3-aminobenzamide has been researched along with Injury, Ischemia-Reperfusion in 32 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of 3-aminobenzamide, an inhibitor of poly(adenosine diphosphate-ribose) polymerase (PARP), on the long-term histologic damage in testicular ischemia-reperfusion injury." | 3.72 | Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury. ( Acar, D; Akbay, E; Aktaş, S; Bozlu, M; Cayan, S; Coşkun, B; Ulusoy, E, 2004) |
| " The apparent median terminal half-life (t(1/2)) of INO-1001 was 7." | 2.74 | A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary perc ( Baran, K; Brickman, CM; Dauerman, H; Grip, L; Krakover, R; Kumar, S; McCabe, CH; Morrow, DA; Murphy, SA; Salzman, AL; Slomowitz, N, 2009) |
| "Lung malondialdehyde (MDA) levels were significantly depressed in ischaemic and ONOO(-) preconditioning groups." | 1.33 | Preconditioning effects of peroxynitrite in the rat lung. ( Demiryürek, AT; Turan, NN, 2006) |
| "After 60 min of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or INO-1001 (1 mg/kg), a potent PARP inhibitor (n = 6)." | 1.32 | INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. ( Bährle, S; Cziráki, A; Flechtenmacher, C; Gries, A; Hagl, S; Heger, U; Mandera, S; Seres, L; Soós, P; Szabó, C; Szabó, G; Vahl, CF; Zsengellér, Z, 2004) |
| "However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage." | 1.31 | Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 24 (75.00) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tas Hekimoglu, A | 1 |
| Toprak, G | 1 |
| Akkoc, H | 1 |
| Evliyaoglu, O | 1 |
| Tas, T | 1 |
| Kelle, I | 1 |
| Colpan, L | 1 |
| Zhao, H | 1 |
| Ning, J | 1 |
| Lemaire, A | 1 |
| Koumpa, FS | 1 |
| Sun, JJ | 1 |
| Fung, A | 1 |
| Gu, J | 1 |
| Yi, B | 1 |
| Lu, K | 1 |
| Ma, D | 1 |
| Oztas, E | 1 |
| Guven, A | 1 |
| Turk, E | 1 |
| Uysal, B | 1 |
| Akgul, EO | 1 |
| Cayci, T | 1 |
| Ersoz, N | 1 |
| Korkmaz, A | 1 |
| Hekimoglu, A | 1 |
| Kurcer, Z | 1 |
| Aral, F | 1 |
| Baba, F | 1 |
| Atessahin, A | 1 |
| Sakin, F | 1 |
| Strosznajder, RP | 1 |
| Gadamski, R | 2 |
| Czapski, GA | 1 |
| Jesko, H | 1 |
| Strosznajder, JB | 1 |
| Bozlu, M | 2 |
| Eskandari, G | 1 |
| Cayan, S | 2 |
| Canpolat, B | 1 |
| Akbay, E | 2 |
| Atik, U | 1 |
| Fiorillo, C | 1 |
| Ponziani, V | 1 |
| Giannini, L | 1 |
| Cecchi, C | 1 |
| Celli, A | 1 |
| Nediani, C | 1 |
| Perna, AM | 1 |
| Liguori, P | 1 |
| Nassi, N | 1 |
| Formigli, L | 1 |
| Tani, A | 1 |
| Nassi, P | 1 |
| Gupta, S | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Coşkun, B | 1 |
| Acar, D | 1 |
| Aktaş, S | 1 |
| Ulusoy, E | 1 |
| Koksel, O | 1 |
| Yildirim, C | 1 |
| Cinel, L | 1 |
| Tamer, L | 1 |
| Ozdulger, A | 1 |
| Bastürk, M | 1 |
| Degirmenci, U | 1 |
| Kanik, A | 1 |
| Cinel, I | 1 |
| Strosznajder, R | 2 |
| Walski, M | 1 |
| Nagata, H | 1 |
| Horiguchi, T | 1 |
| Enzan, K | 1 |
| Nishikawa, T | 1 |
| Suzuki, K | 1 |
| Yeh, CH | 1 |
| Chen, TP | 1 |
| Lee, CH | 1 |
| Wu, YC | 1 |
| Lin, YM | 1 |
