3-hydroxy-3-methylglutaryl-coenzyme a and Hypercholesterolemia

3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with Hypercholesterolemia in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (42.31)18.2507
2000's5 (19.23)29.6817
2010's6 (23.08)24.3611
2020's4 (15.38)2.80

Authors

AuthorsStudies
Gunasekaran, B; Shukor, MY1
Adorni, MP; Biancorosso, N; Bressan, A; Brilli, E; Chen, H; Dall'Acqua, S; Faggin, E; Ferri, N; Lupo, MG; Neutel, C; Rattazzi, M; Salvalaio, M; Sut, S; Tarantino, G; Vivian, G1
Cerqueira, NMFS; Gesto, DS; Pereira, CMS; Sousa, SF1
Akamo, AJ; Akinloye, OA; Metibemu, DS; Okoye, JO; Omotuyi, IO1
Celeghini, C; Kleiner, G; Loganes, C; Marcuzzi, A1
Ghosh, M; Sengupta, A1
Khokhar, M; Tiwari, V1
Browne, RW; Carrier, B; Harding, SV; Raslawsky, A; Rideout, TC; Wen, S1
Hanaková, Z; Hošek, J; Hřibová, P; Khazneh, E; Kollár, P; Legáth, J; Miłek, M; Muselík, J; Pražanová, G; Šmejkal, K; Suchý, P; Václavík, J1
Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J1
Aragoncillo, P; Cachofeiro, V; Cediel, E; de las Heras, N; Díaz, C; Hernández, G; Lahera, V; Oubiña, MP; Sanz-Rosa, D1
Beg, ZH; Iqbal, J; Minhajuddin, M1
Arai, H; Iizuka, Y; Inaba, T; Ishibashi, S; Isoo, N; Kadowaki, T; Kitamine, T; Nagai, RZ; Ohashi, K; Okazaki, H; Okazaki, M; Okazaki, S; Osuga, J; Sekiya, M; Shibata, N; Shimano, H; Tazoe, F; Tozawa, R; Tsukamoto, K; Yagyu, H; Yahagi, N1
Ma, C; Wang, X; Wei, J1
Himberg, JJ; Jokelainen, K; Laaksonen, R; Sahi, T; Tikkanen, MJ1
Cooper, ME; Gilbert, RE; Jerums, G1
Echevaría-Vázquez, D; Lijnen, P; Petrov, V1
Hahn, C; von Bergmann, K1
Parhofer, KG; Richter, WO; Schwandt, P1
Hidaka, H; Kashiwagi, A; Kawabata, T; Kikkawa, R; Kojima, H; Konaka, K; Nakamura, T; Shigeta, Y1
Asai, Y; Esaki, T; Hayashi, T; Iguchi, A; Jayachandran, M; Kano, H; Sumi, D; Thakur, NK1
Côté, I; Gaudet, M; Grégoire, JP; Leach, A; Moisan, J; Vaillancourt, R1
Mabuchi, H1
Jacobson, TA1
Berkson, DM; Colfer, HT; Cressman, MD; Farmer, JA; Farnham, DJ; Jones, PH; McKenney, JM; Proctor, JD; Wolfson, PM; Wright, JT1
Allan, J; Johnson, BF; LaBelle, P; Ronca, PD; Wilson, J; Zupkis, RV1

Reviews

6 review(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Hypercholesterolemia

ArticleYear
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia.
    Molecules (Basel, Switzerland), 2020, Aug-26, Volume: 25, Issue:17

    Topics: Acyl Coenzyme A; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent; Hypercholesterolemia; Protein Multimerization

2020
Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice.
    Current medicinal chemistry, 2018, Volume: 25, Issue:24

    Topics: Acyl Coenzyme A; Cholesterol; Drug Repositioning; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hypercholesterolemia; Mevalonate Kinase Deficiency; Oxazepines; Phosphotransferases (Alcohol Group Acceptor); Piperidines

