3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile and Cognitive-Dysfunction

The serotonin system has been implicated in the pathophysiology of anorexia nervosa (AN). A recent report proposed that body image distortion (BID), a core symptom of AN, may relate to abnormalities of the serotonin system, especially the serotonin transporter (5HTT). Positron emission tomography (PET) studies of underweight patients with active AN reported alterations in serotonin receptors, but not 5HTT. Here, we aimed to disclose the clinicopathophysiology of AN by focusing on 5HTT and cognitive functions, including BID, in groups with active AN. Twenty-two underweight female patients with AN (12 restricting-type AN (ANR); 10 binge-eating/purging-type AN (ANBP)) and 20 age-matched healthy female subjects underwent PET with a 5HTT radioligand [

Topics: Adolescent; Adult; Aniline Compounds; Anorexia Nervosa; Body Dysmorphic Disorders; Cognitive Dysfunction; Female; Humans; Positron-Emission Tomography; Serotonin Plasma Membrane Transport Proteins; Sulfides; Young Adult