| Jing Lin, P | 1 |
| Gajkowska, B | 1 |
| Turan, NN | 1 |
| Demiryürek, AT | 1 |
| Aalto, TK | 1 |
| Raivio, KO | 1 |
| Thiemermann, C | 2 |
| Bowes, J | 1 |
| Myint, FP | 1 |
| Vane, JR | 1 |
| Lam, TT | 2 |
| Cuzzocrea, S | 2 |
| Zingarelli, B | 1 |
| Costantino, G | 1 |
| Szabó, A | 1 |
| Salzman, AL | 2 |
| Caputi, AP | 1 |
| Szabó, C | 6 |
| Sun, AY | 1 |
| Cheng, JS | 1 |
| Kokura, S | 1 |
| Wolf, RE | 1 |
| Yoshikawa, T | 1 |
| Ichikawa, H | 1 |
| Granger, DN | 1 |
| Aw, TY | 1 |
| Chatterjee, PK | 1 |
| Zacharowski, K | 1 |
| Otto, M | 1 |
| Ducrocq, S | 1 |
| Benjelloun, N | 1 |
| Plotkine, M | 1 |
| Ben-Ari, Y | 1 |
| Charriaut-Marlangue, C | 1 |
| Chiang, SK | 1 |
| Martin, DR | 1 |
| Lewington, AJ | 1 |
| Hammerman, MR | 1 |
| Padanilam, BJ | 1 |
| Tabuchi, K | 1 |
| Ito, Z | 1 |
| Tsuji, S | 1 |
| Nakagawa, A | 1 |
| Serizawa, F | 1 |
| Hara, A | 1 |
| Kusakari, J | 1 |
| Liaudet, L | 1 |
| Timashpolsky, L | 1 |
| Virág, L | 1 |
| Cziráki, A | 2 |
| Morrow, DA | 1 |
| Brickman, CM | 1 |
| Murphy, SA | 1 |
| Baran, K | 1 |
| Krakover, R | 1 |
| Dauerman, H | 1 |
| Kumar, S | 1 |
| Slomowitz, N | 1 |
| Grip, L | 1 |
| McCabe, CH | 1 |
| Murthy, KG | 1 |
| Xiao, CY | 1 |
| Mabley, JG | 1 |
| Chen, M | 1 |
| Szabó, G | 1 |
| Soós, P | 1 |
| Mandera, S | 1 |
| Heger, U | 1 |
| Flechtenmacher, C | 1 |
| Bährle, S | 1 |
| Seres, L | 1 |
| Gries, A | 1 |
| Zsengellér, Z | 1 |
| Vahl, CF | 1 |
| Hagl, S | 1 |
| Woolley, SM | 1 |
| Farivar, AS | 1 |
| Naidu, BV | 1 |
| Salzman, A | 1 |
| Thomas, R | 1 |
| Fraga, C | 1 |
| Mulligan, MS | 1 |
| Hauser, B | 1 |
| Gröger, M | 1 |
| Ehrmann, U | 1 |
| Albicini, M | 1 |
| Brückner, UB | 1 |
| Schelzig, H | 1 |
| Venkatesh, B | 1 |
| Li, H | 1 |
| Speit, G | 1 |
| Radermacher, P | 1 |
| Kick, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Randomized, Placebo-Controlled, Single-Blind, Multi-Center Dose-Escalation Study to Evaluate Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of a Single Intravenous Administration of INO-1001 in Subjects With ST-Elevation Myocardia[NCT00271765] | Phase 2 | 40 participants | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 3-aminobenzamide and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary perc
Topics: Angioplasty, Balloon, Coronary; Dose-Response Relationship, Drug; Electrocardiography; Female; Half- | 2009 |
31 other studies available for 3-aminobenzamide and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in rats.
Topics: Animals; Aryldialkylphosphatase; Benzamides; Kidney Diseases; Liver; Liver Diseases; Male; Malondial | 2014 |
Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats.
Topics: Acute Lung Injury; Animals; Benzamides; Cells, Cultured; Culture Media, Conditioned; Cyclosporine; D | 2015 |
3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.
Topics: Animals; Benzamides; Blood Chemical Analysis; Blood Urea Nitrogen; Creatinine; Disease Models, Anima | 2009 |
Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition?
