congenital malformations in diabetic pregnancy.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Congenital Abnormalities; Diabetes Mellitus, Experime | 1987 |
105 other studies available for 3-hydroxybutyric acid and Alloxan Diabetes
Article | Year |
---|---|
Ketone Ester D-β-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice.
Topics: 3-Hydroxybutyric Acid; Animals; Butylene Glycols; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2021 |
Systemic Beta-Hydroxybutyrate Affects BDNF and Autophagy into the Retina of Diabetic Mice.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Brain-Derived Neurotrophic Factor; Connexin 43; Diabetes | 2022 |
D-beta-hydroxybutyrate reduced the enhanced cardiac microvascular endothelial FoxO1 to play protective roles in diabetic rats and high glucose-stimulated human cardiac microvascular endothelial cells.
Topics: 3-Hydroxybutyric Acid; Animals; Claudin-5; Diabetes Mellitus, Experimental; Endothelial Cells; Forkh | 2023 |
β-hydroxybutyrate antagonizes aortic endothelial injury by promoting generation of VEGF in diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Histo | 2020 |
β-Hydroxybutyrate inhibits histone deacetylase 3 to promote claudin-5 generation and attenuate cardiac microvascular hyperpermeability in diabetes.
Topics: 3-Hydroxybutyric Acid; Animals; beta Catenin; Capillary Permeability; Claudin-5; Coronary Vessels; D | 2021 |
β-Hydroxybutyrate inhibits cardiac microvascular collagen 4 accumulation by attenuating oxidative stress in streptozotocin-induced diabetic rats and high glucose treated cells.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cells, Cultured; Collagen Type IV; Coronary Vessels; D | 2021 |
Biochemical efficacy of vitamin D in ameliorating endocrine and metabolic disorders in diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2014 |
Brain cell swelling during hypocapnia increases with hyperglycemia or ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Brain Edema; Carbon Dioxide; Cell Size; Cerebral Cort | 2014 |
Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus, Exper | 2016 |
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-S | 2017 |
Vitamin A status affects the plasma parameters and regulation of hepatic genes in streptozotocin-induced diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Blotting, Western; Cells, Cultured; Diabetes Mellitus | 2017 |
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animals; Blood Glucose; Cardiovascular Agents; Carnitin | 2009 |
Ketogenesis evaluation in perfused liver of diabetic rats submitted to short-term insulin-induced hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Caprylates; Diabetes Mellitus, Experim | 2009 |
Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages.
Topics: 3-Hydroxybutyric Acid; Age Factors; Analysis of Variance; Animals; Blood Glucose; Body Weight; Chrom | 2011 |
GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.
Topics: 3-Hydroxybutyric Acid; Aged; Animals; Cell Line; Chemokine CCL2; Diabetes Mellitus, Experimental; Di | 2012 |
Acetone concentration in gas emanating from tails of diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gases; Male | 2012 |
The implantable and biodegradable PHBHHx 3D scaffolds loaded with protein-phospholipid complex for sustained delivery of proteins.
Topics: 3-Hydroxybutyric Acid; Animals; Biocompatible Materials; Caproates; Delayed-Action Preparations; Dia | 2013 |
Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Butyrates; Carnitine; Carnitine O-Palmitoyltransferas | 2003 |
Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes.
Topics: 3-Hydroxybutyric Acid; Alloxan; Animals; Blood Glucose; Blood Pressure; Body Weight; Carbon Dioxide; | 2003 |
Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme | 2003 |
Physical training reverses defect in 3-ketoacid CoA-transferase activity in skeletal muscle of diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Coenzyme A-Transferases; Diabetes Mellit | 2005 |
Development of atherosclerosis in the diabetic BALB/c mice. Prevention with Vitamin E administration.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Arteries; Atherosclerosis; Blood Glucose; Body Weight; | 2005 |
Physical training reverses the increased activity of the hepatic ketone body synthesis pathway in chronically diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Animals; Chronic Disease; Diabetes Mellitus, Exper | 2006 |
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; | 2006 |
Effect of high glucagon infusions on blood glucose, plasma insulin and beta-OH-butyrate concentrations in streptozotocin-diabetic and normal Osborne Mendel rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Hy | 1982 |
Stimulatory effect of beta-hydroxybutyrate on the release of somatostatin from the isolated pancreas of normal and streptozotocin-diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; | 1982 |
[Diabetes mellitus in dwarf goats; model experiments with streptozocin].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Goats | 1982 |
Altered biochemical responses by rat Sertoli cells and peritubular cells cultured under simulated diabetic conditions.
