Compounds > 3-amino-1-methyl-5h-pyrido(4-3-b)indole

3-amino-1-methyl-5h-pyrido(4-3-b)indole and Hepatitis--Chronic

3-amino-1-methyl-5h-pyrido(4-3-b)indole has been researched along with Hepatitis--Chronic* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-1-methyl-5h-pyrido(4-3-b)indole and Hepatitis--Chronic

Article	Year
Metabolic activation of hepatocarcinogens in chronic hepatitis B. Mutation research, 1985, Volume: 144, Issue:3 S9 fraction pools of liver biopsy samples, collected from 129 patients in two consecutive studies, were comparatively assayed for their ability to activate aflatoxin B1 (AFB1) and a tryptophan pyrolysate product (Trp-P-2) in a miniaturized Salmonella mutagenicity test system. Metabolic activation was not affected to a significant extent by most of the monitored variability factors, such as sex, alcohol, cigarette smoking and liver histology (minimal changes, chronic persistent (CPH) or active (CAH) hepatitis, CAH steatosis, or cirrhosis). Conversely, a significant enhancement of activation was observed for AFB1 in cases of mild CAH and especially for Trp-P-2 in hepatitis B virus carriers, irrespective of their histologic diagnosis. Topics: Aflatoxin B1; Aflatoxins; Biotransformation; Carbolines; Carcinogens; Hepatitis B; Hepatitis, Chronic; Humans; Liver; Mutagenicity Tests; Salmonella typhimurium	1985

Article

Year

Metabolic activation of hepatocarcinogens in chronic hepatitis B.

Mutation research, 1985, Volume: 144, Issue:3

S9 fraction pools of liver biopsy samples, collected from 129 patients in two consecutive studies, were comparatively assayed for their ability to activate aflatoxin B1 (AFB1) and a tryptophan pyrolysate product (Trp-P-2) in a miniaturized Salmonella mutagenicity test system. Metabolic activation was not affected to a significant extent by most of the monitored variability factors, such as sex, alcohol, cigarette smoking and liver histology (minimal changes, chronic persistent (CPH) or active (CAH) hepatitis, CAH steatosis, or cirrhosis). Conversely, a significant enhancement of activation was observed for AFB1 in cases of mild CAH and especially for Trp-P-2 in hepatitis B virus carriers, irrespective of their histologic diagnosis.

Topics: Aflatoxin B1; Aflatoxins; Biotransformation; Carbolines; Carcinogens; Hepatitis B; Hepatitis, Chronic; Humans; Liver; Mutagenicity Tests; Salmonella typhimurium

1985