3-aminobenzamide has been researched along with Cerebral Ischemia in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors examined whether genetic deletion of PARP (PARP null mice) or its pharmacologic inhibition by 3-aminobenzamide (3-AB) attenuates tissue injury after transient cerebral ischemia." | 3.69 | Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. ( Endres, M; Moskowitz, MA; Namura, S; Waeber, C; Wang, ZQ, 1997) |
| "After permanent focal cerebral ischemia, intravenous rt-PA application significantly increased early postischemic PARP-1 activation within ischemic hemispheres and infarct volumes compared with control mice without affecting cerebral blood flow." | 1.34 | Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. ( Bähr, M; Crome, O; Doeppner, TR; Müller, B; Schwarting, S; Weise, J, 2007) |
| " The specific PARP inhibitor 3-aminobenzamide was injected 10 min before induction of ischemia at a dosage of 5, 10, and 20 mg/kg intracerebroventricularly." | 1.31 | The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. ( Bardenheuer, HJ; Kopitz, J; Martin, E; Plaschke, K; Weigand, MA, 2000) |
| "However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage." | 1.31 | Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 11 (91.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madinier, A | 1 |
| Bertrand, N | 1 |
| Mossiat, C | 1 |
| Prigent-Tessier, A | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Garnier, P | 1 |
| Joly, LM | 1 |
| Benjelloun, N | 2 |
| Plotkine, M | 3 |
| Charriaut-Marlangue, C | 3 |
| Gupta, S | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Hatip-Al-Khatib, I | 1 |
| Iwasaki, K | 1 |
| Chung, EH | 1 |
| Egashira, N | 1 |
| Mishima, K | 1 |
| Fujiwara, M | 1 |
| Koh, SH | 2 |
| Park, Y | 1 |
| Song, CW | 1 |
| Kim, JG | 1 |
| Kim, K | 1 |
| Kim, J | 2 |
| Kim, MH | 2 |
| Lee, SR | 1 |
| Kim, DW | 2 |
| Yu, HJ | 1 |
| Chang, DI | 2 |
| Hwang, SJ | 1 |
| Kim, SH | 2 |
| Strosznajder, RP | 1 |
| Walski, M | 1 |
| Kim, HT | 1 |
| Kim, KS | 1 |
| Bae, I | 1 |
| Kim, H | 1 |
| Crome, O | 1 |
| Doeppner, TR | 1 |
| Schwarting, S | 1 |
| Müller, B | 1 |
| Bähr, M | 1 |
| Weise, J | 1 |
| Endres, M | 1 |
| Wang, ZQ | 1 |
| Namura, S | 1 |
| Waeber, C | 1 |
| Moskowitz, MA | 1 |
| Plaschke, K | 1 |
| Kopitz, J | 1 |
| Weigand, MA | 1 |
| Martin, E | 1 |
| Bardenheuer, HJ | 1 |
| Ducrocq, S | 1 |
| Ben-Ari, Y | 1 |
| Boulu, RG | 1 |
| Mesenge, C | 1 |
| Verrecchia, C | 1 |
1 review available for 3-aminobenzamide and Cerebral Ischemia
| Article | Year |
|---|---|
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase].
Topics: Animals; Apoptosis; Benzamides; Brain Ischemia; Disease Models, Animal; DNA Damage; Gene Deletion; H | 2001 |
11 other studies available for 3-aminobenzamide and Cerebral Ischemia
| Article | Year |
|---|---|
Microglial involvement in neuroplastic changes following focal brain ischemia in rats.
Topics: Animals; Antigens, Nuclear; Benzamides; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic | 2009 |
Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Disease Models, Animal; Female; M | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.
Topics: Animals; Apoptosis; Benzamides; Brain Ischemia; Caspase 1; Caspase 3; Caspase Inhibitors; Dose-Respo | 2004 |
The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.
Topics: Animals; Benzamides; Blotting, Western; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Caspas | 2004 |
Effects 3-aminobenzamide on ultrastructure of hippocampal CA1 layer after global ischemia in gerbils.
Topics: Animals; Benzamides; Brain Ischemia; Gerbillinae; Hippocampus; Neuroglia; Neurons; Poly Adenosine Di | 2004 |
Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.
Topics: Animals; Benzamides; Brain; Brain Ischemia; Disease Models, Animal; Matrix Metalloproteinase 9; NF-k | 2005 |
Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.
Topics: Animals; Benzamides; Blood Gas Analysis; Blood Pressure; Blood-Brain Barrier; Brain; Brain Infarctio | 2007 |
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Topics: Animals; Benzamides; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebral Infarction; DNA Damage; | 1997 |
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
Topics: Animals; Arterial Occlusive Diseases; Benzamides; Brain Ischemia; Carotid Artery, Common; Cerebral C | 2000 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis | 2000 |