3-hydroxybutyric acid has been researched along with Akinetic-Rigid Variant of Huntington Disease in 4 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Huntington's disease is a fatal neurodegenerative disease, where dysfunction and loss of striatal and cortical neurons are central to the pathogenesis of the disease." | 1.48 | Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism. ( Aldana, BI; Andersen, JV; Nielsen, ML; Nørremølle, A; Santos, A; Skotte, NH; Waagepetersen, HS; Willert, CW, 2018) |
| "Progressive weight loss is a hallmark feature of Huntington's disease, yet we found that the ketogenic diet-which generally causes weight loss in normal animals-delayed the reduction in body weight of the transgenic mice." | 1.37 | A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease. ( Geiger, JD; Kawamura, M; Masino, SA; Ross, JL; Ruiz, TL; Ruskin, DN, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skotte, NH | 1 |
| Andersen, JV | 1 |
| Santos, A | 1 |
| Aldana, BI | 1 |
| Willert, CW | 1 |
| Nørremølle, A | 1 |
| Waagepetersen, HS | 1 |
| Nielsen, ML | 1 |
| Chen, JY | 1 |
| Tran, C | 1 |
| Hwang, L | 1 |
| Deng, G | 1 |
| Jung, ME | 1 |
| Faull, KF | 1 |
| Levine, MS | 1 |
| Cepeda, C | 1 |
| Ruskin, DN | 1 |
| Ross, JL | 1 |
| Kawamura, M | 1 |
| Ruiz, TL | 1 |
| Geiger, JD | 1 |
| Masino, SA | 1 |
| Lim, S | 1 |
| Chesser, AS | 1 |
| Grima, JC | 1 |
| Rappold, PM | 1 |
| Blum, D | 1 |
| Przedborski, S | 1 |
| Tieu, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835] | 0 participants (Actual) | Interventional | 2020-09-01 | Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for 3-hydroxybutyric acid and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism.
Topics: 3-Hydroxybutyric Acid; Acetates; Animals; Astrocytes; Brain; Disease Models, Animal; Energy Metaboli | 2018 |
Partial Amelioration of Peripheral and Central Symptoms of Huntington's Disease via Modulation of Lipid Metabolism.
Topics: 3-Hydroxybutyric Acid; Animals; Cholesterol; Diet, Ketogenic; Female; Huntington Disease; Inhibitory | 2016 |
A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Diet, Ketogenic; Disease Models, Animal; Female; Humans | 2011 |
D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.
Topics: 3-Hydroxybutyric Acid; Acetylation; Animals; Histones; Huntington Disease; Immunoblotting; Male; Mic | 2011 |