3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with Elevated Cholesterol in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Gunasekaran, B; Shukor, MY | 1 |
| Adorni, MP; Biancorosso, N; Bressan, A; Brilli, E; Chen, H; Dall'Acqua, S; Faggin, E; Ferri, N; Lupo, MG; Neutel, C; Rattazzi, M; Salvalaio, M; Sut, S; Tarantino, G; Vivian, G | 1 |
| Cerqueira, NMFS; Gesto, DS; Pereira, CMS; Sousa, SF | 1 |
| Akamo, AJ; Akinloye, OA; Metibemu, DS; Okoye, JO; Omotuyi, IO | 1 |
| Celeghini, C; Kleiner, G; Loganes, C; Marcuzzi, A | 1 |
| Ghosh, M; Sengupta, A | 1 |
| Khokhar, M; Tiwari, V | 1 |
| Browne, RW; Carrier, B; Harding, SV; Raslawsky, A; Rideout, TC; Wen, S | 1 |
| Hanaková, Z; Hošek, J; Hřibová, P; Khazneh, E; Kollár, P; Legáth, J; Miłek, M; Muselík, J; Pražanová, G; Šmejkal, K; Suchý, P; Václavík, J | 1 |
| Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J | 1 |
| Aragoncillo, P; Cachofeiro, V; Cediel, E; de las Heras, N; Díaz, C; Hernández, G; Lahera, V; Oubiña, MP; Sanz-Rosa, D | 1 |
| Beg, ZH; Iqbal, J; Minhajuddin, M | 1 |
| Arai, H; Iizuka, Y; Inaba, T; Ishibashi, S; Isoo, N; Kadowaki, T; Kitamine, T; Nagai, RZ; Ohashi, K; Okazaki, H; Okazaki, M; Okazaki, S; Osuga, J; Sekiya, M; Shibata, N; Shimano, H; Tazoe, F; Tozawa, R; Tsukamoto, K; Yagyu, H; Yahagi, N | 1 |
| Ma, C; Wang, X; Wei, J | 1 |
| Himberg, JJ; Jokelainen, K; Laaksonen, R; Sahi, T; Tikkanen, MJ | 1 |
| Cooper, ME; Gilbert, RE; Jerums, G | 1 |
| Echevaría-Vázquez, D; Lijnen, P; Petrov, V | 1 |
| Hahn, C; von Bergmann, K | 1 |
| Parhofer, KG; Richter, WO; Schwandt, P | 1 |
| Hidaka, H; Kashiwagi, A; Kawabata, T; Kikkawa, R; Kojima, H; Konaka, K; Nakamura, T; Shigeta, Y | 1 |
| Asai, Y; Esaki, T; Hayashi, T; Iguchi, A; Jayachandran, M; Kano, H; Sumi, D; Thakur, NK | 1 |
| Côté, I; Gaudet, M; Grégoire, JP; Leach, A; Moisan, J; Vaillancourt, R | 1 |
| Mabuchi, H | 1 |
| Jacobson, TA | 1 |
| Berkson, DM; Colfer, HT; Cressman, MD; Farmer, JA; Farnham, DJ; Jones, PH; McKenney, JM; Proctor, JD; Wolfson, PM; Wright, JT | 1 |
| Allan, J; Johnson, BF; LaBelle, P; Ronca, PD; Wilson, J; Zupkis, RV | 1 |
6 review(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Elevated Cholesterol
| Article | Year |
|---|---|
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia.
Topics: Acyl Coenzyme A; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent; Hypercholesterolemia; Protein Multimerization | 2020 |
Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice.
Topics: Acyl Coenzyme A; Cholesterol; Drug Repositioning; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hypercholesterolemia; Mevalonate Kinase Deficiency; Oxazepines; Phosphotransferases (Alcohol Group Acceptor); Piperidines | 2018 |
Mechanism of action of anti-hypercholesterolemia drugs and their resistance.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Binding Sites; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Protein Structure, Secondary | 2014 |
Drug therapy of severe hypercholesterolemia in patients with coronary artery disease.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol, LDL; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Humans; Hypercholesterolemia; Hypolipidemic Agents; Triglycerides | 1996 |
[Clinical studies on hyperlipidemia].
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Blood Component Removal; Clinical Trials as Topic; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin | 1999 |
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Risk Factors; Simvastatin | 2000 |
3 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Elevated Cholesterol
| Article | Year |
|---|---|
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Simvastatin; Ubiquinone | 1995 |
Influence of cholesterol-lowering on plasma membrane lipids and function.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Apolipoproteins; Blood Platelets; Cell Membrane; Cholesterol; Double-Blind Method; Enzyme Inhibitors; Erythrocytes; Female; Humans; Hypercholesterolemia; Male; Membrane Lipids; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipids; Pravastatin; Sodium-Potassium-Exchanging ATPase; Triglycerides | 1996 |
Once-daily pravastatin in patients with primary hypercholesterolemia: a dose-response study.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Naphthalenes; Placebos; Pravastatin; Time Factors; Triglycerides | 1991 |
17 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and Elevated Cholesterol
| Article | Year |
|---|---|
HMG-CoA Reductase as Target for Drug Development.
