3-hydroxybutyric acid has been researched along with Acute Disease in 19 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of acute pancreatitis on the energy metabolism of the liver and on the fragility of hepatic cells and subcellular organelles, we studies (1) the arterial blood ketone body ratio (BKBR) (aceto acetate/beta-hydroxy butyrate), which is in equilibrium with the free NAD+/NADH ratio in liver mitochondria; (2) the hepatic energy charge (EC) = (ATP + 1/2 ADP)/(ATP + ADP + AMP); (3) the cathepsin B leakage from hepatic lysosomes and the malate dehydrogenase leakage from hepatic mitochondria in vitro; and (4) the protective effects of prostaglandin E2 (PGE2) and a new synthetic protease inhibitor ONO 3307 on hepatic injury in acute pancreatitis induced in rats by a supramaximal dose of caerulein." | 7.68 | Impaired hepatic energy metabolism in rat acute pancreatitis: protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307. ( Hirano, T; Manabe, T; Tobe, T, 1992) |
| "To evaluate the effects of acute pancreatitis on the energy metabolism of the liver and on the fragility of hepatic cells and subcellular organelles, we studies (1) the arterial blood ketone body ratio (BKBR) (aceto acetate/beta-hydroxy butyrate), which is in equilibrium with the free NAD+/NADH ratio in liver mitochondria; (2) the hepatic energy charge (EC) = (ATP + 1/2 ADP)/(ATP + ADP + AMP); (3) the cathepsin B leakage from hepatic lysosomes and the malate dehydrogenase leakage from hepatic mitochondria in vitro; and (4) the protective effects of prostaglandin E2 (PGE2) and a new synthetic protease inhibitor ONO 3307 on hepatic injury in acute pancreatitis induced in rats by a supramaximal dose of caerulein." | 3.68 | Impaired hepatic energy metabolism in rat acute pancreatitis: protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307. ( Hirano, T; Manabe, T; Tobe, T, 1992) |
| "Acute pancreatitis and hyperamylasemia are often seen in patients with acute liver failure (ALF)." | 1.72 | β-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb. ( Chen, J; Cui, B; Li, B; Li, X; Liu, J; Liu, L; Shan, C; Sun, N; Sun, W; Xing, H; Xu, Q; Yang, T; Zheng, Y; Zhu, W, 2022) |
| "The only seizure test where short-term rapamycin treatment protected mice was against tonic hindlimb extension in the MES threshold test, though this protection waned with longer rapamycin treatment." | 1.38 | The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. ( Dolce, A; Hardwick, JM; Hartman, AL; Santos, P, 2012) |
| "Metabolic acidosis is associated with most severe malaria deaths in African children, and most deaths occur before maximum antimalarial action is achieved." | 1.33 | Characterisation of metabolic acidosis in Kenyan children admitted to hospital for acute non-surgical conditions. ( Berkley, J; English, M; Kokwaro, G; Lowe, B; Mwakesi, R; Sasi, P; Shebe, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Shi, J | 1 |
| Du, D | 1 |
| Niu, N | 1 |
| Liu, S | 1 |
| Yang, X | 1 |
| Lu, P | 1 |
| Shen, X | 1 |
| Shi, N | 1 |
| Yao, L | 1 |
| Zhang, R | 1 |
| Hu, G | 1 |
| Lu, G | 1 |
| Zhu, Q | 1 |
| Zeng, T | 1 |
| Liu, T | 1 |
| Xia, Q | 1 |
| Huang, W | 1 |
| Xue, J | 1 |
| Zheng, Y | 1 |
| Sun, W | 1 |
| Shan, C | 1 |
| Li, B | 1 |
| Liu, J | 1 |
| Xing, H | 1 |
| Xu, Q | 1 |
| Cui, B | 1 |
| Zhu, W | 1 |
| Chen, J | 1 |
| Liu, L | 1 |
| Yang, T | 1 |
| Sun, N | 1 |
| Li, X | 1 |
| Stryeck, S | 1 |
| Gastrager, M | 1 |
| Degoricija, V | 1 |
| Trbušić, M | 1 |
| Potočnjak, I | 1 |
| Radulović, B | 1 |
| Pregartner, G | 1 |
| Berghold, A | 1 |
| Madl, T | 1 |
| Frank, S | 1 |
| Hurrell, FE | 1 |
| Drobatz, KJ | 1 |
| Hess, RS | 1 |
| Page, KA | 1 |
| Williamson, A | 1 |
| Yu, N | 1 |
| McNay, EC | 1 |
| Dzuira, J | 1 |
| McCrimmon, RJ | 1 |
| Sherwin, RS | 2 |
| Hartman, AL | 1 |
| Santos, P | 1 |
| Dolce, A | 1 |
| Hardwick, JM | 1 |
| Jacob, RJ | 1 |
| Fan, X | 1 |
| Evans, ML | 1 |
| Dziura, J | 1 |
| Skiba, M | 1 |
| Maciejewska-Paszek, I | 1 |
| Pawłowska-Góral, K | 1 |
| Aleksiewicz, R | 1 |
| Wardas, M | 1 |
| Linde, R | 1 |
