Page last updated: 2024-10-17

3-hydroxybutyric acid and Aging

3-hydroxybutyric acid has been researched along with Aging in 64 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The present study was designed to evaluate the effects of age on the efficacy of the ketogenic diet in suppressing seizures evoked by tail-vein infusion of pentylenetetrazole (PTZ)."3.70Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. ( Bough, KJ; Eagles, DA; Han, FT; Valiyil, R, 1999)
"It is widely accepted that ketosis (increased blood ketone body levels, e."2.72Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases. ( Ari, C; Brunner, B; Kovács, Z, 2021)
"Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i."1.30Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. ( Bough, KJ; Chen, RS; Eagles, DA, 1999)
"Urea levels were highest in controls, and lowest in cafeteria rats fed from day 30, a consequence of the different setting of nitrogen sparing induced by the timing of initiation of cafeteria feeding."1.29Long-term effects of cafeteria diet feeding on young Wistar rats. ( Alemany, M; Arola, L; Salvadó, J; Segués, T, 1994)

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199016 (25.00)18.7374
1990's20 (31.25)18.2507
2000's12 (18.75)29.6817
2010's9 (14.06)24.3611
2020's7 (10.94)2.80

Authors

AuthorsStudies
Wang, L1
Chen, P1
Xiao, W1
Stekovic, S1
Hofer, SJ1
Tripolt, N1
Aon, MA1
Royer, P1
Pein, L1
Stadler, JT1
Pendl, T1
Prietl, B1
Url, J1
Schroeder, S1
Tadic, J1
Eisenberg, T1
Magnes, C1
Stumpe, M1
Zuegner, E1
Bordag, N1
Riedl, R1
Schmidt, A1
Kolesnik, E1
Verheyen, N1
Springer, A1
Madl, T1
Sinner, F1
de Cabo, R1
Kroemer, G1
Obermayer-Pietsch, B1
Dengjel, J1
Sourij, H1
Pieber, TR1
Madeo, F1
Suissa, L1
Flachon, V1
Guigonis, JM1
Olivieri, CV1
Burel-Vandenbos, F1
Guglielmi, J1
Ambrosetti, D1
Gérard, M1
Franken, P1
Darcourt, J1
Pellerin, L1
Pourcher, T1
Lindenthal, S1
Morittu, VM1
Minuti, A1
Spina, A1
Riboni, MV1
Piccioli-Cappelli, F1
Trevisi, E1
Britti, D1
Lopreiato, V1
Sharma, R1
Ramanathan, A1
Han, YM1
Ramprasath, T1
Zou, MH1
Park, JS1
Kim, YJ1
Kovács, Z1
Brunner, B1
Ari, C1
Newman, JC2
Verdin, E2
Kim, DH1
Park, MH1
Ha, S1
Bang, EJ1
Lee, Y1
Lee, AK1
Lee, J1
Yu, BP1
Chung, HY1
Edwards, C1
Copes, N1
Bradshaw, PC1
Kojima-Yuasa, A1
Yamamoto, T1
Yaku, K1
Hirota, S1
Takenaka, S1
Kawabe, K1
Matsui-Yuasa, I1
Crane, EM1
Munro, JC1
Bourgon, SL1
Diel de Amorim, M1
Ventura, R1
Fredeen, AH1
Montanholi, YR1
Studzinski, CM1
MacKay, WA1
Beckett, TL1
Henderson, ST1
Murphy, MP1
Sullivan, PG1
Burnham, WM1
Balietti, M2
Giorgetti, B2
Fattoretti, P2
Grossi, Y1
Di Stefano, G2
Casoli, T2
Platano, D2
Solazzi, M2
Orlando, F1
Aicardi, G2
Bertoni-Freddari, C2
Plourde, M2
Tremblay-Mercier, J1
Fortier, M1
Pifferi, F1
Cunnane, SC2
Freemantle, E1
Vandal, M1
Tremblay Mercier, J1
