3-aminobenzamide has been researched along with Brain Ischemia in 12 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors examined whether genetic deletion of PARP (PARP null mice) or its pharmacologic inhibition by 3-aminobenzamide (3-AB) attenuates tissue injury after transient cerebral ischemia." | 3.69 | Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. ( Endres, M; Moskowitz, MA; Namura, S; Waeber, C; Wang, ZQ, 1997) |
| "After permanent focal cerebral ischemia, intravenous rt-PA application significantly increased early postischemic PARP-1 activation within ischemic hemispheres and infarct volumes compared with control mice without affecting cerebral blood flow." | 1.34 | Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo. ( Bähr, M; Crome, O; Doeppner, TR; Müller, B; Schwarting, S; Weise, J, 2007) |
| " The specific PARP inhibitor 3-aminobenzamide was injected 10 min before induction of ischemia at a dosage of 5, 10, and 20 mg/kg intracerebroventricularly." | 1.31 | The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. ( Bardenheuer, HJ; Kopitz, J; Martin, E; Plaschke, K; Weigand, MA, 2000) |
| "However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage." | 1.31 | Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 11 (91.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madinier, A | 1 |
| Bertrand, N | 1 |
| Mossiat, C | 1 |
| Prigent-Tessier, A | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Garnier, P | 1 |
| Joly, LM | 1 |
| Benjelloun, N | 2 |
| Plotkine, M | 3 |
| Charriaut-Marlangue, C | 3 |
| Gupta, S | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Hatip-Al-Khatib, I | 1 |
| Iwasaki, K | 1 |
| Chung, EH | 1 |
| Egashira, N | 1 |
| Mishima, K | 1 |
| Fujiwara, M | 1 |
| Koh, SH | 2 |
| Park, Y | 1 |
| Song, CW | 1 |
| Kim, JG | 1 |
| Kim, K | 1 |
| Kim, J | 2 |
| Kim, MH | 2 |
| Lee, SR | 1 |
| Kim, DW | 2 |
| Yu, HJ | 1 |
| Chang, DI | 2 |
| Hwang, SJ | 1 |
| Kim, SH | 2 |
| Strosznajder, RP | 1 |
| Walski, M | 1 |
| Kim, HT | 1 |
| Kim, KS | 1 |
| Bae, I | 1 |
| Kim, H | 1 |
| Crome, O | 1 |
| Doeppner, TR | 1 |
| Schwarting, S | 1 |
| Müller, B | 1 |
| Bähr, M | 1 |
| Weise, J | 1 |
| Endres, M | 1 |
| Wang, ZQ | 1 |
| Namura, S | 1 |
| Waeber, C | 1 |
| Moskowitz, MA | 1 |
| Plaschke, K | 1 |
| Kopitz, J | 1 |
| Weigand, MA | 1 |
| Martin, E | 1 |
| Bardenheuer, HJ | 1 |
| Ducrocq, S | 1 |
| Ben-Ari, Y | 1 |
| Boulu, RG | 1 |
| Mesenge, C | 1 |
| Verrecchia, C | 1 |
1 review available for 3-aminobenzamide and Brain Ischemia
| Article | Year |
|---|---|
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase].
Topics: Animals; Apoptosis; Benzamides; Brain Ischemia; Disease Models, Animal; DNA Damage; Gene Deletion; H | 2001 |
11 other studies available for 3-aminobenzamide and Brain Ischemia
| Article | Year |
|---|---|
Microglial involvement in neuroplastic changes following focal brain ischemia in rats.
Topics: Animals; Antigens, Nuclear; Benzamides; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic | 2009 |
Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Disease Models, Animal; Female; M | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.
Topics: Animals; Apoptosis; Benzamides; Brain Ischemia; Caspase 1; Caspase 3; Caspase Inhibitors; Dose-Respo | 2004 |
The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.
Topics: Animals; Benzamides; Blotting, Western; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Caspas | 2004 |
Effects 3-aminobenzamide on ultrastructure of hippocampal CA1 layer after global ischemia in gerbils.
Topics: Animals; Benzamides; Brain Ischemia; Gerbillinae; Hippocampus; Neuroglia; Neurons; Poly Adenosine Di | 2004 |
Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.
Topics: Animals; Benzamides; Brain; Brain Ischemia; Disease Models, Animal; Matrix Metalloproteinase 9; NF-k | 2005 |
Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.
Topics: Animals; Benzamides; Blood Gas Analysis; Blood Pressure; Blood-Brain Barrier; Brain; Brain Infarctio | 2007 |
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Topics: Animals; Benzamides; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebral Infarction; DNA Damage; | 1997 |
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
Topics: Animals; Arterial Occlusive Diseases; Benzamides; Brain Ischemia; Carotid Artery, Common; Cerebral C | 2000 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis | 2000 |