Topics: 3-Hydroxybutyric Acid; Androgen-Binding Protein; Animals; Bicarbonates; Carrier Proteins; Cells, Cul | 1984 |
Islet innervation of nondiabetic and diabetic Chinese hamsters. I. Acetylcholinesterase histochemistry and norepinephrine fluorescence.
Topics: 3-Hydroxybutyric Acid; Acetylcholinesterase; Adrenergic Fibers; Animals; Blood Glucose; Cholinergic | 1983 |
Metabolic responses to intraduodenal glucose loading in insulin-infused diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty | 1983 |
Effect of elevated substrates on substrate oxidation in normal and diabetic aorta.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Glucose; Hydroxybutyrates; M | 1983 |
Effects of diabetes on glucose oxidation in rat aorta after hypophysectomy and adrenalectomy.
Topics: 3-Hydroxybutyric Acid; Adrenal Glands; Adrenalectomy; Animals; Aorta; Blood Glucose; Blood Vessels; | 1984 |
Metabolic alterations in normal and streptozotocin-diabetic rats in vivo: influence of prolonged starvation.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimen | 1984 |
Regulation of substrate oxidation in isolated myocardial cells by beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Animals; Caprylates; Cells, Cultured; Diabetes Mellitus, Experimental; Hydrox | 1984 |
Comparison of the metabolic responses to portal and peripheral infusions of insulin in diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gluca | 1981 |
Influence of diabetes on oxidation of exogenous substrates in rat aorta.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Glucose; Hydroxybutyrates; I | 1981 |
Fetal hormones and neonatal survival in response to altered maternal serum glucose and free fatty acid concentrations in pigs.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Fa | 1982 |
A comparative study of the transport of pyruvate in liver mitochondria from normal and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biological Transport; Blood Glucose; Diabetes Mellitu | 1981 |
Haemodynamic and metabolic effects in diabetic ketoacidosis in rats of treatment with sodium bicarbonate or a mixture of sodium bicarbonate and sodium carbonate.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Pressure; Carbon Dioxide; Carbonates; Diabetes Mellitus, Exper | 1995 |
NAD synthesis from nicotinic acid by the hepatocytes prepared from diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Carbon Radioisotopes; Cells, Cultured; | 1995 |
The effects of chronic diabetes and physiological insulin concentration on ketone bodies metabolism in the heart.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Experimental; Dose-Response Relati | 1994 |
Acetylcholine synthesis in nerve terminals of diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Diabetes Mellitus, Experime | 1994 |
Diabetic teratogenesis. In vitro evidence for a multifactorial etiology with little contribution from glucose per se.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Congenital Abnormalities; Diabetes Mellitus, Experime | 1994 |
Manifestations of diabetes mellitus on mouse preimplantation development: effect of elevated concentration of metabolic intermediates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Butyrates; Cleavage Stage, Ovum; Culture | 1994 |
Effects of diabetes on the activity and content of the branched-chain alpha-ketoacid dehydrogenase complex in liver.
Topics: 3-Hydroxybutyric Acid; 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acetoacetates; Animals; Bl | 1993 |
Metabolic control in streptozotocin diabetic rats following transplantation of microencapsulated pancreatic islets.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Experimental; Gl | 1993 |
Effects of diabetes on cardiac glycogen metabolism in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Fasting; Glycogen; Hydroxybutyrates | 1993 |
Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs.
Topics: 3-Hydroxybutyric Acid; Alloxan; Animals; Diabetes Mellitus, Experimental; Dogs; Epoxy Compounds; Fat | 1993 |
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Biological Transport, Active; Buformin; Cell | 1993 |
Uptake of ketone bodies in perfused hindquarter and kidney of starved, thyrotoxic, and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Biological Transport; Diabete | 1993 |
Insulin treatment fails to abolish the teratogenic potential of serum from diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Co | 1996 |
Effect of physical training on mitochondrial function in skeletal muscle of normal and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diabetes Mellitus, Ex | 1996 |
Altered renal intermediary metabolism and the onset of renal dysfunction in the streptozotocin diabetic rat.
Topics: 3-Hydroxybutyric Acid; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; | 1996 |
Altered ovarian sterol carrier protein expression in the pregnant streptozotocin-treated diabetic rat.
