3-deazauridine has been researched along with Leukopenia* in 1 studies
1 other study(ies) available for 3-deazauridine and Leukopenia
Article | Year |
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Phase I trial and pharmacokinetics of a daily x 5 schedule of 3-deazauridine.
The uridine analog 3-deazauridine has been given to 19 patients in a phase I and pharmacokinetic study. Only mild toxicity was seen at doses less than 1200 mg/m2/day for 5 days. At a dose of 1200 mg/m2/day x 5, leukopenia (mean wbc count nadir of 2650/mm3) was seen in nine of 12 patients and thrombocytopenia (mean platelet count nadir of 47,000/mm3) in five of 12 patients. Nausea and vomiting and oral toxicity were each seen in two patients, and diarrhea and skin toxicity occurred in one patient each. Pharmacokinetic studies indicate a biphasic plasma decay with a beta-half-life of 6.9 hours and urinary excretion, mostly of unchanged drug, as the most important route for drug elimination. A dose of 1200 mg/m2/day x 5 is recommended for phase II studies and great caution is advised in administering the drug in the presence of renal impairment. Topics: 3-Deazauridine; Adult; Aged; Child, Preschool; Drug Evaluation; Female; Humans; Kinetics; Leukopenia; Male; Middle Aged; Thrombocytopenia; Uridine | 1982 |