3-hydroxyanthranilic acid has been researched along with Arthritis, Rheumatoid in 2 studies
3-Hydroxyanthranilic Acid: An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
3-hydroxyanthranilic acid : An aminobenzoic acid that is benzoic acid substituted at C-2 by an amine group and at C-3 by a hydroxy group. It is an intermediate in the metabolism of the amino acid tryptophan.
3-hydroxyanthranilate : A hydroxybenzoate that is the conjugate base of 3-hydroxyanthranilic acid.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mean plasma total tryptophan concentration of 13 long-standing rheumatoid arthritis patients was found to be lower than that of seven nonrheumatoid control subjects, but the plasma nicotinic acid concentration was unchanged." | 7.66 | Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis. ( Dickerson, JW; Labadarios, D; McKenzie, DY; Parke, DV, 1978) |
| "The mean plasma total tryptophan concentration of 13 long-standing rheumatoid arthritis patients was found to be lower than that of seven nonrheumatoid control subjects, but the plasma nicotinic acid concentration was unchanged." | 3.66 | Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis. ( Dickerson, JW; Labadarios, D; McKenzie, DY; Parke, DV, 1978) |
| "It completely abrogated thermal and mechanical hyperalgesia." | 1.34 | The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis. ( Andrews, M; Criado, G; Feldmann, M; Inglis, JJ; Selley, ML; Williams, RO, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inglis, JJ | 1 |
| Criado, G | 1 |
| Andrews, M | 1 |
| Feldmann, M | 1 |
| Williams, RO | 1 |
| Selley, ML | 1 |
| Labadarios, D | 1 |
| McKenzie, DY | 1 |
| Dickerson, JW | 1 |
| Parke, DV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Blinded, Randomised, Crossover Pilot Study to Investigate the Safety, Tolerability and Pharmacokinetics of Tranilast in Patients With Rheumatoid Arthritis on Methotrexate[NCT00717808] | Phase 1 | 0 participants (Actual) | Interventional | 2008-09-30 | Withdrawn (stopped due to Due to unforeseen circumstances this study will not now start.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for 3-hydroxyanthranilic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
Topics: 3-Hydroxyanthranilic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroida | 2007 |
Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis.
Topics: 3-Hydroxyanthranilic Acid; Arthritis, Rheumatoid; Feeding Behavior; Humans; Kynuramine; Niacinamide; | 1978 |