Compounds > 3-carbamoyl-2-2-5-5-tetramethyl-3-pyrroline-1-yloxyl

3-carbamoyl-2-2-5-5-tetramethyl-3-pyrroline-1-yloxyl and Epilepsy

3-carbamoyl-2-2-5-5-tetramethyl-3-pyrroline-1-yloxyl has been researched along with Epilepsy* in 1 studies

Other Studies

1 other study(ies) available for 3-carbamoyl-2-2-5-5-tetramethyl-3-pyrroline-1-yloxyl and Epilepsy

Article	Year
Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance. Neuroscience letters, 1996, Mar-01, Volume: 205, Issue:3 In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitroxide radicals in the iron-injected regions at the subacute stage of epileptogenesis was prolonged. The Japanese herbal medicine, sho-saiko-to-go-keishi-ka- shakuyakuto (TJ-960), a compound known to have free radical scavenging activity, inhibited the delay of nitroxide radical decay in the rat cerebrum with an iron-induced epileptic focus following injection of carbamoyl-PROXYL. TJ-960 did not affect the decay of nitroxide radicals in the control rats' brain. These data show that TJ-960 has the scavenging activity for free radicals generated within an iron-induced epileptogenic regions of rat brain. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain; Cyclic N-Oxides; Disease Models, Animal; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Epilepsy; Free Radicals; Iron; Male; Rats; Rats, Wistar; Spin Labels	1996

Article

Year

Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance.

Neuroscience letters, 1996, Mar-01, Volume: 205, Issue:3

In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitroxide radicals in the iron-injected regions at the subacute stage of epileptogenesis was prolonged. The Japanese herbal medicine, sho-saiko-to-go-keishi-ka- shakuyakuto (TJ-960), a compound known to have free radical scavenging activity, inhibited the delay of nitroxide radical decay in the rat cerebrum with an iron-induced epileptic focus following injection of carbamoyl-PROXYL. TJ-960 did not affect the decay of nitroxide radicals in the control rats' brain. These data show that TJ-960 has the scavenging activity for free radicals generated within an iron-induced epileptogenic regions of rat brain.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain; Cyclic N-Oxides; Disease Models, Animal; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Epilepsy; Free Radicals; Iron; Male; Rats; Rats, Wistar; Spin Labels

1996