3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile and Autistic-Disorder

The oxytocin (OT)-related serotonergic system is thought to play an important role in the etiology and social symptoms of autism spectrum disorder (ASD). However, no evidence exists for the relation between the prosocial effect of chronic OT administration and the brain serotonergic system. Ten male subjects with ASD were administered OT for 8-10 weeks in an open-label, single-arm, non-randomized, uncontrolled manner. Before and during the OT treatment, positron emission tomography was used with the (

Topics: Adult; Aniline Compounds; Autistic Disorder; Brain; Emotions; Facial Recognition; Humans; Male; Oxytocin; Pilot Projects; Positron-Emission Tomography; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sulfides; Young Adult