| Hasselbalch, SG | 1 |
| Topp, S | 1 |
| Paulson, OB | 1 |
| Madsen, PL | 1 |
| Sasi, P | 1 |
| English, M | 1 |
| Berkley, J | 1 |
| Lowe, B | 1 |
| Shebe, M | 1 |
| Mwakesi, R | 1 |
| Kokwaro, G | 1 |
| Webber, J | 1 |
| Simpson, E | 1 |
| Parkin, H | 1 |
| Macdonald, IA | 1 |
| Nagamine, T | 1 |
| Saito, S | 1 |
| Yamada, S | 1 |
| Arai, T | 1 |
| Takehara, K | 1 |
| Fukui, T | 1 |
| Pan, JW | 1 |
| Telang, FW | 1 |
| Lee, JH | 1 |
| de Graaf, RA | 1 |
| Rothman, DL | 1 |
| Stein, DT | 1 |
| Hetherington, HP | 1 |
| Blomqvist, G | 1 |
| Alvarsson, M | 1 |
| Grill, V | 1 |
| Von Heijne, G | 1 |
| Ingvar, M | 1 |
| Thorell, JO | 1 |
| Stone-Elander, S | 1 |
| Widén, L | 1 |
| Ekberg, K | 1 |
| Riegel, W | 1 |
| Hörl, WH | 1 |
| Hirano, T | 1 |
| Manabe, T | 1 |
| Tobe, T | 1 |
| Fulop, M | 1 |
| Bock, J | 1 |
| Ben-Ezra, J | 1 |
| Antony, M | 1 |
| Danzig, J | 1 |
| Gage, JS | 1 |
| Sorisky, A | 1 |
| Devlin, JT | 1 |
| Adrogué, HJ | 1 |
| Chap, Z | 1 |
| Ishida, T | 1 |
| Field, JB | 1 |
2 trials available for 3-hydroxybutyric acid and Acute Disease
| Article | Year |
|---|---|
Metabolic effects of acute hyperketonaemia in man before and during an hyperinsulinaemic euglycaemic clamp.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adipose Tissue; Adult; Basal Metabolism; Blood Glucose; Fatty | 1994 |
Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Brain; Carbon Radioisotopes; Diabetes Mellitus, Type 1; | 2002 |
17 other studies available for 3-hydroxybutyric acid and Acute Disease
| Article | Year |
|---|---|
Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adolescent; Animals; Ceruletide; China; Disease Models, Animal | 2022 |
β-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Ferroptosis; Hyperamylasemia; Liver Failure, Acute; M | 2022 |
Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Aged; Aged, 80 and over; Biomarkers; Citric Acid; Comorbidity; | 2019 |
Beta-hydroxybutyrate Concentrations in Dogs with Acute Pancreatitis and Without Diabetes Mellitus.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anorexia; Dog Diseases; Dogs; Fasting; Pancreatitis; | 2016 |
Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Cognition; Cognition Disorders; Diabetes Mellitus, Type 1; Fat | 2009 |
The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anticonvulsants; Blood Glucose; Blotting, Western; Ce | 2012 |
Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adaptation, Physiological; Animals; Blood-Brain Barrier; Brain | 2002 |
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Anesthesia; Animals; Brain; Cerebrovascular Circulation; Disea | 2006 |
Characterisation of metabolic acidosis in Kenyan children admitted to hospital for acute non-surgical conditions.
Topics: 3-Hydroxybutyric Acid; Acidosis; Acute Disease; Biomarkers; Child, Preschool; Creatinine; Female; Ga | 2006 |
Biotinidase activity in patients with liver disease.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Aged; Amidohydrolases; Biotin; Biotinidase; Carcinoma, | 1993 |
Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Biological Transport; Brain Chemistry; Fasting; Humans; | 2001 |
Ketone body-induced dissociation between hepatocyte gluconeogenesis and ureagenesis in acutely uremic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Animals; Butyrates; Female; Gluconeogenesis; Hy | 1992 |
Impaired hepatic energy metabolism in rat acute pancreatitis: protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Adenosine Diphosphate; Adenosine Triphosphate; | 1992 |
Plasma lactate and 3-hydroxybutyrate levels in patients with acute ethanol intoxication.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Aged; Alcoholic Intoxication; Blood Glucose; Diabetic K | 1986 |
Intraoperative ketoacidosis and malnutrition.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Acute Disease; Drug Therapy, Combination; Female; Gl | 1988 |
Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs.
Topics: 3-Hydroxybutyric Acid; Acidosis; Acute Disease; Animals; Bicarbonates; Blood Glucose; Dogs; Electrol | 1985 |