2018
Mechanism of action of anti-hypercholesterolemia drugs and their resistance.
    European journal of pharmacology, 2014, Oct-15, Volume: 741

    Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Binding Sites; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Protein Structure, Secondary

2014
Drug therapy of severe hypercholesterolemia in patients with coronary artery disease.
    Artificial organs, 1996, Volume: 20, Issue:4

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol, LDL; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Humans; Hypercholesterolemia; Hypolipidemic Agents; Triglycerides

1996
[Clinical studies on hyperlipidemia].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1999, Sep-10, Volume: 88, Issue:9

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Blood Component Removal; Clinical Trials as Topic; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin

1999
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?.
    Annals of internal medicine, 2000, Oct-03, Volume: 133, Issue:7

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Risk Factors; Simvastatin

2000

Trials

3 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Hypercholesterolemia

ArticleYear
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
    Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:1

    Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Simvastatin; Ubiquinone

1995
Influence of cholesterol-lowering on plasma membrane lipids and function.
    Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18, Issue:2

    Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Apolipoproteins; Blood Platelets; Cell Membrane; Cholesterol; Double-Blind Method; Enzyme Inhibitors; Erythrocytes; Female; Humans; Hypercholesterolemia; Male; Membrane Lipids; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipids; Pravastatin; Sodium-Potassium-Exchanging ATPase; Triglycerides

1996
Once-daily pravastatin in patients with primary hypercholesterolemia: a dose-response study.
    Clinical cardiology, 1991, Volume: 14, Issue:2

    Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Naphthalenes; Placebos; Pravastatin; Time Factors; Triglycerides

1991

Other Studies

17 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Hypercholesterolemia

ArticleYear
HMG-CoA Reductase as Target for Drug Development.
    Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2089

    Topics: Acyl Coenzyme A; Animals; Biological Products; Cholesterol; Drug Development; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Plant Extracts

2020
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
    Nutrients, 2020, Feb-09, Volume: 12, Issue:2

    Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine; Dietary Supplements; Humans; Hypercholesterolemia; Iron; Magnesium; Male; Rats, Sprague-Dawley; Receptors, LDL; Renal Insufficiency, Chronic; Simvastatin; Uremia; Vascular Calcification

2020
In-silico HMG-CoA reductase-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin.
    The Journal of pharmacy and pharmacology, 2021, Sep-07, Volume: 73, Issue:10

    Topics: Acyl Coenzyme A; Anacardiaceae; Animals; Anticholesteremic Agents; Antineoplastic Agents, Phytogenic; beta Carotene; Breast; Breast Neoplasms; Carotenoids; Down-Regulation; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lipids; Molecular Docking Simulation; Phytotherapy; Plant Extracts; Rats, Wistar; Xanthophylls

2021
Protective role of phytosterol esters in combating oxidative hepatocellular injury in hypercholesterolemic rats.
    Pakistan journal of biological sciences : PJBS, 2013, Jan-15, Volume: 16, Issue:2

    Topics: Acyl Coenzyme A; Animals; Antioxidants; Esters; Fatty Acids; Hypercholesterolemia; Lipid Metabolism; Liver; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Mevalonic Acid; Oxidative Stress; Phytosterols; Rats; Rats, Wistar

2013
Complementary Cholesterol-Lowering Response of a Phytosterol/α-Lipoic Acid Combination in Obese Zucker Rats.
    Journal of dietary supplements, 2016, Volume: 13, Issue:3

    Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Antioxidants; Bile Acids and Salts; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Dietary Fats; Dietary Supplements; Drug Synergism; Hypercholesterolemia; Intestinal Absorption; Liver; Male; Obesity; Phytosterols; Proprotein Convertase 9; Rats, Zucker; RNA, Messenger; Serine Endopeptidases; Thioctic Acid

2016
The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.
    Molecules (Basel, Switzerland), 2016, Mar-25, Volume: 21, Issue:4

