3-hydroxybutyric acid has been researched along with Adult Sandhoff Disease in 2 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These data suggest that the KD-R and NB-DNJ may be a potential combinatorial therapy for Sandhoff disease by enhancing NB-DNJ delivery to the brain and may allow lower dosing to achieve the same degree of efficacy as high dose monotherapy." | 1.36 | Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. ( Baek, RC; Bronson, RT; Butters, TD; Denny, CA; Heinecke, KA; Kim, YP; Loh, KS; Platt, FM; Seyfried, TN, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denny, CA | 2 |
| Heinecke, KA | 1 |
| Kim, YP | 1 |
| Baek, RC | 1 |
| Loh, KS | 1 |
| Butters, TD | 1 |
| Bronson, RT | 2 |
| Platt, FM | 1 |
| Seyfried, TN | 2 |
| Kasperzyk, JL | 1 |
| Gorham, KN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Synergistic Enteral Regimen for Treatment of the Gangliosidoses (Syner-G)[NCT02030015] | Phase 4 | 16 participants (Actual) | Interventional | 2015-12-22 | Terminated (stopped due to Efficacy) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for 3-hydroxybutyric acid and Adult Sandhoff Disease
| Article | Year |
|---|---|
Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.
Topics: 1-Deoxynojirimycin; 3-Hydroxybutyric Acid; Analysis of Variance; Animals; beta-N-Acetylhexosaminidas | 2010 |
Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Diff | 2006 |