Poirier, J1
Norouzian, MA1
Valizadeh, R1
Vahmani, P1
Żarnowski, T1
Chorągiewicz, T1
Tulidowicz-Bielak, M1
Thaler, S1
Rejdak, R1
Żarnowski, I1
Turski, WA1
Gasior, M1
Swithers, SE2
McCurley, M1
Hagopian, K1
Ramsey, JJ1
Weindruch, R1
Ohtsu, H1
Sato, K1
Nishida, H1
Akiba, Y1
Vannucci, SJ1
Simpson, IA1
Lust, WD1
Pundik, S1
Zechel, J1
Zhou, Y1
Buczek, M1
Selman, WR1
Coverdale, JA1
Tyler, HD1
Quigley, JD3
Brumm, JA1
Regen, DM1
Callis, JT1
Sugden, MC1
Roeder, LM2
Tildon, JT3
Stevenson, JH1
Yeh, YY1
Booth, RF1
Clark, JB1
Nehlig, A2
Lehr, PR1
Linz, DN1
Garcia, VF1
Arya, G1
Hug, G1
Tombragel, E1
Landrigan, E1
Chuck, G1
Tsoras, M1
Ryan, M1
Ziegler, MM1
Gatnau, R1
Zimmerman, DR1
Nissen, SL1
Wannemuehler, M1
Ewan, RC1
Lean, IJ1
Bruss, ML1
Troutt, HF1
Galland, JC1
Farver, TB1
Rostami, J1
Holmberg, CA1
Weaver, LD1
Segués, T1
Salvadó, J1
Arola, L1
Alemany, M1
Rejman, JJ1
Martin, KR2
Bernard, JK1
Tyberendt, TL1
Adams, SH1
Odle, J1
Fleming, SE1
Fitch, MD1
Hudes, M1
Dean, DJ1
Cartee, GD1
Mahagna, M1
Nir, I1
Barb, CR1
Kraeling, RR1
Rampacek, GB1
Dove, CR1
Chapman, IM1
Hartman, ML1
Pezzoli, SS1
Harrell, FE1
Hintz, RL1
Alberti, KG1
Thorner, MO1
Krishnan, S1
Ramakrishna, BS1
Marker, JC1
Clutter, WE1
Cryer, PE1
Bough, KJ2
Valiyil, R1
Han, FT1
Eagles, DA2
Chen, RS1
Melendez, RI1
Watkins, BA1
Davis, RJ1
Giesecke, D1
Beck, U1
Wiesmayr, S1
Stangassinger, M1
Davis, TA1
Fiorotto, ML1
Nguyen, HV1
Burrin, DG1
Reeds, PJ1
Chugani, HT1
Hovda, DA1
Villablanca, JR1
Phelps, ME1
Xu, WF1
Paolisso, G1
Buonocore, S1
Gentile, S1
Sgambato, S1
Varricchio, M1
Scheen, A1
D'Onofrio, F1
Lefèbvre, PJ1
Corbisier, P1
Remacle, J1
Ando, M1
Itoh, T1
Okuda, Y1
Kawai, K1
Yamashita, K1
McKenna, MC1
Bezold, LI1
Kimatian, SJ1
London, ED1
Margolin, RA1
Duara, R1
Holloway, HW1
Robertson-Tchabo, EA1
Cutler, NR1
Rapoport, SI1
Pereira de Vasconcelos, A1
Schroeder, H1
Sapolsky, RM1
Menon, NK1
Lopez, RR1
Lamers, KJ1
Doesburg, WH1
Gabreëls, FJ1
Romsom, AC1
Renier, WO1
Wevers, RA1
Lemmens, WA1
Vömel, T1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy[NCT02673515]60 participants (Actual)Interventional2015-04-30Completed
Effect of Sodium-glucose Cotransporter-2 Inhibitor in Cellular Senescence in Patients With Cardiovascular Diseases or Advanced Type 2 Diabetes[NCT05975528]Phase 487 participants (Anticipated)Interventional2023-08-31Not yet recruiting
The Effect of Acipimox on GLP-1 Secretion in Healthy Subjects: a Pilot Study[NCT02796950]8 participants (Actual)Interventional2016-06-30Completed
A Randomised Controlled Trial Evaluating the Efficacy and Mechanisms of a Ketogenic Diet as an Adjunctive Treatment for People With Treatment-resistant Depression[NCT06091163]100 participants (Anticipated)Interventional2024-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Insulin Sensitivity (HOMA-IR)

