3-aminopropionaldehyde has been researched along with Brain Ischemia in 5 studies
3-aminopropionaldehyde: structure given in first source
3-aminopropanal : A propanal having an amino substituent at the 3-position
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process." | 9.14 | A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010) |
| "The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process." | 5.14 | A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010) |
| "In ongoing studies of the neuroprotective properties of monoamine oxidase inhibitors, we found that phenelzine provided robust neuroprotection in the gerbil model of transient forebrain ischemia, with drug administration delayed up to 3 h post reperfusion." | 3.73 | Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. ( Baker, G; Khan, MA; Moskal, JR; Tanay, VA; Todd, KG; Wood, PL, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, GH | 1 |
| Kellner, CP | 1 |
| Hickman, ZL | 1 |
| Zacharia, BE | 1 |
| Starke, RM | 1 |
| Hwang, BY | 1 |
| Ducruet, AF | 1 |
| Fernandez, L | 1 |
| Mayer, SA | 1 |
| Tracey, KJ | 4 |
| Connolly, ES | 2 |
| Li, W | 1 |
| Yuan, XM | 1 |
| Ivanova, S | 3 |
| Eaton, JW | 3 |
| Brunk, UT | 1 |
| Wood, PL | 1 |
| Khan, MA | 1 |
| Moskal, JR | 1 |
| Todd, KG | 1 |
| Tanay, VA | 1 |
| Baker, G | 1 |
| Botchkina, GI | 1 |
| Al-Abed, Y | 2 |
| Meistrell, M | 1 |
| Batliwalla, F | 2 |
| Dubinsky, JM | 1 |
| Iadecola, C | 1 |
| Wang, H | 1 |
| Gregersen, PK | 2 |
| Mocco, J | 1 |
| Kiss, S | 1 |
| Huang, J | 1 |
| Mack, W | 1 |
| Coon, A | 1 |
| Shohami, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 3-aminopropionaldehyde and Brain Ischemia
| Article | Year |
|---|---|
A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aldehydes; Brain Ischemia; Cohort Studies; Female; Humans; Male; Middle Aged; Neuroprot | 2010 |
4 other studies available for 3-aminopropionaldehyde and Brain Ischemia
| Article | Year |
|---|---|
3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin.
Topics: Acridine Orange; Aldehydes; Astrocytoma; Brain Ischemia; Cell Survival; Humans; Lysosomes; Neurotoxi | 2003 |
Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine.
Topics: Acrolein; Aldehydes; Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Gerbil | 2006 |
Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death.
Topics: Aldehydes; Animals; Brain Ischemia; Cell Death; Cell Line; Magnetic Resonance Spectroscopy; Neurogli | 1998 |
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal.
Topics: Aldehydes; Animals; Antioxidants; Brain; Brain Ischemia; Cell Line; Cells, Cultured; Disease Models, | 2002 |