3-hydroxyanthranilic acid has been researched along with Inflammation in 10 studies
3-Hydroxyanthranilic Acid: An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
3-hydroxyanthranilic acid : An aminobenzoic acid that is benzoic acid substituted at C-2 by an amine group and at C-3 by a hydroxy group. It is an intermediate in the metabolism of the amino acid tryptophan.
3-hydroxyanthranilate : A hydroxybenzoate that is the conjugate base of 3-hydroxyanthranilic acid.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 7.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "Healthy young adults (n = 737) aged 18-28 y without any known diseases or clinical evidence of inflammation provided blood samples for analysis of serum tryptophan/kynurenine metabolites, neopterin, C-reactive protein (CRP), and plasma pyridoxal 5'-phosphate (PLP) with LC-tandem mass spectrometry methodologies." | 3.83 | Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. ( Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM, 2016) |
| "Median serum CRP and neopterin concentrations were well below established clinical cutoffs for inflammation." | 3.83 | Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. ( Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM, 2016) |
| "Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway." | 3.79 | A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. ( Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE, 2013) |
| " In contrast, resolution of inflammation coincided with the decreased concentration of tryptophan and accumulation of its catabolites: kynurenine, anthranilic acid, and 3-hydroxyanthranilic acid in lymph nodes but not in the spleen." | 3.78 | An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis. ( Kolodziej, L, 2012) |
| "New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease." | 3.76 | Insights into therapy: tryptophan oxidation and HIV infection. ( Murray, MF, 2010) |
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 3.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "About 350 million people worldwide have type 2 diabetes (T2D)." | 1.42 | Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes. ( Oxenkrug, GF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Gerdes, N | 1 |
| Winkels, H | 1 |
| Weber, C | 1 |
| Theofylaktopoulou, D | 1 |
| Midttun, Ø | 2 |
| Ulvik, A | 1 |
| Ueland, PM | 2 |
| Tell, GS | 1 |
| Vollset, SE | 1 |
| Nygård, O | 1 |
| Eussen, SJ | 1 |
| Oxenkrug, GF | 1 |
| Deac, OM | 1 |
| Mills, JL | 1 |
| Gardiner, CM | 1 |
| Shane, B | 1 |
| Quinn, L | 1 |
| McCann, A | 1 |
| Meyer, K | 1 |
| Fan, R | 1 |
| Lu, Z | 1 |
| Brody, LC | 1 |
| Molloy, AM | 1 |
| Backhaus, C | 1 |
| Rahman, H | 1 |
| Scheffler, S | 1 |
| Laatsch, H | 1 |
| Hardeland, R | 1 |
| Murray, MF | 1 |
| Favre, D | 1 |
| Mold, J | 1 |
| Hunt, PW | 1 |
| Kanwar, B | 1 |
| Loke, P | 1 |
| Seu, L | 1 |
| Barbour, JD | 1 |
| Lowe, MM | 1 |
| Jayawardene, A | 1 |
| Aweeka, F | 1 |
| Huang, Y | 1 |
| Douek, DC | 1 |
| Brenchley, JM | 1 |
| Martin, JN | 1 |
| Hecht, FM | 1 |
| Deeks, SG | 1 |
| McCune, JM | 1 |
| Brouns, R | 1 |
| Verkerk, R | 1 |
| Aerts, T | 1 |
| De Surgeloose, D | 1 |
| Wauters, A | 1 |
| Scharpé, S | 1 |
| De Deyn, PP | 1 |
| Kolodziej, L | 1 |
10 other studies available for 3-hydroxyanthranilic acid and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Atherosclerosis: cell biology and lipoproteins-focus on anti-inflammatory mechanisms as therapeutic options.
Topics: 3-Hydroxyanthranilic Acid; Animals; Atherosclerosis; Cell Biology; Humans; Inflammation; Interleukin | 2013 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inf | 2013 |
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agen | 2015 |
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross | 2016 |
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compo | 2008 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Prog | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigm | 2010 |
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; | 2010 |
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; | 2012 |