"HOMA-Index was calculated by using the following formula:~HOMA-IR= FPG(mmol/l)*FSI (U/l)/22.5 FSI=fasting serum insulin FPG=fasting plasma glucose" (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Mean)
Alternate Day Fasting0.05
Control Group0.06

Insulin Sensitivity (ISI-Index)

ISI was calculated by using the following formula: ISI=0,222-0,00333 x BMI-0,0000779 x Ins120-0,000422 x age FSI=fasting serum insulin FPG=fasting plasma glucose (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting0
Control Group0

Insulin Sensitivity (Matsuda-Index)

"Matsuda index was calculated by using the following formula:~Matsuda-Index = 10000√(FPG∗FSI)∗(mean glucose*mean insulin) FSI=fasting serum insulin FPG=fasting plasma glucose" (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting-0.4
Control Group-0.7

Insulin Sensitivity (QUICKI)

QUICKI was calculated by using the following formula: QUICKI= log(FSI)+log (FPG) FSI=fasting serum insulin FPG=fasting plasma glucose (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting0
Control Group0

Blood Pressure (Systolic and Diastolic)

Change of blood pressure from Baseline to 4 weeks (NCT02673515)
Timeframe: 4 weeks

,
InterventionmmHg (Median)
Systolic blood pressureDiastolic blood pressure
Alternate Day Fasting-4.5-2.5
Control Group-10

Reviews

6 reviews available for 3-hydroxybutyric acid and Aging

ArticleYear
β-hydroxybutyrate as an Anti-Aging Metabolite.
    Nutrients, 2021, Sep-28, Volume: 13, Issue:10

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Antioxidants; Biomarkers; Disease Susceptibility; Energy Meta

2021
The Aging Metabolome-Biomarkers to Hub Metabolites.
    Proteomics, 2020, Volume: 20, Issue:5-6

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Biomarkers; Citric Acid Cycle; DNA Damage; Epigenesis, Geneti

2020
β-hydroxybutyrate and its metabolic effects on age-associated pathology.
    Experimental & molecular medicine, 2020, Volume: 52, Issue:4

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Disease Susceptibility; Humans; Lipid Metabolism; Skin Aging

2020
Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases.
    Nutrients, 2021, Jun-26, Volume: 13, Issue:7

    Topics: 3-Hydroxybutyric Acid; Aging; Alzheimer Disease; Diet, Ketogenic; Dietary Supplements; Epigenomics;

2021
β-Hydroxybutyrate: A Signaling Metabolite.
    Annual review of nutrition, 2017, 08-21, Volume: 37

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Epigenesis, Genetic; Humans; Liver; Signal Transduction; Star

2017
Ketone bodies as signaling metabolites.
    Trends in endocrinology and metabolism: TEM, 2014, Volume: 25, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Caloric Restriction; Histone Deacetylase Inhibitors; Histone

2014

Trials

4 trials available for 3-hydroxybutyric acid and Aging

ArticleYear
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
    Cell metabolism, 2019, 09-03, Volume: 30, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Aging; Biomarkers; Body Mass Index; Caloric Restriction; Energy Intake

2019
Age-related metabolic changes of pre-weaned Simmental calves fed whole bulk milk and ad libitum calf starter.
    Research in veterinary science, 2021, Volume: 135