Topics: 3-Hydroxybutyric Acid; 3-Hydroxysteroid Dehydrogenases; Acetyl-CoA C-Acetyltransferase; Animals; Blo | 1996 |
Favourable, significant effect of the dose-dependent treatment with RU 38486 (RU) on the alterations of the hepatic mitochondrial function of diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adrenalectomy; Animals; Anti-Inflammatory Agents; Corticosterone; Diabetes Me | 1996 |
Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Cholesterol; Congenital Abnormalities; Diabete | 1996 |
Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes.
Topics: 3-Hydroxybutyric Acid; 3-O-Methylglucose; Animals; Biological Transport; Cells, Cultured; Deoxygluco | 1997 |
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
Topics: 3-Hydroxybutyric Acid; Animals; Carrier Proteins; Culture Techniques; Diabetes Mellitus, Experimenta | 1997 |
Beta-hydroxybutyrate increases reactive oxygen species in late but not in early postimplantation embryonic cells in vitro.
Topics: 3-Hydroxybutyric Acid; Animals; Culture Techniques; Diabetes Mellitus, Experimental; Embryo, Mammali | 1998 |
Effect of insulin on intramuscular 3-hydroxybutyrate levels in diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hydroxybutyrates; Hy | 1998 |
Intramuscular 3-hydroxybutyrate levels after 60 tetani/min contraction in diabetic and non-diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Lactic Acid; Male; Muscle Contracti | 1998 |
Protein turnover in skeletal muscle of the diabetic rat: activation of ubiquitin-dependent proteolysis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Animals; Body Weight; Diabetes Mellitus, Exper | 1998 |
MCT/LCT emulsion ameliorate liver fat deposition in insulin-treated diabetic rats receiving total parenteral nutrition.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabete | 1998 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; | 1999 |
Effects of the dimethyl ester on succinic acid on the hormonal and metabolic response to exercise in hereditarily diabetic starved rats.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Diabetes Mellitus, Experimental; Fatty Acids, Nonesteri | 2000 |
Effect of endogenous beta-hydroxybutyrate on glucose metabolism in the diabetic rabbit brain: a (13)C-magnetic resonance spectroscopy study of [U-(13)C]glucose metabolites.
Topics: 3-Hydroxybutyric Acid; Alloxan; Amino Acids; Animals; Brain; Carbon Isotopes; Diabetes Mellitus, Exp | 2001 |
Simultaneous determination of D-lactic acid and 3-hydroxybutyric acid in rat plasma using a column-switching HPLC with fluorescent derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ).
Topics: 3-Hydroxybutyric Acid; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimenta | 2001 |
Effect of endogenous beta-hydroxybutyrate on brain glucose metabolism in fetuses of diabetic rabbits, studied by (13)C magnetic resonance spectroscopy.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Brain; Carbon Isotopes; Diabetes Mellitu | 2002 |
Hypoglycemic effects of a beta-agonist, Ro 16-8714, in streptozotocin-diabetic rats: decreased hepatic glucose production and increased glucose utilization in oxidative muscles.
Topics: 2-Hydroxyphenethylamine; 3-Hydroxybutyric Acid; Adrenergic beta-Agonists; Animals; Diabetes Mellitus | 1992 |
Effects of tolbutamide on fructose-2,6-bisphosphate formation and ketogenesis in hepatocytes from diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fructosediphosphates | 1992 |
Effects of diabetes and insulin on ketone bodies metabolism in heart.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Experimental; Hydroxybutyrates; In | 1992 |
Malonyl-CoA in skeletal muscle and liver of streptozotocin-diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Fatty Ac | 1991 |
Assay of 3-hydroxybutyrate in the picomolar range.
Topics: 3-Hydroxybutyric Acid; Animals; Carbon Radioisotopes; Cattle; Diabetes Mellitus, Experimental; Diazo | 1991 |
Uptake of beta-hydroxybutyrate in perfused hindquarter of starved and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Experimental; Glucose; Hindlimb; H | 1991 |
Tumor necrosis factor-increased hepatic very-low-density lipoprotein production and increased serum triglyceride levels in diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Animals; Blood Glucose; Diabetes Mellitus, Experiment | 1990 |
Secretion of triglyceride and ketogenesis by livers from spontaneous diabetic BB Wistar rats.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; | 1991 |
Effect of diabetes and time after in vivo insulin administration on ketogenesis and gluconeogenesis in isolated rat hepatocytes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Hyd | 1990 |
Validation of two-pool model for in vivo ketone body kinetics.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carbon Isotopes; Carbon Radioisotopes; Diabetes Melli | 1990 |
Effects of D-glucose and beta-hydroxybutyric acid on the in vitro development of (pre)chondrocytes from embryos of normal and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Cartilage; Cell Differentiation; Cell Division; Cells, Cultured; Den | 1990 |
Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental | 1990 |
Gluconeogenesis and the protection of hepatic intracellular pH during diabetic ketoacidosis in rats.
