3-aminobenzamide has been researched along with Down Syndrome in 2 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lymphocytes from normal and Down syndrome (DS) subjects were examined to determine the effect of 3-aminobenzamide (3AB) on X-ray-induced chromosome aberrations." | 7.67 | The effect of 3-aminobenzamide on X-ray induction of chromosome aberrations in Down syndrome lymphocytes. ( Au, WW; Legator, MS; MacLaren, RA, 1989) |
| "Human lymphocytes from normal and Down syndrome (DS) subjects were examined to determine the effect of 3-aminobenzamide (3AB) on X-ray-induced chromosome aberrations." | 3.67 | The effect of 3-aminobenzamide on X-ray induction of chromosome aberrations in Down syndrome lymphocytes. ( Au, WW; Legator, MS; MacLaren, RA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caria, H | 1 |
| Quintas, A | 1 |
| Chaveca, T | 1 |
| Rueff, J | 1 |
| MacLaren, RA | 1 |
| Au, WW | 1 |
| Legator, MS | 1 |
2 other studies available for 3-aminobenzamide and Down Syndrome
| Article | Year |
|---|---|
The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells.
Topics: Benzamides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Down Syndrome; Enzyme Inh | 1997 |
The effect of 3-aminobenzamide on X-ray induction of chromosome aberrations in Down syndrome lymphocytes.
Topics: Benzamides; Chromosome Aberrations; Chromosomes, Human; Down Syndrome; Humans; In Vitro Techniques; | 1989 |