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Biom

2021
Metabolic response to a ketogenic breakfast in the healthy elderly.
    The journal of nutrition, health & aging, 2009, Volume: 13, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Apolipoprotein E4

2009
Bovine ketosis and somatotrophin: risk factors for ketosis and effects of ketosis on health and production.
    Research in veterinary science, 1994, Volume: 57, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Analysis of Variance; Animals; Blood Glucose; Body Weight; Cattle; Cat

1994

Other Studies

54 other studies available for 3-hydroxybutyric acid and Aging

ArticleYear
Urinary ketone body loss leads to degeneration of brain white matter in elderly SLC5A8-deficient mice.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020, Volume: 40, Issue:8

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Glucose; Ketone Bodies; Kidney; Leukoencephalopathies; Male;

2020
Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in
    International journal of molecular sciences, 2020, May-15, Volume: 21, Issue:10

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Centrosome; DNA Damage; Drosophila melanogaster; Heterochroma

2020
Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction.
    Aging, 2019, 02-27, Volume: 11, Issue:4

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Anti-Inflammatory Agents; Caloric Restriction; Gene Expressio

2019
D-ß-hydroxybutyrate: an anti-aging ketone body.
    Oncotarget, 2015, Feb-28, Volume: 6, Issue:6

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Caenorhabditis elegans; Humans; Ketone Bodies; Mice

2015
1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells.
    Chemico-biological interactions, 2016, Sep-25, Volume: 257

    Topics: 3-Hydroxybutyric Acid; Aging; Alpinia; Animals; Benzyl Alcohols; Energy Metabolism; Hippocampus; Ket

2016
Metabolic blood profile of beef heifers during oestrous and non-oestrous states.
    Reproduction in domestic animals = Zuchthygiene, 2016, Volume: 51, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Aging; Alkaline Phosphatase; Animals; Aspartate Aminotransfer

2016
Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.
    Brain research, 2008, Aug-21, Volume: 1226

    Topics: 3-Hydroxybutyric Acid; Aging; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precurs

2008
Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats.
    Rejuvenation research, 2008, Volume: 11, Issue:3

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Dentate Gyrus

2008
Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly.
    Nutrition (Burbank, Los Angeles County, Calif.), 2009, Volume: 25, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Area Under Curve; Blood Gl

2009
A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes.
    Annals of the New York Academy of Sciences, 2009, Volume: 1171

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Diet, Ketogenic; Male; Microscopy, Electron; Mitochondria, He

2009
Rumen development and growth of Balouchi lambs offered alfalfa hay pre- and post-weaning.
    Tropical animal health and production, 2011, Volume: 43, Issue:6

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet

2011
Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:6

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood Glucose; Brain Chemistry; Cerebral Cortex; Corpus Stria

2012
Effects of 2-mercaptoacetate on ingestive behavior in 18- and 21-day-old rats.
    Behavioural brain research, 2002, Nov-15, Volume: 136, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Blood Glucose; Body Weight; Diet; Dose-Res

2002
Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice.
    Experimental gerontology, 2003, Volume: 38, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Caloric Restriction; Fructosediphosphates; Glu

2003
High beta-hydroxybutyrate concentration in liver and skeletal muscle of newly hatched chicks.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2003, Volume: 134, Issue:3

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Chickens; Ketone Bodies; Liver; Liver Extra

2003
Developmental switch in brain nutrient transporter expression in the rat.
    American journal of physiology. Endocrinology and metabolism, 2003, Volume: 285, Issue:5

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood Glucose; Blood-Brain Barrier; Brain; Brain Chemistry; C

2003
Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain.
    Metabolic brain disease, 2003, Volume: 18, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Blood Glucose; Brai

2003
Effect of various levels of forage and form of diet on rumen development and growth in calves.
    Journal of dairy science, 2004, Volume: 87, Issue:8

