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3-hydroxybutyric acid and Acute Brain Injuries

3-hydroxybutyric acid has been researched along with Acute Brain Injuries in 11 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Research Excerpts

ExcerptRelevanceReference
"Ischemic stroke is a leading cause of disability worldwide."1.91Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke. ( Bernal-Vicente, BN; Gerónimo-Olvera, C; Gómora-García, JC; Heras-Romero, Y; Massieu, L; Montiel, T; Pérez-Martínez, X; Tovar-Y-Romo, LB, 2023)
"Hypoglycemia has emerged as a prominent complication in anti-diabetic drug therapy or negative energy balance of animals, which causes brain damage, cognitive impairment, and even death."1.72β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. ( Chai, X; Huang, J; Li, C; Pan, J; Wu, Y; Xue, Y; Yang, J; Zhao, S; Zhou, W; Zhu, X, 2022)
"Rats fed a KD had a higher seizure threshold (longer latency to flurothyl-induced seizure activity) than rats fed a standard diet (SD); this effect was seen when KD was in place at the time of seizure testing (3 and 6 weeks following FPI), but was absent when KD had been replaced by SD at time of testing."1.36Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury? ( Campos, L; Delance, A; Lyeth, BG; Nguyen, DV; Poon, CC; Schwartzkroin, PA; Van, KC; Wenzel, HJ, 2010)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Li, C1
Chai, X1
Pan, J1
Huang, J1
Wu, Y1
Xue, Y1
Zhou, W1
Yang, J1
Zhu, X1
Zhao, S1
Cascant-Vilaplana, MM1
Lara-Cantón, I1
Núñez-Ramiro, A1
Solaz-García, Á1
Llorens-Salvador, R1
Quintás, G1
Kuligowski, J1
Vento, M1
Montiel, T2
Gómora-García, JC1
Gerónimo-Olvera, C2
Heras-Romero, Y1
Bernal-Vicente, BN1
Pérez-Martínez, X1
Tovar-Y-Romo, LB1
Massieu, L2
Boruczkowski, D1
Pujal, JM1
Zdolińska-Malinowska, I1
Julio-Amilpas, A1
Soto-Tinoco, E1
White, H1
Venkatesh, B1
Jones, M1
Fuentes, H1
Hu, ZG1
Wang, HD1
Jin, W1
Yin, HX1
Schwartzkroin, PA1
Wenzel, HJ1
Lyeth, BG1
Poon, CC1
Delance, A1
Van, KC1
Campos, L1
Nguyen, DV1
Deng-Bryant, Y1
Prins, ML2
Hovda, DA2
Harris, NG1
Lee, SM1
Fujima, LS1
Robertson, CS1
Goodman, JC1
Narayan, RK1
Contant, CF1
Grossman, RG1

Reviews

1 review available for 3-hydroxybutyric acid and Acute Brain Injuries

ArticleYear
Autologous cord blood in children with cerebral palsy: a review.
    International journal of molecular sciences, 2019, May-16, Volume: 20, Issue:10

    Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Brain Diseases; Brain Injuries; Carnitine; Cerebral Pal

2019

Trials

1 trial available for 3-hydroxybutyric acid and Acute Brain Injuries

ArticleYear
The effect of glucose administration on carbohydrate metabolism after head injury.
    Journal of neurosurgery, 1991, Volume: 74, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Blood Glucose; Brain Injuries; Carbohydrate Metab

1991

Other Studies

9 other studies available for 3-hydroxybutyric acid and Acute Brain Injuries

ArticleYear
β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling.
    Journal of molecular neuroscience : MN, 2022, Volume: 72, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Brain Injuries; Caspase 3; Glucose; Hypoglycemia; NF-kapp

2022
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
    Pediatric research, 2023, Volume: 94, Issue:1

    Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B

2023
Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke.
    Journal of neurochemistry, 2023, Volume: 166, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Brain Injuries; Endoplasmic Reticulum Stress; Endoribonuc

2023
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi

2015
Serial changes in plasma ketone concentrations in patients with acute brain injury.
    Neurological research, 2017, Volume: 39, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Brain Injuries; Female; Glasgow Coma Scale; Human

2017
Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats.
    Annals of clinical and laboratory science, 2009,Winter, Volume: 39, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Blood Glucose; Brain; Brain Injuries; Caspase 3; Cytochro

2009
Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury?
    Epilepsy research, 2010, Volume: 92, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Brain Injuries; CD11b Antigen; Cell Count; Cell Death; Diet, Ketogen

2010
Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury.
    Journal of neurotrauma, 2011, Volume: 28, Issue:9

    Topics: 3-Hydroxybutyric Acid; Age Factors; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Diet

2011
Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats.
    Journal of neurochemistry, 2004, Volume: 90, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Brain; Brain Injuries; Carbon Dioxide; Carbo

2004