3-hydroxy-4-methoxybenzaldehyde-thiosemicarbazone has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for 3-hydroxy-4-methoxybenzaldehyde-thiosemicarbazone and Neoplasms
| Article | Year |
|---|---|
Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol-thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated for their antitumor activities. Among them, the most promising compound, 11, showed excellent selective PARP-1 inhibitory activity (IC Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; DNA Breaks, Double-Stranded; Drug Discovery; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Mice; Neoplasms; Phenols; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species; Thiosemicarbazones; Xenograft Model Antitumor Assays | 2019 |