Page last updated: 2024-08-25

3-deazaneplanocin and Disease Models, Animal

3-deazaneplanocin has been researched along with Disease Models, Animal in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's7 (46.67)24.3611
2020's7 (46.67)2.80

Authors

AuthorsStudies
Cheng, L; Hou, C; Xiao, L; Yan, N; Zhao, L; Zheng, S1
Kurata, Y; Mimura, I; Nangaku, M; Tanaka, T; Yamazaki, T1
Liu, N; Ma, X; Qiu, A; Shi, Y; Tao, M; Wang, Y; Zang, X; Zhuang, S1
Pan, YM; Rao, ZQ; Wan, SS; Yang, WJ; Yang, YN1
Liebisch, M; Wolf, G1
Chen, D; Li, H; Li, J; Lu, T; Luo, X; Ma, R; Sun, W; Wen, W; Xu, R1
Ding, C; He, F; Jiang, Y; Jin, L; Wang, H; Wang, J; Wang, L; Xiang, C; Zhang, Y; Zhao, Y; Zhong, F1
Chen, D; Cheng, L; Liu, Y; Wang, Y; Xiao, L; Yan, N; Zhang, J; Zheng, S1
Bayliss, G; Guan, Y; Tolbert, T; Zang, X; Zhao, TC; Zhou, X; Zhuang, S1
Alahmari, B; Choi, J; Cooper, M; DiPersio, JF; Ritchey, J; Ziga, E1
Chung, AY; Hui, KM; Huynh, H; Lam, PY; Lim, KH; Ooi, LL; Sia, KC1
Li, L; Rong, R; Wang, J; Xu, M; Zhu, T1
Alisi, A; Ceccarelli, S; Crudele, A; De Stefanis, C; Gaspari, S; Gnani, D; Locatelli, F; Marquez, VE; Nobili, V; Rota, R; Vella, S1
Chu, DCK; Di Paolo, D; Hardy, T; Leslie, J; Luli, S; Mann, DA; Mann, J; Mendivil, EJ; Moran Salvador, E; Oakley, F; Page, A; Perri, P; Ponzoni, M; Sabater, L; Sharkey, V; Singh, US; Tsukamoto, H; Zeybel, M1
Baker, RO; Bray, M; Geisbert, T; Raymond, JL1

Other Studies

15 other study(ies) available for 3-deazaneplanocin and Disease Models, Animal

ArticleYear
DZNep protects against retinal ganglion cell death in an NMDA-induced mouse model of retinal degeneration.
    Experimental eye research, 2021, Volume: 212

    Topics: Adenosine; Animals; Cell Count; Cell Death; Disease Models, Animal; Electroretinography; Intravitreal Injections; Male; Mice; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells

2021
Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia.
    Physiological reports, 2023, Volume: 11, Issue:17

    Topics: Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Epigenesis, Genetic; Histone Code; Humans; Mice; Tissue Inhibitor of Metalloproteinase-2

2023
Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis.
    The Journal of pathology, 2020, Volume: 250, Issue:1

    Topics: Adenosine; Animals; Apoptosis; Cell Movement; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Peritoneal Fibrosis; Peritoneum; RNA Interference; RNA, Small Interfering; Signal Transduction

2020
Inhibition of EZH2 alleviates angiogenesis in a model of corneal neovascularization by blocking FoxO3a-mediated oxidative stress.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8

    Topics: Adenosine; Animals; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Forkhead Box Protein O3; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transcription, Genetic

2020
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
    American journal of nephrology, 2020, Volume: 51, Issue:9

    Topics: Adenosine; Animals; Cell Line; Diabetic Nephropathies; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glycation End Products, Advanced; Humans; Intracellular Signaling Peptides and Proteins; Mice; Podocytes; RNA, Small Interfering

2020
DZNep attenuates allergic airway inflammation in an ovalbumin-induced murine model.
    Molecular immunology, 2021, Volume: 131

    Topics: Adenosine; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hypersensitivity; Inflammation; Lung; Mice; Mice, Inbred BALB C; Ovalbumin

2021
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
    Theranostics, 2021, Volume: 11, Issue:1

    Topics: Adenosine; Animals; Apoptosis; Benzazepines; Bile Ducts; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Hepatic Stellate Cells; Humans; Indoles; Interleukin-10; Jumonji Domain-Containing Histone Demethylases; Ligation; Liver; Liver Cirrhosis; Mice; Pyridones; Pyrimidines; Rats; RNA Interference

2021
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
    Cell death & disease, 2018, 02-22, Volume: 9, Issue:3

    Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration

2018
Targeting enhancer of zeste homolog 2 protects against acute kidney injury.
    Cell death & disease, 2018, 10-19, Volume: 9, Issue:11

    Topics: Acute Kidney Injury; Adenosine; Adherens Junctions; Animals; Apoptosis; Cadherins; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Folic Acid; Hydrogen Peroxide; Jumonji Domain-Containing Histone Demethylases; Kidney; Kidney Tubules; Lipocalin-2; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Phosphatidylethanolamine Binding Protein; Phosphorylation; Proto-Oncogene Proteins c-raf; Reperfusion Injury; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Zonula Occludens-1 Protein

2018
Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation.
    PloS one, 2018, Volume: 13, Issue:11

    Topics: Adenosine; Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histone Code; Histones; Humans; Indoles; Methylation; Mice; Morpholines; Pyridones; T-Lymphocytes

2018
Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:8

    Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Liver Neoplasms; Mice; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transgenes; Xenograft Model Antitumor Assays

2013
Modulation of allogeneic CD8+ T-cell response by DZNep controls GVHD while preserving hematopoietic chimerism.
    Transplantation, 2013, Nov-15, Volume: 96, Issue:9

    Topics: Adenosine; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Fas Ligand Protein; Female; Graft vs Host Disease; Granzymes; Hematopoietic Stem Cell Transplantation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C3H; T-Lymphocytes, Cytotoxic; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transplantation Chimera; Transplantation Tolerance; Transplantation, Homologous; Tumor Necrosis Factor-alpha

2013
EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
    International journal of molecular sciences, 2013, Dec-12, Volume: 14, Issue:12

    Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Fatty Liver; Hep G2 Cells; Histones; Humans; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Polycomb Repressive Complex 2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2013
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 01-04, Volume: 25, Issue:1

    Topics: Adenosine; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disease Progression; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Hepatic Stellate Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Liver Cirrhosis; Male; Mice; Myofibroblasts

2017
3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice.
    Antiviral research, 2002, Volume: 55, Issue:1

    Topics: Adenosine; Animals; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Immunohistochemistry; Interferon-alpha; Liver; Mice; Mice, Inbred BALB C; Viremia

2002