Topics: 3-Hydroxybutyric Acid; Adenine Nucleotides; Animals; Carbon Dioxide; Diabetes Mellitus, Experimental | 1989 |
Effects of lipolytic and antilipolytic agents on glycerol and free fatty acid release from isolated adipocytes of normal and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Bucladesine; Diabetes Mellitus, Experimental; Dose-R | 1989 |
Morphological and physiological effects of beta-hydroxybutyrate on rat embryos grown in vitro at different stages.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Embryo, Mamma | 1989 |
Normal insulin sensitivity during the phase of glucose intolerance but insulin resistance at the onset of diabetes in the spontaneously diabetic BB rat.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Crosses, Genetic; Diabetes Mellitus, Experimental; Ep | 1989 |
Glucocorticoid effects on IGF-1/somatomedin-C and somatomedin inhibitor in streptozotocin-diabetic rats.
Topics: 3-Hydroxybutyric Acid; Adrenalectomy; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experi | 1989 |
Evidence for multifactorial origin of diabetes-induced embryopathies.
Topics: 3-Hydroxybutyric Acid; Animals; Congenital Abnormalities; Diabetes Mellitus, Experimental; Female; F | 1989 |
Regional ketone body utilization by rat brain in starvation and diabetes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Autoradiography; Brain; Diabetes Mellitus, Experiment | 1986 |
Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels.
Topics: 3-Hydroxybutyric Acid; Animals; Capillaries; Cerebrovascular Circulation; Diabetes Mellitus, Experim | 1988 |
Effects of diabetes on fructose 2, 6-P2, glucose 1, 6-P2 and 6-phosphofructo 2-kinase in rat liver.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Ketoacidosi | 1986 |
Age-related change in ketone body metabolism: diminished glucagon effect on ketogenesis in adult rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Cyclic AMP; Diabetes Mellitus, Expe | 1987 |
Effect of diabetic ketosis on jejunal glutaminase.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Fasting; Glu | 1986 |
Possible mechanisms responsible for the rise in plasma vasopressin associated with diabetic ketoacidosis in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Arginine Vasopressin; Blood Pressure; Diabetes Mellitus, Experimenta | 1988 |
Nutrition and somatomedin. XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes.
Topics: 3-Hydroxybutyric Acid; Animals; Biological Assay; Blood Glucose; Body Weight; Cartilage; Chromatogra | 1985 |
Effects of diabetes, beta-hydroxybutyric acid and metabolic acidosis on the pituitary-thyroid axis in the rat.
Topics: 3-Hydroxybutyric Acid; Acidosis; Ammonium Chloride; Animals; Diabetes Mellitus, Experimental; Hydrox | 1985 |
Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat.
Topics: 3-Hydroxybutyric Acid; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Diabetes Mellit | 1988 |
Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acyltransferases; Animals; Blood Glucose; Carnitine O-Palmitoy | 1988 |
Direct inhibition of collagen production in vitro by diabetic rat serum.
Topics: 3-Hydroxybutyric Acid; Animals; Cartilage; Collagen; Diabetes Mellitus, Experimental; DNA; Glucose; | 1988 |
Lipogenesis from ketone bodies in perfused livers from streptozocin-induced diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Coenzyme A Ligases; Diabetes Mellitus, Experimental; | 1988 |
Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Noneste | 1986 |
Effects of metabolic factors in the diabetic state on the in vitro development of preimplantation mouse embryos.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blastocyst; Culture Techniques; Diabetes Mellitus, Ex | 1987 |
Effect of diabetes, adrenalectomy and hypophysectomy on D-3-hydroxybutyrate dehydrogenase activity and substrate oxidation by rat mitochondria.
Topics: 3-Hydroxybutyric Acid; Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Hydroxybutyrate Dehy | 1987 |
Effects of oral hypoglycemic agent methylpalmoxirate on exercise capacity of streptozocin diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epoxy Compounds; Eth | 1986 |
Renal beta-hydroxybutyrate (beta OHB) transport in streptozotocin (Sz)-induced diabetic rats.
Topics: 3-Hydroxybutyric Acid; Absorption; Animals; Biological Transport, Active; Diabetes Mellitus, Experim | 1985 |
Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; | 1985 |
Elevated levels of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic Chinese hamsters.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Cricetinae; Cricetulus; Diabetes Mellitu | 1985 |