Compounds > 3-amino-1-methyl-5h-pyrido(4-3-b)indole

3-amino-1-methyl-5h-pyrido(4-3-b)indole and Liver-Neoplasms

3-amino-1-methyl-5h-pyrido(4-3-b)indole has been researched along with Liver-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 3-amino-1-methyl-5h-pyrido(4-3-b)indole and Liver-Neoplasms

Article	Year
Inhibition of DNA adduct formation and mutagenic action of 3-amino-1-methyl-5h-pyrido[4,3-b]indole by chlorophyllin-chitosan in rpsL transgenic mice. Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:8 We have studied the inhibitory effect of chlorophyllin-chitosan (Chl-Chi) complex, an insoluble form of chlorophyllin, on the DNA adduct formation and mutagenesis by a heterocyclic food mutagen-carcinogen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), in mice carrying the E. coli rpsL gene as a mutagenesis reporter. Upon administration of a diet containing 0.002% or 0.01% Trp-P-2, DNA adducts were formed in various tissues in a dose-dependent manner, with the maximum level observed in the liver. Addition of 3% Chl-Chi to the diet reduced the Trp-P-2 adduct by up to 90%. The rpsL mutant frequencies increased significantly in both the liver and spleen upon administration of a 0.01% Trp-P-2 diet. Addition of Chl-Chi to the diet decreased these induced mutant frequencies to the background level. No harmful effect of Chl-Chi was detected during these experiments. The results show that Chl-Chi may be a candidate chemopreventive agent against the genotoxic action of Trp-P-2, and possibly also other aromatic carcinogens in the diet. Topics: Animals; Carbolines; Carcinoma, Hepatocellular; Chitin; Chitosan; Chlorophyllides; Chromatography, Thin Layer; Diet; DNA Adducts; Dose-Response Relationship, Drug; Drug Combinations; Escherichia coli Proteins; Gene Frequency; Liver Neoplasms; Mice; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutagens; Ribosomal Protein S9; Ribosomal Proteins	2001
Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan. Cancer letters, 1981, Volume: 13, Issue:1 The carcinogenic activity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan, was studied in inbred strain ACI rats. Twenty rats received a diet containing 0.01% Trp-P-2 for 870 days. Nineteen rats survived for more than 400 days after the start of feeding, 1 rat developed a hemangioendothelial sarcoma of the liver, and 6 rats developed neoplastic liver nodules. These liver tumors were found only in female rats that died 666--870 days after the start of feeding. No liver tumors were found in control animals. Topics: Animals; Carbolines; Carcinogens; Female; Indoles; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred ACI	1981

Article

Year

Inhibition of DNA adduct formation and mutagenic action of 3-amino-1-methyl-5h-pyrido[4,3-b]indole by chlorophyllin-chitosan in rpsL transgenic mice.

Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:8

We have studied the inhibitory effect of chlorophyllin-chitosan (Chl-Chi) complex, an insoluble form of chlorophyllin, on the DNA adduct formation and mutagenesis by a heterocyclic food mutagen-carcinogen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), in mice carrying the E. coli rpsL gene as a mutagenesis reporter. Upon administration of a diet containing 0.002% or 0.01% Trp-P-2, DNA adducts were formed in various tissues in a dose-dependent manner, with the maximum level observed in the liver. Addition of 3% Chl-Chi to the diet reduced the Trp-P-2 adduct by up to 90%. The rpsL mutant frequencies increased significantly in both the liver and spleen upon administration of a 0.01% Trp-P-2 diet. Addition of Chl-Chi to the diet decreased these induced mutant frequencies to the background level. No harmful effect of Chl-Chi was detected during these experiments. The results show that Chl-Chi may be a candidate chemopreventive agent against the genotoxic action of Trp-P-2, and possibly also other aromatic carcinogens in the diet.

Topics: Animals; Carbolines; Carcinoma, Hepatocellular; Chitin; Chitosan; Chlorophyllides; Chromatography, Thin Layer; Diet; DNA Adducts; Dose-Response Relationship, Drug; Drug Combinations; Escherichia coli Proteins; Gene Frequency; Liver Neoplasms; Mice; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutagens; Ribosomal Protein S9; Ribosomal Proteins

2001

Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan.

Cancer letters, 1981, Volume: 13, Issue:1

The carcinogenic activity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan, was studied in inbred strain ACI rats. Twenty rats received a diet containing 0.01% Trp-P-2 for 870 days. Nineteen rats survived for more than 400 days after the start of feeding, 1 rat developed a hemangioendothelial sarcoma of the liver, and 6 rats developed neoplastic liver nodules. These liver tumors were found only in female rats that died 666--870 days after the start of feeding. No liver tumors were found in control animals.

Topics: Animals; Carbolines; Carcinogens; Female; Indoles; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred ACI

1981