Topics: Acyl Coenzyme A; Animals; Biological Products; Cholesterol; Drug Development; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Plant Extracts | 2020 |
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine; Dietary Supplements; Humans; Hypercholesterolemia; Iron; Magnesium; Male; Rats, Sprague-Dawley; Receptors, LDL; Renal Insufficiency, Chronic; Simvastatin; Uremia; Vascular Calcification | 2020 |
In-silico HMG-CoA reductase-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin.
Topics: Acyl Coenzyme A; Anacardiaceae; Animals; Anticholesteremic Agents; Antineoplastic Agents, Phytogenic; beta Carotene; Breast; Breast Neoplasms; Carotenoids; Down-Regulation; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lipids; Molecular Docking Simulation; Phytotherapy; Plant Extracts; Rats, Wistar; Xanthophylls | 2021 |
Protective role of phytosterol esters in combating oxidative hepatocellular injury in hypercholesterolemic rats.
Topics: Acyl Coenzyme A; Animals; Antioxidants; Esters; Fatty Acids; Hypercholesterolemia; Lipid Metabolism; Liver; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Mevalonic Acid; Oxidative Stress; Phytosterols; Rats; Rats, Wistar | 2013 |
Complementary Cholesterol-Lowering Response of a Phytosterol/α-Lipoic Acid Combination in Obese Zucker Rats.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Antioxidants; Bile Acids and Salts; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Dietary Fats; Dietary Supplements; Drug Synergism; Hypercholesterolemia; Intestinal Absorption; Liver; Male; Obesity; Phytosterols; Proprotein Convertase 9; Rats, Zucker; RNA, Messenger; Serine Endopeptidases; Thioctic Acid | 2016 |
The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.
Topics: Achillea; Acyl Coenzyme A; Animals; Antioxidants; Cell Line; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Flavonoids; Humans; Hypercholesterolemia; Hyperglycemia; Inflammation; Inflammation Mediators; Mice; Mice, Inbred NOD; Molecular Docking Simulation; Phenols; Plant Extracts; Risk Factors | 2016 |
Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.
Topics: Acyl Coenzyme A; Animals; Benzazepines; Blood Pressure; Cardiovascular Agents; Cholesterol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ivabradine; Lipids; Male; Models, Statistical; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Risk Factors; Simvastatin | 2012 |
Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits.
Topics: Acyl Coenzyme A; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Arteriosclerosis; Atorvastatin; Blood Pressure; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fibrinolysis; Heptanoic Acids; Hypercholesterolemia; In Vitro Techniques; Inflammation Mediators; Male; Pyrroles; Quinapril; Rabbits; Tetrahydroisoquinolines; Tunica Intima; Vasodilation | 2003 |
Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyl Coenzyme A; Administration, Oral; Alkaline Phosphatase; Animals; Antioxidants; Carcinogens; Cell Transformation, Neoplastic; Cholesterol; Female; Glutathione Transferase; Hypercholesterolemia; Liver; Mammary Neoplasms, Animal; Plant Oils; Rats; Rats, Sprague-Dawley; Rice Bran Oil; Tocotrienols | 2003 |
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Topics: Acyl Coenzyme A; Adenoviridae; Animals; Apoptosis; Blotting, Western; Body Weight; Cholesterol; Farnesyl-Diphosphate Farnesyltransferase; Hypercholesterolemia; In Situ Nick-End Labeling; Lipid Metabolism; Lipids; Lipoproteins; Lipoproteins, VLDL; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 expression of glomerular mesangial cells in hypercholesterolemic rabbits.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Diet, Atherogenic; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Male; Mesangial Cells; Plasminogen Activator Inhibitor 1; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Thromboplastin; Triglycerides | 2006 |
Primary prevention of stroke.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Arteriosclerosis; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Oxidoreductases; Pravastatin; Simvastatin | 1996 |
Relationship between the serum concentration of 7 alpha-hydroxycholesterol and fecal bile acid excretion in humans.
Topics: Acyl Coenzyme A; Adolescent; Adult; Aged; Bile Acids and Salts; Child; Child, Preschool; Feces; Female; Fenofibrate; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Hypercholesterolemia; Hypolipidemic Agents; Male; Metabolic Diseases; Middle Aged | 1996 |
Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholestyramine Resin; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Phytosterols; Pravastatin | 1995 |
A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA.
Topics: Acyl Coenzyme A; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol, Dietary; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation, Enzymologic; Hypercholesterolemia; Indoles; Lipids; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rabbits; RNA, Messenger; Superoxide Dismutase; Up-Regulation | 1999 |
Preferred hydroxymethylglutaryl-coenzyme A reductase inhibitors: treatment-modification program and outcomes.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Canada; Cost-Benefit Analysis; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Medical Records; Military Personnel; Simvastatin; Treatment Outcome | 1999 |
Effects of lovastatin in diabetic patients treated with chlorpropamide.
Topics: Acyl Coenzyme A; Administration, Oral; Apolipoproteins B; Blood Glucose; Chlorpropamide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Time Factors | 1990 |