3-hydroxy-4-3--4--5--tetramethoxychalcone has been researched along with Neuroblastoma* in 1 studies
1 other study(ies) available for 3-hydroxy-4-3--4--5--tetramethoxychalcone and Neuroblastoma
| Article | Year |
|---|---|
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
In the chalcone scaffold, it is thought that the double bond is an important structural linker but it is likely not essential for the interaction with tubulin. Yet, it may be a potential site of metabolic degradation and interaction with biological nucleophiles. In this letter, we have replaced this olefinic portion of chalcones with two metabolically stable and chemically inert heterocyclic rings, namely triazole or tetrazole. Yet, our biologic data suggest that, unlike in other antitubulinic structures, the olephinic ring might not be merely a structural linker. Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcones; Humans; Models, Molecular; Neuroblastoma; Tetrazoles; Triazoles; Tubulin; Tubulin Modulators | 2011 |