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Catt

2004
Studies of cerebral beta-hydroxybutyrate transport by carotid injection; effects of age, diet and injectant composition.
    Brain research, 1983, Jul-25, Volume: 271, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood-Brain Barrier; Capillary Permeability; Dietary Fats; El

1983
Antiketonemic effect of glycerol during development of the rat.
    The Journal of nutrition, 1982, Volume: 112, Issue:7

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Animals, Newborn; Animals, Suckling; Blood Glu

1982
Antiketonemic and antiketogenic actions of carnitine in vivo and in vitro in rats.
    The Journal of nutrition, 1981, Volume: 111, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Coenzyme A; Corn Oil; Dietary Fats;

1981
Energy metabolism in rat brain: inhibition of pyruvate decarboxylation by 3-hydroxybutyrate in neonatal mitochondria.
    Journal of neurochemistry, 1981, Volume: 37, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Brain; Female; Hydroxybutyrates; Male; Mito

1981
Glucose and 3-hydroxybutyrate utilization by chick telencephalon during postnatal development.
    Experientia, 1981, Volume: 37, Issue:6

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood-Brain Barrier; Chickens; Glucose; Hydroxybutyrates; Kin

1981
Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis.
    Journal of pediatric surgery, 1995, Volume: 30, Issue:7

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Bacterial Infections; Blood Glucose; Carnitine; Fatty Acids;

1995
Effects of excess dietary leucine and leucine catabolites on growth and immune responses in weanling pigs.
    Journal of animal science, 1995, Volume: 73, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids; Animals; Avena; Blood Urea Nitrogen; Crosses, Genetic; De

1995
Long-term effects of cafeteria diet feeding on young Wistar rats.
    Biochemistry and molecular biology international, 1994, Volume: 33, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood Glucose; Body Weight; Diet; Female; Glycerol; Hydroxybu

1994
Response of peripheral blood mononuclear cells to mitogenic stimulation in young calves.
    Journal of dairy science, 1994, Volume: 77, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Blood Glucose; Cattle; Hydroxybutyrates; Le

1994
Intake, growth, and selected blood parameters in calves fed calf starter via bucket or bottle.
    Journal of dairy science, 1994, Volume: 77, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animal Feed; Animals; Blood Glucose; Blood Urea Nitrogen; Bottle Feedi

1994
Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine.
    The American journal of physiology, 1993, Volume: 265, Issue:4 Pt 2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Caprylates; Hydroxybutyrates; Ketone Bodies

1993
Intestinal cell respiration is influenced by animal age, strain, and feeding status.
    Journal of gerontology, 1994, Volume: 49, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetates; Aging; Animals; Butyrates; Cells, Cultured; Colon; Fasting; Food; G

1994
Brief dietary restriction increases skeletal muscle glucose transport in old Fischer 344 rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:3

    Topics: 3-Hydroxybutyric Acid; 3-O-Methylglucose; Aging; Animals; Biological Transport; Body Weight; Diet; F

1996
Comparative development of digestive organs, intestinal disaccharidases and some blood metabolites in broiler and layer-type chicks after hatching.
    British poultry science, 1996, Volume: 37, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Alkaline Phosphatase; alpha-Amylases; alpha-Glucosidases; Analysis of

1996
Metabolic changes during the transition from the fed to the acute feed-deprived state in prepuberal and mature gilts.
    Journal of animal science, 1997, Volume: 75, Issue:3

    Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids, Essential; Animals; Blood Glucose; Eating; Fatty Acids, N

1997
Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:9

    Topics: 3-Hydroxybutyric Acid; Adult; Aging; Blood Glucose; Dose-Response Relationship, Drug; Fatty Acids, N

1997
Butyrate and glucose metabolism in isolated colonocytes in the developing rat colon.
    Journal of pediatric gastroenterology and nutrition, 1998, Volume: 26, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Animals, Newborn; Butyrates; Butyric Acid; Car

