3-azabicyclo(3.1.0)hexane and Pruritus

3-azabicyclo(3.1.0)hexane has been researched along with Pruritus* in 1 studies

Other Studies

1 other study(ies) available for 3-azabicyclo(3.1.0)hexane and Pruritus

Article	Year
SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the μ receptor over δ and κ subtypes. Some subtleties of functional activity will also be described. Topics: Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Guinea Pigs; Hexanes; Humans; In Vitro Techniques; Kinetics; Ligands; Pruritus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2012

Article

Year

SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands.

Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6

3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the μ receptor over δ and κ subtypes. Some subtleties of functional activity will also be described.

Topics: Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Guinea Pigs; Hexanes; Humans; In Vitro Techniques; Kinetics; Ligands; Pruritus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2012