Topics: Animals; Benzamides; Catalase; Enzyme Inhibitors; Glutathione; Glutathione Peroxidase; Male; Poly(AD | 2010 |
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.
Topics: Animals; Benzamides; Cell Death; DNA Damage; Drug Administration Schedule; Edema; Excitatory Amino A | 2003 |
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
Topics: 1-Naphthylamine; Animals; Benzamides; Isoquinolines; Male; Naphthalimides; Niacinamide; Poly(ADP-rib | 2003 |
Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzamides; Blotting, Western; Caspase 3; Caspases; Cell | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury.
Topics: Animals; Benzamides; Biopsy; Dimethyl Sulfoxide; Disease Models, Animal; Humans; Male; Poly(ADP-ribo | 2004 |
Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.
Topics: Animals; Benzamides; Cell Membrane; Enzyme Inhibitors; Female; Hindlimb; Lipid Peroxidation; Lung; L | 2005 |
Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury.
Topics: Animals; Astrocytes; Benzamides; Enzyme Activation; Enzyme Inhibitors; Gerbillinae; Glial Fibrillary | 2005 |
Inhibition of poly (ADP-ribose) synthetase improves pulmonary arterial endothelium-dependent relaxation after ischemic-reperfusion injury of splanchnic artery in rats.
Topics: Acetylcholine; Animals; Benzamides; Calcimycin; Endothelium, Vascular; Enzyme Inhibitors; Male; Mese | 2005 |
Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass.
Topics: Aminobenzoates; Animals; Apoptosis; Benzamides; Cardioplegic Solutions; Cardiopulmonary Bypass; Enzy | 2006 |
Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study.
Topics: Animals; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Benzamides; Disease Models, Animal; | 2006 |
Preconditioning effects of peroxynitrite in the rat lung.
Topics: Animals; Benzamides; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning; Lung; Male; M | 2006 |
Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants and 3-aminobenzamide.
Topics: Adenine Nucleotides; Antioxidants; Benzamides; Catalase; Cells, Cultured; Endothelium, Vascular; Glu | 1993 |
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
Topics: Animals; Benzamides; Enzyme Inhibitors; Male; Muscle, Skeletal; Myocardial Infarction; Myocardium; N | 1997 |
The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina.
Topics: Animals; Apoptosis; Benzamides; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationshi | 1997 |
Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Benzamides; Blood Pressure; Cell Membrane Permeability; Enzyme Activation; Enzyme Inhibitor | 1997 |
Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.
Topics: ADP Ribose Transferases; Animals; Benzamides; Brain; Enzyme Inhibitors; Ischemic Attack, Transient; | 1998 |
Endothelial cells exposed to anoxia/reoxygenation are hyperadhesive to T-lymphocytes: kinetics and molecular mechanisms.
Topics: Antibodies, Monoclonal; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cell Hypoxia; Cells, Cul | 2000 |
Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.
Topics: Anesthesia; Animals; Benzamides; Creatinine; Enzyme Inhibitors; Glomerular Filtration Rate; Isoquino | 2000 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis | 2000 |
Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage.
Topics: Animals; Benzamides; Blotting, Western; Enzyme Inhibitors; Immunohistochemistry; Injections; Male; P | 2000 |
Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.
Topics: Adenosine Triphosphate; Animals; Benzamides; Blotting, Western; DNA Repair; Enzyme Inhibitors; Immun | 2000 |
Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia.
Topics: Action Potentials; Analysis of Variance; Animals; Auditory Threshold; Benzamides; Blood Flow Velocit | 2001 |
Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.
Topics: Animals; Benzamides; Creatine Kinase; Disease Models, Animal; Enzyme Activation; Heart; Hemodynamics | 2001 |
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Topics: Animals; Blotting, Western; Cell Line, Tumor; DNA; DNA Damage; Enzyme Activation; Enzyme Inhibitors; | 2004 |
INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation.
Topics: Acetylcholine; Adenosine Diphosphate Ribose; Animals; Disease Models, Animal; Dogs; Enzyme Inhibitor | 2004 |
Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury.
Topics: Animals; Indoles; Male; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; | 2004 |
The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion.
Topics: Animals; Aorta, Thoracic; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; DNA Damage; | 2006 |