    Topics: Achillea; Acyl Coenzyme A; Animals; Antioxidants; Cell Line; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Flavonoids; Humans; Hypercholesterolemia; Hyperglycemia; Inflammation; Inflammation Mediators; Mice; Mice, Inbred NOD; Molecular Docking Simulation; Phenols; Plant Extracts; Risk Factors

2016
Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Acyl Coenzyme A; Animals; Benzazepines; Blood Pressure; Cardiovascular Agents; Cholesterol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ivabradine; Lipids; Male; Models, Statistical; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Risk Factors; Simvastatin

2012
Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:6

    Topics: Acyl Coenzyme A; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Arteriosclerosis; Atorvastatin; Blood Pressure; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fibrinolysis; Heptanoic Acids; Hypercholesterolemia; In Vitro Techniques; Inflammation Mediators; Male; Pyrroles; Quinapril; Rabbits; Tetrahydroisoquinolines; Tunica Intima; Vasodilation

2003
Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2003, Volume: 12, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyl Coenzyme A; Administration, Oral; Alkaline Phosphatase; Animals; Antioxidants; Carcinogens; Cell Transformation, Neoplastic; Cholesterol; Female; Glutathione Transferase; Hypercholesterolemia; Liver; Mammary Neoplasms, Animal; Plant Oils; Rats; Rats, Sprague-Dawley; Rice Bran Oil; Tocotrienols

2003
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
    Journal of lipid research, 2006, Volume: 47, Issue:9

    Topics: Acyl Coenzyme A; Adenoviridae; Animals; Apoptosis; Blotting, Western; Body Weight; Cholesterol; Farnesyl-Diphosphate Farnesyltransferase; Hypercholesterolemia; In Situ Nick-End Labeling; Lipid Metabolism; Lipids; Lipoproteins; Lipoproteins, VLDL; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2006
Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 expression of glomerular mesangial cells in hypercholesterolemic rabbits.
    Biomedical research (Tokyo, Japan), 2006, Volume: 27, Issue:4

    Topics: Acyl Coenzyme A; Animals; Cholesterol; Diet, Atherogenic; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Male; Mesangial Cells; Plasminogen Activator Inhibitor 1; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Thromboplastin; Triglycerides

2006
Primary prevention of stroke.
    The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Arteriosclerosis; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Oxidoreductases; Pravastatin; Simvastatin

1996
Relationship between the serum concentration of 7 alpha-hydroxycholesterol and fecal bile acid excretion in humans.
    Scandinavian journal of gastroenterology, 1996, Volume: 31, Issue:8

    Topics: Acyl Coenzyme A; Adolescent; Adult; Aged; Bile Acids and Salts; Child; Child, Preschool; Feces; Female; Fenofibrate; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Hypercholesterolemia; Hypolipidemic Agents; Male; Metabolic Diseases; Middle Aged

1996
Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects.
    Journal of atherosclerosis and thrombosis, 1995, Volume: 2, Issue:1

    Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholestyramine Resin; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Phytosterols; Pravastatin

1995
A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA.
    Biochemical and biophysical research communications, 1999, Jun-07, Volume: 259, Issue:2

    Topics: Acyl Coenzyme A; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol, Dietary; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation, Enzymologic; Hypercholesterolemia; Indoles; Lipids; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rabbits; RNA, Messenger; Superoxide Dismutase; Up-Regulation

1999
Preferred hydroxymethylglutaryl-coenzyme A reductase inhibitors: treatment-modification program and outcomes.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Jul-15, Volume: 56, Issue:14

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Canada; Cost-Benefit Analysis; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Medical Records; Military Personnel; Simvastatin; Treatment Outcome

1999
Effects of lovastatin in diabetic patients treated with chlorpropamide.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:4

    Topics: Acyl Coenzyme A; Administration, Oral; Apolipoproteins B; Blood Glucose; Chlorpropamide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Time Factors

1990