Page last updated: 2024-10-15

3-aminopropionaldehyde and Brain Ischemia

3-aminopropionaldehyde has been researched along with Brain Ischemia in 5 studies

3-aminopropionaldehyde: structure given in first source
3-aminopropanal : A propanal having an amino substituent at the 3-position

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process."9.14A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010)
"The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process."5.14A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010)
"In ongoing studies of the neuroprotective properties of monoamine oxidase inhibitors, we found that phenelzine provided robust neuroprotection in the gerbil model of transient forebrain ischemia, with drug administration delayed up to 3 h post reperfusion."3.73Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. ( Baker, G; Khan, MA; Moskal, JR; Tanay, VA; Todd, KG; Wood, PL, 2006)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, GH1
Kellner, CP1
Hickman, ZL1
Zacharia, BE1
Starke, RM1
Hwang, BY1
Ducruet, AF1
Fernandez, L1
Mayer, SA1
Tracey, KJ4
Connolly, ES2
Li, W1
Yuan, XM1
Ivanova, S3
Eaton, JW3
Brunk, UT1
Wood, PL1
Khan, MA1
Moskal, JR1
Todd, KG1
Tanay, VA1
Baker, G1
Botchkina, GI1
Al-Abed, Y2
Meistrell, M1
Batliwalla, F2
Dubinsky, JM1
Iadecola, C1
Wang, H1
Gregersen, PK2
Mocco, J1
Kiss, S1
Huang, J1
Mack, W1
Coon, A1
Shohami, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731]Phase 260 participants (Actual)Interventional2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for 3-aminopropionaldehyde and Brain Ischemia

ArticleYear
A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage.
    Neurosurgery, 2010, Volume: 67, Issue:1

    Topics: Adult; Aged; Aldehydes; Brain Ischemia; Cohort Studies; Female; Humans; Male; Middle Aged; Neuroprot

2010

Other Studies

4 other studies available for 3-aminopropionaldehyde and Brain Ischemia

ArticleYear
3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin.
    The Biochemical journal, 2003, Apr-15, Volume: 371, Issue:Pt 2

    Topics: Acridine Orange; Aldehydes; Astrocytoma; Brain Ischemia; Cell Survival; Humans; Lysosomes; Neurotoxi

2003
Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine.
    Brain research, 2006, Nov-29, Volume: 1122, Issue:1

    Topics: Acrolein; Aldehydes; Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Gerbil

2006
Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death.
    The Journal of experimental medicine, 1998, Jul-20, Volume: 188, Issue:2

    Topics: Aldehydes; Animals; Brain Ischemia; Cell Death; Cell Line; Magnetic Resonance Spectroscopy; Neurogli

1998
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Apr-16, Volume: 99, Issue:8

    Topics: Aldehydes; Animals; Antioxidants; Brain; Brain Ischemia; Cell Line; Cells, Cultured; Disease Models,

2002