1998
Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals.
    The American journal of physiology, 1998, Volume: 275, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aging; Alanine; Blood Glucose; Blood Pressure; Epinephrine; Fatt

1998
Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet.
    Epilepsy research, 1999, Volume: 35, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Behavior, Animal; Convulsants; Diet; Energy Intake; Growth; K

1999
Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat.
    Developmental neuroscience, 1999, Volume: 21, Issue:3-5

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Convulsants; Diet; Differential Threshold; Disea

1999
Metabolic and behavioral responses in pre-weanling rats following alteration of maternal diet.
    Physiology & behavior, 2001, Volume: 72, Issue:1-2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Behavior, Animal; Blood Glucose; Diet; Diet

2001
The effect of rumen epithelial development on metabolic activities and ketogenesis by the tissue in vitro.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1979, Volume: 62, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Butyrates; Butyric Acid; Epithelium; Glucose;

1979
Response of muscle protein synthesis to fasting in suckling and weaned rats.
    The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Blood Glucose; Fasting; Hydroxybutyrates;

1991
Metabolic maturation of the brain: a study of local cerebral glucose utilization in the developing cat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1991, Volume: 11, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Autoradiography; Blood Glucose; Brain; Cats

1991
Pulsatile glucagon has greater hyperglycaemic, lipolytic and ketogenic effects than continuous hormone delivery in man: effect of age.
    Diabetologia, 1990, Volume: 33, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Age Factors; Aged; Aging; Blood Glucose; C-Peptide; Drug Administratio

1990
Involvement of mitochondria in cell degeneration.
    European journal of cell biology, 1990, Volume: 51, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Cell Division; Cell Fractionation; Cell Line; Cell Survival;

1990
Changes of amino acid by the deprivation of energy sources in the cerebral cortex.
    Brain & development, 1989, Volume: 11, Issue:3

    Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids; Animals; Cerebral Cortex; Energy Metabolism; Female; Hydr

1989
Age-related change in ketone body metabolism: diminished glucagon effect on ketogenesis in adult rats.
    Endocrinology, 1987, Volume: 120, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Cyclic AMP; Diabetes Mellitus, Expe

1987
Competition of glycerol with other oxidizable substrates in rat brain.
    The Biochemical journal, 1986, Jul-01, Volume: 237, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Brain; Carbon Dioxide; Female; Glucose; Glutamine; Glycerol;

1986
Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain.
    The American journal of physiology, 1988, Volume: 255, Issue:2 Pt 1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Biological Transport; Brain; Hydrogen-Ion Concentration; Hydr

1988
Effects of fasting on ketone body concentrations in healthy men of different ages.
    Journal of gerontology, 1986, Volume: 41, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Aging; Brain; Fasting; Glucose; Humans; Hydroxybu

1986
Effects of early chronic phenobarbital treatment on the maturation of energy metabolism in the developing rat brain. II. Incorporation of beta-hydroxybutyrate into amino acids.
    Brain research, 1987, Dec-01, Volume: 433, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Amino Acids; Animals; Animals, Newborn; Cerebellum; Cer

1987
Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1986, Volume: 6, Issue:8

    Topics: 3-Hydroxybutyric Acid; Adrenalectomy; Aging; Animals; Cell Survival; Corticosterone; Drug Synergism;

1986
The effects of mild congenital methylmercury intoxication on the metabolism of 3-hydroxybutyrate and glucose in the brains of suckling rats.
    Neurotoxicology, 1985,Spring, Volume: 6, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Body Weight; Brain; Female; Glucose; Hydro

1985
Reference values of blood components related to fuel metabolism in children after an overnight fast.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Jan-15, Volume: 145, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Aging; Alanine; Blood Glucose; Child; Child, Presc

1985
Age-dependent changes of biochemical parameters during the perfusion of the isolated rat liver.
    Mechanisms of ageing and development, 1985, Volume: 31, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Alanine Transaminase; Animals; Aspartate Aminotransfera

1985